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1. Mathematical models of Plasmodium vivax transmission: a scoping review

Author

Anwar, Md Nurul, Smith, Lauren, Devine, Angela, Mehra, Somya, Walker, Camelia R., Ivory, Elizabeth, Conway, Eamon, Mueller, Ivo, McCaw, James M., Flegg, Jennifer A., and Hickson, Roslyn I.

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Plasmodium vivax is one of the most geographically widespread malaria parasites in the world due to its ability to remain dormant in the human liver as hypnozoites and subsequently reactivate after the initial infection (i.e. relapse infections). More than 80% of P. vivax infections are due to hypnozoite reactivation. Mathematical modelling approaches have been widely applied to understand P. vivax dynamics and predict the impact of intervention outcomes. In this article, we provide a scoping review of mathematical models that capture P. vivax transmission dynamics published between January 1988 and May 2023 to provide a comprehensive summary of the mathematical models and techniques used to model P. vivax dynamics. We aim to assist researchers working on P. vivax transmission and other aspects of P. vivax malaria by highlighting best practices in currently published models and highlighting where future model development is required. We provide an overview of the different strategies used to incorporate the parasite's biology, use of multiple scales (within-host and population-level), superinfection, immunity, and treatment interventions. In most of the published literature, the rationale for different modelling approaches was driven by the research question at hand. Some models focus on the parasites' complicated biology, while others incorporate simplified assumptions to avoid model complexity. Overall, the existing literature on mathematical models for P. vivax encompasses various aspects of the parasite's dynamics. We recommend that future research should focus on refining how key aspects of P. vivax dynamics are modelled, including spatial heterogeneity in exposure risk, the accumulation of hypnozoite variation, the interaction between P. falciparum and P. vivax, acquisition of immunity, and recovery under superinfection.

Published
2023
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5. Primaquine for uncomplicated Plasmodium vivax malaria in children younger than 15 years: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Baird, J Kevin, Boyd, Sarah C, Chau, Nguyen H, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo U, Ghimire, Prakash, Khan, Wasif A, Ley, Benedikt, Mekuria, Asrat H, Mueller, Ivo, Naadim, Mohammad N, Nosten, Francois, Price, David J, Pukrittayakamee, Sasithon, Rowland, Mark, Sattabongkot, Jetsumon, SuarezKurtz, Guilherme, Sutanto, Inge, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Commons, Robert J, Rajasekhar, Megha, Allen, Elizabeth N, Yilma, Daniel, Chotsiri, Palang, Abreha, Tesfay, Adam, Ishag, Awab, Ghulam Rahim, Barber, Bridget E, Brasil, Larissa W, Chu, Cindy S, Cui, Liwang, Edler, Peta, Gomes, Margarete do Socorro M, Gonzalez‑Ceron, Lilia, Grigg, Matthew J, Hamid, Muzamil Mahdi Abdel, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Leslie, Toby, Longley, Rhea J, Monteiro, Wuelton Marcelo, Pasaribu, Ayodhia Pitaloka, Poespoprodjo, Jeanne Rini, Richmond, Caitlin L, Rijal, Komal Raj, Taylor, Walter R J, Thanh, Pham Vinh, Thriemer, Kamala, Vieira, José Luiz F, White, Nicholas J, Zuluaga-Idarraga, Lina M, Workman, Lesley J, Tarning, Joel, Stepniewska, Kasia, Guerin, Philippe J, Simpson, Julie A, Barnes, Karen I, and Price, Ric N

Published
2024
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7. Fetal sex and risk of pregnancy-associated malaria in Plasmodium falciparum-endemic regions: a meta-analysis

Author

Unger, Holger W., Hadiprodjo, Anastasia Jessica, Gutman, Julie R., Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, D’Alessandro, Umberto, Landis, Sarah H., Ter Kuile, Feiko, Ouma, Peter, Oneko, Martina, Mwapasa, Victor, Slutsker, Laurence, Terlouw, Dianne J., Kariuki, Simon, Ayisi, John, Nahlen, Bernard, Desai, Meghna, Madanitsa, Mwayi, Kalilani-Phiri, Linda, Ashorn, Per, Maleta, Kenneth, Tshefu-Kitoto, Antoinette, Mueller, Ivo, Stanisic, Danielle, Cates, Jordan, Van Eijk, Anna Maria, Ome-Kaius, Maria, Aitken, Elizabeth H., and Rogerson, Stephen J.

Published
2023
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9. Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Koh, Gavin CKW, Mekuria, Asrat Hailu, Mueller, Ivo, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Price, David J, Sattabongkot, Jetsumon, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Commons, Robert J, Rajasekhar, Megha, Edler, Peta, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Chu, Cindy S, Cui, Liwang, Daher, André, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Lidia, Kartini, Llanos-Cuentas, Alejandro, Longley, Rhea J, Pereira, Dhelio B, Pasaribu, Ayodhia P, Pukrittayakamee, Sasithon, Rijal, Komal R, Sutanto, Inge, Taylor, Walter R J, Thanh, Pham V, Thriemer, Kamala, Vieira, José Luiz F, Watson, James A, Zuluaga-Idarraga, Lina M, White, Nicholas J, Guerin, Philippe J, Simpson, Julie A, and Price, Ric N

Published
2024
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12. Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis

