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1. Operational issues in preventing mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire, 1998-99

Author

Msellati Philippe, Hingst Gepke, Kaba Fanta, Viho Ida, Welffens-Ekra Christiane, and Dabis François

Subjects
HIV infections/therapy, HIV infections/diagnosis, HIV-1/immunology, HIV seropositivity, Disease transmission, Vertical/prevention and control, Breast feeding/adverse effects, Pregnancy, AIDS serodiagnosis, Counseling, Truth disclosure, Zidovudine/therapeutic use, Program evaluation, Côte d'Ivoire, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: To demonstrate the feasibility, from the public health standpoint, of preventing mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in Africa. METHODS: Voluntary counselling and HIV serotesting were routinely provided in four health centres in Abidjan, Côte d'Ivoire, for six months in 1998-99. Peripartum treatment with zidovudine and alternatives to breastfeeding were provided free to HIV-infected women. FINDINGS: Of the 4309 pregnant women in the study who attended their first antenatal care visit, 3756 benefited from individual counselling and pretesting (87.2%), and 3452 (80.1%) agreed to undergo HIV serotesting. Overall HIV prevalence was (12.89%) and 5% for women aged under 18 years. Among the 2998 HIV-negative women, 71% returned for their test result, whereas only 60% of the 445 HIV-positive women did so. A total of 124 HIV-positive women were informed of their serostatus and the possibility of preventing mother-to-child transmission of HIV; 100 started treatment and 80 completed zidovudine prophylaxis. At 6 weeks of age, 36 of the 78 liveborn children were being breastfed (46%), two were being mixed-fed and 41 (52%) were being artificially fed. CONCLUSION: In Abidjan, voluntary counselling and HIV testing with a view to preventing mother-to-child transmission was feasible in antenatal care units and was well accepted by pregnant women. An insufficient proportion of women returned to obtain their test results. This was especially so among HIV-positive women, the target group for preventing mother-to-child transmission of HIV. Additional staff were required in order to offer voluntary counselling and HIV testing to the study women. Close supervision and strong commitment of health workers were essential. Alternatives to breastfeeding were effectively proposed to HIV-positive women, with active follow-up of children and clinical, nutritional and social support.

Published
2001

2. Evolution of the biological follow-up of efficiency and tolerance of a once daily antiretroviral treatment with 3TC+DDI+EFV in children infected with HIV-1 (CLINICAL TRIAL ANRS 12 103)

Author

Hien Alain, Yameogo Souleymane, Kania Dramane, Rouet François, Ouiminga Adama, Drabo Aly, Van de Perre Philippe, Diabouga Potiendi, Zoure Emmanuelle, Diasso Yaya, Nacro Boubacar, Hien Hervé, and Msellati Philippe

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2009
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3. Didanosine population pharmacokinetics in West African HIV-infected children administered once daily tablets in relation to efficacy after one year of treatment (ANRS 12103)

Author

Van de Perre Philippe, Foulongue Vincent, Urien Saïk, Ouiminga Adama, Rouet François, Zouré Emmanuelle, Hien Hervé, Nacro Boubacar, Diagbouga Serge, Bardin Christophe, Hirt Déborah, Tréluyer Jean-Marc, and Msellati Philippe

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2009
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6. 18-month occurrence of severe events among early diagnosed HIV-infected children before antiretroviral therapy in Abidjan, Côte d'Ivoire: A cohort study

Author

Dabis François, Rouet François, Touré Pety, Becquet Renaud, Fassinou Patricia, Harambat Jérôme, Msellati Philippe, Blanche Stéphane, Timité-Konan Marguerite, Salamon Roger, and Leroy Valériane

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Objective To assess the 18-month field effectiveness on severe events of a pediatric package combining early HIV-diagnosis and targeted cotrimoxazole prophylaxis in HIV-infected children from age six-week before the antiretroviral era, in Abidjan, Côte d'Ivoire. Methods Data from two consecutive prevention of HIV mother-to-child transmission programs were compared: the ANRS 1201/1202 Ditrame-Plus cohort (2001–2005) and the pooled data of the ANRS 049a Ditrame randomized trial and its following open-labeled cohort (1995–2000), used as a reference group. HIV-infected pregnant women ≥ 32–36 weeks of gestation were offered a short-course peri-partum antiretroviral prophylaxis (ZDV in Ditrame, and ZDV ± 3TC+single-dose (sd) NVP in Ditrame-Plus). Neonatal prophylaxis was provided in Ditrame-Plus only: 7-day ZDV and sdNVP 48–72 h after birth. A 6-week pediatric HIV-RNA diagnosis was provided on-line in the Ditrame-Plus while it was only oriented on clinical symptoms in Ditrame. Six-week HIV-infected children received a daily cotrimoxazole prophylaxis in Ditrame-Plus while no prophylaxis was provided in Ditrame. The determinants of severe events (death or hospitalization > 1 day) were assessed in a Cox regression model. Results Between 1995 and 2003, 98 out of the 1121 live-births were diagnosed as HIV-infected in peri-partum: 45 from Ditrame-Plus and 53 from Ditrame. The 18-month Kaplan-Meier cumulative probability of presenting a severe event was 66% in Ditrame-Plus (95% confidence interval [95%CI]: 50%–81%) and 77% in Ditrame (95%CI: 65%–89%), Log Rank test: p = 0.47. After adjustment on maternal WHO clinical stage, maternal death, 6-week pediatric viral load, birth-weight, and breastfeeding exposure, the 18-month risk of severe event was lower in Ditrame-Plus than in Ditrame (adjusted Hazard Ratio (aHR): 0.55, 95%CI: 0.3–1.1), although the difference was not statistically significant; p = 0.07). Maternal death was the only variable determinant of the occurrence of severe events in children (aHR: 3.73; CI: 2.2–11.2; p = 0.01). Conclusion Early cotrimoxazole from 6 weeks of age in HIV-infected infants seemed to reduce probability of severe events but the study lacked statistical power to prove this. Even with systematic cotrimoxazole prophylaxis, infant morbidity and mortality remained high pointing towards a need for early pediatric HIV-diagnosis and antiretroviral treatment in Africa.

Published
2008
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8. Illness-related behaviour and utilization of oral health services among adult city-dwellers in Burkina Faso: evidence from a household survey

Author

Ouattara Seydou, Gary Jean, Msellati Philippe, Fournet Florence, Petersen Poul, Varenne Benoît, Harang Maud, and Salem Gérard

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background In sub-Saharan Africa, the availability and accessibility of oral health services are seriously constrained and the provision of essential oral care is limited. Reports from the region show a very low utilization of oral health care services, and visits to dental-care facilities are mostly undertaken for symptomatic reasons. The objectives of the present study were to describe the prevalence of oral symptoms among adults in Ouagadougou, capital city of Burkina Faso and the use of oral health services and self-medication in response to these symptoms and to measure the associations between predisposing, enabling and needs factors and decisions to seek oral health care. Methods The conceptual design of the study was derived from both the Andersen-Newman model of health care utilization and the conceptual framework of the WHO International Collaborative Study of Oral Health Outcomes. Data were obtained by two-stage stratified sampling through four areas representative of different stages of urbanization of Ouagadougou. The final study population comprised 3030 adults aged 15 years or over and the response rate was 65%. Results Overall, 28% of the respondents had experienced an oral health problem during the past 12 months; a high proportion (62%) reported pain or acute discomfort affecting daily life. In response to symptoms, only 28% used oral health facilities, 48% used self-medication and 24% sought no treatment at all. Multivariate analyses revealed that several socio-economic and socio-cultural factors such as religious affiliation, material living conditions and participation in a social network were significantly associated with the use of oral health care services by adults who had experienced oral health problems during the previous year. Conclusion The proportion of people who have obtained oral health care is alarmingly low in Ouagadougou and self-medication appears to be an important alternative source of care for adult city-dwellers. Decision-makers in sub-Saharan countries must seek to ensure that access to essential oral health care is improved.

