Search

Objective: In this study, the epidemiology, clinical features, and diagnosis of paediatric asthma in a Pakistani hospital were examined. Methods: Between January 2018 and January 2019, a cross-sectional study was carried out in the paediatrics department of the LRH hospital in Peshawar. The research gathered information on the epidemiology, clinical traits, and diagnosis of paediatric asthma. To analyze the data, descriptive statistics were used. Results: The results of the study showed that the prevalence of asthma in the study population was 54%. The most common clinical symptoms reported by the children were wheezing (62.7%), coughing (58.2%), and shortness of breath (50%). The most common diagnosis of pediatric asthma was based on clinical symptoms (77.5%), followed by spirometry (17.5%) and laboratory tests (5%). Conclusion: The findings of this study suggest that asthma is a significant health concern among the pediatric population in Pakistan.

To examine the prevalence and pattern of hypoxic-ischemic encephalopathy (HIE) in pediatric patients This retrospective, cross-sectional study was conducted in the Department of Pediatrics LRH Peshawar from Jan 2020 to July 2020 and included 50 pediatric patients newly born to 16 years old with HIE. All patients had MRIs. HIE, damage pattern, and affected regions were evaluated on the MRI. The overall prevalence of HIE was 28%. Mild to moderate HIE was the most prevalent pattern, accounting for 19% of the cases. The most common pattern of injury was global (14%), followed by focal (12%) and multifocal (2%). The most affected areas were the basal ganglia, thalamus, and cortical white matter. The results showed that HIE was 28%, with the majority of cases being moderate to mild. The most common pattern of injury was global, followed by focal and multifocal.

To assess the prevalence and treatment of malaria in children hospitalized in district hospitals in Pakistan. This study was conducted in Department of Pediatrics MMC hospital Mardan from Jan 2019 to Jan 2020. Data was collected from 100 patients aged 7 to 14 years who were admitted in district hospitals. All patients had their blood samples checked for malarial parasites and a detailed history was taken. The results were then analyzed by SPSS. The study showed that the prevalence of malaria was 10%, with fever being the most common symptom reported. The most commonly prescribed drugs were quinine, chloroquine, artesunate, and mefloquine. This study demonstrated that malaria is a public health issue in Pakistan and that prompt diagnosis and appropriate treatment are essential for successful control of the disease.

Objective: To determine the frequency of hypothyroidism in patients with pulmonary hypertension. Study Design: Observational Cross-sectional study. Setting: Department of Medicine, Sandeman Provincial Hospital, Bolan University of Medical & Health Sciences Quetta Pakistan. Period: March 2020 to March 2021. Material & Methods: Pulmonary Hypertension was defined as mPASP of >25 mm Hg at rest on transthoracic echocardiogram and hypothyroidism was labeled when TSH was high with low Free T4 and/or Free T3. Patients with congestive cardiac failure, pulmonary malignancy or pulmonary metastasis assessed by history and examination were excluded from the study. Using non-probability consecutive sampling, 186 patients of both genders, aged 20-65 years with pulmonary hypertension were included. Demographic information along with clinical variables noted, echocardiography was done and thyroid profile was sent for each patient. Results: Mean age was 41.2+11.2 years with 56 (30.1%) males and 130 (69.9%) females. The mean height, weight and BMI were 1.6+0.2 meters, 56.5+14.4 kilograms and 21.8+3.6 kg/m2 respectively. The mean mPASP was 40.2+7.1 mmHg. The mean serum TSH, free T3 and free T4 levels were 6.6+4.8 IU/L, 2.5+1.0 pmol/L and 1.1+0.4 pmol/L respectively. In our study, hypothyroidism was seen in 46 (24.7%) and was not significantly associated with age, gender, BMI or mPASP. Conclusion: Hypothyroidism was noted in about a quarter of the patients with pulmonary hypertension in this study.