Author

van Eijk, Anna Maria, Stepniewska, Kasia, Hill, Jenny, Taylor, Steve M., Rogerson, Stephen J., Cottrell, Gilles, Chico, R. Matthew, Gutman, Julie R., Tinto, Hallidou, Unger, Holger W., Yanow, Stephanie K., Accrombessi, Manfred, Adegnika, Ayola A., Ahmed, Rukhsana, Arango-Flórez, Eliana María, Arevalo-Herrera, Myriam, Arinaitwe, Emmanual, Arnaldo, Paulo, Ashorn, Per, Ashorn, Ulla, Bardaji, Azucena, Betuela, Inoni, Bharti, Praveen K., Bohissou, Francis, Bôtto-Menezes, Camila, Braun, Vera, Briand, Valerie, Briggs, Jessica, Castellanos, María Eugenia, Chandramohan, Daniel, Chaponda, Enesia Banda, Chitnis, Chetan, Cohee, Lauren M., Cot, Michel, d'Alessandro, Umberto, Denoeud-Ndam, Lise, Desai, Meghna, Dicko, Alassane, Ding, Xavier, Dorsey, Grant, Duffy, Patrick E., Elbadry, Maha A., Enosse, Sonia M., Fan, Yue, Fievet, Nadine, Fried, Michal, Genton, Blaise, Gonzalez, Raquel, Greenwood, Brian, Kalilani, Linda, Kattenberg, Johanna H., Kayentao, Kassoum, Khairallah, Carole, King, Christopher L., Kochar, Dhanpat Kumar, Kochar, Swati, Koukouikila-Koussounda, Felix, Landis, Sarah H., Laufer, Miriam K., Leke, Rose F., Macete, Eusebio, Maculuve, Sonia, Madanitsa, Mwayiwawo, Mahamar, Almahamoudou, Maleta, Ken, Malhotra, Indu, Zoleko Manego, Rella, Martinez-Espinosa, Flor Ernestina, Massougbodji, Achille, Mathanga, Don, Menegon, Michela, Menendez, Clara, Mens, Petra, Meremikwu, Martin, Mockenhaupt, Frank P., Mombo-Ngoma, Ghyslain, Mosha, Dominic, Mueller, Ivo, Nahum, Alain, Natureeba, Paul, Ndam, Nicaise, Ntoumi, Francine, Oduwole, Olabisi A., Okech, Bernard A., Ome-Kaius, Maria, Otieno, Kephas, Padilla, Norma, Ramharter, Michal, Rochford, Rosemary, Rosanas-Urgell, Anna, Ruperez, Maria, Sabourin, Katherine R., Sanz, Sergi, Schallig, Henk D., Scott, Susana, Sevene, Esperanca, Severini, Carlo, Tagbor, Harry, Taylor, Diane Wallace, Traore Coulibaly, Maminata, Vasquez, Ana, Walker-Abbey, Annie, Wylie, Blair J., Zannou, Djimon M., Meshnick, Stephen R., ter Kuile, Feiko O., Mayor, Alfredo, Taylor, Steve M, Rogerson, Stephen J, Chico, R Matthew, Gutman, Julie R, Tinto, Halidou, Unger, Holger W, Yanow, Stephanie K, Meshnick, Steven R, and ter Kuile, Feiko O

Published
2023
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13. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author

