335 results on '"Msellati, P"'
Search Results
2. An Assessment of Men Semen Alterations in SARS-CoV-2: Is Fever the Principal Concern?
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Abdelhamid, Mohamed Hadi Mohamed, Fellah, Abdulmunam A., Elmarghani, Ahmed, and Al msellati, Iman Amin
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- 2023
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3. Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: a Cameroonian cohort study (ANRS-12140 Pediacam study, 2008–2013, Cameroon)
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Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Penda, Calixte Ida, Ndiang, Suzie Tetang, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Tagnouokam-ngoupo, Paul Alain, Kfutwah, Anfumbom, Msellati, Philippe, Faye, Albert, and Warszawski, Josiane
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- 2021
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4. Pediatric Presentations of COVID-19 and Pertinent Radiologic Findings.
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Msellati, Augustin, Loo, Caitlyn, Toerien, Lara, and Catanzano, Tara
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Since the 2019 worldwide pandemic, Severe Acute Respiratory Syndrome coronavirus 2 responsible for COVID-19 disease, not only had global economic repercussions but millions of individuals health were also put at risk. Like any other respiratory illness, COVID-19 has a variety of presentations and radiological features. While COVID-19 infections in the pediatric population generally present with better prognosis and lower mortality rates when compared to those of adults, in the vulnerable populations however, severe presentations are often more frequent and can have catastrophic consequences. This paper will specifically address pediatric presentations of COVID-19 including those suffering from multisystem inflammation, along with their radiologic manifestations and image findings. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Emergency Presentations of Coronavirus Disease (COVID-19): A Review of the Literature and Radiologic Perspective.
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Loo, Caitlyn, Treacy, Molly Godson, Toerien, Lara, Msellati, Augustin, and Catanzano, Tara
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the debilitating global pandemic known as Coronavirus disease (COVID-19). In this paper, we highlight the widespread manifestations and complications across disease systems. In addition, we present their relevant imaging findings to inform appropriate investigations and management in patients presenting to the Emergency Department with COVID-19 and its respective sequalae. Of note, we outline considerations for diagnosis of long COVID, an important medium to long term sequalae in patients with previous COVID-19 infections. [ABSTRACT FROM AUTHOR]
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- 2024
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6. High level of treatment failure and drug resistance to first-line antiretroviral therapies among HIV-infected children receiving decentralized care in Senegal
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Cissé, Abdoul-Magib, Laborde-Balen, Gabrièle, Kébé-Fall, Khady, Dramé, Aboubacry, Diop, Halimatou, Diop, Karim, FatouNiasse-Traoré, Coulibaly, Mohamed, Have, Ndeye-Ngone, Vidal, Nicole, Thiam, Safiatou, Wade, Abdoulaye S., Peeters, Martine, Taverne, Bernard, Msellati, Philippe, and Touré-Kane, Coumba
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- 2019
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7. Low prevalence of lipodystrophy in HIV-infected Senegalese children on long-term antiretroviral treatment: the ANRS 12279 MAGGSEN Pediatric Cohort Study
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Cames, Cecile, Pascal, Lea, Ba, Aissatou, Mbodj, Hélène, Ouattara, Baly, Diallo, Ndeye-Fatou, Msellati, Philippe, Mbaye, Ngagne, Sy Signate, Haby, Blanche, Stephane, Diack, Aminata, and for the MAGGSEN Cohort Study Group
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- 2018
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8. Santé sexuelle et reproductive des adolescent(e)s vivant avec le VIH dans les programmes de prise en charge pédiatrique à Abidjan : offre de services des structures et perceptions des professionnels de santé en 2019
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Revegue, M. H. Dassi Tchoupa, primary, Jesson, J., additional, Dago-Akribi, H. Aka, additional, Dahourou, D.L., additional, Ogbo, P., additional, Moh, C., additional, Amoussou-Bouah, U.B., additional, N'Gbeche, M-S., additional, Eboua, F. Tanoh, additional, Kouassi, E. Messou, additional, Kouadio, K., additional, Cacou, M-C., additional, Horo, A., additional, Msellati, P., additional, Sturm, G., additional, and Leroy, V., additional
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- 2022
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9. Incidence of unintended pregnancies and pregnancy experience among adolescents living with perinatally-acquired HIV in West Africa: a mixed-method study
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Dahourou, Désiré Lucien, Tisseron, Clément, Yonaba, Caroline, Djaha, Joël, N’Gbeche, Marie-Sylvie, Moh, Corinne, Kouadio, Kouakou, Nindjin, Patricia, Eboua, François, Bouah, Belinda, Malateste, Karen, Azani, Jean-Claude, Kangah, Eulalie, Thio, Elisabeth, Msellati, Philippe, Jesson, Julie, and Leroy, Valériane
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- 2025
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10. A community-based peer-facilitated psychological and social support model to improve retention in care among Cameroonian adolescents perinatally infected with human immunodeficiency virus: A randomized controlled trial
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Ndongo, Francis Ateba, Noah, Jean-Pierre Yves Awono, Kana, Rogacien, Ndie, Justin, Nono, MariusTchassep, Ndzie, Patrice, Tejiokem, Mathurin Cyrille, Biheng, Emmanuelle Hopp, Nkoa, Tatiana Avang, Coulibaly, Yacouba Aba, Fokam, Joseph, Ketchaji, Alice, Ngako, Joëlle Nounouce, Penda, Calixte Ida, Ndombo, Paul Olivier Koki, Hawa, Hubert Mbassi, Msellati, Philippe, Faye, Albert, Lallemant, Marc, and Bissek, Anne Cécile Zoung-Kani
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Psychological and social support for adolescents living with HIV remains undocumented and unaddressed in Central Africa. This study aimed at assessing effectiveness of a peer-facilitated community-based support model in improving retention in care among adolescents living with HIV and attending care in Chantal Biya Foundation, Yaounde, Cameroon.
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- 2024
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11. 24-Month adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in African HIV-1 infected children: ANRS 12103/12167
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Hien, H, Meda, N, Diagbouga, S, Zoure, E, Yaméogo, S, Tamboura, H, Somé, J, Ouiminga, A, Rouet, F, Drabo, A, Hien, A, Nicolas, J, Chappuy, H, Van de Perre, P, Msellati, P, and Nacro, B
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- 2013
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12. Nutritional status and dietary intakes in human immunodeficiency virus (HIV)-infected outpatients in Abidjan, Côte D’Ivoire, 1995
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Castetbon, K, Kadio, A, Bondurand, A, Yao, A Boka, Barouan, C, Coulibaly, Y, Anglaret, X, Msellati, P, Malvy, D, and Dabis, F
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- 1997
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13. Respiratory manifestations in HIV-infected children pre- and post-HAART in Abidjan, the Ivory Coast
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Kouakoussui, A., Fassinou, P., Anaky, M.F., Elenga, N., Laguide, R., Wemin, M.L., Toure, R., Menan, H., Rouet, F., and Msellati, P.
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- 2004
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14. Prophylactic use of cotrimoxazole against opportunistic infections in HIV-positive patients: knowledge and practices of health care providers in Côte dʼIvoire
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Brou, H., Desgrées-du-loû, A., Souville, M., Moatti, J.-P., and Msellati, P.