Published
2006
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9. Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: a Cameroonian cohort study (ANRS-12140 Pediacam study, 2008–2013, Cameroon)

Author

Francis Ateba Ndongo, Mathurin Cyrille Tejiokem, Calixte Ida Penda, Suzie Tetang Ndiang, Jean-Audrey Ndongo, Georgette Guemkam, Casimir Ledoux Sofeu, Paul Alain Tagnouokam-ngoupo, Anfumbom Kfutwah, Philippe Msellati, Albert Faye, and Josiane Warszawski

Subjects
HIV-infected children, Early initiated antiretroviral treatment, Long-term outcomes, Pediatrics, RJ1-570
Abstract

Abstract Background In most studies, the virological response is assessed during the first two years of antiretroviral treatment initiated in HIV-infected infants. However, early initiation of antiretroviral therapy exposes infants to very long-lasting treatment. Moreover, maintaining viral suppression in children is difficult. We aimed to assess the virologic response and mortality in HIV-infected children after five years of early initiated antiretroviral treatment (ART) and identify factors associated with virologic success in Cameroon. Methods In the ANRS-12140 Pediacam cohort study, 2008–2013, Cameroon, we included all the 149 children who were still alive after two years of early ART. Virologic response was assessed after 5 years of treatment. The probability of maintaining virologic success between two and five years of ART was estimated using Kaplan-Meier curve. The immune status and mortality were also studied at five years after ART initiation. Factors associated with a viral load

Published
2021
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10. Pediatric Presentations of COVID-19 and Pertinent Radiologic Findings.

Author

Msellati, Augustin, Loo, Caitlyn, Toerien, Lara, and Catanzano, Tara

Abstract

Since the 2019 worldwide pandemic, Severe Acute Respiratory Syndrome coronavirus 2 responsible for COVID-19 disease, not only had global economic repercussions but millions of individuals health were also put at risk. Like any other respiratory illness, COVID-19 has a variety of presentations and radiological features. While COVID-19 infections in the pediatric population generally present with better prognosis and lower mortality rates when compared to those of adults, in the vulnerable populations however, severe presentations are often more frequent and can have catastrophic consequences. This paper will specifically address pediatric presentations of COVID-19 including those suffering from multisystem inflammation, along with their radiologic manifestations and image findings. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Emergency Presentations of Coronavirus Disease (COVID-19): A Review of the Literature and Radiologic Perspective.

Author

Loo, Caitlyn, Treacy, Molly Godson, Toerien, Lara, Msellati, Augustin, and Catanzano, Tara

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the debilitating global pandemic known as Coronavirus disease (COVID-19). In this paper, we highlight the widespread manifestations and complications across disease systems. In addition, we present their relevant imaging findings to inform appropriate investigations and management in patients presenting to the Emergency Department with COVID-19 and its respective sequalae. Of note, we outline considerations for diagnosis of long COVID, an important medium to long term sequalae in patients with previous COVID-19 infections. [ABSTRACT FROM AUTHOR]

Published
2024
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14. High level of treatment failure and drug resistance to first-line antiretroviral therapies among HIV-infected children receiving decentralized care in Senegal

Author

Cissé, Abdoul-Magib, Laborde-Balen, Gabrièle, Kébé-Fall, Khady, Dramé, Aboubacry, Diop, Halimatou, Diop, Karim, FatouNiasse-Traoré, Coulibaly, Mohamed, Have, Ndeye-Ngone, Vidal, Nicole, Thiam, Safiatou, Wade, Abdoulaye S., Peeters, Martine, Taverne, Bernard, Msellati, Philippe, and Touré-Kane, Coumba

Published
2019
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16. Santé sexuelle et reproductive des adolescent(e)s vivant avec le VIH dans les programmes de prise en charge pédiatrique à Abidjan : offre de services des structures et perceptions des professionnels de santé en 2019

Author

Revegue, M. H. Dassi Tchoupa, primary, Jesson, J., additional, Dago-Akribi, H. Aka, additional, Dahourou, D.L., additional, Ogbo, P., additional, Moh, C., additional, Amoussou-Bouah, U.B., additional, N'Gbeche, M-S., additional, Eboua, F. Tanoh, additional, Kouassi, E. Messou, additional, Kouadio, K., additional, Cacou, M-C., additional, Horo, A., additional, Msellati, P., additional, Sturm, G., additional, and Leroy, V., additional

Published
2022
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21. HIV Disclosure to the Child/Adolescent in Central and West Francophone Africa

Author

Dahourou, DL., Masson, D., Aka-Dago-Akribi, H., Gauthier-Lafaye, C., Cacou, C., Raynaud, JP, Moh, C., Bouah, B., Sturm, G., Oga, M., Msellati, P., Leroy, V., Centre Muraz [Bobo-Dioulasso, Burkina Faso], Université Félix Houphouët-Boigny (UFHB), Université Toulouse - Jean Jaurès (UT2J), Institut de Recherche pour le Développement (IRD), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Montpellier (UM)

Subjects
Health Knowledge, Attitudes, Practice, Adolescent, Attitude of Health Personnel, Health Personnel, HIV Infections, Disclosure, Mali, République démocratique du Congo, Sénégal, Cameroun, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Burkina Faso, Humans, Benin, Bénin, Africa, Central, Child, Professional practices, Sub-Saharan Africa, Pratiques professionnelles, Côte d’Ivoire, Annonce, HIV, VIH, Senegal, Enfan, Africa, Western, Togo, Democratic Republic of the Congo, Afrique intertropicale, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; We report the attitudes and practices of health care workers involved in the disclosure process to adolescents living with HIV (ALHIV) in a network including West and Central African French- speaking countries, and the experiences of young living with HIV (YLHIV). During a three-day workshop in Abidjan, Côte d’Ivoire, caregivers (doctors, psychologists, social workers) from 19 pediatric HIV treatment sites shared their practices and difficulties, and four YPLHIV their own disclosure experience. Thirty five participants from eight West/Central African countries (Benin, Burkina Faso, Ivory Coast, Cameroon, Mali, Democratic Republic of Congo, Senegal, Togo) contributed: 14 doctors, eight psychologists, six counselors, three social workers. The experience of the centers was variable, but the age at disclosure was late: 34% of 1296 adolescents between 10 and 12 years of age knew their status. The median age at disclosure was 13 years (range: 11-15 years). The practice of the disclosure was often complex, because of multiple factors (fear of the parents of the breaking of the secrecy, lack of communication between professionals). The individual disclosure was the main practice. Four centers practiced HIV disclosure in group sessions to facilitate mirror support, and one used peer-to-peer support. YPLHIV have advocated for an earlier disclosure, from 10 years. In West and Central Africa, the process of HIV disclosure remains complex for parents and caregivers, and occurs too late. The development of a good practice guideline for HIV disclosing adapted to socio-cultural contexts should help to improve this process.; Nous rapportons les attitudes et pratiques des soignants en Afrique francophone concernant l’annonce du statut VIH aux adolescents, et les témoignages de jeunes vivant avec le VIH (jvVIH). Lors d’un atelier de trois jours à Abidjan, Côte d’Ivoire, en novembre 2016, les soignants (médecins, psychologues, travailleurs sociaux) de 19 sites de prise en charge pédiatrique du VIH ont partagé leurs pratiques et difficultés et 4 jvVIH leur vécu de l’annonce. Au total, 35 participants de 8 pays d’Afrique de l’Ouest/centrale (Bénin, Burkina Faso, Côte d’Ivoire, Cameroun, Mali, République démocratique du Congo, Sénégal, Togo) ont contribué : 14 médecins, 8 psychologues, 6 conseillers, 3 travailleurs sociaux. L’expérience des centres était variable, mais l’âge à l’annonce restait tardif : 34 % des 1 296 adolescents âgés entre 10 et 12 ans connaissaient leur statut. L’âge médian à l’annonce était de 13 ans (étendue : 11-15 ans). La pratique de l’annonce s’avérait complexe, en raison de multiples facteurs (crainte des parents de la rupture du secret, manque de communication entre professionnels). L’annonce individuelle était la pratique majoritairement adoptée. Quatre centres pratiquaient une annonce en séances de groupe pour faciliter le soutien en miroir, et un avait recours à l’appui de pairs-adolescents. Les jvVIH ont plaidé pour une annonce plus précoce, dès 10 ans. En Afrique de l’Ouest/centrale francophone, le processus de l’annonce reste complexe pour parents et soignants, et l’annonce trop tardive. L’élaboration d’un guide de bonnes pratiques de l’annonce du VIH, adapté aux contextes socio-culturels devrait permettre d’améliorer ce processus.