Ashorn, Per, Black, Robert E, Lawn, Joy E, Ashorn, Ulla, Klein, Nigel, Hofmeyr, G Justus, Temmerman, Marleen, Askari, Sufia, Ohuma, Eric O, Moller, Ann-Beth, Bradley, Ellen, Chakwera, Samuel, Hussain-Alkhateeb, Laith, Lewin, Alexandra, Okwaraji, Yemisrach B, Retno Mahanani, Wahyu, White Johansson, Emily, Lavin, Tina, Estevez Fernandez, Diana, Gatica Domínguez, Giovanna, de Costa, Ayesha, Cresswell, Jenny A, Krasevec, Julia, Blencowe, Hannah, Requejo, Jennifer, Moran, Allisyn C, Pingray, Veronica, Cormick, Gabriela, Gibbons, Luz, Belizan, José, Guevel, Carlos, Warrilow, Kara, Gordon, Adrienne, Flenady, Vicki, Sexton, Jessica, Lawford, Harriet, Paixao, Enny S., Rocha Falcão, Ila, Lima Barreto, Mauricio, Lisonkova, Sarka, Wen, Qi, Mardones, Francisco, Caulier-Cisterna, Raúl, Acuña, José, Velebil, Petr, Jirova, Jitka, Horváth-Puhó, Erzsébet, Sørensen, Henrik Toft, Sakkeus, Luule, Abuladze, Liili, Gissler, Mika, Moradi-Lakeh, Maziar, Heidarzadeh, Mohammad, Khalili, Narjes, A. Yunis, Khalid, Al Bizri, Ayah, Nakad, Pascale, Devi Karalasingam, Shamala, R Jeganathan, J Ravichandran, binti Baharum, Nurakman, Suárez-Idueta, Lorena, Barranco Flores, Arturo, Gonzalez Roldan, Jesus F, Lopez Alvarez, Sonia, van Dijk, Aimée E., Broeders, Lisa, Huicho, Luis, Quezada Pinedo, Hugo G, Cajachagua-Torres, Kim N, Carrillo-Larco, Rodrigo M, Tarazona Meza, Carla Estefania, Guzman-Vilca, Wilmer Cristobal, Olukade, Tawa O., Ali, Hamdy A., Alyafei, Fawziya, AlQubaisi, Mai, Alturk, Mohamad R, Kim, Ho Yeon, Cho, Geum Joon, Razaz, Neda, Söderling, Jonas, Smith, Lucy K, Kurinczuk, Jennifer J, Matthews, Ruth J, Manktelow, Bradley N, Draper, Elizabeth S, Fenton, Alan C, Lowry, Estelle, Rowland, Neil, Wood, Rachael, Monteath, Kirsten, Pereyra, Isabel, Pravia, Gabriella, Davis, Celina, Clarke, Samantha, Wu, Lee S.F., Yoshida, Sachiyo, Bahl, Rajiv, Grandi, Carlos, Labrique, Alain B, Rashid, Mabhubur, Ahmed, Salahuddin, Roy, Arunangshu D., Haque, Rezwanul, Shaikh, Saijuddin, Baqui, Abdullah H., Saha, Samir K., Khanam, Rasheda, Rahman, Sayedur, Shapiro, Roger, Zash, Rebecca, Silveira, Mariângela F., Buffarini, Romina, Kolsteren, Patrick, Lachat, Carl, Huybregts, Lieven, Roberfroid, Dominique, Zeng, Lingxia, Zhu, Zhonghai, He, Jianrong, Qui, Xiu, Gebreyesus, Seifu H., Tesfamariam, Kokeb, Bekele, Delayehu, Chan, Grace, Baye, Estifanos, Workneh, Firehiwot, Asante, Kwaku P., Boanmah-Kaali, Ellen, Adu-Afarwuah, Seth, Dewey, Kathryn G., Gyaase, Stephaney, Wylie, Blair J., Kirkwood, Betty R., Manu, Alexander, Thulasiraj, Ravilla D, Tielsch, James, Chowdhury, Ranadip, Taneja, Sunita, Babu, Giridhara R, Shriyan, Prafulla, Maleta, Kenneth, Mangani, Charles, Acevedo-Gallegos, Sandra, Rodriguez-Sibaja, Maria J., Khatry, Subarna K., LeClerq, Steven C., Mullany, Luke C., Jehan, Fyezah, Ilyas, Muhammad, Rogerson, Stephen J., Unger, Holger W., Ghosh, Rakesh, Musange, Sabine, Ramokolo, Vundli, Zembe-Mkabile, Wanga, Lazzerini, Marzia, Mohamed, Rishard, Wang, Dongqing, Fawzi, Wafaie W., Minja, Daniel T.R., Schmiegelow, Christentze, Masanja, Honorati, Smith, Emily, Lusingu, John P.A., Msemo, Omari A., Kabole, Fathma M., Slim, Salim N., Keentupthai, Paniya, Mongkolchati, Aroonsri, Kajubi, Richard, Kakuru, Abel, Waiswa, Peter, Walker, Dilys, Hamer, Davidson H., Semrau, Katherine E.A., Chaponda, Enesia B., Chico, R. Matthew, Banda, Bowen, Musokotwane, Kebby, Manasyan, Albert, Pry, Jake M., Chasekwa, Bernard, Humphrey, Jean, Shamim, Abu Ahmed, Christian, Parul, Ali, Hasmot, Klemm, Rolf D.W., Massie, Alan B., Mitra, Maithili, Mehra, Sucheta, Schulze, Kerry J., Shamim, Abu Amed, Sommer, Alfred, Ullah, Barkat, West, Keith P., Jr, Begum, Nazma, Chowdhury, Nabidul Haque, Islam, Shafiqul, Mitra, Dipak Kumar, Quaiyum, Abdul, Diseko, Modiegi, Makhema, Joseph, Cheng, Yue, Guo, Yixin, Yuan, Shanshan, Roro, Meselech, Shikur, Bilal, Goddard, Frederick, Haneuse, Sebastien, Hunegnaw, Bezawit, Berhane, Yemane, Worku, Alemayehu, Kaali, Seyram, Arnold, Charles D., Jack, Darby, Amenga-Etego, Seeba, Hurt, Lisa, Shannon, Caitlin, Soremekun, Seyi, Bhandari, Nita, Martines, Jose, Mazumder, Sarmila, Ana, Yamuna, R, Deepa, Hallamaa, Lotta, Pyykkö, Juha, Lumbreras-Marquez, Mario I., Mendoza-Carrera, Claudia E., Hussain, Atiya, Karim, Muhammad, Kausar, Farzana, Mehmood, Usma, Nadeem, Naila, Nisar, Muhammad Imran, Sajid, Muhammad, Mueller, Ivo, Ome-Kaius, Maria, Butrick, Elizabeth, Sayinzoga, Felix, Mariani, Ilaria, Urassa, Willy, Theander, Thor, Deloron, Phillippe, Nielsen, Birgitte Bruun, Muhihi, Alfa, Noor, Ramadhani Abdallah, Bygbjerg, Ib, Moeller, Sofie Lykke, Aftab, Fahad, Ali, Said M., Dhingra, Pratibha, Dhingra, Usha, Dutta, Arup, Sazawal, Sunil, Suleiman, Atifa, Mohammed, Mohammed, Deb, Saikat, Kamya, Moses R., Nakalembe, Miriam, Mulowooz, Jude, Santos, Nicole, Biemba, Godfrey, Herlihy, Julie M., Mbewe, Reuben K., Mweena, Fern, Yeboah-Antwi, Kojo, Bruce, Jane, Chandramohan, Daniel, Prendergast, Andrew, Idueta, Lorena Suárez, Hazel, Elizabeth, Erchick, Daniel J, Yargawa, Judith, Katz, Joanne, Lee, Anne C C, Diaz, Mike, Salasibew, Mihretab, Hayashi, Chika, and Borghi, Elaine