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- 2003
15. 15 Month follow up of African children following vaginal cleansing with benzalkonium chloride of their HIV infected mothers during late pregnancy and delivery
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Mandelbrot, L, Msellati, P, Meda, N, Leroy, V, Likikouët, R, Van de Perre, P, Dequae-Merchadoux, L, Sylla-Koko, F, Ouangre, A, Ouassa, T, Ramon, R, Gautier-Charpentier, L, Cartoux, M, Dosso, M, Dabis, F, and Welffens-Ekra, C
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- 2002
16. Genital mycoplasmas among pregnant women in Côte d'Ivoire, West Africa: prevalence and risk factors
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Faye-Ketté, H, La Ruche, G, Ali-Napo, L, Messou, N, Viho, I, Welffens-Ekra, C, Dosso, M, and Msellati, P
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- 2000
17. HIV Disclosure to the Child/Adolescent in Central and West Francophone Africa
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Dahourou, DL., Masson, D., Aka-Dago-Akribi, H., Gauthier-Lafaye, C., Cacou, C., Raynaud, JP, Moh, C., Bouah, B., Sturm, G., Oga, M., Msellati, P., Leroy, V., Centre Muraz [Bobo-Dioulasso, Burkina Faso], Université Félix Houphouët-Boigny (UFHB), Université Toulouse - Jean Jaurès (UT2J), Institut de Recherche pour le Développement (IRD), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Montpellier (UM)
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Health Knowledge, Attitudes, Practice ,Adolescent ,Attitude of Health Personnel ,Health Personnel ,HIV Infections ,Disclosure ,Mali ,République démocratique du Congo ,Sénégal ,Cameroun ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Burkina Faso ,Humans ,Benin ,Bénin ,Africa, Central ,Child ,Professional practices ,Sub-Saharan Africa ,Pratiques professionnelles ,Côte d’Ivoire ,Annonce ,HIV ,VIH ,Senegal ,Enfan ,Africa, Western ,Togo ,Democratic Republic of the Congo ,Afrique intertropicale ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; We report the attitudes and practices of health care workers involved in the disclosure process to adolescents living with HIV (ALHIV) in a network including West and Central African French- speaking countries, and the experiences of young living with HIV (YLHIV). During a three-day workshop in Abidjan, Côte d’Ivoire, caregivers (doctors, psychologists, social workers) from 19 pediatric HIV treatment sites shared their practices and difficulties, and four YPLHIV their own disclosure experience. Thirty five participants from eight West/Central African countries (Benin, Burkina Faso, Ivory Coast, Cameroon, Mali, Democratic Republic of Congo, Senegal, Togo) contributed: 14 doctors, eight psychologists, six counselors, three social workers. The experience of the centers was variable, but the age at disclosure was late: 34% of 1296 adolescents between 10 and 12 years of age knew their status. The median age at disclosure was 13 years (range: 11-15 years). The practice of the disclosure was often complex, because of multiple factors (fear of the parents of the breaking of the secrecy, lack of communication between professionals). The individual disclosure was the main practice. Four centers practiced HIV disclosure in group sessions to facilitate mirror support, and one used peer-to-peer support. YPLHIV have advocated for an earlier disclosure, from 10 years. In West and Central Africa, the process of HIV disclosure remains complex for parents and caregivers, and occurs too late. The development of a good practice guideline for HIV disclosing adapted to socio-cultural contexts should help to improve this process.; Nous rapportons les attitudes et pratiques des soignants en Afrique francophone concernant l’annonce du statut VIH aux adolescents, et les témoignages de jeunes vivant avec le VIH (jvVIH). Lors d’un atelier de trois jours à Abidjan, Côte d’Ivoire, en novembre 2016, les soignants (médecins, psychologues, travailleurs sociaux) de 19 sites de prise en charge pédiatrique du VIH ont partagé leurs pratiques et difficultés et 4 jvVIH leur vécu de l’annonce. Au total, 35 participants de 8 pays d’Afrique de l’Ouest/centrale (Bénin, Burkina Faso, Côte d’Ivoire, Cameroun, Mali, République démocratique du Congo, Sénégal, Togo) ont contribué : 14 médecins, 8 psychologues, 6 conseillers, 3 travailleurs sociaux. L’expérience des centres était variable, mais l’âge à l’annonce restait tardif : 34 % des 1 296 adolescents âgés entre 10 et 12 ans connaissaient leur statut. L’âge médian à l’annonce était de 13 ans (étendue : 11-15 ans). La pratique de l’annonce s’avérait complexe, en raison de multiples facteurs (crainte des parents de la rupture du secret, manque de communication entre professionnels). L’annonce individuelle était la pratique majoritairement adoptée. Quatre centres pratiquaient une annonce en séances de groupe pour faciliter le soutien en miroir, et un avait recours à l’appui de pairs-adolescents. Les jvVIH ont plaidé pour une annonce plus précoce, dès 10 ans. En Afrique de l’Ouest/centrale francophone, le processus de l’annonce reste complexe pour parents et soignants, et l’annonce trop tardive. L’élaboration d’un guide de bonnes pratiques de l’annonce du VIH, adapté aux contextes socio-culturels devrait permettre d’améliorer ce processus.
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- 2019
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18. Safety and acceptability of vaginal disinfection with benzalkonium chloride in HIV infected pregnant women in west Africa: ANRS 049b phase II randomised, double blinded placebo controlled trial
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Msellati, P, Meda, N, Leroy, V, Likikouët, R, Van de Perre, P, Cartoux, M, Bonard, D, Ouangre, A, Combe, P, Gautier-Charpentier, L, Sylla-Koko, F, Lassalle, R, Dosso, M, Welffens-Ekra, C, Dabis, F, and Mandelbrot, L
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- 1999
19. Estimation of HIV-1 prevalence in the population of Abidjan by adjustment of the prevalence observed in antenatal centres
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Desgrées du Loû, A., Msellati, P., La Ruche, G., Welffens-Ekra, C., Ramon, R., and Dabis, F.
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- 1999
20. Illness-related behaviour and utilization of oral health services among adult city-dwellers in Burkina Faso: evidence from a household survey
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Varenne, Benoît, Petersen, Poul Erik, Fournet, Florence, Msellati, Philippe, Gary, Jean, Ouattara, Seydou, Harang, Maud, and Salem, Gérard
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- 2006
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21. Tuberculosis Diagnosis in HIV-Infected Children: Comparison of the 2012 and 2015 Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease
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Marcy, Olivier, Goyet, Sophie, Borand, Laurence, Msellati, Philippe, Ung, Vibol, Tejiokem, Mathurin, Do Chau, Giang, Ateba-Ndongo, Francis, Ouedraogo, Abdoul Salam, Dim, Bunnet, Perez, Paul, Asselineau, Julien, Carcelain, Guislaine, Blanche, Stéphane, Delacourt, Christophe, and Godreuil, Sylvain
- Abstract
We compared the 2012 and 2015 Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children in 438 HIV-infected children with presumptive tuberculosis. Agreement between the classifications was substantial but more children were considered as tuberculosis using the 2015 version.
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- 2022
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22. HIV-1 group O virus infection in Abidjan, Côte dʼlvoire
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Nkengasong, J, Sylla-Koko, F, Peeters, M, Ellenberger, D, Sassan-Morokro, M, Ekpini, R-A, Msellati, P, Greenberg, A E., Combe, P, and Rayfield, M
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- 1998
23. Prevention of mother-to-child transmission of HIV in Africa: uptake of pregnant women in a clinical trial in Abidjan, Côte dʼIvoire
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Msellati, P, Ramon, R, Viho, I, Noba, V, Mandelbrot, L, Dabis, F, and Ekra, C Welffens
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- 1998
24. Living with HIV at the time of its normalization: a routine experience for women?
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Servais, S., additional, Desclaux, A., additional, Berthé, A., additional, Bila, B., additional, and Msellati, P., additional
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- 2018
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25. Les obstacles au dépistage des enfants et adolescents infectés par le VIH en Afrique : chercher ces enfants, là où ils se trouvent !
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Msellati, P., Ateba Ndongo, F., Hejoaka, F., Nacro, B., and Institut de Recherche pour le Développement (IRD)
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SIDA ,dépistage ,VIH ,[SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology ,ADOLESCENT ,NOURRISSON ,POLITIQUE DE SANTE ,CENTRE DE SANTE ,Afrique ,ENFANT ,DEPISTAGE ,adolescent ,FAMILLE ,enfant - Abstract
International audience; Un nombre important d’enfants et d’adolescents infectés par le VIH ne sont pas pris en charge ou le sont très tardivement. Sur les 3,2 millions enfants infectés dans le monde, 2,8 auraient besoin de traitements et environ 700 000 sont effectivement traités. La première raison de ce défaut d’accès aux soins est le manque de dépistage des enfants, qu’il s’agisse du dépistage précoce des nourrissons, ou, bien plus encore, de celui des enfants plus grands et des adolescents. Cet article se veut à la fois une revue de la situation actuelle et un plaidoyer en faveur du dépistage proposé systématiquement aux enfants et adolescents exposés au VIH (mère infectée, transfusions répétées) ou possiblement infectés (malnutrition, tuberculose, autres maladies évocatrices). Enfin les adultes vivant avec le VIH devraient être sensibilisés au dépistage systématique de leurs enfants, y compris ceux qui sont asymptomatiques.
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- 2016
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26. Prevention of Mother-to-Child Transmission of HIV in Yaounde: Barrier to Care
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Landefeld, C. C., primary, Fomenou, L. A., additional, Ateba, F., additional, and Msellati, P., additional
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- 2017
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27. Extraordinary long-term and fluctuating persistence of Ebola virus RNA in semen of survivors in Guinea: implications for public health
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Keita, A.K., primary, Toure, A., additional, Sow, M.S., additional, Raoul, H., additional, Magassouba, N'F., additional, Delaporte, E., additional, Etard, J.-F., additional, Abel, L., additional, Ayouba, A., additional, Baize, S., additional, Bangoura, K., additional, Barry, A., additional, Barry, M., additional, Cissé, M., additional, Delmas, C., additional, Desclaux, A., additional, Diallo, S., additional, Diallo, M.S., additional, Étard, J.-F., additional, Etienne, C., additional, Faye, O., additional, Fofana, I., additional, Granouillac, B., additional, Hébert, E.H., additional, Izard, S., additional, Kassé, D., additional, Keita, A.K., additional, Koivugui, L., additional, Kpamou, C., additional, Lacarabaratz, C., additional, Leroy, S., additional, Marchal, C.L., additional, Levy, Y., additional, March, L., additional, Msellati, P., additional, Niane, H., additional, Peeters, M., additional, Pers, Y.-M., additional, Sacko, S.L., additional, Savané, I., additional, Taverne, B., additional, Touré, A., additional, and Traoré, F.A., additional
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- 2017
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28. Séquelles neurologiques de l’infection à virus Ebola
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Bompaire, Flavie, primary, Saliou Sow, M., additional, Duron, Sandrine, additional, Toure, A., additional, Msellati, P., additional, Delaporte, E., additional, and De Greslan, Thierry, additional
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- 2017
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29. Acceptability of interventions to reduce mother-to-child transmission of HIV-1 in West Africa
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Cartoux, M., Msellati, P., Rouamba, O., Coulibaly, D., Meda, N., Blibolo, D., Mandelbrot, L., Van de Perre, P., and Dabis, F.