Published
2019

22. A community-based peer-facilitated psychological and social support model to improve retention in care among Cameroonian adolescents perinatally infected with human immunodeficiency virus: A randomized controlled trial

Author

Ndongo, Francis Ateba, Noah, Jean-Pierre Yves Awono, Kana, Rogacien, Ndie, Justin, Nono, MariusTchassep, Ndzie, Patrice, Tejiokem, Mathurin Cyrille, Biheng, Emmanuelle Hopp, Nkoa, Tatiana Avang, Coulibaly, Yacouba Aba, Fokam, Joseph, Ketchaji, Alice, Ngako, Joëlle Nounouce, Penda, Calixte Ida, Ndombo, Paul Olivier Koki, Hawa, Hubert Mbassi, Msellati, Philippe, Faye, Albert, Lallemant, Marc, and Bissek, Anne Cécile Zoung-Kani

Abstract

Psychological and social support for adolescents living with HIV remains undocumented and unaddressed in Central Africa. This study aimed at assessing effectiveness of a peer-facilitated community-based support model in improving retention in care among adolescents living with HIV and attending care in Chantal Biya Foundation, Yaounde, Cameroon.

Published
2024
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26. Tuberculosis Diagnosis in HIV-Infected Children: Comparison of the 2012 and 2015 Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease

Author

Marcy, Olivier, Goyet, Sophie, Borand, Laurence, Msellati, Philippe, Ung, Vibol, Tejiokem, Mathurin, Do Chau, Giang, Ateba-Ndongo, Francis, Ouedraogo, Abdoul Salam, Dim, Bunnet, Perez, Paul, Asselineau, Julien, Carcelain, Guislaine, Blanche, Stéphane, Delacourt, Christophe, and Godreuil, Sylvain

Abstract

We compared the 2012 and 2015 Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children in 438 HIV-infected children with presumptive tuberculosis. Agreement between the classifications was substantial but more children were considered as tuberculosis using the 2015 version.

Published
2022
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33. Association between mental disorders with detectable viral load and poor adherence to antiretroviral therapy among adolescents infected with Human Immunodeficiency Virus on follow-up at Chantal Biya Foundation, Cameroon

Author

Ndongo, Francis Ateba, Kana, Rogacien, Nono, Marius Tchassep, Noah, Jean-Pierre Yves Awono, Ndzie, Patrice, Tejiokem, Mathurin Cyrille, Biheng, Emmanuelle Hopp, Ndie, Justin, Nkoa, Tatiana Avang, Ketchaji, Alice, Ngako, Joëlle Nounouce, Penda, Calixte Ida, Bissek, Anne Cécile Zoung-Kani, Ndombo, Paul Olivier Koki, Hawa, Hubert Mbassi, Msellati, Philippe, Lallemant, Marc, and Faye, Albert

Abstract

Perinatally HIV-Infected Adolescents (HIVIA) are more likely to have mental health problems than their uninfected peers. In resource-limited settings, mental health disorders are rarely taken into account in the care offered to HIVIA and have an impact on their routine follow-up. The objective of this study was to assess the baseline socio-demographic factors and mental health conditions associated with detectable viral load or poor ART adherence in HIVIA on ART followed at the Mother and Child Centre of the Chantal Biya Foundation in Yaoundé (CME-FCB), Cameroon.

Published
2024
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35. Abstracts of the Eighth EDCTP Forum, 6-9 November 2016.