Published
2023
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15. Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination

Author

Greenhouse, Bryan, Daily, Jennifer, Guinovart, Caterina, Goncalves, Bronner, Beeson, James, Bell, David, Chang, Michelle A, Cohen, Justin M, Ding, Xavier, Domingo, Gonzalo, Eisele, Thomas P, Lammie, Patrick J, Mayor, Alfredo, Merienne, Nicolas, Monteiro, Wuelto, Painter, John, Rodriguez, Isabel, White, Michael, Drakeley, Chris, and Mueller, Ivo

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Malaria, Vector-Borne Diseases, Infectious Diseases, Biotechnology, HIV/AIDS, Detection, screening and diagnosis, 4.4 Population screening, Infection, Good Health and Well Being, Malaria Serology Convening, Elimination, Serology, Use Cases, Biomedical and clinical sciences, Health sciences
Abstract

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;  and testing and treating P. vivax hypnozoite carriers.

Published
2019

16. Quantifying spatial heterogeneity of malaria in the endemic Papua region of Indonesia: Analysis of epidemiological surveillance data

Author

Fadilah, Ihsan, Djaafara, Bimandra A., Lestari, Karina D., Fajariyani, Sri B., Sunandar, Edi, Makamur, Billy G., Wopari, Beeri, Mabui, Silas, Ekawati, Lenny L., Sagara, Rahmat, Lina, Rosa N., Argana, Guntur, Ginting, Desriana E., Sumiwi, Maria E., Laihad, Ferdinand J., Mueller, Ivo, McVernon, Jodie, Baird, J. Kevin, Surendra, Henry, and Elyazar, Iqbal R.F.

Published
2022
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17. Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

Author

Longley, Rhea J., Grigg, Matthew J., Schoffer, Kael, Obadia, Thomas, Hyslop, Stephanie, Piera, Kim A., Nekkab, Narimane, Mazhari, Ramin, Takashima, Eizo, Tsuboi, Takafumi, Harbers, Matthias, Tetteh, Kevin, Drakeley, Chris, Chitnis, Chetan E., Healer, Julie, Tham, Wai-Hong, Sattabongkot, Jetsumon, White, Michael T., Cooper, Daniel J., Rajahram, Giri S., Barber, Bridget E., William, Timothy, Anstey, Nicholas M., and Mueller, Ivo

Published
2022
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23. A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria

Author

Trimarsanto, Hidayat, Amato, Roberto, Pearson, Richard D., Sutanto, Edwin, Noviyanti, Rintis, Trianty, Leily, Marfurt, Jutta, Pava, Zuleima, Echeverry, Diego F., Lopera-Mesa, Tatiana M., Montenegro, Lidia M., Tobón-Castaño, Alberto, Grigg, Matthew J., Barber, Bridget, William, Timothy, Anstey, Nicholas M., Getachew, Sisay, Petros, Beyene, Aseffa, Abraham, Assefa, Ashenafi, Rahim, Awab G., Chau, Nguyen H., Hien, Tran T., Alam, Mohammad S., Khan, Wasif A., Ley, Benedikt, Thriemer, Kamala, Wangchuck, Sonam, Hamedi, Yaghoob, Adam, Ishag, Liu, Yaobao, Gao, Qi, Sriprawat, Kanlaya, Ferreira, Marcelo U., Laman, Moses, Barry, Alyssa, Mueller, Ivo, Lacerda, Marcus V. G., Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Mohammed, Rezika, Yilma, Daniel, Pereira, Dhelio B., Espino, Fe E. J., Chu, Cindy S., Vélez, Iván D., Namaik-larp, Chayadol, Villegas, Maria F., Green, Justin A., Koh, Gavin, Rayner, Julian C., Drury, Eleanor, Gonçalves, Sónia, Simpson, Victoria, Miotto, Olivo, Miles, Alistair, White, Nicholas J., Nosten, Francois, Kwiatkowski, Dominic P., Price, Ric N., and Auburn, Sarah

Published
2022
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26. Long-term sustained malaria control leads to inbreeding and fragmentation of Plasmodium vivax populations

Author

Waltmann, Andreea, Koepfli, Cristian, Tessier, Natacha, Karl, Stephan, Darcy, Andrew W., Wini, Lyndes, Harrison, G. L. Abby, Barnadas, Celine, Jennison, Charlie, Karunajeewa, Harin, Boyd, Sarah, Whittaker, Maxine, Kazura, James, Bahlo, Melanie, Mueller, Ivo, and Barry, Alyssa E.