Granulomatosis with polyangiitis (GPA) is an uncommon pauci-immune small-vessel necrotising granulomatous vasculitis mostly seen in age 45–60 years. We present the case of a formerly healthy 44 years old male presenting with dysuria and intermittent urinary retention for 8 months, not responding to empirical antibiotic therapy and TURP. A prostate biopsy showed necrotising granulomatous prostatitis. Urinalysis demonstrated persistent pyuria and haematuria, but cultures showed no growth. Subsequently he complained of fever, cough, dyspnoea and skin ulcers. CT of the chest showed multiple cavitatory lesions and pleural effusion. On work up, c-ANCA was positive and a diagnosis of granulomatosis with polyangiitis was established. This depicts a rarely seen presentation of prostatitis as the initial feature of GPA.

Objective: To determine frequency of hyponatremia in liver cirrhosis patients presenting with hepatic encephalopathy. Study Design: Descriptive Cross-sectional study. Setting: Department of Medicine, Sandeman Provincial Hospital, Bolan University of Medical and Health Sciences Quetta. Period: June 2020 to December 2020. Material & Methods: Cirrhosis was characterised on Ultrasound abdomen with altered liver parenchyma, shrunken liver and coarse echo texture. HE was defined as a spectrum of neuropsychiatric abnormalities diagnosed clinically with adequate history taking and physical examination. After taking informed consent from the patients’ attendants, 172 patients of liver cirrhosis presenting with HE were enrolled. Detailed clinical history and examination along with investigations were done. Hyponatremia was defined as serum sodium level 3 days was seen in 47 (27.3%) while 125 (72.7%) had stay of >3 days. It was observed that 14 (8.1%) patients expired. Hyponatremia was found in 69 (40.1%). Conclusion: Hyponatremia was a common feature in liver cirrhosis patients presenting with hepatic encephalopathy. Furthermore a significant association of hyponatremia was seen with hospital stay and all-cause mortality.

Background: Neonatal encephalopathy is a diverse and clinically well-known syndrome. The objectives of this study were to determine the prevalence and determinants of hypoxic-ischemic encephalopathy (HIE) in perinatal asphyxia population of District Mardan, Pakistan. Materials & Methods: This cross-sectional study was conducted in Department of Pediatrics, Bacha Khan Medical College, Mardan, Pakistan from 1st January 2017 to 30th June 2017. 160 term neonates with perinatal asphyxia were included. Sex, age groups, gestational age, mode of delivery, weight groups and presence of HIE were variables. Presence of HIE was dependent while five demographic variables were independent variables respectively for five chi-square tests of association. Results: Mean age of sample of 160 infants was 2.537±1.26 (1-7, range 6) days, mean gestational age was 38.681±1.24 weeks and mean weight 3.275±0.36 kg. Out of 160 infants with perinatal asphyxia, 16 (8.16%, 95%CI 7.35-13.46) had HIE (HIE). These positive 16 cases included 11 (6.88%) boys & 5 (3.12%) girls, 15 (9.38%) of 1-3 & one (0.62%) of 4-7 days, 14 (8.75%) of gestational age 37-39 & two (1.25%) of >39 weeks, 15 (9.38%) with vaginal delivery & one (0.62%) with C-section and 14 (8.75%) of ≤3 & two (1.25%) of >3 kg weight groups. There was association between presence of HIE and weight groups, but not with sex, age groups, gestational age and mode of delivery. Conclusion: We found 10% prevalence of HIE in perinatal asphyxia population of District Mardan, Pakistan. The prevalence was higher in boys than girls, in age group 1-3 days than 4-7 days, in gestational age ≤37-39 than >39 weeks, in vaginal than C-section delivery and in weight group ≤3 kg than >3 kg group. There was association between presence of HIE and weight groups, but not with sex, age groups, gestational age and mode of delivery.