Author

Makanga, M, Beattie, P, Breugelmans, G, Nyirenda, T, Bockarie, M, Tanner, M, Volmink, J, Hankins, C, Walzl, G, Chegou, N, Malherbe, S, Hatherill, M, Scriba, TJ, Zak, DE, Barry, CE, Kaufmann, SHE, Noor, A, Strub-Wourgaft, N, Phillips, P, Munguambe, K, Ravinetto, R, Tinto, H, Diro, E, Mahendrahata, Y, Okebe, J, Rijal, S, Garcia, C, Sundar, S, Ndayisaba, G, Sopheak, T, Ngoduc, T, Van Loen, H, Jacobs, J, D'Alessandro, U, Boelaert, M, Buvé, A, Kamalo, P, Manda-Taylor, L, Rennie, S, Mokgatla, B, Bahati, Ijsselmuiden, C, Afolabi, M, Mcgrath, N, Kampmann, B, Imoukhuede, E, Alexander, N, Larson, H, Chandramohan, D, Bojang, K, Kasaro, MP, Muluka, B, Kaunda, K, Morse, J, Westfall, A, Kapata, N, Kruuner, A, Henostroza, G, Reid, S, Alabi, A, Foguim, F, Sankarganesh, J, Bruske, E, Mfoumbi, A, Mevyann, C, Adegnika, A, Lell, B, Kranzer, K, Kremsner, P, Grobusch, M, Sabiiti, W, Ntinginya, N, Kuchaka, D, Azam, K, Kampira, E, Mtafya, B, Bowness, R, Bhatt, N, Davies, G, Kibiki, G, Gillespie, S, Lejon, V, Ilboudo, H, Mumba, D, Camara, M, Kaba, D, Lumbala, C, Fèvre, E, Jamonneau, V, Bucheton, B, Büscher, P, Chisenga, C, Sinkala, E, Chilengi, R, Chitundu, H, Zyambo, Z, Wandeler, G, Vinikoor, M, Emilie, D, Camara, O, Mathurin, K, Guiguigbaza-Kossigan, D, Philippe, B, Regassa, F, Hassane, S, Bienvenu, SM, Fabrice, C, Ouédraogo, E, Kouakou, L, Owusu, M, Mensah, E, Enimil, A, Mutocheluh, M, Ndongo, FA, Tejiokem, MC, Texier, G, Penda, C, Ndiang, S, Ndongo, J-A, Guemkam, G, Sofeu, CL, Afumbom, K, Faye, A, Msellati, P, Warszawski, J, Vos, A, Devillé, W, Barth, R, Klipstein-Grobusch, K, Tempelman, H, Venter, F, Coutinho, R, Grobbee, D, Ssemwanga, D, Lyagoba, F, Magambo, B, Kapaata, A, Kirangwa, J, Nannyonjo, M, Nassolo, F, Nsubuga, R, Yebra, G, Brown, A, Kaleebu, P, Nylén, H, Habtewold, A, Makonnen, E, Yimer, G, Burhenne, J, Diczfalusy, U, Aklillu, E, Steele, D, Walker, R, Simuyandi, M, Beres, L, Bosomprah, S, Ansumana, R, Taitt, C, Lamin, JM, Jacobsen, KH, Mulvaney, SP, Leski, T, Bangura, U, Stenger, D, De Vries, S, Zinsou, FJ, Honkpehedji, J, Dejon, JC, Loembe, MM, Bache, B, Pakker, N, Van Leeuwen, R, Hounkpatin, AB, Yazdanbakhsh, M, Bethony, J, Hotez, P, Diemert, D, Bache, BE, Fernandes, JF, Obiang, RM, Kabwende, AL, Grobusch, MP, Krishna, S, Kremsner, PG, Todagbe, AS, Nambozi, M, Kabuya, J-B, Hachizovu, S, Mwakazanga, D, Kasongo, W, Buyze, J, Mulenga, M, Geertruyden, J-P, Gitaka, J, Chan, C, Kongere, J, Kagaya, W, Kaneko, A, Kabore, N, Barry, N, Kabre, Z, Werme, K, Fofana, A, Compaore, D, Nikiema, F, Some, F, Djimde, A, Zongo, I, Ouedraogo, B, Kone, A, Sagara, I, Björkman, A, Gil, JP, Nchinda, G, Bopda, A, Nji, N, Ambada, G, Ngu, L, Tchadji, J, Sake, C, Magagoum, S, Njambe, GD, Lisom, A, Park, CG, Tait, D, Sibusiso, H, Manda, O, Croucher, K, Van Der Westhuizen, A, Mshanga, I, Levin, J, Nanvubya, A, Kibengo, F, Jaoko, W, Pala, P, Perreau, M, Namuniina, A, Kitandwe, P, Tapia, G, Serwanga, J, Yates, N, Fast, P, Mayer, B, Montefiori, D, Tomaras, G, Robb, M, Lee, C, Wagner, R, Sanders, E, Kilembe, W, Kiwanuka, N, Gilmour, J, Kuipers, H, Vooij, D, Chinyenze, K, Priddy, F, Ding, S, Hanke, T, Pantaleo, G, Ngasala, B, Jovel, I, Malmberg, M, Mmbando, B, Premji, Z, Mårtensson, A, Mwaiswelo, R, Agbor, L, Apinjoh, T, Mwanza, S, Chileshe, J, Joshi, S, Malunga, P, Manyando, C, Laufer, M, Dara, A, Niangaly, A, Sinha, I, Brodin, D, Fofana, B, Dama, S, Dembele, D, Sidibe, B, Diallo, N, Thera, M, Wright, K, Gil, J, Doumbo, O, Baraka, V, Nabasumba, C, Francis, F, Lutumba, P, Mavoko, H, Alifrangis, M, Van Geertruyden, J-P, Sissoko, S, Sangaré, C, Toure, S, Sanogo, K, Diakite, H, Doumbia, D, Haidara, K, Julé, A, Ashurst, H, Merson, L, Olliaro, P, Marsh, V, Lang, T, Guérin, P, Awuondo, K, Njenga, D, Nyakarungu, E, Titus, P, Sutamihardja, A, Lowe, B, Ogutu, B, Billingsley, P, Soulama, I, Kaboré, M, Coulibaly, A, Ouattara, M, Sanon, S, Diarra, A, Bougouma, E, Ouedraogo, A, Sombie, B, Kargougou, D, Ouattara, D, Issa, N, Tiono, A, Sirima, S, Chaponda, M, Dabira, E, Dao, F, Dara, N, Coulibaly, M, Tolo, A, Maiga, H, Ouologuem, N, Niangaly, H, Botchway, F, Wilson, N, Dickinson-Copeland, CM, Adjei, AA, Wilson, M, Stiles, JK, Hamid, MA, Awad-Elgeid, M, Nasr, A, Netongo, P, Kamdem, S, Velavan, T, Lasry, E, Diarra, M, Bamadio, A, Traore, A, Coumare, S, Soma, B, Dicko, Y, Sangare, B, Tembely, A, Traore, D, Haidara, A, Dicko, A, Diawara, E, Beavogui, A, Camara, D, Sylla, M, Yattara, M, Sow, A, Camara, GC, Diallo, S, Mombo-Ngoma, G, Remppis, J, Sievers, M, Manego, RZ, Endamne, L, Hutchinson, D, Held, J, Supan, C, Salazar, CLO, Bonkian, LN, Nahum, A, Sié, A, Abdulla, S, Cantalloube, C, Djeriou, E, Bouyou-Akotet, M, Mordmüller, B, Siribie, M, Sirima, SB, San Maurice Ouattara, Coulibaly, S, Kabore, JM, Amidou, D, Tekete, M, Traore, O, Haefeli, W, Borrmann, S, Kaboré, N, Kabré, Z, Nikèma, F, Compaoré, D, Somé, F, Djimdé, A, Ouédraogo, J, Chalwe, V, Miller, J, Diakité, H, Greco, B, Spangenberg, T, Kourany-Lefoll, E, Oeuvray, C, Mulry, J, Tyagarajan, K, Magsaam, B, 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J, Supan, C, Salazar, CLO, Bonkian, LN, Nahum, A, Sié, A, Abdulla, S, Cantalloube, C, Djeriou, E, Bouyou-Akotet, M, Mordmüller, B, Siribie, M, Sirima, SB, San Maurice Ouattara, Coulibaly, S, Kabore, JM, Amidou, D, Tekete, M, Traore, O, Haefeli, W, Borrmann, S, Kaboré, N, Kabré, Z, Nikèma, F, Compaoré, D, Somé, F, Djimdé, A, Ouédraogo, J, Chalwe, V, Miller, J, Diakité, H, Greco, B, Spangenberg, T, Kourany-Lefoll, E, Oeuvray, C, Mulry, J, Tyagarajan, K, Magsaam, B, Barnes, K, Hodel, EM, Humphreys, G, Pace, C, Banda, CG, Denti, P, Allen, E, Lalloo, D, Mwapasa, V, Terlouw, A, Mwesigwa, J, Achan, J, Jawara, M, Ditanna, G, Worwui, A, Affara, M, Koukouikila-Koussounda, F, Kombo, M, Vouvoungui, C, Ntoumi, F, Etoka-Beka, MK, Deibert, J, Poulain, P, Kobawila, S, Gueye, NG, Seda, B, Kwambai, T, Jangu, P, Samuels, A, Kuile, FT, Kariuki, S, Barry, A, Bousema, T, Okech, B, Egwang, T, Corran, P, Riley, E, Ezennia, I, Ekwunife, O, Muleba, M, Stevenson, J, Mbata, K, Coetzee, M, Norris, D, Moneke-Anyanwoke, N, Momodou, J, Clarke, E, Scott, S, Tijani, A, Djimde, M, Vaillant, M, Samouda, H, Mensah, V, Roetynck, S, Kanteh, E, Bowyer, G, Ndaw, A, Oko, F, Bliss, C, Jagne, YJ, Cortese, R, Nicosia, A, Roberts, R, D'Alessio, F, Leroy, O, Faye, B, Cisse, B, Gerry, S, Viebig, N, Lawrie, A, Ewer, K, Hill, A, Nebie, I, Tiono, AB, Sanou, G, Konate, AT, Yaro, BJ, Sodiomon, S, Honkpehedji, Y, Agobe, JCD, Zinsou, F, Mengue, J, Richie, T, Hoffman, S, Nouatin, O, Ngoa, UA, Edoa, JR, Homoet, A, Engelhon, JE, Massinga-Louembe, M, Esen, M, Theisen, M, Sim, KL, Luty, AJ, Moutairou, K, Dinko, B, King, E, Targett, G, Sutherland, C, Likhovole, C, Ouma, C, Vulule, J, Musau, S, Khayumbi, J, Okumu, A, Murithi, W, Otu, J, Gehre, F, Zingue, D, Kudzawu, S, Forson, A, Mane, M, Rabna, P, Diarra, B, Kayede, S, Adebiyi, E, Kehinde, A, Onyejepu, N, Onubogu, C, Idigbe, E, Ba, A, Diallo, A, Mboup, S, Disse, K, Kadanga, G, Dagnra, Y, Baldeh, I, Corrah, T, De