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Plasmodium vivax populations are more resistant to malaria control strategies than Plasmodium falciparum, maintaining high genetic diversity and gene flow even at low transmission. To quantify the impact of declining transmission on P. vivax populations, we investigated population genetic structure over time during intensified control efforts and over a wide range of transmission intensities and spatial scales in the Southwest Pacific. Analysis of 887 P. vivax microsatellite haplotypes (Papua New Guinea, PNG = 443, Solomon Islands = 420, Vanuatu =24) revealed substantial population structure among countries and modestly declining diversity as transmission decreases over space and time. In the Solomon Islands, which has had sustained control efforts for 20 years, significant population structure was observed on different spatial scales down to the sub-village level. Up to 37% of alleles were partitioned between populations and significant multilocus linkage disequilibrium was observed indicating substantial inbreeding. High levels of haplotype relatedness around households and within a range of 300m are consistent with a focal and clustered infections suggesting that restricted local transmission occurs within the range of vector movement and that subsequent focal inbreeding may be a key factor contributing to the observed population structure. We conclude that unique transmission strategies, including relapse allows P. vivax populations to withstand pressure from control efforts for longer than P. falciparum. However sustained control efforts do eventually impact parasite population structure and with further control pressure, populations may eventually fragment into clustered foci that could be targeted for elimination., Comment: After peer review this has been extensively rewritten and is also housed on another preprint server

Published
2016

27. Taking Sharper Pictures of Malaria with CAMERAs: Combined Antibodies to Measure Exposure Recency Assays.

Author

Greenhouse, Bryan, Smith, David L, Rodríguez-Barraquer, Isabel, Mueller, Ivo, and Drakeley, Chris J

Subjects
Humans, Plasmodium falciparum, Malaria, Antibodies, Protozoan, Antigens, Protozoan, Serologic Tests, Antibody Formation, Epidemiological Monitoring, Antibodies, Protozoan, Antigens, Tropical Medicine, Medical and Health Sciences
Abstract

Antibodies directed against malaria parasites are easy and inexpensive to measure but remain an underused surveillance tool because of a lack of consensus on what to measure and how to interpret results. High-throughput screening of antibodies from well-characterized cohorts offers a means to substantially improve existing assays by rationally choosing the most informative sets of responses and analytical methods. Recent data suggest that high-resolution information on malaria exposure can be obtained from a small number of samples by measuring a handful of properly chosen antibody responses. In this review, we discuss how standardized multi-antibody assays can be developed and efficiently integrated into existing surveillance activities, with potential to greatly augment the breadth and quality of information available to direct and monitor malaria control and elimination efforts.

Published
2018

28. Mathematical models of Plasmodium vivax transmission: A scoping review

Author

Anwar, Md Nurul, primary, Smith, Lauren, additional, Devine, Angela, additional, Mehra, Somya, additional, Walker, Camelia R., additional, Ivory, Elizabeth, additional, Conway, Eamon, additional, Mueller, Ivo, additional, McCaw, James M., additional, Flegg, Jennifer A., additional, and Hickson, Roslyn I., additional

Published
2024
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30. Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data.

Author

Cates, Jordan E, Unger, Holger W, Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, D'Alessandro, Umberto, Landis, Sarah H, Adu-Afarwuah, Seth, Dewey, Kathryn G, Ter Kuile, Feiko O, Desai, Meghna, Dellicour, Stephanie, Ouma, Peter, Gutman, Julie, Oneko, Martina, Slutsker, Laurence, Terlouw, Dianne J, Kariuki, Simon, Ayisi, John, Madanitsa, Mwayiwawo, Mwapasa, Victor, Ashorn, Per, Maleta, Kenneth, Mueller, Ivo, Stanisic, Danielle, Schmiegelow, Christentze, Lusingu, John PA, van Eijk, Anna Maria, Bauserman, Melissa, Adair, Linda, Cole, Stephen R, Westreich, Daniel, Meshnick, Steven, and Rogerson, Stephen

Subjects
Humans, Malaria, Malnutrition, Prevalence, Pregnancy, Infant, Newborn, Infant, Low Birth Weight, Africa South of the Sahara, Asia, Pacific Islands, Female, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundFour studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW;

Published
2017

31. Primaquine for uncomplicated Plasmodium vivaxmalaria in children younger than 15 years: a systematic review and individual patient data meta-analysis

Author

Commons, Robert J, Rajasekhar, Megha, Allen, Elizabeth N, Yilma, Daniel, Chotsiri, Palang, Abreha, Tesfay, Adam, Ishag, Awab, Ghulam Rahim, Barber, Bridget E, Brasil, Larissa W, Chu, Cindy S, Cui, Liwang, Edler, Peta, Gomes, Margarete do Socorro M, Gonzalez‑Ceron, Lilia, Grigg, Matthew J, Hamid, Muzamil Mahdi Abdel, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Leslie, Toby, Longley, Rhea J, Monteiro, Wuelton Marcelo, Pasaribu, Ayodhia Pitaloka, Poespoprodjo, Jeanne Rini, Richmond, Caitlin L, Rijal, Komal Raj, Taylor, Walter R J, Thanh, Pham Vinh, Thriemer, Kamala, Vieira, José Luiz F, White, Nicholas J, Zuluaga-Idarraga, Lina M, Workman, Lesley J, Tarning, Joel, Stepniewska, Kasia, Guerin, Philippe J, Simpson, Julie A, Barnes, Karen I, Price, Ric N, Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Baird, J Kevin, Boyd, Sarah C, Chau, Nguyen H, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo U, Ghimire, Prakash, Khan, Wasif A, Ley, Benedikt, Mekuria, Asrat H, Mueller, Ivo, Naadim, Mohammad N, Nosten, Francois, Price, David J, Pukrittayakamee, Sasithon, Rowland, Mark, Sattabongkot, Jetsumon, SuarezKurtz, Guilherme, Sutanto, Inge, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, and Woyessa, Adugna

Abstract

Primaquine, the only widely available treatment to prevent relapsing Plasmodium vivaxmalaria, is produced as 15 mg tablets, and new paediatric formulations are being developed. To inform the optimal primaquine dosing regimen for children, we aimed to determine the efficacy and safety of different primaquine dose strategies in children younger than 15 years.