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Africans -- Beliefs, opinions and attitudes ,HIV testing -- Public opinion ,HIV infection in pregnancy ,Health - Abstract
Many African women appear to be willing to be tested for HIV and to undergo treatment if they test positive. However, a survey of 607 women from two West African cities found that 64% to 91% of the women needed the permission of their partner to be tested. A majority said they would accept treatment if they were found to be HIV-positive to reduce the chance that they would transmit the virus to their baby.
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- 1996
30. Abstracts of the Eighth EDCTP Forum, 6-9 November 2016.
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Makanga, M, Beattie, P, Breugelmans, G, Nyirenda, T, Bockarie, M, Tanner, M, Volmink, J, Hankins, C, Walzl, G, Chegou, N, Malherbe, S, Hatherill, M, Scriba, TJ, Zak, DE, Barry, CE, Kaufmann, SHE, Noor, A, Strub-Wourgaft, N, Phillips, P, Munguambe, K, Ravinetto, R, Tinto, H, Diro, E, Mahendrahata, Y, Okebe, J, Rijal, S, Garcia, C, Sundar, S, Ndayisaba, G, Sopheak, T, Ngoduc, T, Van Loen, H, Jacobs, J, D'Alessandro, U, Boelaert, M, Buvé, A, Kamalo, P, Manda-Taylor, L, Rennie, S, Mokgatla, B, Bahati, Ijsselmuiden, C, Afolabi, M, Mcgrath, N, Kampmann, B, Imoukhuede, E, Alexander, N, Larson, H, Chandramohan, D, Bojang, K, Kasaro, MP, Muluka, B, Kaunda, K, Morse, J, Westfall, A, Kapata, N, Kruuner, A, Henostroza, G, Reid, S, Alabi, A, Foguim, F, Sankarganesh, J, Bruske, E, Mfoumbi, A, Mevyann, C, Adegnika, A, Lell, B, Kranzer, K, Kremsner, P, Grobusch, M, Sabiiti, W, Ntinginya, N, Kuchaka, D, Azam, K, Kampira, E, Mtafya, B, Bowness, R, Bhatt, N, Davies, G, Kibiki, G, Gillespie, S, Lejon, V, Ilboudo, H, Mumba, D, Camara, M, Kaba, D, Lumbala, C, Fèvre, E, Jamonneau, V, Bucheton, B, Büscher, P, Chisenga, C, Sinkala, E, Chilengi, R, Chitundu, H, Zyambo, Z, Wandeler, G, Vinikoor, M, Emilie, D, Camara, O, Mathurin, K, Guiguigbaza-Kossigan, D, Philippe, B, Regassa, F, Hassane, S, Bienvenu, SM, Fabrice, C, Ouédraogo, E, Kouakou, L, Owusu, M, Mensah, E, Enimil, A, Mutocheluh, M, Ndongo, FA, Tejiokem, MC, Texier, G, Penda, C, Ndiang, S, Ndongo, J-A, Guemkam, G, Sofeu, CL, Afumbom, K, Faye, A, Msellati, P, Warszawski, J, Vos, A, Devillé, W, Barth, R, Klipstein-Grobusch, K, Tempelman, H, Venter, F, Coutinho, R, Grobbee, D, Ssemwanga, D, Lyagoba, F, Magambo, B, Kapaata, A, Kirangwa, J, Nannyonjo, M, Nassolo, F, Nsubuga, R, Yebra, G, Brown, A, Kaleebu, P, Nylén, H, Habtewold, A, Makonnen, E, Yimer, G, Burhenne, J, Diczfalusy, U, Aklillu, E, Steele, D, Walker, R, Simuyandi, M, Beres, L, Bosomprah, S, Ansumana, R, Taitt, C, Lamin, JM, Jacobsen, KH, Mulvaney, SP, Leski, T, Bangura, U, Stenger, D, De Vries, S, Zinsou, FJ, Honkpehedji, J, Dejon, JC, Loembe, MM, Bache, B, Pakker, N, Van Leeuwen, R, Hounkpatin, AB, Yazdanbakhsh, M, Bethony, J, Hotez, P, Diemert, D, Bache, BE, Fernandes, JF, Obiang, RM, Kabwende, AL, Grobusch, MP, Krishna, S, Kremsner, PG, Todagbe, AS, Nambozi, M, Kabuya, J-B, Hachizovu, S, Mwakazanga, D, Kasongo, W, Buyze, J, Mulenga, M, Geertruyden, J-P, Gitaka, J, Chan, C, Kongere, J, Kagaya, W, Kaneko, A, Kabore, N, Barry, N, Kabre, Z, Werme, K, Fofana, A, Compaore, D, Nikiema, F, Some, F, Djimde, A, Zongo, I, Ouedraogo, B, Kone, A, Sagara, I, Björkman, A, Gil, JP, Nchinda, G, Bopda, A, Nji, N, Ambada, G, Ngu, L, Tchadji, J, Sake, C, Magagoum, S, Njambe, GD, Lisom, A, Park, CG, Tait, D, Sibusiso, H, Manda, O, Croucher, K, Van Der Westhuizen, A, Mshanga, I, Levin, J, Nanvubya, A, Kibengo, F, Jaoko, W, Pala, P, Perreau, M, Namuniina, A, Kitandwe, P, Tapia, G, Serwanga, J, Yates, N, Fast, P, Mayer, B, Montefiori, D, Tomaras, G, Robb, M, Lee, C, Wagner, R, Sanders, E, Kilembe, W, Kiwanuka, N, Gilmour, J, Kuipers, H, Vooij, D, Chinyenze, K, Priddy, F, Ding, S, Hanke, T, Pantaleo, G, Ngasala, B, Jovel, I, Malmberg, M, Mmbando, B, Premji, Z, Mårtensson, A, Mwaiswelo, R, Agbor, L, Apinjoh, T, Mwanza, S, Chileshe, J, Joshi, S, Malunga, P, Manyando, C, Laufer, M, Dara, A, Niangaly, A, Sinha, I, Brodin, D, Fofana, B, Dama, S, Dembele, D, Sidibe, B, Diallo, N, Thera, M, Wright, K, Gil, J, Doumbo, O, Baraka, V, Nabasumba, C, Francis, F, Lutumba, P, Mavoko, H, Alifrangis, M, Van Geertruyden, J-P, Sissoko, S, Sangaré, C, Toure, S, Sanogo, K, Diakite, H, Doumbia, D, Haidara, K, Julé, A, Ashurst, H, Merson, L, Olliaro, P, Marsh, V, Lang, T, Guérin, P, Awuondo, K, Njenga, D, Nyakarungu, E, Titus, P, Sutamihardja, A, Lowe, B, Ogutu, B, Billingsley, P, Soulama, I, Kaboré, M, Coulibaly, A, Ouattara, M, Sanon, S, Diarra, A, Bougouma, E, Ouedraogo, A, Sombie, B, Kargougou, D, Ouattara, D, Issa, N, Tiono, A, Sirima, S, Chaponda, M, Dabira, E, Dao, F, 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J-P, Sissoko, S, Sangaré, C, Toure, S, Sanogo, K, Diakite, H, Doumbia, D, Haidara, K, Julé, A, Ashurst, H, Merson, L, Olliaro, P, Marsh, V, Lang, T, Guérin, P, Awuondo, K, Njenga, D, Nyakarungu, E, Titus, P, Sutamihardja, A, Lowe, B, Ogutu, B, Billingsley, P, Soulama, I, Kaboré, M, Coulibaly, A, Ouattara, M, Sanon, S, Diarra, A, Bougouma, E, Ouedraogo, A, Sombie, B, Kargougou, D, Ouattara, D, Issa, N, Tiono, A, Sirima, S, Chaponda, M, Dabira, E, Dao, F, Dara, N, Coulibaly, M, Tolo, A, Maiga, H, Ouologuem, N, Niangaly, H, Botchway, F, Wilson, N, Dickinson-Copeland, CM, Adjei, AA, Wilson, M, Stiles, JK, Hamid, MA, Awad-Elgeid, M, Nasr, A, Netongo, P, Kamdem, S, Velavan, T, Lasry, E, Diarra, M, Bamadio, A, Traore, A, Coumare, S, Soma, B, Dicko, Y, Sangare, B, Tembely, A, Traore, D, Haidara, A, Dicko, A, Diawara, E, Beavogui, A, Camara, D, Sylla, M, Yattara, M, Sow, A, Camara, GC, Diallo, S, Mombo-Ngoma, G, Remppis, J, Sievers, M, Manego, RZ, Endamne, L, Hutchinson, D, Held, J, Supan, C, Salazar, CLO, Bonkian, LN, Nahum, A, Sié, A, Abdulla, S, Cantalloube, C, Djeriou, E, Bouyou-Akotet, M, Mordmüller, B, Siribie, M, Sirima, SB, Ouattara, SM, Coulibaly, S, Kabore, JM, Amidou, D, Tekete, M, Traore, O, Haefeli, W, Borrmann, S, Kaboré, N, Kabré, Z, Nikèma, F, Compaoré, D, Somé, F, Djimdé, A, Ouédraogo, J, Chalwe, V, Miller, J, Diakité, H, Greco, B, Spangenberg, T, Kourany-Lefoll, E, Oeuvray, C, Mulry, J, Tyagarajan, K, Magsaam, B, Barnes, K, Hodel, EM, Humphreys, G, Pace, C, Banda, CG, Denti, P, Allen, E, Lalloo, D, Mwapasa, V, Terlouw, A, Mwesigwa, J, Achan, J, Jawara, M, Ditanna, G, Worwui, A, Affara, M, Koukouikila-Koussounda, F, Kombo, M, Vouvoungui, C, Ntoumi, F, Etoka-Beka, MK, Deibert, J, Poulain, P, Kobawila, S, Gueye, NG, Seda, B, Kwambai, T, Jangu, P, Samuels, A, Kuile, FT, Kariuki, S, Barry, A, Bousema, T, Okech, B, Egwang, T, Corran, P, Riley, E, Ezennia, I, Ekwunife, O, Muleba, M, Stevenson, J, Mbata, K, Coetzee, M, Norris, D, Moneke-Anyanwoke, N, Momodou, J, Clarke, E, Scott, S, Tijani, A, Djimde, M, Vaillant, M, Samouda, H, Mensah, V, Roetynck, S, Kanteh, E, Bowyer, G, Ndaw, A, Oko, F, Bliss, C, Jagne, YJ, Cortese, R, Nicosia, A, Roberts, R, D'Alessio, F, Leroy, O, Faye, B, Cisse, B, Gerry, S, Viebig, N, Lawrie, A, Ewer, K, Hill, A, Nebie, I, Tiono, AB, Sanou, G, Konate, AT, Yaro, BJ, Sodiomon, S, Honkpehedji, Y, Agobe, JCD, Zinsou, F, Mengue, J, Richie, T, Hoffman, S, Nouatin, O, Ngoa, UA, Edoa, JR, Homoet, A, Engelhon, JE, Massinga-Louembe, M, Esen, M, Theisen, M, Sim, KL, Luty, AJ, Moutairou, K, Dinko, B, King, E, Targett, G, Sutherland, C, Likhovole, C, Ouma, C, Vulule, J, Musau, S, Khayumbi, J, Okumu, A, Murithi, W, Otu, J, Gehre, F, Zingue, D, Kudzawu, S, Forson, A, Mane, M, Rabna, P, Diarra, B, Kayede, S, Adebiyi, E, Kehinde, A, Onyejepu, N, Onubogu, C, Idigbe, E, Ba, A, Diallo, A, Mboup, S, Disse, K, Kadanga, G, Dagnra, Y, Baldeh, I, Corrah, T, De Jong, B, Antonio, M, Musanabaganwa, C, Musabyimana, JP, Karita, E, Diop, B, Nambajimana, A, Dushimiyimana, V, Karame, P, Russell, J, Ndoli, J, Hategekimana, T, Sendegeya, A, Condo, J, Binagwaho, A, Okonko, I, Okerentugba, P, Opaleye, O, Awujo, E, Frank-Peterside, N, Moyo, S, Kotokwe, K, Mohammed, T, Boleo, C, Mupfumi, L, Chishala, S, Gaseitsiwe, S, Tsalaile, L, Bussmann, H, Makhema, J, Baum, M, Marlink, R, Engelbretch, S, Essex, M, Novitsky, V, Saka, E, Kalipalire, Z, Bhairavabhotla, R, Midiani, D, Sherman, J, Mgode, G, Cox, C, Bwana, D, Mtui, L, Magesa, D, Kahwa, A, Mfinanga, G, Mulder, C, Borain, N, Petersen, L, Du Plessis, J, Theron, G, Holm-Hansen, C, Tekwu, EM, Sidze, LK, Assam, JPA, Eyangoh, S, Niemann, S, Beng, VP, Frank, M, Atiadeve, S, Hilmann, D, Awoniyi, D, Baumann, R, Kriel, B, Jacobs, R, Kidd, M, Loxton, A, Kaempfer, S, Singh, M, Mwanza, W, Milimo, D, Moyo, M, Kasese, N, Cheeba-Lengwe, M, Munkondya, S, Ayles, H, De Haas, P, Muyoyeta, M, Namuganga, AR, Kizza, HM, Mendy, A, Tientcheu, L, Ayorinde, A, Coker, E, Egere, U, Coussens, A, Naude, C, Chaplin, G, Noursadeghi, M, Martineau, A, Jablonski, N, Wilkinson, R, Ouedraogo, HG, Matteelli, A, Regazzi, M, Tarnagda, G, Villani, P, Sulis, G, Diagbouga, S, Roggi, A, Giorgetti, F, Kouanda, S, Bidias, A, Ndjonka, D, Olemba, C, Souleymanou, A, Mukonzo, J, Kuteesa, R, Ogwal-Okeng, J, Gustafsson, LL, Owen, J, Bassi, P, Gashau, W, Olaf, K, Dodoo, A, Okonkwo, P, Kanki, P, Maruapula, D, Seraise, B, Einkauf, K, Reilly, A, Rowley, C, Musonda, R, Framhein, A, Mpagama, S, Semvua, H, Maboko, L, Hoelscher, M, Heinrich, N, Mulenga, L, Kaayunga, C, Davies, M-A, Egger, M, Musukuma, K, Dambe, R, Usadi, B, Ngari, M, Thitiri, J, Mwalekwa, L, Fegan, G, Berkley, J, Nsagha, D, Munamunungu, V, Bolton, C, Siyunda, A, Shilimi, J, Bucciardini, R, Fragola, V, Abegaz, T, Lucattini, S, Halifom, A, Tadesse, E, Berhe, M, Pugliese, K, De Castro, P, Terlizzi, R, Fucili, L, Di Gregorio, M, Mirra, M, Zegeye, T, Binelli, A, Vella, S, Abraham, L, Godefay, H, Rakotoarivelo, R, Raberahona, M, Randriamampionona, N, Andriamihaja, R, Rasamoelina, T, Cornet, M, De Dieu Randria, MJ, Benet, T, Vanhems, P, Andrianarivelo, MR, Chirwa, U, Michelo, C, Hamoonga, R, Wandiga, S, Oduor, P, Agaya, J, Sharma, A, Cavanaugh, S, Cain, K, Mukisa, J, Mupere, E, Worodria, W, Ngom, JT, Koro, F, Godwe, C, Adande, C, Ateugieu, R, Onana, T, Ngono, A, Kamdem, Y, Ngo-Niobe, S, Etoa, F-X, Kanengoni, M, Ruzario, S, Ndebele, P, Shana, M, Tarumbiswa, F, Musesengwa, R, Gutsire, R, Fisher, K, Thyagarajan, B, Akanbi, O, Binuyo, M, Ssengooba, W, Respeito, D, Mambuque, E, Blanco, S, Mandomando, I, Cobelens, F, Garcia-Basteiro, A, Tamene, A, Topp, S, Mwamba, C, Padian, N, Sikazwe, I, Geng, E, Holmes, C, Sikombe, K, Hantuba, Czaicki, N, Simbeza, S, Somwe, P, Umulisa, M, Ilo, J, Kestelyn, E, Uwineza, M, Agaba, S, Delvaux, T, Wijgert, J, Gethi, D, Odeny, L, Tamandjou, C, Kaindjee-Tjituka, F, Brandt, L, Cotton, M, Nel, E, Preiser, W, Andersson, M, Adepoju, A, Magana, M, Etsetowaghan, A, Chilikwazi, M, Sutcliffe, C, Thuma, P, Sinywimaanzi, K, Matakala, H, Munachoonga, P, Moss, W, Masenza, IS, Geisenberger, O, Agrea, P, Rwegoshora, F, Mahiga, H, Olomi, W, Kroidl, A, Kayode, G, Amoakoh-Coleman, M, Ansah, E, Uthman, O, Fokam, J, Santoro, M-M, Musolo, C, Chimbiri, I, Chikwenga, G, Deula, R, Massari, R, Lungu, A, Perno, C-F, Ndzengue, G, Loveline, N, Lissom, A, Flaurent, T, Sosso, S, Essomba, C, Kpeli, G, Otchere, I, Lamelas, A, Buultjens, A, Bulach, D, Baines, S, Seemann, T, Giulieri, S, Nakobu, Z, Aboagye, S, Owusu-Mireku, E, Danso, E, Hauser, J, Hinic, V, Pluschke, G, Stinear, T, Yeboah-Manu, D, Elshayeb, A, Siddig, ME, Ahmed, AA, Hussien, AE, Kabwe, M, Tembo, J, Chilukutu, L, Chilufya, M, Ngulube, F, Lukwesa, C, Enne, V, Wexner, H, Mwananyanda, L, Hamer, D, Sinyangwe, S, Ahmed, Y, Klein, N, Maeurer, M, Zumla, A, Bates, M, Beyala, L, Etienne, G, Anthony, N, Benjamin, A, Ateudjieu, J, Chibwe, B, Ojok, D, Tarr, CA, Perez, GM, Omeonga, S, Kibungu, F, Meyer, A, Lansana, P, Mayor, A, Onyango, P, Van Loggerenberg, F, Furtado, T, Boggs, L, Segrt, A, Dochez, C, Burnett, R, Mphahlele, MJ, Miiro, G, Mbidde, E, Peshu, N, Kivaya, E, Ngowi, B, Kavishe, R, Maowia, M, Sandstrom, E, Ayuo, E, Mmbaga, B, Leisegang, C, Thorpe, M, Batchilly, E, N'Guessan, J-P, Kanteh, D, Søfteland, S, Sebitloane, M, Vwalika, B, Taylor, M, Galappaththi-Arachchige, H, Holmen, S, Gundersen, SG, Ndhlovu, P, Kjetland, EF, Kombe, F, Toohey, J, Pienaar, E, Kredo, T, Cham, PM, Abubakar, I, Dondeh, BL, Vischer, N, Pfeiffer, C, Burri, C, Musukwa, K, Zürcher, S, Mwandu, T, Bauer, S, Adriko, M, Mwaura, P, Omolloh, K, Jones, C, Malecela, M, Hamidu, BA, Jenner, TE, Asiedu, LJ, Osei-Atweneboana, M, Afeke, I, Addo, P, Newman, M, Durnez, L, Eddyani, M, Ammisah, N, Abas, M, Quartey, M, Ablordey, A, Akinwale, O, Adeneye, A, Ezeugwu, S, Olukosi, Y, Adewale, B, Sulyman, M, Mafe, M, Okwuzu, J, Gyang, P, Nwafor, T, Henry, U, Musa, B, Ujah, I, Agobé, JCD, Grau-Pujol, B, Sacoor, C, Nhabomba, A, Casellas, A, Quintó, L, Subirà, C, Giné, R, Valentín, A, Muñoz, J, Nikiema, M, Ky-Ba, A, Comapore, KAM, Sangare, L, Oluremi, A, Michel, M, Camara, Y, Sanneh, B, Cuamba, I, Gutiérrez, J, Lázaro, C, Mejia, R, Adedeji, A, Folorunsho, S, Demehin, P, Akinsanya, B, Cowley, G, Da Silva, ET, Nabicassa, M, De Barros, PDP, Blif, MM, Bailey, R, Last, A, Mahendradhata, Y, Gotuzzo, E, De Nys, K, Casteels, M, Nona, SK, Lumeka, K, Todagbe, A, Djima, MM, Ukpong, M, Sagay, A, Khamofu, H, Torpey, K, Afiadigwe, E, Anenih, J, Ezechi, O, Nweneka, C, Idoko, J, Muhumuza, S, Katahoire, A, Nuwaha, F, Olsen, A, Okeyo, S, Omollo, R, Kimutai, R, Ochieng, M, Egondi, T, Moonga, C, Chileshe, C, Magwende, G, Anumudu, C, Onile, O, Oladele, V, Adebayo, A, Awobode, H, Oyeyemi, O, Odaibo, A, Kabuye, E, Lutalo, T, Njua-Yafi, C, Nkuo-Akenji, T, Anchang-Kimbi, J, Mugri, R, Chi, H, Tata, R, Njumkeng, C, Dodoo, D, Achidi, E, Fernandes, J, Bache, EB, Matakala, K, Searle, K, Greenman, M, and Rainwater-Lovett, K
