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1,597 results on '"Muccioli, Giulio"'

13. Chemical Compositional Changes in Over-oxidized Fish Oils.

Author

Bannenberg, Gerard, Phung, Austin, Vigor, Claire, Reversat, Guillaume, Oger, Camille, Roumain, Martin, Galano, Jean-Marie, Durand, Thierry, Muccioli, Giulio, Ismail, Adam, and Wang, Selina

Subjects
Chemical Engineering, Nutrition & Dietetics, Food sciences
Abstract

A recent study has reported that the administration during gestation of a highly rancid hoki liver oil, obtained by oxidation through sustained exposure to oxygen gas and incident light for 30 days, causes newborn mortality in rats. This effect was attributed to lipid hydroperoxides formed in the omega-3 long-chain polyunsaturated fatty acid-rich oil, while other chemical changes in the damaged oil were overlooked. In the present study, the oxidation condition employed to damage the hoki liver oil was replicated, and the extreme rancidity was confirmed. A detailed analysis of temporal chemical changes resulting from the sustained oxidative challenge involved measures of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) omega-3 oil oxidative quality (peroxide value, para-anisidine value, total oxidation number, acid value, oligomers, antioxidant content, and induction time) as well as changes in fatty acid content, volatiles, isoprostanoids, and oxysterols. The chemical description was extended to refined anchovy oil, which is a more representative ingredient oil used in omega-3 finished products. The present study also analyzed the effects of a different oxidation method involving thermal exposure in the dark in contact with air, which is an oxidation condition that is more relevant to retail products. The two oils had different susceptibility to the oxidation conditions, resulting in distinct chemical oxidation signatures that were determined primarily by antioxidant protection as well as specific methodological aspects of the applied oxidative conditions. Unique isoprostanoids and oxysterols were formed in the over-oxidized fish oils, which are discussed in light of their potential biological activities.

Published
2021

18. Endothelial cell‐derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis

Author

Ruiz, Florian, Peter, Benjamin, Rebeaud, Jessica, Vigne, Solenne, Bressoud, Valentine, Roumain, Martin, Wyss, Tania, Yersin, Yannick, Wagner, Ingrid, Kreutzfeldt, Mario, Pimentel Mendes, Marisa, Kowalski, Camille, Boivin, Gael, Roth, Leonard, Schwaninger, Markus, Merkler, Doron, Muccioli, Giulio G, Hugues, Stephanie, Petrova, Tatiana V, and Pot, Caroline

Published
2023
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20. Anatatomic Shoulder Arthroplasty: Causes and Indications to Surgery

Author

Marcheggiani Muccioli, Giulio Maria, Fratini, Stefano, Rinaldi, Vito Gaetano, Cammisa, Eugenio, Alesi, Domenico, Di Sarsina, Tommaso Roberti, Lullini, Giada, Guerra, Enrico, Zaffagnini, Stefano, Huri, Gazi, editor, Familiari, Filippo, editor, Moon, Young Lae, editor, Doral, Mahmut Nedim, editor, and Marcheggiani Muccioli, Giulio Maria, editor

Published
2020
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21. Total Shoulder Arthroplasty: Principles and Biomechanics

Author

Marcheggiani Muccioli, Giulio Maria, Rinaldi, Vito Gaetano, Fratini, Stefano, Cammisa, Eugenio, Alesi, Domenico, Di Sarsina, Tommaso Roberti, Lullini, Giada, Rotini, Roberto, Zaffagnini, Stefano, Huri, Gazi, editor, Familiari, Filippo, editor, Moon, Young Lae, editor, Doral, Mahmut Nedim, editor, and Marcheggiani Muccioli, Giulio Maria, editor

Published
2020
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22. Rehabilitation Following Shoulder Arthroplasty

Author

Lullini, Giada, Marcheggiani Muccioli, Giulio Maria, Ravazzolo, Giovanni, Zaffagnini, Stefano, Huri, Gazi, editor, Familiari, Filippo, editor, Moon, Young Lae, editor, Doral, Mahmut Nedim, editor, and Marcheggiani Muccioli, Giulio Maria, editor

