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114 results on '"Muench, Alexandria"'

2. Types of insomnia

Author

Perlis, Michael, primary, Gehrman, Phil, additional, Muench, Alexandria, additional, and Posner, Donn, additional

Published
2023
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5. Acute sleep deprivation and the selective consolidation of emotional memories.

Author

Vargas, Ivan, Payne, Jessica D, Muench, Alexandria, Kuhlman, Kate R, and Lopez-Duran, Nestor L

Subjects
Medical and Health Sciences, Biological Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Research suggests that sleep preferentially consolidates the negative aspects of memories at the expense of the neutral aspects. However, the mechanisms by which sleep facilitates this emotional memory trade-off remain unknown. Although active processes associated with sleep-dependent memory consolidation have been proposed to underlie this effect, this trade-off may also be modulated by non-sleep-related processes, such as the circadian factors, stress-related factors, and/or mood congruent context effects involved in sleep deprivation. We sought to examine the potential role of these factors by randomizing 39 young adults into either a total sleep deprivation condition (26 consecutive hours awake) or a sleep condition (8 h sleep opportunity). Replicating the emotional memory trade-off effect, negative objects were better remembered than neutral objects or background images. However, in spite of generally worse memory performance (for neutral and background information), sleep-deprived participants showed similar recognition rates for negative emotional memories relative to participants who were given a full night of sleep.

Published
2019

6. Comparative short‐term safety and efficacy of hypnotics: A quantitative risk–benefit analysis.

Author

Cheung, Janet M. Y., Scott, Hannah, Muench, Alexandria, Grunstein, Ronald R., Krystal, Andrew D., Riemann, Dieter, and Perlis, Michael

Subjects
SLEEP duration, SLEEP latency, RISK assessment, ANTIHISTAMINES, BENZODIAZEPINE receptors, H2 receptor antagonists, OREXINS
Abstract

Summary: Several professional societies have provided recommendations for prescribing medications for insomnia. None has provided an integrative analysis that concurrently quantifies safety and efficacy (e.g., risk–benefit ratios). This represents an important gap for informing clinician decision‐making. Accordingly, the aim of the present review is to provide such an analysis for five classes of sleep‐promoting medications. Adverse event data values were extracted from the most recent FDA‐approved package inserts and converted to an integer before being placebo‐adjusted and standardized as a rate per 1000 (AEr). Efficacy data, pre‐to‐post self‐reported data for active and placebo conditions were acquired from pivotal trials identified in "white papers" and systematic reviews/meta‐analyses. Weighted effect sizes were calculated for subjective sleep latency, wake time after sleep onset and total sleep time, and then were averaged by medication class for each sleep continuity variable. Overall efficacy was represented by a single variable, SWT (sleep latency + wake time after sleep onset + total sleep time). Risk–benefit was represented using a simple ratio value. For safety, it was found that melatonin receptor agonists had the lowest adverse event rate (AEr = 43.1), and non‐benzodiazepine benzodiazepine receptor agonists had the highest rate (AEr = 255.0). For efficacy, it was found that the pre‐to‐post placebo adjusted effect sizes were largest for benzodiazepines (effect size = 1.94) and smallest for melatonin receptor agonists (effect size = 0.109). For risk–benefit, histamine antagonist had the most favourable profile (risk–benefit = 69.5), while melatonin receptor agonist had the least favourable profile (risk–benefit = 395.7). Overall, the combined metric for risk–benefit suggests that treatment with a histamine antagonist is optimal and potentially represents the best first‐line therapy for the medical management of insomnia. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Contributors

Author

Almklov, Erin A., primary, Baron, Kelly Glazer, additional, Bowyer, Gabrielle E., additional, Brooks, Trevor M., additional, Cheng, Philip, additional, Conroy, Deirdre A., additional, Crew, Earl Charles, additional, Cuddihy, Leisha J., additional, Dawson, Darius B., additional, Dawson, Spencer, additional, Esquivel, Denise Rodriguez, additional, Evans, Marissa A., additional, Fernandez-Mendoza, Julio, additional, Garland, Sheila N., additional, Gasperetti, Caitlin E., additional, Gehrman, Philip, additional, Goldschmied, Jennifer, additional, Grandner, Michael A., additional, Hartman, Alison R., additional, Harvey, Allison G., additional, Hasler, Brant P., additional, Hughes, Jaime M., additional, MacKinnon, Anna L., additional, Manber, Rachel, additional, Martin, Jennifer L., additional, Meers, Jessica M., additional, Moore, Melisa E., additional, Muench, Alexandria, additional, Nowakowski, Sara, additional, Ong, Jason C., additional, Orff, Henry, additional, Perlis, Michael L., additional, Posner, Donn, additional, Rivera, Guadalupe L., additional, Schuiling, Matthew D., additional, Sedov, Ivan D., additional, Simpson, Norah, additional, Smith, Michael T., additional, Tomfohr-Madsen, Lianne M., additional, Tubbs, Andrew Scott, additional, and Vargas, Ivan, additional

Published
2022
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11. Acute Sleep Deprivation and the Selective Consolidation of Emotional Memories

Author

Vargas, Ivan, Payne, Jessica D., Muench, Alexandria, Kuhlman, Kate R., and Lopez-Duran, Nestor L.