Single Cell Omics (SCO) is an evolving field in biomedical research which offers prime application in neurosciences. The human nervous system is complex and shows variability in cell types. It includes neurons (functional components), glial cells (supporting cells), astrocytes (provide nourishment), oligodendrocytes (synthesize myelin sheath), and microglia (defense mechanism). To understand the functional and disease states of the nervous system, it is essential to investigate them at the single-cell level. It has been estimated that every 1 in 9 people is affected by mental or neurological disorders, including psychological disorders (generally referred to as mental disorders), psychotic disorders (involving psychosis), and neurological disorders (involving neurological factors), globally. These disorders have multifactorial etiology and are caused by genetic and environmental factors. Every disorder has distinct pathophysiology affecting multiple brain regions. SCO has excellent potential to provide insight regarding the diagnosis, pathophysiology, and treatment of neurological disorders. The stringent well directed SCO methods enhance the understanding of complex nervous system disorders, such as meningitis, stroke, schizophrenia, Parkinson’s disease, and Alzheimer’s disease, which paves the way for future research.

Background: Chronic Subdural Hematoma (C.S.D.H.) is familiar with the collection of blood on the brain's surface, and in everyday neurological practices, it is the most ordinary clinical entity. This leads to the commendatory prognosis of infection. Surgical therapy is linked with numerous complications because of patients' medical problems and advanced generations. C.S.D.H. is commonly not being out symptoms, but it requisite surgical approaches when it occurs. C.S.D.H. has very well diagnosis and treatment approaches that are most effective, but some essential factors that lead to this disease are still unknown. This study is to know about the surgical outcome. Method: Out of 80 C.S.D.H. Patients between 60 to 70 years were selected.50 male and 30 female C.S.D.H. patients were treated with one burr hole and catheter drainage. The study was conducted at the neurosurgery unit of MartbaChuhan Medical College and Mardan Medical Complex from April 2018 to March 2021. A total of 80 patients were included in this study. Burhhole and Cather Drainage were performed for all patients. These patients were reviewed after 2, 5, and 6 weeks at O.P.D. Results: Mostly the patients, 94% show a good recovery, and 4% represent no recovery. However, only 2% show the complications against this approach. As for the burr hole and catheter drainage, there was a remarkable reduction of the C.S.D.H. However, 5% of the sample patients show the repetition of Hematoma after the 1 week of operation. In contrast, 2% suffered from some operative complications. Conclusion: Burr hole and Catheter drainage is an affected way of treatment for the patients suffering from C.D.S.H.

Objective: The study was conducted on the incidence of meconium aspiration syndrome which is still high in the developing world and contributing significantly to the neonatal mortality. The study was aimed to know the risk factors contributing to meconium aspiration syndrome and neonatal outcome in a tertiary hospital (Punjab) Department of pediatric Medicine PAK Emirates Military hospital Rawalpindi in the Pakistan. Materials and Methods: It was a hospital based cross sectional study This descriptive case series was carried at Department of Peadiatric Medicine PAK Emirates Military hospital Rawalpindi in the Pakistan over a period of one year, from Jan 2019 to Dec 2020, involving 2820 patients; All live newborns born through meconium-stained liquor were enrolled and all the details regarding the mother and neonate were recorded. Odd’s ratio and bivariate analysis was done to assess the risk factors for meconium aspiration syndrome. Results: Out of all the deliveries 12.4% were born through meconium-stained amniotic fluid and meconium aspiration syndrome developed in 5 .6% of the neonates. Low Apgar score and premature rupture of membranes was significantly associated with the risk of occurrence of meconium aspiration syndrome. Neonates who developed meconium aspiration syndrome had mortality of 6.7% Conclusion: The Perinatal asphyxia and premature rupture of membranes were significantly associated with the development of meconium aspiration syndrome and neonates who developed meconium aspiration syndrome had high mortality.