Jong, B, Antonio, M, Musanabaganwa, C, Musabyimana, JP, Karita, E, Diop, B, Nambajimana, A, Dushimiyimana, V, Karame, P, Russell, J, Ndoli, J, Hategekimana, T, Sendegeya, A, Condo, J, Binagwaho, A, Okonko, I, Okerentugba, P, Opaleye, O, Awujo, E, Frank-Peterside, N, Moyo, S, Kotokwe, K, Mohammed, T, Boleo, C, Mupfumi, L, Chishala, S, Gaseitsiwe, S, Tsalaile, L, Bussmann, H, Makhema, J, Baum, M, Marlink, R, Engelbretch, S, Essex, M, Novitsky, V, Saka, E, Kalipalire, Z, Bhairavabhotla, R, Midiani, D, Sherman, J, Mgode, G, Cox, C, Bwana, D, Mtui, L, Magesa, D, Kahwa, A, Mfinanga, G, Mulder, C, Borain, N, Petersen, L, Du Plessis, J, Theron, G, Holm-Hansen, C, Tekwu, EM, Sidze, LK, Assam, JPA, Eyangoh, S, Niemann, S, Beng, VP, Frank, M, Atiadeve, S, Hilmann, D, Awoniyi, D, Baumann, R, Kriel, B, Jacobs, R, Kidd, M, Loxton, A, Kaempfer, S, Singh, M, Mwanza, W, Milimo, D, Moyo, M, Kasese, N, Cheeba-Lengwe, M, Munkondya, S, Ayles, H, De Haas, P, Muyoyeta, M, Namuganga, AR, Kizza, HM, Mendy, A, Tientcheu, L, Ayorinde, A, Coker, E, Egere, U, Coussens, A, Naude, C, Chaplin, G, Noursadeghi, M, Martineau, A, Jablonski, N, Wilkinson, R, Ouedraogo, HG, Matteelli, A, Regazzi, M, Tarnagda, G, Villani, P, Sulis, G, Diagbouga, S, Roggi, A, Giorgetti, F, Kouanda, S, Bidias, A, Ndjonka, D, Olemba, C, Souleymanou, A, Mukonzo, J, Kuteesa, R, Ogwal-Okeng, J, Gustafsson, LL, Owen, J, Bassi, P, Gashau, W, Olaf, K, Dodoo, A, Okonkwo, P, Kanki, P, Maruapula, D, Seraise, B, Einkauf, K, Reilly, A, Rowley, C, Musonda, R, Framhein, A, Mpagama, S, Semvua, H, Maboko, L, Hoelscher, M, Heinrich, N, Mulenga, L, Kaayunga, C, Davies, M-A, Egger, M, Musukuma, K, Dambe, R, Usadi, B, Ngari, M, Thitiri, J, Mwalekwa, L, Fegan, G, Berkley, J, Nsagha, D, Munamunungu, V, Bolton, C, Siyunda, A, Shilimi, J, Bucciardini, R, Fragola, V, Abegaz, T, Lucattini, S, Halifom, A, Tadesse, E, Berhe, M, Pugliese, K, De Castro, P, Terlizzi, R, Fucili, L, Di Gregorio, M, Mirra, M, Zegeye, T, Binelli, A, Vella, S, Abraham, L, Godefay, H, Rakotoarivelo, R, Raberahona, M, Randriamampionona, N, Andriamihaja, R, Rasamoelina, T, Cornet, M, De Dieu Randria, MJ, Benet, T, Vanhems, P, Andrianarivelo, MR, Chirwa, U, Michelo, C, Hamoonga, R, Wandiga, S, Oduor, P, Agaya, J, Sharma, A, Cavanaugh, S, Cain, K, Mukisa, J, Mupere, E, Worodria, W, Ngom, JT, Koro, F, Godwe, C, Adande, C, Ateugieu, R, Onana, T, Ngono, A, Kamdem, Y, Ngo-Niobe, S, Etoa, F-X, Kanengoni, M, Ruzario, S, Ndebele, P, Shana, M, Tarumbiswa, F, Musesengwa, R, Gutsire, R, Fisher, K, Thyagarajan, B, Akanbi, O, Binuyo, M, Ssengooba, W, Respeito, D, Mambuque, E, Blanco, S, Mandomando, I, Cobelens, F, Garcia-Basteiro, A, Tamene, A, Topp, S, Mwamba, C, Padian, N, Sikazwe, I, Geng, E, Holmes, C, Sikombe, K, Hantuba, Czaicki, N, Simbeza, S, Somwe, P, Umulisa, M, Ilo, J, Kestelyn, E, Uwineza, M, Agaba, S, Delvaux, T, Wijgert, J, Gethi, D, Odeny, L, Tamandjou, C, Kaindjee-Tjituka, F, Brandt, L, Cotton, M, Nel, E, Preiser, W, Andersson, M, Adepoju, A, Magana, M, Etsetowaghan, A, Chilikwazi, M, Sutcliffe, C, Thuma, P, Sinywimaanzi, K, Matakala, H, Munachoonga, P, Moss, W, Masenza, IS, Geisenberger, O, Agrea, P, Rwegoshora, F, Mahiga, H, Olomi, W, Kroidl, A, Kayode, G, Amoakoh-Coleman, M, Ansah, E, Uthman, O, Fokam, J, Santoro, M-M, Musolo, C, Chimbiri, I, Chikwenga, G, Deula, R, Massari, R, Lungu, A, Perno, C-F, Ndzengue, G, Loveline, N, Lissom, A, Flaurent, T, Sosso, S, Essomba, C, Kpeli, G, Otchere, I, Lamelas, A, Buultjens, A, Bulach, D, Baines, S, Seemann, T, Giulieri, S, Nakobu, Z, Aboagye, S, Owusu-Mireku, E, Danso, E, Hauser, J, Hinic, V, Pluschke, G, Stinear, T, Yeboah-Manu, D, Elshayeb, A, Siddig, ME, Ahmed, AA, Hussien, AE, Kabwe, M, Tembo, J, Chilukutu, L, Chilufya, M, Ngulube, F, Lukwesa, C, Enne, V, Wexner, H, Mwananyanda, L, Hamer, D, Sinyangwe, S, Ahmed, Y, Klein, N, Maeurer, M, Zumla, A, Bates, M, Beyala, L, Etienne, G, Anthony, N, Benjamin, A, Ateudjieu, J, Chibwe, B, Ojok, D, Tarr, CA, Perez, GM, Omeonga, S, Kibungu, F, Meyer, A, Lansana, P, Mayor, A, Onyango, P, Van Loggerenberg, F, Furtado, T, Boggs, L, Segrt, A, Dochez, C, Burnett, R, Mphahlele, MJ, Miiro, G, Mbidde, E, Peshu, N, Kivaya, E, Ngowi, B, Kavishe, R, Maowia, M, Sandstrom, E, Ayuo, E, Mmbaga, B, Leisegang, C, Thorpe, M, Batchilly, E, N'Guessan, J-P, Kanteh, D, Søfteland, S, Sebitloane, M, Vwalika, B, Taylor, M, Galappaththi-Arachchige, H, Holmen, S, Gundersen, SG, Ndhlovu, P, Kjetland, EF, Kombe, F, Toohey, J, Pienaar, E, Kredo, T, Cham, PM, Abubakar, I, Dondeh, BL, Vischer, N, Pfeiffer, C, Burri, C, Musukwa, K, Zürcher, S, Mwandu, T, Bauer, S, Adriko, M, Mwaura, P, Omolloh, K, Jones, C, Malecela, M, Hamidu, BA, Jenner, TE, Asiedu, LJ, Osei-Atweneboana, M, Afeke, I, Addo, P, Newman, M, Durnez, L, Eddyani, M, Ammisah, N, Abas, M, Quartey, M, Ablordey, A, Akinwale, O, Adeneye, A, Ezeugwu, S, Olukosi, Y, Adewale, B, Sulyman, M, Mafe, M, Okwuzu, J, Gyang, P, Nwafor, T, Henry, U, Musa, B, Ujah, I, Agobé, JCD, Grau-Pujol, B, Sacoor, C, Nhabomba, A, Casellas, A, Quintó, L, Subirà, C, Giné, R, Valentín, A, Muñoz, J, Nikiema, M, Ky-Ba, A, Comapore, KAM, Sangare, L, Oluremi, A, Michel, M, Camara, Y, Sanneh, B, Cuamba, I, Gutiérrez, J, Lázaro, C, Mejia, R, Adedeji, A, Folorunsho, S, Demehin, P, Akinsanya, B, Cowley, G, Da Silva, ET, Nabicassa, M, De Barros, PDP, Blif, MM, Bailey, R, Last, A, Mahendradhata, Y, Gotuzzo, E, De Nys, K, Casteels, M, Nona, SK, Lumeka, K, Todagbe, A, Djima, MM, Ukpong, M, Sagay, A, Khamofu, H, Torpey, K, Afiadigwe, E, Anenih, J, Ezechi, O, Nweneka, C, Idoko, J, Muhumuza, S, Katahoire, A, Nuwaha, F, Olsen, A, Okeyo, S, Omollo, R, Kimutai, R, Ochieng, M, Egondi, T, Moonga, C, Chileshe, C, Magwende, G, Anumudu, C, Onile, O, Oladele, V, Adebayo, A, Awobode, H, Oyeyemi, O, Odaibo, A, Kabuye, E, Lutalo, T, Njua-Yafi, C, Nkuo-Akenji, T, Anchang-Kimbi, J, Mugri, R, Chi, H, Tata, R, Njumkeng, C, Dodoo, D, Achidi, E, Fernandes, J, Bache, EB, Matakala, K, Searle, K, Greenman, M, and Rainwater-Lovett, K

