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Aim This is an update of the interdisciplinary S3-guideline on the Diagnosis, Therapy and Follow-up of Cervical Cancer (AWMF Registry No. 032/033OL), published in March 2021. The work on the updated guideline was funded by German Cancer Aid (Deutsche Krebshilfe) as part of the German Guideline Program in Oncology. The guideline was coordinated by the German Society of Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG) and the Working Group on Gynecological Oncology (Arbeitsgemeinschaft Gynäkologische Onkologie, AGO) of the German Cancer Society (Deutsche Krebsgesellschaft, DKG). Method The process used to update the 2014 S3-guideline was based on an appraisal of the available evidence using the criteria of evidence-based medicine, adaptations of existing evidence-based national and international guidelines or – if evidence was lacking – on the consensus of the specialists involved in compiling the update. After an initial review of the current literature was carried out according to a prescribed algorithm, several areas were identified which, in contrast to the predecessor version from September 2014, required new recommendations or statements which would take account of more recently published literature and the recent appraisal of new evidence. Recommendations The short version of this guideline consists of recommendations and statements on palliative therapy and follow-up of patients with cervical cancer. The most important aspects included in this updated guideline are the new FIGO classification published in 2018, the radical open surgery approach used to treat cervical cancer up to FIGO stage IB1, and the use of the sentinel lymph node technique for tumors ≤ 2 cm. Other changes include the use of PET-CT, new options in radiotherapy (e.g., intensity-modulated radiotherapy, image-guided adaptive brachytherapy), and drug therapies to treat recurrence or metastasis.

Apitherapy is a therapeutic approach based on the use of beehive products. It is frequently suggested for the treatment of rheumatoid arthritis. This study was to assess the recommendations of apitherapists regarding the treatment of rheumatoid arthritis. 129 books written by apitherapists were reviewed regarding their recommendations for rheumatoid arthritis. These recommendations were compared to the findings of preclinical and clinical studies on the subject. Sixty-eight (52.7%) of the books mention the topic of rheumatoid arthritis and there were 44 different recommendations. They include all bee products (honey, pollen, propolis, etc.) but mainly bee venom (15 times) and royal jelly (5 times). Bee venom acupuncture (apipuncture) is mentioned only once. Compared to analyses from the scientific literature, only bee venom but mainly apipuncture are supported. This analysis shows that the majority of apitherapeutic books do not provide adequate information. However, some reports supported the scientific evidence that bee venom and apipuncture could be an interesting means of treatment of rheumatoid arthritis but more and higher quality clinical investigations are necessary., Apiterapi, arı kovanı ürünlerinin kullanımına dayalı bir tedavi yaklaşımıdır. Romatoid artrit tedavisi için sıklıkla önerilmektedir. Bu çalışma, apiterapistlerin romatoid artrit tedavisine ilişkin önerilerini değerlendirmek amacıyla yapılmıştır. Apiterapistler tarafından yazılan 129 kitap, romatoid artrit önerileri açısından gözden geçirilmiştir. Bu öneriler, konuyla ilgili klinik öncesi ve klinik çalışmaların bulgularıyla karşılaştırılmıştır. Kitapların 68'i (%52.7) romatoid artrit konusuna değinmektedir ve 44 farklı öneri bulunmaktadır. Bu öneriler tüm arı ürünlerini (bal, polen, propolis vb.) içermekle birlikte başlıca arı zehiri (15 kez) ve arı sütüne (5 kez) değinilmiştir. Arı zehri akupunkturundan (apipunktur) sadece bir kez bahsedilmiştir. Bilimsel literatürdeki analizlerle karşılaştırıldığında, sadece arı zehri ancak ağırlıklı olarak apipunktur desteklenmektedir. Bu analiz, apiterapötik kitapların çoğunun yeterli bilgi sağlamadığını göstermektedir. Bazı araştırmalar arı zehri ve apipunkturun romatoid artrit tedavisine yönelik farklı bir tedavi yaklaşımı olabileceğine yönelik bilimsel kanıtları desteklemekte olup bununla birlikte bu konuda daha fazla ve daha kaliteli klinik araştırmalara ihiyaç vardır.

Aims Annual opportunistic screening for cervical carcinoma has been done in Germany since 1971. The creation of this S3 guideline meets an important need, outlined in the National Cancer Plan, with regard to screening for cervical cancer, as this guideline aims to provide important information and support for planned organized screening for cervical cancer in Germany. Methods With the financial support of German Cancer Aid, 21 professional societies developed evidence-based statements and recommendations (classified using the GRADE system) for the screening, management and treatment of precancerous conditions of the cervix. Two independent scientific institutes compiled systematic reviews for this guideline. Recommendations The second part of this short summary deals with the triage, treatment and follow-up care of cervical dysplasia. With regard to those women who do not participate in screening, the guideline authors recommend sending out repeat invitation letters or an HPV self-collection kit. Colposcopy should be carried out for further investigation if cytology findings are Pap II-p and HPV test results are positive or if the results of an HPV 16 or HPV 18 screening test are positive. A single abnormal Pap smear should be triaged and investigated using HPV testing or p16/Ki67 dual staining.