- Published
- 2017
31. Association between mental disorders with detectable viral load and poor adherence to antiretroviral therapy among adolescents infected with Human Immunodeficiency Virus on follow-up at Chantal Biya Foundation, Cameroon
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Ndongo, Francis Ateba, Kana, Rogacien, Nono, Marius Tchassep, Noah, Jean-Pierre Yves Awono, Ndzie, Patrice, Tejiokem, Mathurin Cyrille, Biheng, Emmanuelle Hopp, Ndie, Justin, Nkoa, Tatiana Avang, Ketchaji, Alice, Ngako, Joëlle Nounouce, Penda, Calixte Ida, Bissek, Anne Cécile Zoung-Kani, Ndombo, Paul Olivier Koki, Hawa, Hubert Mbassi, Msellati, Philippe, Lallemant, Marc, and Faye, Albert
- Abstract
Perinatally HIV-Infected Adolescents (HIVIA) are more likely to have mental health problems than their uninfected peers. In resource-limited settings, mental health disorders are rarely taken into account in the care offered to HIVIA and have an impact on their routine follow-up. The objective of this study was to assess the baseline socio-demographic factors and mental health conditions associated with detectable viral load or poor ART adherence in HIVIA on ART followed at the Mother and Child Centre of the Chantal Biya Foundation in Yaoundé (CME-FCB), Cameroon.
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- 2024
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32. 15 Month follow up of African children following vaginal cleansing with benzalkonium chloride of their HIV infected mothers during late pregnancy and delivery
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L Gautier-Charpentier, Dabis F, Msellati P, L Dequae-Merchadoux, R Likikouët, A Ouangre, R. Ramon, T. Ouassa, Laurent Mandelbrot, Valériane Leroy, Christiane Welffens-Ekra, M Dosso, Fatoumata Sylla-Koko, M Cartoux, Nicolas Meda, P. Van de Perre, Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Recherche pour le Développement (IRD), Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), Departement de Gynécologie Obstétrique, CHU de Youpougon, The ANRS 049/Ditrame project was funded by the French Agence Nationale de Recherches sur le SIDA (ANRS) and the French Ministry of Cooperation (Action Coordonnée no 12)., and The authors wish to thank the nurses and counsellors working with the Ditrame project and the staff from the participating prenatal care and delivery unit for their daily compassionate work. Special thanks to Drs MA Nandeuil, M Mathieu, and C Meignant (Innothéra, France) for assisting in the preparation of the trial, especially drug supply, packaging, and shipping.
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Pediatrics ,TRANSMISSION MERE ENFANT ,ESSAI CLINIQUE ,Placebo-controlled study ,HIV Infections ,NAISSANCE ,MESH: Proportional Hazards Models ,MESH: Pregnancy ,0302 clinical medicine ,Pregnancy ,Risk Factors ,GROSSESSE ,MESH: Risk Factors ,Infant Mortality ,INFECTION ,MESH: Administration, Intravaginal ,Childbirth ,MESH: Double-Blind Method ,MESH: Infant Mortality ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,reproductive and urinary physiology ,ANALYSE STATISTIQUE ,MESH: Treatment Outcome ,education.field_of_study ,integumentary system ,SIDA ,Obstetrics ,virus diseases ,Prenatal Care ,MESH: HIV Infections ,MESH: Follow-Up Studies ,MESH: Infant ,female genital diseases and pregnancy complications ,3. Good health ,MESH: Infectious Disease Transmission, Vertical ,Perinatal Care ,Treatment Outcome ,Infectious Diseases ,MESH: Survival Analysis ,MESH: Perinatal Care ,Female ,Original Article ,Benzalkonium Compounds ,HYGIENE ,MESH: Benzalkonium Compounds ,Maternal Age ,Adult ,medicine.medical_specialty ,TRANSMISSION ,MESH: Cote d'Ivoire ,Population ,Dermatology ,Prenatal care ,Placebo ,MESH: Multivariate Analysis ,03 medical and health sciences ,MESH: Anti-Infective Agents, Local ,Double-Blind Method ,030225 pediatrics ,Burkina Faso ,medicine ,Humans ,MESH: Pregnancy Complications, Infectious ,MESH: Burkina Faso ,education ,MESH: Prenatal Care ,MESH: Suppositories ,Proportional Hazards Models ,MESH: Humans ,Intention-to-treat analysis ,business.industry ,Suppositories ,Infant ,MESH: Adult ,Delivery, Obstetric ,medicine.disease ,Survival Analysis ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Infectious Disease Transmission, Vertical ,Infant mortality ,body regions ,Administration, Intravaginal ,ACCOUCHEMENT ,Cote d'Ivoire ,Multivariate Analysis ,Anti-Infective Agents, Local ,MESH: Delivery, Obstetric ,MESH: Maternal Age ,MORTALITE INFANTILE ,business ,MESH: Female ,Follow-Up Studies - Abstract
International audience; OBJECTIVES: To study mother to child HIV-1 transmission (MTCT) and infant mortality following benzalkonium chloride (BC) disinfection. METHODS: A randomised, double blind phase II placebo controlled trial. Women testing positive for HIV-1 infection in prenatal care units in Abidjan, Côte d'Ivoire, and Bobo-Dioulasso, Burkina Faso, from November 1996 to April 1997 were eligible, with their informed consent. Women self administered daily a vaginal suppository of 1% BC (53) or matched placebo (54) from 36 weeks of pregnancy, plus a single dose during labour. The neonate was bathed with 1% BC solution or placebo within 30 minutes after birth. MTCT rate was assessed based on repeated polymerase chain reaction (PCR) and serology results. For the present analysis, children were followed up to 15 months. RESULTS: A total of 107 women were enrolled. Of 103 eligible liveborn children, 23 were HIV infected, 75 uninfected, and five of indeterminate status. MTCT transmission rate was 24.2% overall (95% confidence interval (CI): 14.3% to 30.4%). On an intent to treat basis, the transmission rate did not differ between the two groups (23.5%, CI 13.8 to 38.5, in the BC group and 24.8%, CI 15.0 to 39.6, in the placebo group at 15 months). Similarly, there was no difference in mortality at 15 months (22.9%, CI 13.7 to 36.9, in the BC group and 16.5%, CI 9.0 to 29.4, in the placebo group). CONCLUSION: This analysis failed to suggest any benefit of BC disinfection on mother to child HIV transmission or perinatal and infant mortality.