Published
2017

36. Les obstacles au dépistage des enfants et adolescents infectés par le VIH en Afrique : chercher ces enfants, là où ils se trouvent !

Author

Msellati, P., Ateba Ndongo, F., Hejoaka, F., Nacro, B., and Institut de Recherche pour le Développement (IRD)

Subjects
SIDA, dépistage, VIH, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, ADOLESCENT, NOURRISSON, POLITIQUE DE SANTE, CENTRE DE SANTE, Afrique, ENFANT, DEPISTAGE, adolescent, FAMILLE, enfant
Abstract

International audience; Un nombre important d’enfants et d’adolescents infectés par le VIH ne sont pas pris en charge ou le sont très tardivement. Sur les 3,2 millions enfants infectés dans le monde, 2,8 auraient besoin de traitements et environ 700 000 sont effectivement traités. La première raison de ce défaut d’accès aux soins est le manque de dépistage des enfants, qu’il s’agisse du dépistage précoce des nourrissons, ou, bien plus encore, de celui des enfants plus grands et des adolescents. Cet article se veut à la fois une revue de la situation actuelle et un plaidoyer en faveur du dépistage proposé systématiquement aux enfants et adolescents exposés au VIH (mère infectée, transfusions répétées) ou possiblement infectés (malnutrition, tuberculose, autres maladies évocatrices). Enfin les adultes vivant avec le VIH devraient être sensibilisés au dépistage systématique de leurs enfants, y compris ceux qui sont asymptomatiques.

Published
2016

38. Extraordinary long-term and fluctuating persistence of Ebola virus RNA in semen of survivors in Guinea: implications for public health

Author

Keita, A.K., primary, Toure, A., additional, Sow, M.S., additional, Raoul, H., additional, Magassouba, N'F., additional, Delaporte, E., additional, Etard, J.-F., additional, Abel, L., additional, Ayouba, A., additional, Baize, S., additional, Bangoura, K., additional, Barry, A., additional, Barry, M., additional, Cissé, M., additional, Delmas, C., additional, Desclaux, A., additional, Diallo, S., additional, Diallo, M.S., additional, Étard, J.-F., additional, Etienne, C., additional, Faye, O., additional, Fofana, I., additional, Granouillac, B., additional, Hébert, E.H., additional, Izard, S., additional, Kassé, D., additional, Keita, A.K., additional, Koivugui, L., additional, Kpamou, C., additional, Lacarabaratz, C., additional, Leroy, S., additional, Marchal, C.L., additional, Levy, Y., additional, March, L., additional, Msellati, P., additional, Niane, H., additional, Peeters, M., additional, Pers, Y.-M., additional, Sacko, S.L., additional, Savané, I., additional, Taverne, B., additional, Touré, A., additional, and Traoré, F.A., additional

Published
2017
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40. Annonce à l'enfant et à l'adolescent de son statut VIH en Afrique francophone centrale et de l'Ouest.

Author

Dahourou, D. L., Masson, D., Aka-Dago-Akribi, H., Gauthier-Lafaye, C., Cacou, C., Raynaud, J.-P., Moh, C., Bouah, B., Sturm, G., Oga, M., Msellati, P., and Leroy, V.

Abstract

Copyright of Bulletin de la Société de Pathologie Exotique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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41. Acceptability of interventions to reduce mother-to-child transmission of HIV-1 in West Africa

Author

Cartoux, M., Msellati, P., Rouamba, O., Coulibaly, D., Meda, N., Blibolo, D., Mandelbrot, L., Van de Perre, P., and Dabis, F.

Subjects
Africans -- Beliefs, opinions and attitudes, HIV testing -- Public opinion, HIV infection in pregnancy, Health
Abstract

Many African women appear to be willing to be tested for HIV and to undergo treatment if they test positive. However, a survey of 607 women from two West African cities found that 64% to 91% of the women needed the permission of their partner to be tested. A majority said they would accept treatment if they were found to be HIV-positive to reduce the chance that they would transmit the virus to their baby.

Published
1996

42. 15 Month follow up of African children following vaginal cleansing with benzalkonium chloride of their HIV infected mothers during late pregnancy and delivery

Author

L Gautier-Charpentier, Dabis F, Msellati P, L Dequae-Merchadoux, R Likikouët, A Ouangre, R. Ramon, T. Ouassa, Laurent Mandelbrot, Valériane Leroy, Christiane Welffens-Ekra, M Dosso, Fatoumata Sylla-Koko, M Cartoux, Nicolas Meda, P. Van de Perre, Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Recherche pour le Développement (IRD), Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), Departement de Gynécologie Obstétrique, CHU de Youpougon, The ANRS 049/Ditrame project was funded by the French Agence Nationale de Recherches sur le SIDA (ANRS) and the French Ministry of Cooperation (Action Coordonnée no 12)., and The authors wish to thank the nurses and counsellors working with the Ditrame project and the staff from the participating prenatal care and delivery unit for their daily compassionate work. Special thanks to Drs MA Nandeuil, M Mathieu, and C Meignant (Innothéra, France) for assisting in the preparation of the trial, especially drug supply, packaging, and shipping.

