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28 results on '"Mudgal, Richa"'

1. Magnetic Proximity induced efficient charge-to-spin conversion in large area PtSe$_{2}$/Ni$_{80}$Fe$_{20}$ heterostructures

Author

Mudgal, Richa, Jakhar, Alka, Gupta, Pankhuri, Yadav, Ram Singh, Biswal, B., Sahu, P., Bangar, Himanshu, Kumar, Akash, Chowdhury, Niru, Satpati, Biswarup, Nanda, B. R. K., Satpathy, S., Das, Samaresh, and Muduli, P. K.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

As a topological Dirac semimetal with controllable spin-orbit coupling and conductivity, PtSe$_2$, a transition-metal dichalcogenide, is a promising material for several applications from optoelectric to sensors. However, its potential for spintronics applications is yet to be explored. In this work, we demonstrate that PtSe$_{2}$/Ni$_{80}$Fe$_{20}$ heterostructure can generate a large damping-like current-induced spin-orbit torques (SOT), despite the absence of spin-splitting in bulk PtSe$_{2}$. The efficiency of charge-to-spin conversion is found to be $(-0.1 \pm 0.02)$~nm$^{-1}$ in PtSe$_{2}$/Ni$_{80}$Fe$_{20}$, which is three times that of the control sample, Ni$_{80}$Fe$_{20}$/Pt. Our band structure calculations show that the SOT due to the PtSe$_2$ arises from an unexpectedly large spin splitting in the interfacial region of PtSe$_2$ introduced by the proximity magnetic field of the Ni$_{80}$Fe$_{20}$ layer. Our results open up the possibilities of using large-area PtSe$_{2}$ for energy-efficient nanoscale devices by utilizing the proximity-induced SOT., Comment: 18 pages, 4 figures

Published
2023
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2. Large spin-to-charge conversion at the two-dimensional interface of transition metal dichalcogenides and permalloy

Author

Bangar, Himanshu, Kumar, Akash, Chowdhury, Niru, Mudgal, Richa, Gupta, Pankhuri, Yadav, Ram Singh, Das, Samaresh, and Muduli, P. K.

Subjects
Physics - Applied Physics
Abstract

Spin-to-charge conversion is an essential requirement for the implementation of spintronic devices. Recently, monolayers of semiconducting transition metal dichalcogenides (TMDs) have attracted considerable interest for spin-to-charge conversion due to their high spin-orbit coupling and lack of inversion symmetry in their crystal structure. However, reports of direct measurement of spin-to-charge conversion at TMD-based interfaces are very much limited. Here, we report on the room temperature observation of a large spin-to-charge conversion arising from the interface of Ni$_{80}$Fe$_{20}$ (Py) and four distinct large area ($\sim 5\times2$~mm$^2$) monolayer (ML) TMDs namely, MoS$_2$, MoSe$_2$, WS$_2$, and WSe$_2$. We show that both spin mixing conductance and the Rashba efficiency parameter ($\lambda_{IREE}$) scales with the spin-orbit coupling strength of the ML TMD layers. The $\lambda_{IREE}$ parameter is found to range between $-0.54$ and $-0.76$ nm for the four monolayer TMDs, demonstrating a large spin-to-charge conversion. Our findings reveal that TMD/ferromagnet interface can be used for efficient generation and detection of spin current, opening new opportunities for novel spintronic devices., Comment: This document is the unedited Author's version of a Submitted Work that was subsequently accepted for publication in ACS Appl. Mater. Interfaces [copyright ACS Publishing] after peer review

Published
2022
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4. Observation of a non-trivial in-plane field-like torque due to out-of-plane spin polarization in Al/Ni80Fe20/AlOx heterostructures.

Author

Mudgal, Richa, Gupta, Pankhuri, Das, Samaresh, and Muduli, P. K.

Subjects
*SPIN polarization, *TORQUE, *HETEROSTRUCTURES, *HALL effect, *FERROMAGNETIC resonance
Abstract

We performed spin-torque ferromagnetic resonance studies on the Al/NiFe/AlOx heterostructure. We observed a large non-trivial field-like torque, τ FL z , due to the out-of-plane spin polarization, despite the lack of heavy metal in our multilayer. The torque conductivity is found to be significant with a value equal to σ FL z = (21 ± 2) ℏ 2 e × 10 3 Ω − 1 m − 1 . From a detailed Al thickness dependence, we show that τ FL z arises from the interface between Al and NiFe. We demonstrate that the observed τ FL z arises from the spin-swapping mechanism at the Al/NiFe interface rather than the orbital Hall effect of Al. This observation of a non-trivial spin–orbit torque in the low-cost light element, Al, is highly significant for the energy-efficient control of spintronic devices. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Magnetic-Proximity-Induced Efficient Charge-to-Spin Conversion in Large-Area PtSe2/Ni80Fe20 Heterostructures