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- 2002
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33. Annonce à l'enfant et à l'adolescent de son statut VIH en Afrique francophone centrale et de l'Ouest.
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Dahourou, D. L., Masson, D., Aka-Dago-Akribi, H., Gauthier-Lafaye, C., Cacou, C., Raynaud, J.-P., Moh, C., Bouah, B., Sturm, G., Oga, M., Msellati, P., and Leroy, V.
- Abstract
Copyright of Bulletin de la Société de Pathologie Exotique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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34. 24-Month adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in African HIV-1 infected children: ANRS 12103/12167
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H Chappuy, Serge Diagbouga, Joëlle Nicolas, Msellati P, Aly Drabo, Hervé Hien, Nicolas Meda, Jerôme Somé, Souleymane Yameogo, Adama Ouiminga, Alain Hien, François Rouet, Hassane Tamboura, Emmanuelle Zoure, P Van de Perre, and Boubacar Nacro
- Subjects
Cyclopropanes ,Male ,medicine.medical_specialty ,Efavirenz ,Adolescent ,Anti-HIV Agents ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Medication Adherence ,Virological response ,chemistry.chemical_compound ,Internal medicine ,Surveys and Questionnaires ,medicine ,Confidence Intervals ,Humans ,once-a-day therapy, Didanosine, Lamivudine, and Efavirenz, child ,Child ,Didanosine ,child ,business.industry ,Lamivudine ,General Medicine ,Original Articles ,Viral Load ,Antiretroviral therapy ,Benzoxazines ,CD4 Lymphocyte Count ,once-a-day therapy ,Regimen ,chemistry ,Alkynes ,Child, Preschool ,Immunology ,Africa ,RNA, Viral ,Lamivudine and Efavirenz ,Female ,business ,Viral load ,medicine.drug - Abstract
Background: There is no data on long-term benefit of once-a-day antiretroviral therapy (ART) with combination of DDI, 3TC and EFV to allow its use in future therapeutic strategies.Objectives: To assess 24-month immuno-virological, adherence, tolerance, and effectiveness of a once-a-day ART with DDI, 3TC and EFV.Methods: A phase 2 open trial including 51 children aged from 30 months to 15 years, monitored a once-a-day regimen for 24 months from 2006 to 2008 in the Departement de Pediatrie du CHUSS, at Bobo-Dioulasso in Burkina Faso. We tested immunological and virological response, adherence, tolerance and resistance of the treatment.Results: Children with CD4 >25% at 24 months were 67.4% (33/49) CI 95% [54%, 80%].The proportion of children with viral plasma RNA 95% over the 24 months. Drugs were well tolerated.Conclusions: Given the limited number of antiretroviral drugs available in Africa and the inadequacy of laboratory monitoring in support program, once-a-day treatment and especially the DDI-based combination strategies could be an attractive operational option.Key words: once-a-day therapy, Didanosine, Lamivudine, and Efavirenz, child.
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- 2013
35. Vivre avec le VIH au temps de la normalisation, une expérience banalisée pour les femmes ?
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Servais, S., Desclaux, A., Berthé, A., Bila, B., and Msellati, P.
- Abstract
Copyright of Médecine et Santé Tropicales is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
36. A cohort study of factors associated with failure to return for HIV post-test counselling in pregnant women
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Nyiraziraje M, Dabis F, Msellati P, Ladner J, Van de Perre P, De Clercq A, and Leroy
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Counseling ,law.invention ,Cohort Studies ,DIAGNOSTIC ,Pregnancy ,GROSSESSE ,law ,HIV Seropositivity ,Immunology and Allergy ,Medicine ,PSYCHOLOGIE ,Pregnancy Complications, Infectious ,education.field_of_study ,SIDA ,AIDS Serodiagnosis ,virus diseases ,Sexual Partners ,Infectious Diseases ,Family planning ,Cohort ,Educational Status ,Female ,PRESERVATIF ,Cohort study ,Adult ,medicine.medical_specialty ,Adolescent ,Immunology ,Parenteral transmission ,Population ,Acquired immunodeficiency syndrome (AIDS) ,Condom ,Humans ,Occupations ,education ,Gynecology ,Marital Status ,business.industry ,Rwanda ,VIRUS HIV-1 ,PREVENTION SANITAIRE ,medicine.disease ,DEPISTAGE ,FEMME ,Family medicine ,Patient Compliance ,business ,Serostatus ,TRANSMISSION FOETOMATERNELLE ,COMPORTEMENT SOCIAL - Abstract
This study sought to identify the factors associated with failure to return for HIV post-test counseling in pregnant women in Kigali (Rwanda). In the context of a study on the impact of HIV infection on pregnancy HIV-1-antibody testing was offered to all pregnant women attending the antenatal clinic of the Centre Hospitalier de Kigali from July 1992 to August 1993. Pre-test counseling was performed after verbal informed consent was obtained. Two weeks later the authors formally enrolled all HIV-positive women and a corresponding number of HIV-negative women in a cohort. At this visit post-test counseling was given to those wishing to be informed of their HIV serostatus. Level of knowledge about modes of HIV transmission and condom use were recorded. Four months after delivery another interview was conducted to determine the proportion of women who used condoms regularly. A total of 1233 pregnant women were screened. The HIV seroprevalence was 34.4% (95% confidence interval [CI] 31.7-37.1); 271 (63.9%) out of 424 HIV-positive and 577 (71.3%) out of 809 HIV-negative women asked for their HIV serostatus (p = 0.008). In multivariate analysis the only variable significantly associated with failure to return for post-test counseling was a positive HIV test result (odds ratio 0.7; 95% CI 0.5-0.9; p = 0.009) independently of obstetrical history and socioeconomic characteristics. Among the 848 women who had post-test counseling 50.9% of the HIV-positive women and 94.6% of the HIV-negative women stated that they planned to inform their partner of their serostatus (p = 0.0001). More than 95% of the women interviewed knew about sexual and parenteral transmission of HIV but half were unaware of mother-to-child transmission. More than 80% of the women had seen a condom before but 14% only had used it at least once. Among women who were sexually active four months after delivery 8.8% of the HIV-positive and 3.9% of the HIV-negative women reported using a condom (p = 0.04). Innovative approaches for HIV testing and counseling programs are needed and the importance of psychosocial and cultural factors associated with HIV testing should be emphasized in African populations. (authors)
- Published
- 1996
- Full Text
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37. Impediments to HIV testing in HIV-infected children and teenagers in Africa: look for them where they are!