Subjects
Pediatrics, TRANSMISSION MERE ENFANT, ESSAI CLINIQUE, Placebo-controlled study, HIV Infections, NAISSANCE, MESH: Proportional Hazards Models, MESH: Pregnancy, 0302 clinical medicine, Pregnancy, Risk Factors, GROSSESSE, MESH: Risk Factors, Infant Mortality, INFECTION, MESH: Administration, Intravaginal, Childbirth, MESH: Double-Blind Method, MESH: Infant Mortality, 030212 general & internal medicine, Pregnancy Complications, Infectious, reproductive and urinary physiology, ANALYSE STATISTIQUE, MESH: Treatment Outcome, education.field_of_study, integumentary system, SIDA, Obstetrics, virus diseases, Prenatal Care, MESH: HIV Infections, MESH: Follow-Up Studies, MESH: Infant, female genital diseases and pregnancy complications, 3. Good health, MESH: Infectious Disease Transmission, Vertical, Perinatal Care, Treatment Outcome, Infectious Diseases, MESH: Survival Analysis, MESH: Perinatal Care, Female, Original Article, Benzalkonium Compounds, HYGIENE, MESH: Benzalkonium Compounds, Maternal Age, Adult, medicine.medical_specialty, TRANSMISSION, MESH: Cote d'Ivoire, Population, Dermatology, Prenatal care, Placebo, MESH: Multivariate Analysis, 03 medical and health sciences, MESH: Anti-Infective Agents, Local, Double-Blind Method, 030225 pediatrics, Burkina Faso, medicine, Humans, MESH: Pregnancy Complications, Infectious, MESH: Burkina Faso, education, MESH: Prenatal Care, MESH: Suppositories, Proportional Hazards Models, MESH: Humans, Intention-to-treat analysis, business.industry, Suppositories, Infant, MESH: Adult, Delivery, Obstetric, medicine.disease, Survival Analysis, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Infectious Disease Transmission, Vertical, Infant mortality, body regions, Administration, Intravaginal, ACCOUCHEMENT, Cote d'Ivoire, Multivariate Analysis, Anti-Infective Agents, Local, MESH: Delivery, Obstetric, MESH: Maternal Age, MORTALITE INFANTILE, business, MESH: Female, Follow-Up Studies
Abstract

International audience; OBJECTIVES: To study mother to child HIV-1 transmission (MTCT) and infant mortality following benzalkonium chloride (BC) disinfection. METHODS: A randomised, double blind phase II placebo controlled trial. Women testing positive for HIV-1 infection in prenatal care units in Abidjan, Côte d'Ivoire, and Bobo-Dioulasso, Burkina Faso, from November 1996 to April 1997 were eligible, with their informed consent. Women self administered daily a vaginal suppository of 1% BC (53) or matched placebo (54) from 36 weeks of pregnancy, plus a single dose during labour. The neonate was bathed with 1% BC solution or placebo within 30 minutes after birth. MTCT rate was assessed based on repeated polymerase chain reaction (PCR) and serology results. For the present analysis, children were followed up to 15 months. RESULTS: A total of 107 women were enrolled. Of 103 eligible liveborn children, 23 were HIV infected, 75 uninfected, and five of indeterminate status. MTCT transmission rate was 24.2% overall (95% confidence interval (CI): 14.3% to 30.4%). On an intent to treat basis, the transmission rate did not differ between the two groups (23.5%, CI 13.8 to 38.5, in the BC group and 24.8%, CI 15.0 to 39.6, in the placebo group at 15 months). Similarly, there was no difference in mortality at 15 months (22.9%, CI 13.7 to 36.9, in the BC group and 16.5%, CI 9.0 to 29.4, in the placebo group). CONCLUSION: This analysis failed to suggest any benefit of BC disinfection on mother to child HIV transmission or perinatal and infant mortality.

Published
2002

44. 24-Month adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in African HIV-1 infected children: ANRS 12103/12167

Author

H Chappuy, Serge Diagbouga, Joëlle Nicolas, Msellati P, Aly Drabo, Hervé Hien, Nicolas Meda, Jerôme Somé, Souleymane Yameogo, Adama Ouiminga, Alain Hien, François Rouet, Hassane Tamboura, Emmanuelle Zoure, P Van de Perre, and Boubacar Nacro

Subjects
Cyclopropanes, Male, medicine.medical_specialty, Efavirenz, Adolescent, Anti-HIV Agents, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Medication Adherence, Virological response, chemistry.chemical_compound, Internal medicine, Surveys and Questionnaires, medicine, Confidence Intervals, Humans, once-a-day therapy, Didanosine, Lamivudine, and Efavirenz, child, Child, Didanosine, child, business.industry, Lamivudine, General Medicine, Original Articles, Viral Load, Antiretroviral therapy, Benzoxazines, CD4 Lymphocyte Count, once-a-day therapy, Regimen, chemistry, Alkynes, Child, Preschool, Immunology, Africa, RNA, Viral, Lamivudine and Efavirenz, Female, business, Viral load, medicine.drug
Abstract

Background: There is no data on long-term benefit of once-a-day antiretroviral therapy (ART) with combination of DDI, 3TC and EFV to allow its use in future therapeutic strategies.Objectives: To assess 24-month immuno-virological, adherence, tolerance, and effectiveness of a once-a-day ART with DDI, 3TC and EFV.Methods: A phase 2 open trial including 51 children aged from 30 months to 15 years, monitored a once-a-day regimen for 24 months from 2006 to 2008 in the Departement de Pediatrie du CHUSS, at Bobo-Dioulasso in Burkina Faso. We tested immunological and virological response, adherence, tolerance and resistance of the treatment.Results: Children with CD4 >25% at 24 months were 67.4% (33/49) CI 95% [54%, 80%].The proportion of children with viral plasma RNA 95% over the 24 months. Drugs were well tolerated.Conclusions: Given the limited number of antiretroviral drugs available in Africa and the inadequacy of laboratory monitoring in support program, once-a-day treatment and especially the DDI-based combination strategies could be an attractive operational option.Key words: once-a-day therapy, Didanosine, Lamivudine, and Efavirenz, child.

Published
2013

45. Vivre avec le VIH au temps de la normalisation, une expérience banalisée pour les femmes ?

Author

Servais, S., Desclaux, A., Berthé, A., Bila, B., and Msellati, P.

Abstract

Copyright of Médecine et Santé Tropicales is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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46. Prevention of Mother-to-Child Transmission of HIV in Yaounde: Barrier to Care.

Author

Landefeld, C. C., Fomenou, L. A., Ateba, F., and Msellati, P.

Subjects
HIV prevention, VERTICAL transmission (Communicable diseases), HEALTH services accessibility, QUALITATIVE research, FETUS, PREVENTION
Abstract

Most HIV-infected children in Sub-Saharan Africa are born where programs for the prevention of mother-to-child transmission of HIV (PMTCT) exist but are not universally operational. The expansion of PMTCT programs in Cameroon was among the largest in francophone Africa, but despite highly variable estimates of PMTCT uptake (ranging from 20% to 66%), it is clear that not enough HIV-infected pregnant Cameroonian women benefit from treatment to prevent HIV transmission to their children. The reasons why HIV-infected women in Cameroon do not use treatments to prevent this transmission remain partially unidentified. We conducted a qualitative study of the therapeutic itineraries (treatments taken and motivations) followed by HIV-infected pregnant women in Cameroon to understand the barriers to accessing high-quality PMTCT care. Here we construct the therapeutic itinerary for HIV-infected pregnant women, and identify the barriers at each step. Lack of financial independence, personal support, and empowering information were the primary obstacles at multiple steps. [ABSTRACT FROM PUBLISHER]

Published
2018
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47. A cohort study of factors associated with failure to return for HIV post-test counselling in pregnant women

Author

Nyiraziraje M, Dabis F, Msellati P, Ladner J, Van de Perre P, De Clercq A, and Leroy