Published
2020
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29. Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial

Author

Ranaivo, Harimalala, Zhang, Zhengxiao, Alligier, Maud, Van Den Berghe, Laurie, Sothier, Monique, Lambert-Porcheron, Stéphanie, Feugier, Nathalie, Cuerq, Charlotte, Machon, Christelle, Neyrinck, Audrey M., Seethaler, Benjamin, Rodriguez, Julie, Roumain, Martin, Muccioli, Giulio G., Maquet, Véronique, Laville, Martine, Bischoff, Stephan C., Walter, Jens, Delzenne, Nathalie M., and Nazare, Julie-Anne

Published
2022
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32. Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination.

Author

Mwema, Ariane, Gratpain, Viridiane, Ucakar, Bernard, Vanvarenberg, Kevin, Perdaens, Océane, van Pesch, Vincent, Muccioli, Giulio G., and des Rieux, Anne

Abstract

Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system (CNS) in need of a curative treatment. MS research has recently focused on the development of pro-remyelinating treatments and neuroprotective therapies. Here, we aimed at favoring remyelination and reducing neuro-inflammation in a cuprizone mouse model of brain demyelination using nanomedicines. We have selected lipid nanocapsules (LNC) coated with the cell-penetrating peptide transactivator of translation (TAT), loaded with either a pro-remyelinating compound, calcitriol (Cal-LNC TAT), or an anti-inflammatory bioactive lipid, prostaglandin D2-glycerol ester (PGD2-G) (PGD2-G-LNC TAT). Following the characterization of these formulations, we showed that Cal-LNC TAT in combination with PGD2-G-LNC TAT increased the mRNA expression of oligodendrocyte differentiation markers both in the CG-4 cell line and in primary mixed glial cell (MGC) cultures. However, while the combination of Cal-LNC TAT and PGD2-G-LNC TAT showed promising results in vitro, no significant impact, in terms of remyelination, astrogliosis, and microgliosis, was observed in vivo in the corpus callosum of cuprizone-treated mice following intranasal administration. Thus, although calcitriol's beneficial effects have been abundantly described in the literature in the context of MS, here, we show that the different doses of calcitriol tested had a negative impact on the mice well-being and showed no beneficial effect in the cuprizone model in terms of remyelination and neuro-inflammation, alone and when combined with PGD2-G-LNC TAT. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.

Author

Paone, Paola, Latousakis, Dimitris, Terrasi, Romano, Vertommen, Didier, Ching Jian, Borlandelli, Valentina, Suriano, Francesco, Johansson, Malin E. V., Puel, Anthony, Bouzin, Caroline, Delzenne, Nathalie M., Salonen, Anne, Juge, Nathalie, Florea, Bogdan I., Muccioli, Giulio G., Overkleeft, Herman, Van Hul, Matthias, and Cani, Patrice D.

Subjects
LIFE sciences, TRANSCRIPTION factors, CYTOLOGY, WEIGHT gain, WEIGHT loss, GLYCANS, LEPTIN, CHOLANGITIS, METABOLIC disorders
Published
2024
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34. Mechanically Aligned Second-Generation Medial Pivot Primary Total Knee Arthroplasty Does Not Reproduce Normal Knee Biomechanics: A Gait Analysis Study.

Author

La Verde, Matteo, Belvedere, Claudio, Cammisa, Eugenio, Alesi, Domenico, Fogacci, Alberto, Ortolani, Maurizio, Sileoni, Nicoletta, Lullini, Giada, Leardini, Alberto, Zaffagnini, Stefano, and Marcheggiani Muccioli, Giulio Maria

Subjects
KNEE joint, TOTAL knee replacement, ANATOMICAL planes, KNEE osteoarthritis, VISUAL analog scale
Abstract