Published
2024
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32. Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific.

Author

Unger, Holger W, Cates, Jordan E, Gutman, Julie, Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, d'Alessandro, Umberto, Landis, Sarah H, Adu-Afarwuah, Seth, Dewey, Kathryn G, Ter Kuile, Feiko, Dellicour, Stephanie, Ouma, Peter, Slutsker, Laurence, Terlouw, Dianne J, Kariuki, Simon, Ayisi, John, Nahlen, Bernard, Desai, Meghna, Madanitsa, Mwayi, Kalilani-Phiri, Linda, Ashorn, Per, Maleta, Kenneth, Mueller, Ivo, Stanisic, Danielle, Schmiegelow, Christentze, Lusingu, John, Westreich, Daniel, van Eijk, Anna Maria, Meshnick, Steven, and Rogerson, Stephen

Subjects
Humans, Malaria, Pregnancy Complications, Malnutrition, Prenatal Care, Cohort Studies, Nutritional Status, Fetal Development, Gestational Age, Pregnancy, Adult, Infant, Newborn, Africa, Papua New Guinea, Female, Male, Datasets as Topic, malaria, malnutrition, pregnancy, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

PurposeThe Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists.ParticipantsData were pooled on 14 635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015.Findings to dateData are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort.Future plansThis pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

Published
2016

33. Eveningness is associated with more severe depressive symptoms independently of sleep quality and fatigue level only in first-episode but not recurrent depression in major depressive disorder.

Author

Hu, Shuang, Wang, Fan, Huang, Qinte, Chen, Yiming, Lyu, Dongbin, Zhou, Ni, Wang, Meiti, Zhang, Mengke, Xu, Chuchen, Mueller, Ivo, Yao, Guanqun, Liu, Xirui, Zhang, Qinting, and Hong, Wu

Subjects
SLEEP quality, MENTAL depression, FATIGUE (Physiology), CHRONOTYPE, REGRESSION analysis
Abstract

People with an evening chronotype have an increased risk of experiencing a major depressive disorder (MDD). It is unclear if this effect is predominantly related to the initial development of MDD or also present in recurrent episodes. The current study aimed to investigate if the association between chronotype and depressive severity in MDD patients is comparable in MDD patients with first and recurrent episodes. 386 MDD patients, 70.7% females and aged between 16 and 64, participated in the study. The Morningness – Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), Multidimensional Fatigue Inventory (MFI20), and Quick Inventory of Depressive Symptomatology (QIDS-SR16) were administered to participants to determine chronotype, sleep quality, fatigue level, and depressive severity, respectively. Multivariate regression models were utilized to analyze how chronotype influences depressive severity. The study showed that chronotype, sleep quality, and fatigue level were all associated with depressive severity. Eveningness significantly predicted an increase in depressive severity independently of sleep quality and fatigue level only in patients with the first episode (−0.068, p = 0.010), but not in patients with recurrent episodes (0.013, p = 0.594). Circadian-focused treatment should be considered in first-episode depression only. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the Plasmodium falciparum population of Papua New Guinea

Author

Naung, Myo T., primary, Martin, Elijah, additional, Wong, Wilson, additional, Razook, Zahra, additional, Utama, Digjaya, additional, Guy, Andrew J., additional, Harrison, Shannon Takala, additional, Cowman, Alan F., additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Laman, Moses, additional, Mueller, Ivo, additional, and Barry, Alyssa E., additional

Published
2023
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35. Evaluation of CDC light traps for mosquito surveillance in a malaria endemic area on the Thai-Myanmar border.

Author

Sriwichai, Patchara, Karl, Stephan, Samung, Yudthana, Sumruayphol, Suchada, Kiattibutr, Kirakorn, Payakkapol, Anon, Mueller, Ivo, Yan, Guiyun, Cui, Liwang, and Sattabongkot, Jetsumon

Subjects
Animals, Culicidae, Malaria, Feeding Behavior, Entomology, Insect Vectors, Endemic Diseases, Light, Myanmar, Thailand, Female, Male, Epidemiological Monitoring, Mycology & Parasitology, Tropical Medicine, Medical Microbiology, Public Health and Health Services
Abstract