Purpose: To study serum electrolyte derangements among children with acute diarrhea presenting with dehydration. Methodology: Cross-sectional and descriptive study in department of Pediatrics, MMC Hospital, Mardan (Pakistan) for from 01-02-2020 to 31-10-2020. A total of 390 children having acute diarrhea with dehydration were included. Five milliliters (5mls) of blood was drawn and estimation of serum Sodium and potassium levels were done. Findings: In 390 cases, 218 (55.9%) were males while 1 72 (44.1%) were females. The mean age was 2.5±1.5 years. Out of 390 cases, 2(0.51%) had no dehydration, some dehydration was noted in 218 (55.9%) cases while 170 (43.59%) cases had severe dehydration. Hypernatremia was noted in 218 (55.9%) cases and hypokalemia was noted in 77(19.74%) cases. Conclusion: High rate of hyponatremia and hypokalemia was seen in our study in children with acute diarrhea and dehydration. Hyponatremia and hypokalemia was significantly associated with age, gender and grades of dehydration.

Energy is the bridge connecting the economy and the environment and electric energy is an important guarantee for social production. In order to respond to the national dual-carbon goals, a new power system is being constructed. Effective carbon emission forecasts of power energy are essential to achieve a significant guarantee for low carbon and clean production of electric power energy. We analyzed the influencing factors of carbon emissions, such as population, per capita gross domestic product (GDP), urbanization rate, industrial structure, energy consumption, energy structure, regional electrification rate, and degree of opening to the outside world. The original Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model was improved, and the above influencing factors were incorporated into the model for modeling analysis. The ridge regression algorithm was adopted to analyze the biased estimation of historical data. The carbon emission prediction model of Shanghai electric power and energy based on elastic relationship was established. According to the “14th Five-Year” development plan for the Shanghai area, we set up the impact factor forecast under different scenarios to substitute into the forecast models. The new model can effectively assess the carbon emissions of the power sector in Shanghai in the future.

Background: Urinary tract infections (UTIs), which impact 8% of girls and 2% of boys by age seven and have a repeat rate of 10% to 30%, are common in infants and young children. Infantile colic is a very difficult condition for parents to manage. Objective: To discover the prevalence of uti among patients who appear with neonatal distress Material And Methods: 126 male and female painful babies participated in the research. Khyber Teaching Hospital's paediatrics division, Peshawar. Duration: from January 1, 2020, to August 1, 2019, inclusive. Each infant had two clear middle pee samples collected two hours apart to be tested for UTIs. The UTI was considered positive if the child had a history of temperature >99 °F, dysuria, and more than five WBC per HPF or >10 4 CFU/HPF on pee culture. Results: Children in this research ranged in age from 6 weeks to 6 months, with a mean age, weight, and height of 3.1501.42 months, 4.9790.82 kg, and 56.6503.08 cm, respectively. Men made up the overwhelming bulk of the cases. (69.8 per cent). 61.1 per cent of mothers breastfed their babies, while 38.9 per cent used bottles to nurse them. The prevalence of urinary tract infections among individuals was 8.7%. Conclusion: The frequency of UTI among babies who appear with diarrhoea is 8.7%, it can be inferred. This research emphasises the value of early newborn UTI detection and therapy and the requirement for preventative steps to lower the risk of UTI in this group. Keywords: frequency, Infantile colic, urinary tract infection

The study determines the prevalence and resistance among pathogenic bacteria against used antibiotics. The isolates were identified biochemically and subjected to antibiotic sensitivity using disk-diffusion method. A total of 210 bacterial isolates were tested, 175 (83.3%) were reported positive whereas 35 (16.6%) were found negative for HVS. The isolates were initially identified on colonies morphology and later via biochemical tests. The gram positive bacteria isolates i,e Staphylococcus aureus was found 48 (23.3%), followed by lactobacillus and least value belonged to Staphylococcus epidermidis i.e, 7 (3.3%). While gram negative bacteria Escherichia coli were 56 (26.6%), followed by Pseudomonas aeruginosa 36 (17.14%) and least value was of Proteus vulgaris. i.e, 7 (3.3%). All the isolates were subjected to antibiotics susceptibility testing. At least six antibiotics were shown to be resistant in bacterial isolates. Antibiotic resistance was found in considerable abundance in the clinical isolates, according to the findings. Antibiotic susceptibility testing and surveillance are essential on a regular basis to avoid treatment failure and the emergence of antibiotic resistance.