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Msellati, P., additional, Ateba Ndongo, F., additional, Hejoaka, F., additional, and Nacro, B., additional
- Published
- 2016
- Full Text
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38. Is the Recommended Dose of Efavirenz Optimal in Young West African Human Immunodeficiency Virus-Infected Children?▿ ‡
- Author
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Déborah Hirt, Hélène Peyrière, Hervé Hien, Philippe Van de Perre, Serge Diagbouga, Emmanuelle Zoure, Boubacar Nacro, Saïk Urien, Msellati P, Jean-Marc Tréluyer, Mathieu Olivier, and François Rouet
- Subjects
Cyclopropanes ,Male ,Efavirenz ,Adolescent ,Anti-HIV Agents ,Population ,Cmax ,HIV Infections ,Pharmacology ,Biology ,Drug Administration Schedule ,03 medical and health sciences ,chemistry.chemical_compound ,Cmin ,0302 clinical medicine ,Animal science ,Pharmacokinetics ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,education ,Child ,Chromatography, High Pressure Liquid ,Volume of distribution ,0303 health sciences ,education.field_of_study ,030306 microbiology ,Liter ,3. Good health ,NONMEM ,Benzoxazines ,Infectious Diseases ,chemistry ,Alkynes ,Child, Preschool ,Female - Abstract
We aimed in this study to describe efavirenz concentration-time courses in treatment-naïve children after once-daily administration to study the effects of age and body weight on efavirenz pharmacokinetics and to test relationships between doses, plasma concentrations, and efficacy. For this purpose, efavirenz concentrations in 48 children were measured after 2 weeks of didanosine-lamivudine-efavirenz treatment, and samples were available for 9/48 children between months 2 and 5 of treatment. Efavirenz concentrations in 200 plasma specimens were measured using a validated high-performance liquid chromatography method. A population pharmacokinetic model was developed with NONMEM. The influence of individual characteristics was tested using a likelihood ratio test. The estimated minimal and maximal concentrations of efavirenz in plasma (CminandCmax, respectively) and the area under the concentration-time curve (AUC) were correlated to the decrease in human immunodeficiency virus type 1 RNA levels after 3 months of treatment. The thresholdCmin(and AUC) that improved efficacy was determined. The target minimal concentration of 4 mg/liter was considered for toxicity. An optimized dosing schedule that would place the highest percentage of children in the interval of effective and nontoxic concentrations was simulated. The pharmacokinetics of efavirenz was best described by a one-compartment model with first-order absorption and elimination. The mean apparent clearance and volume of distribution for efavirenz were 0.211 liter/h/kg and 4.48 liters/kg, respectively. Clearance decreased significantly with age. When the recommended doses were given to 46 of the 48 children, 19% (44% of children weighing less than 15 kg) hadCmins below 1 mg/liter. A significantly higher percentage of children withCmins of >1.1 mg/liter or AUCs of >51 mg/liter·h than of children with lower values had viral load decreases greater than 2 log10copies/ml after 3 months of treatment. Therefore, to optimize the percentage of children withCmins between 1.1 and 4 mg/liter, children should receive the following once-daily efavirenz doses: 25 mg/kg of body weight from 2 to 6 years, 15 mg/kg from 6 to 10 years, and 10 mg/kg from 10 to 15 years. These assumptions should be prospectively confirmed.
- Published
- 2009
39. Are recommended doses of efavirenz optimal in young children? (ANRS 12103)
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Serge Diagbouga, Déborah Hirt, Philippe Van de Perre, Msellati P, François Rouet, Saïk Urien, Emmanuelle Zoure, Jean-Marc Tréluyer, Hélène Peyrière, Hervé Hien, Boubacar Nacro, and Mathieu Olivier
- Subjects
lcsh:Immunologic diseases. Allergy ,chemistry.chemical_compound ,Infectious Diseases ,Efavirenz ,chemistry ,Anthropology ,Virology ,media_common.quotation_subject ,Art ,lcsh:RC581-607 ,media_common - Abstract
Address: 1Universite paris-descartes, Paris, France, 2Hopital Tarnier, Paris, France, 3Hopital Cochin-Saint Vincent de Paul, Paris, France, 4Hopital Lapeyronie, Montpellier, France, 5CHU Souro Sanou, Bobo Dioulasso, Burkina Faso, 6Centre Muraz, Bobo Dioulasso, Burkina Faso, 7Universite Paul Cezanne, Aix en Provence, France, 8Hopital Arnaud de Villeneuve, Montpellier, France and 9Universite Montpellier 1, Montpellier, France * Corresponding author
- Published
- 2009
40. Extraordinary long-term and fluctuating persistence of Ebola virus RNA in semen of survivors in Guinea: implications for public health
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Abel, L., Ayouba, A., Baize, S., Bangoura, K., Barry, A., Barry, M., Cissé, M., Delaporte, E., Delmas, C., Desclaux, A., Diallo, S., Diallo, M.S., Étard, J.-F., Etienne, C., Faye, O., Fofana, I., Granouillac, B., Hébert, E.H., Izard, S., Kassé, D., Keita, A.K., Koivugui, L., Kpamou, C., Lacarabaratz, C., Leroy, S., Marchal, C.L., Levy, Y., Magassouba, N'F., March, L., Msellati, P., Niane, H., Peeters, M., Pers, Y.-M., Raoul, H., Sacko, S.L., Savané, I., Sow, M.S., Taverne, B., Touré, A., Traoré, F.A., Toure, A., and Etard, J.-F.
- Published
- 2017
- Full Text
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41. Prevention of Mother-to-Child Transmission of HIV in Yaounde: Barrier to Care.
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Landefeld, C. C., Fomenou, L. A., Ateba, F., and Msellati, P.
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HIV prevention ,VERTICAL transmission (Communicable diseases) ,HEALTH services accessibility ,QUALITATIVE research ,FETUS ,PREVENTION - Abstract
Most HIV-infected children in Sub-Saharan Africa are born where programs for the prevention of mother-to-child transmission of HIV (PMTCT) exist but are not universally operational. The expansion of PMTCT programs in Cameroon was among the largest in francophone Africa, but despite highly variable estimates of PMTCT uptake (ranging from 20% to 66%), it is clear that not enough HIV-infected pregnant Cameroonian women benefit from treatment to prevent HIV transmission to their children. The reasons why HIV-infected women in Cameroon do not use treatments to prevent this transmission remain partially unidentified. We conducted a qualitative study of the therapeutic itineraries (treatments taken and motivations) followed by HIV-infected pregnant women in Cameroon to understand the barriers to accessing high-quality PMTCT care. Here we construct the therapeutic itinerary for HIV-infected pregnant women, and identify the barriers at each step. Lack of financial independence, personal support, and empowering information were the primary obstacles at multiple steps. [ABSTRACT FROM PUBLISHER]
- Published
- 2018
- Full Text
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42. Acceptability of Outpatient Ready-To-Use Food-Based Protocols in HIV-Infected Senegalese Children and Adolescents Within the MAGGSEN Cohort Study.
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Cames, Cecile, Varloteaux, Marie, Have, Ndeye Ngone, Diom, Alhadji Bassine, Msellati, Philippe, Mbaye, Ngagne, Mbodj, Helene, Signate, Haby Sy, Diack, Aminata, Sy Signate, Haby, and ANRS 12279 MAGGSEN Cohort Study Group
- Abstract
Objectives: To assess the acceptability of ready-to-use food (RUF)-based outpatient protocols in HIV-infected children and adolescents with severe acute malnutrition (SAM) and moderate acute malnutrition (MAM).Methods: Plumpy Nut and Plumpy Sup were supplied every 2 weeks and prescribed by weight to SAM and MAM children, respectively. Forty-three children, 24 MAM and 19 SAM, were enrolled. Organoleptic appreciation, feeding modalities, and perceptions surrounding RUF were recorded at week 2. Sachets were counted to measure adherence throughout the study.Results: Median age was 12.2 years (interquartile range: 9.3-14.8), and 91% were on antiretroviral treatment. Overall, 80%, 76%, 68%, and 68% of children initially rated RUF color, taste, smell, and mouth feeling as good. However, feelings of disgust, refusal to eat, fragmentation of intake, self-stigma, and sharing within the household were commonly reported. Eighteen MAM and 7 SAM experienced weight recovery. Recovery duration was 54 days (31-90) in MAM versus 114 days (69-151) in SAM children ( P = .02). Their rate of RUF consumption compared to amount prescribed was approximately 50% from week 2 to week 10. Nine failed to gain weight or consume RUF and were discontinued for clinical management, and 9 dropped out due to distance to the clinic.Conclusion: Initial RUF acceptability was satisfactory. More than half the children had successful weight recovery, although adherence to RUF prescription was suboptimal. However, further research is needed to propose therapeutic foods with improved palatability, alternative and simpler intervention design, and procedures for continuous and tailored psychosocial support in this vulnerable population.Trial Registration: NCT01771562 (Current Controlled Trials). [ABSTRACT FROM AUTHOR]- Published
- 2017
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43. HIV-1 DNA concentrations and evolution among African HIV-1-infected children under antiretroviral treatment (ANRS 1244/1278)
- Author
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Boulle, C., primary, Rouet, F., additional, Fassinou, P., additional, Msellati, P., additional, Debeaudrap, P., additional, Chaix, M.-L., additional, Rouzioux, C., additional, and Avettand-Fenoel, V., additional
- Published
- 2014
- Full Text
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44. Field acceptability and effectiveness of the routine utilization of zidovudine to reduce mother-to-child transmission of HIV-1 in West Africa
- Author
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Nicolas Meda, Crépin Montcho, Dabis F, Msellati P, Seydou Yaro, Leroy, Laurent Mandelbrot, Olivier Manigart, and Ida Viho
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Adult ,Counseling ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Cost effectiveness ,Anti-HIV Agents ,Immunology ,Population ,HIV Infections ,Drug Administration Schedule ,law.invention ,Cohort Studies ,Zidovudine ,Randomized controlled trial ,Acquired immunodeficiency syndrome (AIDS) ,law ,Pregnancy ,parasitic diseases ,Burkina Faso ,medicine ,Immunology and Allergy ,Humans ,Pregnancy Complications, Infectious ,education ,education.field_of_study ,business.industry ,Infant, Newborn ,virus diseases ,Prenatal Care ,Patient Acceptance of Health Care ,medicine.disease ,Infectious Disease Transmission, Vertical ,Infectious Diseases ,Breast Feeding ,Cote d'Ivoire ,Cohort ,HIV-1 ,Patient Compliance ,Reverse Transcriptase Inhibitors ,Female ,business ,Postpartum period ,medicine.drug ,Cohort study ,Follow-Up Studies - Abstract
OBJECTIVE: To ascertain the field acceptability and effectiveness of the routine utilization of zidovudine in reducing mother-to-child transmission (MTCT) of HIV in breastfed children after a randomized clinical trial demonstrated its efficacy in Cote d'Ivoire and Burkina Faso. METHODS: Pregnant women aged 18 years or older, who had confirmed HIV-1 infection, haemoglobinemia greater than 7 g/dl were enrolled in an open label cohort at 36-38 weeks' gestation to receive an oral short course of zidovudine. Paediatric HIV infection was defined as a positive HIV-1 polymerase chain reaction, or if aged 15 months or older, a positive HIV serology. RESULTS: The acceptability of HIV pretest counselling was significantly higher in the cohort (90.3%) than in the trial (83.7%) (P < 0.001), but the return rate for HIV test results and for inclusion was low. A similar proportion of women accepted starting zidovudine in the cohort, 30.4% compared with 27.3% in the trial (P = 0.13). The proportions of women who took more than 80% of the expected zidovudine regimen were 81.8% before labour, 86.7% during labour, and 88.1% during the postpartum period, compared with those observed during the trial, 78.1, 81.1, and 85%, respectively. The MTCT probability at age 15 months was 19.6% in the cohort (n = 185) versus 21.2% in the trial (P = 0.52). CONCLUSION: The major drawback with the implementation of a short zidovudine regimen to reduce MTCT is HIV counselling and testing procedures. For women who consent, zidovudine is well accepted and efficacious under routine circumstances.