BackgroundCenters for Disease Control and Prevention miniature light traps (CDC-LT) baited with CO2 are a routine tool for adult mosquito sampling used in entomological surveys, and for monitoring and surveillance of disease vectors. The present study was aimed at evaluating the performance of baited and unbaited CDC-LT for indoor and outdoor trapping of endemic mosquito species in northwestern Thailand.MethodsCDC-LT (n = 112) with and without dry ice baits were set both indoors and outdoors in 88 selected houses for stretches of 5 consecutive nights per month in 7 villages in Tha Song Yang district, Tak province between January 2011 and March 2013. Individual traps were repeatedly placed in the same location for a median of 6 (range 1-10) times. Mosquitoes were identified by morphological characteristics and classified into blood-fed, empty, male/female and gravid. Absolute mosquito numbers were converted to capture rates (i.e., mosquitoes per trap and year). Capture rates were compared using multilevel negative binomial regression to account for multiple trap placements and adjust for regional and seasonal differences.ResultsA total of 6,668 mosquitoes from 9 genera were collected from 576 individual CDC-LT placements. Culex was the predominant captured genus (46%), followed by anopheline mosquitoes (45%). Overall, CO2 baited traps captured significantly more Culex (especially Culex vishnui Theobald) and Anopheles mosquitoes per unit time (adjusted capture rate ratio (aCRR) 1.64 and 1.38, respectively). Armigeres spp. mosquitoes were trapped in outdoor traps with significantly higher frequency (aCRR: 1.50), whereas Aedes albopictus (Skuse) had a tendency to be trapped more frequently indoors (aCRR: 1.89, p = 0.07). Furthermore, capture rate ratios between CO2 baited and non-baited CDC-LT were significantly influenced by seasonality and indoor vs. outdoor trap placement.ConclusionThe present study shows that CDC-LT with CO2 baiting capture significantly more Culex and Anopheles mosquitoes, some of which (e.g., Cx. vishnui, Cx. quinquefasciatus Say, An. minimus s.l. Theobald, An. maculatus s.l. Theobald) represent important disease vectors in Thailand. This study also shows significant differences in the capture efficiency of CDC-LT when placed indoors or outdoors and in different seasons. Our study thus provides important guidelines for more targeted future vector trapping studies on the Thai-Myanmar border, which is an important cross-border malaria transmission region in Thailand.

Published
2015

40. Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea

Author

Gul, Desmond, Rodríguez-Rodríguez, Daniela, Nate, Elma, Auwan, Alma, Salib, Mary, Lorry, Lina, Keven, John B., Katusele, Michelle, Rosado, Jason, Hofmann, Natalie, Ome-Kaius, Maria, Koepfli, Cristian, Felger, Ingrid, Kazura, James W., Hetzel, Manuel W., Mueller, Ivo, Karl, Stephan, Clements, Archie C. A., Fowkes, Freya J. I., Laman, Moses, and Robinson, Leanne J.

Published
2021
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46. Development and validation of serological markers for detecting recent Plasmodium vivax infection

Author

Longley, Rhea J., White, Michael T., Takashima, Eizo, Brewster, Jessica, Morita, Masayuki, Harbers, Matthias, Obadia, Thomas, Robinson, Leanne J., Matsuura, Fumie, Liu, Zoe S.J., Li-Wai-Suen, Connie, Tham, Wai-Hong, Healer, Julie, Huon, Christine, Chitnis, Chetan E., Nguitragool, Wang, Monteiro, Wuelton, Proietti, Carla, Doolan, Denise L., Siqueira, Andre M., Ding, Xavier C., Gonzalez, Iveth J., Kazura, James, Lacerda, Marcus, Sattabongkot, Jetsumon, Tsuboi, Takafumi, and Mueller, Ivo

Subjects
Plasmodium vivax -- Testing -- Methods, Serodiagnosis -- Methods, Malaria -- Diagnosis -- Control, Biological markers -- Testing -- Methods, Biological sciences, Health
Abstract

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. Plasmodium vivax can cause a clinically silent liver-stage infection that can reactivate, triggering blood-stage disease. A new test measuring antibody responses can identify P. vivax carriers for targeted treatment intervention., Author(s): Rhea J. Longley [sup.1] [sup.2] [sup.3] , Michael T. White [sup.4] , Eizo Takashima [sup.5] , Jessica Brewster [sup.1] , Masayuki Morita [sup.5] , Matthias Harbers [sup.6] [sup.7] , [...]

Published
2020
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47. Malaria Epidemiology and Control Within the International Centers of Excellence for Malaria Research

Author

Moss, William J, Dorsey, Grant, Mueller, Ivo, Laufer, Miriam K, Krogstad, Donald J, Vinetz, Joseph M, Guzman, Mitchel, Rosas-Aguirre, Angel M, Herrera, Socrates, Arevalo-Herrera, Myriam, Chery, Laura, Kumar, Ashwani, Mohapatra, Pradyumna K, Ramanathapuram, Lalitha, Srivastava, HC, Cui, Liwang, Zhou, Guofa, Parker, Daniel M, Nankabirwa, Joaniter, Kazura, James W, and Research, for the International Centers of Excellence for Malaria

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Malaria, Infectious Diseases, Vector-Borne Diseases, Rare Diseases, Prevention, Clinical Research, 3.2 Interventions to alter physical and biological environmental risks, Prevention of disease and conditions, and promotion of well-being, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Animals, Culicidae, Disease Eradication, Humans, Insect Vectors, International Cooperation, Plasmodium, Population Surveillance, Medical and Health Sciences, Tropical Medicine, Biomedical and clinical sciences, Health sciences
Abstract

Understanding the epidemiological features and metrics of malaria in endemic populations is a key component to monitoring and quantifying the impact of current and past control efforts to inform future ones. The International Centers of Excellence for Malaria Research (ICEMR) has the opportunity to evaluate the impact of malaria control interventions across endemic regions that differ in the dominant Plasmodium species, mosquito vector species, resistance to antimalarial drugs and human genetic variants thought to confer protection from infection and clinical manifestations of plasmodia infection. ICEMR programs are conducting field studies at multiple sites with the aim of generating standardized surveillance data to improve the understanding of malaria transmission and to monitor and evaluate the impact of interventions to inform malaria control and elimination programs. In addition, these epidemiological studies provide a vast source of biological samples linked to clinical and environmental "meta-data" to support translational studies of interactions between the parasite, human host, and mosquito vector. Importantly, epidemiological studies at the ICEMR field sites are integrated with entomological studies, including the measurement of the entomological inoculation rate, human biting index, and insecticide resistance, as well as studies of parasite genetic diversity and antimalarial drug resistance.

