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5. Estimating the reproducibility of psychological science

Author

Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Abstract

Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

Published
2015

6. Estimating the reproducibility of psychological science

Author

Social Networks, Solidarity and Inequality, Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Social Networks, Solidarity and Inequality, Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Published
2015

7. Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1in a patient with bilateral breast and endometrial adenocarcinoma

Author

Heitzer, Ellen, primary, Lax, Sigurd, additional, Lafer, Ingrid, additional, Müller, Stephanie M, additional, Pristauz, Gunda, additional, Ulz, Peter, additional, Jahn, Stephan, additional, Högenauer, Christoph, additional, Petru, Edgar, additional, Speicher, Michael R, additional, and Geigl, Jochen B, additional

Published
2013
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17. Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma.

Author

Heitzer, Ellen, Lax, Sigurd, Lafer, Ingrid, Müller, Stephanie M., Pristauz, Gunda, Ulz, Peter, Jahn, Stephan, Högenauer, Christoph, Petru, Edgar, Speicher, Michael R., and Geigl, Jochen B.

Subjects
CANCER diagnosis, GENETIC disorders, PATHOGENIC microorganisms, BREAST cancer, ADENOCARCINOMA
Abstract

Background Germline genetic testing for familial cancer syndromes is usually performed serially for the most likely genetic causes. In recent years the way genetic testing carried out has changed, as next generation sequencing now allows the simultaneous testing of multiple susceptibility genes at low costs. Case presentation Here, we present a female with bilateral breast cancer and endometrial adenocarcinoma. After simultaneous sequencing of 150 genes (890 kb) associated with hereditary cancer we identified pathogenic mutations in two high-penetrance genes, i.e. TP53 and CDH1 that would most likely not have been elucidated by serial screening of candidate genes. Conclusion As the two mutated genes are located on different chromosomes and cause different cancer syndromes these findings had a tremendous impact not only on genetic counseling of the index patient and her family but also on subsequent surveillance strategies. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
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18. Estimating the reproducibility of psychological science

Author

Open Science Collaboration, Aarts, Alexander A., Anderson, Joanna E., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Cohn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Cramblet Alvarez, Leslie D., Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Della Penna, Nicolás, den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O.Y., Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., LeBel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, Mackinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E.J., Matacotta, Josh, Mathur, Maya B., May, Michael, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima-Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, Colleen, Skorinko, Jeanine L., Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, van ‘t Veer, A. E., Van Aert, Robbie, van Assen, Marcel, van Bork, Riet, van de Ven, Mathijs, van den Bergh, Donald, van der Hulst, Marije, van Dooren, Roel, van Doorn, Johnny, van Renswoude, Daan R., van Rijn, Hedderik, Vanpaemel, Wolf, Vásquez Echeverría, Alejandro, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric-Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Open Science Collaboration, Aarts, Alexander A., Anderson, Joanna E., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Cohn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Cramblet Alvarez, Leslie D., Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Della Penna, Nicolás, den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O.Y., Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., LeBel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, Mackinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E.J., Matacotta, Josh, Mathur, Maya B., May, Michael, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima-Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, Colleen, Skorinko, Jeanine L., Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, van ‘t Veer, A. E., Van Aert, Robbie, van Assen, Marcel, van Bork, Riet, van de Ven, Mathijs, van den Bergh, Donald, van der Hulst, Marije, van Dooren, Roel, van Doorn, Johnny, van Renswoude, Daan R., van Rijn, Hedderik, Vanpaemel, Wolf, Vásquez Echeverría, Alejandro, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric-Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Abstract

Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

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