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease causing morbidity and mortality in all population worldwide. It is present in 1 to 2 % in world's population Objective: To determine the frequency of RA in young females presenting with multiple joints pain using ACR Diagnostic Criteria for RA. Methodology: This study was Descriptive Cross-Sectional Study done at the Department of Medicine, Hayatabad Medical Complex, Peshawar for duration of six months from February 2021 to August 2021. In this study a total of 156 patients were observed to assess the frequency of rheumatoid arthritis in young females with multiple joints pain using ACR Diagnostic Criteria. Results: Serology of RF and ACPA among 156 patients was positive in 93(59.6%) patients and Negative in 63(40.4). Acute phase reactants CRP and ESR among 156 patients were abnormal in 91(58.3%) and Normal in 65(41.7%) patients Conclusion: Our study concludes that in young females with multiple joints pain, the frequency of rheumatoid arthritis was high by using ACR diagnostic criteria. Young females are prone to develop rheumatoid arthritis but remain undiagnosed and this may lead to adverse outcome and failure in prognosis and treatment. If it is diagnosed in early stage it may add to good health outcome and quality of life. Key words: Rheumatoid arthritis; multiple joints pain, ACR Diagnostic Criteria

Forecasting academic performance of student has been a substantial research inquest in the Educational Data-Mining that utilizes Machine-learning (ML) procedures to probe the data of educational setups. Quantifying student academic performance is challenging because academic performance of students hinges on several factors. The in hand research work focuses on students’ grade and marks prediction utilizing supervised ML approaches. The data-set utilized in this research work has been obtained from the Board of Intermediate & Secondary Education (B.I.S.E) Peshawar, Khyber Pakhtunkhwa. There are 7 areas in BISEP i.e., Peshawar, FR-Peshawar, Charsadda, Khyber, Mohmand and Upper and Lower Chitral. This paper aims to examine the quality of education that is closely related to the aims of sustainability. The system has created an abundance of data which needs to be properly analyzed so that most useful information should be obtained for planning and future development. Grade and marks forecasting of students with their historical educational record is a renowned and valuable application in the EDM. It becomes an incredible information source that could be utilized in various ways to enhance the standard of education nationwide. Relevant research study reveals that numerous methods for academic performance forecasting are built to carryout improvements in administrative and teaching staff of academic organizations. In the put forwarded approach, the acquired data-set is pre-processed to purify the data quality, the labeled academic historical data of student (30 optimum attributes) is utilized to train regression model and DT-classifier. The regression will forecast marks, while grade will be forecasted by classification system, eventually analyzed the results obtained by the models. The results obtained show that machine learning technology is efficient and relevant for predicting students performance.

BACKGROUND Dengue is a vector-borne disease endemic to Pakistan as well as to Khyber Pakhtunkhwa. A total of 300 confirmed cases of dengue were reported in District Khyber in 2019, where a prompt response was initiated by the Disease Surveillance and Response Unit. Subsequently, a study was planned to identify the risk factors associated with dengue and to propose recommendations for containment of the disease. OBJECTIVE This study aimed to assess the risk factors associated with dengue in District Khyber and to provide recommendations for improving the existing system and preventing dengue. METHODS A case-control study was conducted in District Khyber from September 2 to November 24, 2019. Cases were enrolled from health care facilities based on predefined criteria, which included the presence of clinical signs and symptoms as well as laboratory confirmation of dengue NS1 antigen. Controls were enrolled from the community at a case-control ratio of 1:2. Data were collected using a pretested questionnaire in face-to-face interviews. RESULTS A total of 300 cases were enrolled; 87% (263) of cases were men. This study found that 45% (269/601; odds ratio [OR] 15, 95% CI 9.9-24.07; PPPPP CONCLUSIONS Dengue is a preventable disease and can be controlled by the proper use of bed nets and mosquito repellents, modification of sleeping habits, and improvement in family structure. Dengue management training for health care personnel and community awareness are recommended.