Abstract

Research suggests that sleep preferentially consolidates the negative aspects of memories at the expense of the neutral aspects. However, the mechanisms by which sleep facilitates this emotional memory trade-off remain unknown. Although active processes associated with sleep-dependent memory consolidation have been proposed to underlie this effect, this trade-off may also be modulated by non-sleep-related processes, such as the circadian factors, stress-related factors, and/or mood congruent context effects involved in sleep deprivation. We sought to examine the potential role of these factors by randomizing 39 young adults into either a total sleep deprivation condition (26 consecutive hours awake) or a sleep condition (8 h sleep opportunity). Replicating the emotional memory trade-off effect, negative objects were better remembered than neutral objects or background images. However, in spite of generally worse memory performance (for neutral and background information), sleep-deprived participants showed similar recognition rates for negative emotional memories relative to participants who were given a full night of sleep.

Published
2019
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23. Do Placebos Primarily Affect Subjective as Opposed to Objective Measures? A Meta-Analysis of Placebo Responses in Insomnia RCTs.

Author

Muench, Alexandria, Giller, Joshua, Morales, Knashawn H., Culnan, Elizabeth, Khader, Waliuddin, Kaptchuk, Ted J., McCall, William V., and Perlis, Michael L.

Subjects
*SLEEP duration, *SLEEP latency, *INSOMNIA, *PLACEBOS
Abstract

Introduction: Little is known about the relative magnitude of placebo responses on objective and subjective measures of sleep continuity. To address this issue, the pre-post effects of placebos on objective and subjective measures (i.e., polysomnography [PSG] and sleep diaries) were evaluated meta-analytically. The guiding hypothesis was that large responses would be observed on sleep diary measures and small responses would be observed on PSG measures. Methods: PubMed searches, 1967–2016, yielded 329 possible articles, 17 of which met the inclusion and exclusion criteria for the present analysis (including 879 subjects with PSG data, 1,209 subjects with diary data, and six studies with both PSG and sleep diary data). Average change and weighted effect sizes (ESs) were computed via modeling for sleep latency (SL), wake after sleep onset (WASO) and total sleep time (TST). Results: Pre-to-post change on PSG measures were: SL −13.7 min., ES = −0.37; WASO −14.3 min., ES = −0.36; and TST 29.8 min., ES = 0.50. Pre-to-post change on sleep diary measures were: SL −13.5 min., ES = −0.36; WASO −13.3 min., ES = −0.20; and TST 25.5 min., ES = 0.36. The modeled average objective subjective difference per sleep continuity measure was less than 5 minutes. The modeled average objective subjective difference per sleep continuity measure (in effect sizes) was less than 0.17. Discussion: The observed outcomes of this analysis suggest that placebos produce comparable effects on objective and subjective measures of sleep continuity. Thus, objective measures do not appear to protect against placebo responses. This being the case and given the importance of the subjective experience of illness severity and recovery, such data suggests that prospectively sampled sleep continuity data (sleep diaries) may be the optimal data for clinical trials, particularly when only one measure is possible. [ABSTRACT FROM AUTHOR]

Published
2023
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34. We know CBT-I works, now what?

Author

Muench, Alexandria, primary, Vargas, Ivan, additional, Grandner, Michael A, additional, Ellis, Jason G, additional, Posner, Donn, additional, Bastien, Célyne H, additional, Drummond, Sean PA, additional, and Perlis, Michael L, additional

Published
2022
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42. The natural history of insomnia: Does sleep extension differentiate between those that do and do not develop chronic insomnia?

Author

Perlis, Michael L., primary, Morales, Knashawn H., additional, Vargas, Ivan, additional, Posner, Donn A., additional, Grandner, Michael A., additional, Muench, Alexandria L., additional, Seewald, Mark W., additional, Gooneratne, Nalaka S., additional, Kloss, Jacqueline D., additional, Gencarelli, Amy M., additional, Khader, Waliuddin S., additional, Thase, Michael E., additional, and Ellis, Jason G., additional

Published
2021
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50. 0687 Sleep Disorder Symptom Endorsement by Age

Author

Boyle, Julia T, primary, Williams, Natasha, additional, Grandner, Michael, additional, Vargas, Ivan, additional, D'Antonio, Breanna, additional, Seewald, Mark, additional, Muench, Alexandria, additional, Ellis, Jason, additional, Posner, Donn, additional, Rosenfield, Bradley, additional, DiTomasso, Robert A, additional, and Perlis, Michael L, additional

Published
2019
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