Subjects
Counseling, law.invention, Cohort Studies, DIAGNOSTIC, Pregnancy, GROSSESSE, law, HIV Seropositivity, Immunology and Allergy, Medicine, PSYCHOLOGIE, Pregnancy Complications, Infectious, education.field_of_study, SIDA, AIDS Serodiagnosis, virus diseases, Sexual Partners, Infectious Diseases, Family planning, Cohort, Educational Status, Female, PRESERVATIF, Cohort study, Adult, medicine.medical_specialty, Adolescent, Immunology, Parenteral transmission, Population, Acquired immunodeficiency syndrome (AIDS), Condom, Humans, Occupations, education, Gynecology, Marital Status, business.industry, Rwanda, VIRUS HIV-1, PREVENTION SANITAIRE, medicine.disease, DEPISTAGE, FEMME, Family medicine, Patient Compliance, business, Serostatus, TRANSMISSION FOETOMATERNELLE, COMPORTEMENT SOCIAL
Abstract

This study sought to identify the factors associated with failure to return for HIV post-test counseling in pregnant women in Kigali (Rwanda). In the context of a study on the impact of HIV infection on pregnancy HIV-1-antibody testing was offered to all pregnant women attending the antenatal clinic of the Centre Hospitalier de Kigali from July 1992 to August 1993. Pre-test counseling was performed after verbal informed consent was obtained. Two weeks later the authors formally enrolled all HIV-positive women and a corresponding number of HIV-negative women in a cohort. At this visit post-test counseling was given to those wishing to be informed of their HIV serostatus. Level of knowledge about modes of HIV transmission and condom use were recorded. Four months after delivery another interview was conducted to determine the proportion of women who used condoms regularly. A total of 1233 pregnant women were screened. The HIV seroprevalence was 34.4% (95% confidence interval [CI] 31.7-37.1); 271 (63.9%) out of 424 HIV-positive and 577 (71.3%) out of 809 HIV-negative women asked for their HIV serostatus (p = 0.008). In multivariate analysis the only variable significantly associated with failure to return for post-test counseling was a positive HIV test result (odds ratio 0.7; 95% CI 0.5-0.9; p = 0.009) independently of obstetrical history and socioeconomic characteristics. Among the 848 women who had post-test counseling 50.9% of the HIV-positive women and 94.6% of the HIV-negative women stated that they planned to inform their partner of their serostatus (p = 0.0001). More than 95% of the women interviewed knew about sexual and parenteral transmission of HIV but half were unaware of mother-to-child transmission. More than 80% of the women had seen a condom before but 14% only had used it at least once. Among women who were sexually active four months after delivery 8.8% of the HIV-positive and 3.9% of the HIV-negative women reported using a condom (p = 0.04). Innovative approaches for HIV testing and counseling programs are needed and the importance of psychosocial and cultural factors associated with HIV testing should be emphasized in African populations. (authors)

Published
1996

48. Is the Recommended Dose of Efavirenz Optimal in Young West African Human Immunodeficiency Virus-Infected Children?▿ ‡

Author

Déborah Hirt, Hélène Peyrière, Hervé Hien, Philippe Van de Perre, Serge Diagbouga, Emmanuelle Zoure, Boubacar Nacro, Saïk Urien, Msellati P, Jean-Marc Tréluyer, Mathieu Olivier, and François Rouet

Subjects
Cyclopropanes, Male, Efavirenz, Adolescent, Anti-HIV Agents, Population, Cmax, HIV Infections, Pharmacology, Biology, Drug Administration Schedule, 03 medical and health sciences, chemistry.chemical_compound, Cmin, 0302 clinical medicine, Animal science, Pharmacokinetics, Humans, Pharmacology (medical), 030212 general & internal medicine, education, Child, Chromatography, High Pressure Liquid, Volume of distribution, 0303 health sciences, education.field_of_study, 030306 microbiology, Liter, 3. Good health, NONMEM, Benzoxazines, Infectious Diseases, chemistry, Alkynes, Child, Preschool, Female
Abstract

We aimed in this study to describe efavirenz concentration-time courses in treatment-naïve children after once-daily administration to study the effects of age and body weight on efavirenz pharmacokinetics and to test relationships between doses, plasma concentrations, and efficacy. For this purpose, efavirenz concentrations in 48 children were measured after 2 weeks of didanosine-lamivudine-efavirenz treatment, and samples were available for 9/48 children between months 2 and 5 of treatment. Efavirenz concentrations in 200 plasma specimens were measured using a validated high-performance liquid chromatography method. A population pharmacokinetic model was developed with NONMEM. The influence of individual characteristics was tested using a likelihood ratio test. The estimated minimal and maximal concentrations of efavirenz in plasma (CminandCmax, respectively) and the area under the concentration-time curve (AUC) were correlated to the decrease in human immunodeficiency virus type 1 RNA levels after 3 months of treatment. The thresholdCmin(and AUC) that improved efficacy was determined. The target minimal concentration of 4 mg/liter was considered for toxicity. An optimized dosing schedule that would place the highest percentage of children in the interval of effective and nontoxic concentrations was simulated. The pharmacokinetics of efavirenz was best described by a one-compartment model with first-order absorption and elimination. The mean apparent clearance and volume of distribution for efavirenz were 0.211 liter/h/kg and 4.48 liters/kg, respectively. Clearance decreased significantly with age. When the recommended doses were given to 46 of the 48 children, 19% (44% of children weighing less than 15 kg) hadCmins below 1 mg/liter. A significantly higher percentage of children withCmins of >1.1 mg/liter or AUCs of >51 mg/liter·h than of children with lower values had viral load decreases greater than 2 log10copies/ml after 3 months of treatment. Therefore, to optimize the percentage of children withCmins between 1.1 and 4 mg/liter, children should receive the following once-daily efavirenz doses: 25 mg/kg of body weight from 2 to 6 years, 15 mg/kg from 6 to 10 years, and 10 mg/kg from 10 to 15 years. These assumptions should be prospectively confirmed.

Published
2009

49. Are recommended doses of efavirenz optimal in young children? (ANRS 12103)

Author

Serge Diagbouga, Déborah Hirt, Philippe Van de Perre, Msellati P, François Rouet, Saïk Urien, Emmanuelle Zoure, Jean-Marc Tréluyer, Hélène Peyrière, Hervé Hien, Boubacar Nacro, and Mathieu Olivier

Subjects
lcsh:Immunologic diseases. Allergy, chemistry.chemical_compound, Infectious Diseases, Efavirenz, chemistry, Anthropology, Virology, media_common.quotation_subject, Art, lcsh:RC581-607, media_common
Abstract

Address: 1Universite paris-descartes, Paris, France, 2Hopital Tarnier, Paris, France, 3Hopital Cochin-Saint Vincent de Paul, Paris, France, 4Hopital Lapeyronie, Montpellier, France, 5CHU Souro Sanou, Bobo Dioulasso, Burkina Faso, 6Centre Muraz, Bobo Dioulasso, Burkina Faso, 7Universite Paul Cezanne, Aix en Provence, France, 8Hopital Arnaud de Villeneuve, Montpellier, France and 9Universite Montpellier 1, Montpellier, France * Corresponding author

Published
2009

50. Extraordinary long-term and fluctuating persistence of Ebola virus RNA in semen of survivors in Guinea: implications for public health

Author

Abel, L., Ayouba, A., Baize, S., Bangoura, K., Barry, A., Barry, M., Cissé, M., Delaporte, E., Delmas, C., Desclaux, A., Diallo, S., Diallo, M.S., Étard, J.-F., Etienne, C., Faye, O., Fofana, I., Granouillac, B., Hébert, E.H., Izard, S., Kassé, D., Keita, A.K., Koivugui, L., Kpamou, C., Lacarabaratz, C., Leroy, S., Marchal, C.L., Levy, Y., Magassouba, N'F., March, L., Msellati, P., Niane, H., Peeters, M., Pers, Y.-M., Raoul, H., Sacko, S.L., Savané, I., Sow, M.S., Taverne, B., Touré, A., Traoré, F.A., Toure, A., and Etard, J.-F.

Published
2017
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