1. The effect of oral anticoagulants on the incidence of dementia in patients with atrial fibrillation: A systematic review and meta-analysis
- Author
-
Fakhar Latif, Muhammad Moiz Nasir, Komail K. Meer, Syed Husain Farhan, Huzaifa Ahmad Cheema, Adam Bilal Khan, Mohammad Umer, Wajeeh Ur Rehman, Adeel Ahmad, Muhammad Aslam Khan, Talal Almas, Sebastian Mactaggart, Abdulqadir J. Nashwan, Raheel Ahmed, and Sourbha S. Dani
- Subjects
Anticoagulants ,DOACs ,Dementia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Dementia is a recognized complication of atrial fibrillation (AF). Oral anticoagulant (OAC) therapy can potentially be protective against this complication. Methods: A comprehensive search of MEDLINE and Embase for comparative observational studies reporting the efficacy of OAC therapy for the incidence of dementia in patients with AF was conducted from its inception until March 2023. Studies that had patients with prior use of OAC or with a previous history of dementia were excluded. Results: A total of 22 studies were included in this review involving 617,204 participants. The pooled analysis revealed that OAC therapy, including direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs), was associated with a reduced incidence of dementia in AF patients. Specifically, compared to non-OAC treatment, OACs demonstrated a significant reduction in dementia incidence (HR 0.68, 95 % CI [0.58, 0.80], p
- Published
- 2024
- Full Text
- View/download PDF