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283 results on '"Muià Carmelo"'

2. Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury

Author

Crimi Nunzio, Sortino Mariangela, Muià Carmelo, Gili Elisa, Mazzon Emanuela, Genovese Tiziana, Failla Marco, Caputi Achille P, Cuzzocrea Salvatore, and Vancheri Carlo

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Leukotrienes are increased locally in idiopathic pulmonary fibrosis. Furthermore, a role for these arachidonic acid metabolites has been thoroughly characterized in the animal bleomycin model of lung fibrosis by using different gene knock-out settings. We investigated the efficacy of pharmacological inhibition of leukotrienes activity in the development of bleomycin-induced lung injury by comparing the responses in wild-type mice with mice treated with zileuton, a 5-lipoxygenase inhibitor and MK-571, a cys-leukotrienes receptor antagonist. Mice were subjected to intra-tracheal administration of bleomycin or saline and were assigned to receive either MK-571 at 1 mg/Kg or zileuton at 50 mg/Kg daily. One week after bleomycin administration, BAL cell counts, lung histology with van Gieson for collagen staining and immunohistochemical analysis for myeloperoxidase, IL-1 and TNF-α were performed. Following bleomycin administration both MK-571 and zileuton treated mice exhibited a reduced degree of lung damage and inflammation when compared to WT mice as shown by the reduction of:(i) loss of body weight, (ii) mortality rate, (iii) lung infiltration by neutrophils (myeloperoxidase activity, BAL total and differential cell counts), (iv) lung edema, (v) histological evidence of lung injury and collagen deposition, (vi) lung myeloperoxidase, IL-1 and TNF-α staining. This is the first study showing that the pharmacological inhibition of leukotrienes activity attenuates bleomycin-induced lung injury in mice. Given our results as well as those coming from genetic studies, it might be considered meaningful to trial this drug class in the treatment of pulmonary fibrosis, a disease that still represents a major challenge to medical treatment.

Published
2006
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3. Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice

Author

Suzuki Hisanory, Zaffini Raffaela, Menegazzi Marta, Genovese Tiziana, Muià Carmelo, Mazzon Emanuela, Di Paola Rosanna, and Cuzzocrea Salvatore

Subjects
green tea extract, carrageenan-induced pleurisy, neutrophils infiltration, lung injury, Diseases of the respiratory system, RC705-779
Abstract

Abstract Here we investigate the effects of the green tea extract in an animal model of acute inflammation, carrageenan-induced pleurisy. We report here that green tea extract (given at 25 mg/kg i.p. bolus 1 h prior to carrageenan), exerts potent anti-inflammatory effects in an animal model of acute inflammation in vivo. Injection of carrageenan (2%) into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained many neutrophils (PMNs), an infiltration of PMNs in lung tissues and increased production of nitrite/nitrate, tumour necrosis factor alpha. All parameters of inflammation were attenuated by green tea extract treatment. Furthermore, carrageenan induced an up-regulation of the adhesion molecule ICAM-1, as well as nitrotyrosine and poly (ADP-ribose) synthetase (PARS) formation, as determined by immunohistochemical analysis of lung tissues. Staining for the ICAM-1, nitrotyrosine, and PARS was reduced by green tea extract. Our results clearly demonstrate that treatment with green tea extract exerts a protective effect and offers a novel therapeutic approach for the management of lung injury.

Published
2005
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4. Retraction notice to “Glycogen synthase kinase-3β inhibition attenuates the degree of arthritis caused by type II collagen in the mouse” [Clin. Immunol. 120/1 (2006) 57–67]

Author

Cuzzocrea, Salvatore, primary, Mazzon, Emanuela, additional, Di Paola, Rosanna, additional, Muià, Carmelo, additional, Crisafulli, Concetta, additional, Dugo, Laura, additional, Collin, Marika, additional, Britti, Domenico, additional, Caputi, Achille P., additional, and Thiemermann, Christoph, additional

Published
2024
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38. TNF-α BLOCKAGE IN A MOUSE MODEL OF SCI

Author

Genovese, Tiziana, primary, Mazzon, Emanuela, additional, Crisafulli, Concetta, additional, Di Paola, Rosanna, additional, Muià, Carmelo, additional, Esposito, Emanuela, additional, Bramanti, Placido, additional, and Cuzzocrea, Salvatore, additional

Published
2008
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46. Protective effect of Hypericum perforatum in zymosan-induced multiple organ dysfunction syndrome: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity

Author

Paola, Rosanna Di, primary, Mazzon, Emanuela, additional, Muià, Carmelo, additional, Crisafulli, Concetta, additional, Genovese, Tiziana, additional, Bella, Paolo Di, additional, Esposito, Emanuela, additional, Menegazzi, Marta, additional, Meli, Rosaria, additional, Suzuki, Hisanori, additional, and Cuzzocrea, Salvatore, additional

Published
2007
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49. 5‐aminoisoquinolin‐1(2H)‐one, a water‐soluble poly (ADP‐ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats

Author

Di Paola, Rosanna, primary, Mazzon, Emanuela, additional, Muià, Carmelo, additional, Terrana, Dino, additional, Greco, Salvatore, additional, Britti, Domenico, additional, Santori, Domenico, additional, Oteri, Giacomo, additional, Cordasco, Giancarlo, additional, and Cuzzocrea, Salvatore, additional

Published
2006
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