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The relationship between ventricular arrhythmias and major depressive disorder (MDD) has been previously revealed. Recently, frontal QRS-T angle (fQRSTa) and Tp-Te/QT ratio proved to provide more accurate predictive data about ventricular arrhythmias than the measurement of QT, QTc, and QT dispersion. The aim of this study was to determine the effects of MDD on contemporary ventricular arrhythmia indicators.57 newly diagnosed MDD patients and 65 healthy subjects were included in the study. Hamilton depression rating scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-A) were administered and ECG measurements were obtained. Ventricular arrhythmia predisposition was assessed by calculating the Tp-Te/QT ratio in addition to fQRSTa.fQRSTa and Tp-Te/QT ratio values in the MDD group were significantly higher than the control group. Correlation analyses revealed that Tp-Te/QT ratio and fQRSTa significantly correlated with (HAM-D). It was found with linear regression analysis, MDD existence and its severities were independent predictors of fQRSTa and Tp-Te/QT ratio.MDD predisposes to ventricular arrhythmia by causing increased fQRSTa and Tp-Te/QT ratio on ECG. Increased fQRSTa and Tp-Te/QT ratio may be useful indicators of dysregulation in the autonomic nervous system and increased risk of ventricular arrhythmias in MDD patients (Tab. 6, Fig. 4, Ref. 38). Text in PDF www.elis.sk Keywords: major depressive disorder, Hamilton depression rating scale, frontal QRS-T angle, Tp-Te/QT ratio.

BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been associated with the risk of clinical cardiovascular events. OBJECTIVES: In this study, we aimed to investigate whether the activity of Lp-PLA2 presents a risk for subclinical atherosclerosis in young patients with premature ovarian failure (POF). METHODS: Consecutive patients with clinical and biochemical evidence of naïve POF (n = 66) in January and February 2018 and age-matched healthy controls (n = 73) were enrolled. Lp-PLA2 activity, fibrinogen concentrations, high- sensitivity C-reactive protein (Hs-CRP) levels, and carotid intima-media thickness (CIMT) were measured in all participants. RESULTS: Plasma Lp-PLA2 activity (24.6 ± 3.2 nmol/mL vs. 18.6 ± 1.6 nmol/mL; p < 0.001), mean Hs-CRP (0.620 ± 0.26 mg/dL vs. 0.450 ± 0.28 mg/dL; p < 0.001) and fibrinogen (0.310 ± 0.12 g/dL vs. 0.24 ± 0.11 g/dL; p < 0.001) levels were significantly higher in the patients with POF than control subjects. Mean CIMT was significantly higher in the POF patients than in controls (0.499 ± 0.122 mm vs. 0.323 ± 0.079 mm; p < 0.001). There was a possitive and strong correlation between CIMT and Lp-PLA2 activity (r = 0.548; 95% CI 0.445-0.644; p < 0.001) and a weak correlation Hs-CRP (r = 0.228, 95% CI 0.060-0.398; p = 0.007). In multivariate analysis, Lp-PLA2 activity (B = 1.456, 95% CI 0.908-2.003; p < 0.001) and 17β-E2 (B = -0.077, 95% CI -0.131 - -0.023; p = 0.006) were found to be independently associated with CIMT (R(2) = 0.46). CONCLUSIONS: The present study showed that mean CIMT and Lp-PLA2 activity were significantly higher in POF subjects than control subjects. Moreover, Lp-PLA2 activity and 17β-E2 levels were independently associated with CIMT in young POF patients.