Author

Mudgal, Richa, primary, Jakhar, Alka, additional, Gupta, Pankhuri, additional, Yadav, Ram Singh, additional, Biswal, Bubunu, additional, Sahu, Pratik, additional, Bangar, Himanshu, additional, Kumar, Akash, additional, Chowdhury, Niru, additional, Satpati, Biswarup, additional, Kumar Nanda, Birabar Ranjit, additional, Satpathy, Sashi, additional, Das, Samaresh, additional, and Muduli, Pranaba Kishor, additional

Published
2023
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14. Resolving protein structure-function-binding site relationships from a binding site similarity network perspective

Author

Mudgal, Richa, Srinivasan, Narayanaswamy, and Chandra, Nagasuma

Subjects
Molecular Biophysics Unit, Biochemistry, Mathematics
Abstract

Functional annotation is seldom straightforward with complexities arising due to functional divergence in protein families or functional convergence between non-homologous protein families, leading to mis-annotations. An enzyme may contain multiple domains and not all domains may be involved in a given function, adding to the complexity in function annotation. To address this, we use binding site information from bound cognate ligands and catalytic residues, since it can help in resolving fold-function relationships at a finer level and with higher confidence. A comprehensive database of 2,020 fold-function-binding site relationships has been systematically generated. A network-based approach is employed to capture the complexity in these relationships, from which different types of associations are deciphered, that identify versatile protein folds performing diverse functions, same function associated with multiple folds and one-to-one relationships. Binding site similarity networks integrated with fold, function, and ligand similarity information are generated to understand the depth of these relationships. Apart from the observed continuity in the functional site space, network properties of these revealed versatile families with topologically different or dissimilar binding sites and structural families that perform very similar functions. As a case study, subtle changes in the active site of a set of evolutionarily related superfamilies are studied using these networks. Tracing of such similarities in evolutionarily related proteins provide clues into the transition and evolution of protein functions. Insights from this study will be helpful in accurate and reliable functional annotations of uncharacterized proteins, poly-pharmacology, and designing enzymes with new functional capabilities. Proteins 2017; 85:1319-1335. (c) 2017 Wiley Periodicals, Inc.

Published
2017

20. Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome using remote homology detection approaches: Insights into structure and function

Author

Ramakrishnan, Gayatri, primary, Ochoa-Montaño, Bernardo, additional, Raghavender, Upadhyayula S., additional, Mudgal, Richa, additional, Joshi, Adwait G., additional, Chandra, Nagasuma R., additional, Sowdhamini, Ramanathan, additional, Blundell, Tom L., additional, and Srinivasan, Narayanaswamy, additional

Published
2015
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28. Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation.

Author

Chandra, Suruchika, Priyadarshini, Raina, Madhavan, Vinoth, Tikoo, Shweta, Hussain, Mansoor, Mudgal, Richa, Modi, Priyanka, Srivastava, Vivek, and Sengupta, Sagar

Subjects
MYC proteins, BLOOM syndrome, HELICASES, PROTEOLYSIS, GENE expression, PROTEASOME inhibitors, TUMOR growth, THERAPEUTICS
Abstract

The spectrum of tumors that arise owing to the overexpression of c-Myc and loss of BLM is very similar. Hence, it was hypothesized that the presence of BLM negatively regulates c-Myc functions. By using multiple isogenic cell lines, we observed that the decrease of endogenous c-Myc levels that occurs in the presence of BLM is reversed when the cells are treated with proteasome inhibitors, indicating that BLM enhances c-Myc turnover. Whereas the N-terminal region of BLM interacts with c-Myc, the rest of the helicase interacts with the c-Myc E3 ligase Fbw7. The two BLM domains act as 'clamp and/or adaptor', enhancing the binding of c-Myc to Fbw7. BLM promotes Fbw7-dependent K48-linked c-Myc ubiquitylation and its subsequent degradation in a helicase-independent manner. A subset of BLM-regulated genes that are also targets of c-Myc were determined and validated at both RNA and protein levels. To obtain an in vivo validation of the effect of BLM on c-Myc-mediated tumor initiation, isogenic cells from colon cancer cells that either do or do not express BLM had been manipulated to block c-Myc expression in a controlled manner. By using these cell lines, the metastatic potential and rate of initiation of tumors in nude mice were determined. The presence of BLM decreases c-Myc-mediated invasiveness and delays tumor initiation in a mouse xenograft model. Consequently, in tumors that express BLM but not c-Myc, we observed a decreased ratio of proliferation to apoptosis together with a suppressed expression of the angiogenesis marker CD31. Hence, partly owing to its regulation of c-Myc stability, BLM acts as a 'caretaker tumor suppressor'. [ABSTRACT FROM AUTHOR]

Published
2013
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