Background: This study aimed to evaluate post-operative lower limb function following second-generation mechanically aligned medial pivot (MP) TKA implantation. Standard gait analysis was performed to collect kinematic and kinetic data, which were then compared with physiological data from the literature obtained using the same evaluation methodology as the present study. The hypothesis was that this TKA would not fully restore normal knee and adjacent joint motion during walking. Methods: Our cohort comprised 15 patients consecutively enrolled from September 2019 to December 2022 who underwent primary TKA with the second-generation MP Evolution Knee System (MicroPort Orthopaedics Inc., Arlington, TN, USA). Pre-operatively and 6 months post-surgery, gait analysis during level walking was performed on all patients, as well as clinical evaluations using the Knee Society Score (KSS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Visual Analogue Scale (VAS). Results: The clinical scores improved significantly (p < 0.001) after surgery (pre-/post-operative KSS functional, KSS clinical, VAS, and KOOS: 51.7 ± 17.3/84 ± 18.4, 45.3 ± 16.2/74.1 ± 12.6, 6.9 ± 1.8/2.0 ± 1.9, and 33.9 ± 11.8/69.1 ± 16.5, respectively). The statistical parametric mapping (SPM) analysis between the post-operative and reference control data revealed significant differences in the initial and final 20% of the gait cycle for the rotation of the knee in the frontal and transverse planes and for the rotation of the ankle in the sagittal plane. Conclusions: This study shows that new-generation MP TKA with mechanical alignment does not fully restore normal gait biomechanics, particularly in knee rotational movements, indicating a need for improved surgical techniques and prosthetic designs. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial

Author

Neyrinck, Audrey M., Rodriguez, Julie, Zhang, Zhengxiao, Seethaler, Benjamin, Sánchez, Cándido Robles, Roumain, Martin, Hiel, Sophie, Bindels, Laure B., Cani, Patrice D., Paquot, Nicolas, Cnop, Miriam, Nazare, Julie-Anne, Laville, Martine, Muccioli, Giulio G., Bischoff, Stephan C., Walter, Jens, Thissen, Jean-Paul, and Delzenne, Nathalie M.

Published
2021
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47. Does gait influence biomechanics in a distal femoral osteotomy? An early post operative fracture after DFO above a Tomofix® plate in a multiple sclerosis and low-density bone affected patient: choose a longer plate—a case report.

Author

Favero, Antongiulio, Alesi, Domenico, Rinaldi, Vito Gaetano, Cerasoli, Tosca, Zaffagnini, Stefano, and Marcheggiani Muccioli, Giulio Maria

Subjects
BONE density, GAIT disorders, FEMORAL fractures, BODY mass index, GAIT in humans
Abstract

Background: Distal femur osteotomies are a well known and valuable treatment option to manage valgus malalignment with unicompartmental arthritis. Early postoperative complications are well known, and risk factors, such as pulmonary diseases, smoke, high dependent functional status, and body mass index, have been studied, but no study is available about osteotomies when gait is abnormal because of neurodegenerative conditions or when mineral density is below the normal rate. Case presentation: We report the case of a 44 year-old female Mediterranean patient who underwent a biplanar distal femur opening wedge osteotomy surgery following a lateral meniscus total removal, which led to the subsequent development of lateral compartment osteoarthritis and pain, despite general comorbidities, such as multiple sclerosis. Additionally, 2 months later a supracondylar femur fracture above the previously applied Tomofix® plate was reported. Fracture was treated by applying a LCP condylar 16 hole (336 mm) plate, a structural fibular graft, and strut fibular graft on the opposite side. Conclusion: The overall aim of this case report is to provide a lesson to surgeons who want to perform a realignment surgery of the lower limb in patients with abnormal gait. Not only mechanical axes are to be considered, but also bone density, patient's gait, and load force distribution along the bone stock. Emerging literature on three-dimensional cutting guides fails to account for these factors, thus promoting a standardized approach to surgery across all patients. The present case highlights a patient with low bone density and abnormal force distribution resulting from a pathologic neurodegenerative gait. In such cases, treatment decisions must carefully consider the biomechanical vulnerabilities of the native bone and the distribution of vector forces. These conditions must lead the choice toward a longer plate if an osteotomy is indicated, because surgery is more likely to fail. [ABSTRACT FROM AUTHOR]

Published
2024
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