Published
2015

48. Rotating-crystal Malaria Diagnosis: Pre-clinical validation

Author

Orban, Agnes, Butykai, Adam, Prohle, Zsofia, Fulop, Gergely, Zelles, Tivadar, Forsyth, Wasan, Hill, Danika, Schofield, Louis, Mueller, Ivo, Karl, Stephan, and Kezsmarki, Istvan

Subjects
Physics - Medical Physics, Physics - Biological Physics
Abstract

Improving the efficiency of malaria diagnosis is one of the main goals of current malaria research. We have recently developed a magneto-optical (MO) method which allows high-sensitivity detection of malaria pigment (hemozoin) crystals via their magnetically induced rotation in blood. Here, we validate this technique on laboratory derived blood samples infected with \textit{Plasmodium falciparum}. Using two parasite cultures, the first containing mostly ring stages and the second corresponding to the end of the parasite life cycle, we demonstrate that our novel method can detect parasite densities as low as $\sim$40 and $\sim$10\,parasites per microliter of blood for ring and schizont stage parasites, respectively. This detection limit exceeds the performance of rapid diagnostic tests and competes with the threshold achievable by light microscopic observation of blood smears. Our method can be performed with as little as 50\,microliter of capillary blood and is sensitive to the presence of hemozoin micro-crystals down to ppm concentrations. The device, designed to a portable format for clinical and in-field tests, requires no special training of the operator or specific reagents, except for an inexpensive lysis solution to release intracellular hemozoin. Beyond diagnostics, this technique may offer an efficient tool to study hemozoin formation, trace hemozoin kinetics in the body and test susceptibility/resistance of parasites to new antimalarial drugs inhibiting hemozoin formation.

Published
2013

50. Chronic malaria exposure is associated with inhibitory markers on T cells that correlate with atypical memory and marginal zone-like B cells.

Author

Mitchell, Robert A, Ubillos, Itziar, Requena, Pilar, Campo, Joseph J, Ome-Kaius, Maria, Hanieh, Sarah, Umbers, Alexandra, Samol, Paula, Barrios, Diana, Jiménez, Alfons, Bardají, Azucena, Mueller, Ivo, Menéndez, Clara, Rogerson, Stephen, Dobaño, Carlota, and Moncunill, Gemma

Subjects
T cells, MONONUCLEAR leukocytes, B cells, MALARIA, T-cell exhaustion
Abstract

Chronic immune activation from persistent malaria infections can induce immunophenotypic changes associated with T-cell exhaustion. However, associations between T and B cells during chronic exposure remain undefined. We analyzed peripheral blood mononuclear cells from malaria-exposed pregnant women from Papua New Guinea and Spanish malaria-naïve individuals using flow cytometry to profile T-cell exhaustion markers phenotypically. T-cell lineage (CD3, CD4, and CD8), inhibitory (PD1, TIM3, LAG3, CTLA4, and 2B4), and senescence (CD28-) markers were assessed. Dimensionality reduction methods revealed increased PD1, TIM3, and LAG3 expression in malaria-exposed individuals. Manual gating confirmed significantly higher frequencies of PD1+CD4+ and CD4+, CD8+, and double-negative (DN) T cells expressing TIM3 in malaria-exposed individuals. Increased frequencies of T cells co-expressing multiple markers were also found in malaria-exposed individuals. T-cell data were analyzed with B-cell populations from a previous study where we reported an alteration of B-cell subsets, including increased frequencies of atypical memory B cells (aMBC) and reduction in marginal zone (MZ-like) B cells during malaria exposure. Frequencies of aMBC subsets and MZ-like B cells expressing CD95+ had significant positive correlations with CD28+PD1+TIM3+CD4+ and DN T cells and CD28+TIM3+2B4+CD8+ T cells. Frequencies of aMBC, known to associate with malaria anemia, were inversely correlated with hemoglobin levels in malaria-exposed women. Similarly, inverse correlations with hemoglobin levels were found for TIM3+CD8+ and CD28+PD1+TIM3+CD4+ T cells. Our findings provide further insights into the effects of chronic malaria exposure on circulating B- and T-cell populations, which could impact immunity and responses to vaccination. Chronic malaria exposure is associated with increased frequencies of T cells with inhibitory markers and expanded atypical memory B cells, which were found to positively correlate with each other. T cells with inhibitory markers and atypical memory B cells had positive correlations with malaria antibodies and negative correlations with hemoglobin levels in the chronically exposed individuals. T-cell subsets with inhibitory markers and B-cell subsets were able to distinguish malaria exposed versus non-exposed individuals using dimensionality reduction analysis. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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