- Published
- 2002
45. Prévalence élevée des troubles de santé mentale dans la population émergente des adolescents vivant avec le VIH en Afrique de l'Ouest
- Author
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Dahourou, D.L., N'Gbeche, M.S., Yonaba, C., Moh, C., Revegue, M. H.D.T., Kouadio, K., Nindjin, P., Malateste, K., Azani, J.C., Kangah, E., Thio, E., Jesson, J., Msellati, P., and Leroy, V.
- Abstract
Grâce aux antirétroviraux, les adolescents vivant avec le VIH (AVVIH) infectés en péri-natal constituent une population émergente en Afrique de l'Ouest depuis les années 2010. Chez eux, les troubles de santé mentale sont des comorbidités mal estimées qui peuvent impacter le suivi et l'observance au traitement antirétroviral (TAR). Nous avons estimé la prévalence de la dépression et de l'anxiété chez les AVVIH dans le projet OPTIMISE-AO au Burkina Faso et en Côte d'Ivoire.
- Published
- 2023
- Full Text
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46. Safety and acceptability of vaginal disinfection with benzalkonium chloride in HIV infected pregnant women in west Africa: ANRS 049b phase II randomized, double blinded placebo controlled trial. DITRAME Study Group
- Author
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Msellati P, R Likikouët, R Lassalle, Fatoumata Sylla-Koko, Vincent Leroy, L Gautier-Charpentier, Laurent Mandelbrot, M Dosso, P. Van de Perre, A Ouangre, M Cartoux, Patrice Combe, Nicolas Meda, Dominique Bonard, Dabis F, and Christiane Welffens-Ekra
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Vaginal Diseases ,Placebo-controlled study ,HIV Infections ,Dermatology ,Prenatal care ,Placebo ,law.invention ,Benzalkonium chloride ,Randomized controlled trial ,Double-Blind Method ,law ,Pregnancy ,Internal medicine ,Burkina Faso ,medicine ,Humans ,Adverse effect ,Gynecology ,Intention-to-treat analysis ,business.industry ,Original Articles ,Middle Aged ,Patient Acceptance of Health Care ,medicine.disease ,Infectious Disease Transmission, Vertical ,Administration, Intravaginal ,Infectious Diseases ,Cote d'Ivoire ,Treatment Outcome ,HIV-2 ,Anti-Infective Agents, Local ,HIV-1 ,Patient Compliance ,Female ,business ,Benzalkonium Compounds ,medicine.drug - Abstract
OBJECTIVES: To study the tolerance and acceptability in Africa of a perinatal intervention to prevent vertical HIV transmission using benzalkonium chloride disinfection. DESIGN: A randomized, double blinded phase II trial. SETTING: Prenatal care units in Abidjan (Cote d'Ivoire) and Bobo-Dioulasso (Burkina Faso). PATIENTS: Women accepting testing and counselling who were seropositive for HIV-1 and under 37 weeks of pregnancy were eligible. A total of 108 women (54 in each group) enrolled from November 1996 to April 1997, with their informed consent. INTERVENTION: Women self administered daily a vaginal suppository of 1% benzalkonium chloride or matched placebo from 36 weeks of pregnancy, and a single intrapartum dose. The neonate was bathed with 1% benzalkonium chloride solution or placebo within 30 minutes after birth. MAIN OUTCOME MEASURES: Adverse events were recorded weekly, with a questionnaire and speculum examination in women through delivery, and examination of the neonate through day 30. The incidence of genital signs and symptoms in the women and cutaneous or ophthalmological events in newborns were compared between groups on an intent to treat basis. RESULTS: The median duration of prepartum treatment was 21 days (range 0-87 days). Compliance was 87% for prepartum and 69% for intrapartum treatment, and 88% for the neonatal bath, without differences between the two groups. In women, the most frequent event was leucorrhoea; the incidence of adverse events did not differ between treatment groups. In children, the incidence of dermatitis and conjunctivitis did not differ between the benzalkonium chloride and placebo groups (p = 0.16 and p = 0.29, respectively). CONCLUSION: Vaginal disinfection with benzalkonium chloride is a feasible and well tolerated intervention in west Africa. Its efficacy in preventing vertical HIV transmission remains to be demonstrated.
- Published
- 2001
47. Family environment and dental health diparities among urban children in Burkina Faso
- Author
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Varenne, B, Fournet, F, Cadot, E, Msellati, P, Quedraogo, H Z, Meyer, P E, Cornu, J-F, Salem, G, Petersen, Poul Erik, Varenne, B, Fournet, F, Cadot, E, Msellati, P, Quedraogo, H Z, Meyer, P E, Cornu, J-F, Salem, G, and Petersen, Poul Erik
- Abstract
Background Dental caries is the most common multifactorial disease in children and has substantial negative impact on daily life. In sub-Saharan Africa, few data are available on the relationship between dental caries and the social and family environment of children. The objectives of the present study were firstly to assess the level of prevalence and severity of dental caries of children in Ouagadougou, the capital city of Burkina Faso and secondly to determine whether or not individual factors, family and living conditions are linked with dental health disparities within the population. Methods Interview and clinical data were obtained from a household-based cross-sectional survey. A two-stage stratified sampling technique was applied in four areas of Ouagadougou representing different stages of urbanization. Results The final study population included 1606 children aged 6–12 years. For the overall group the total caries prevalence rate was 48.2%. Results showed that the dental health status of the mother, social integration of the householder and socioeconomic level of the household were associated with the dental health of children. Disparities in dental health were prominent; poor dental health was relatively frequent in children from households poorly integrated into social networks with rather acceptable standard in terms of material wealth. Conclusion Our study showed that individual factors as well as family-related and environmental factors had an influence on their caries experience. The rapidly changing lifestyle affects oral health and the burden of oral diseases is expected to increase initially in people of upper classes and later in disadvantaged people. Disease prevention focussing on common risk factors of chronic diseases should be enhanced. In addition, the accessibility of quality fluoride products (e.g. toothpaste, salt, water) should be facilitated as soon as possible.
- Published
- 2011
48. Estimation of HIV-1 prevalence in the population of Abidjan by adjustment of the prevalence observed in antenatal centres
- Author
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A. Desgrées du Loû, Dabis F, Msellati P, Christiane Welffens-Ekra, R. Ramon, and G. La Ruche
- Subjects
medicine.medical_specialty ,media_common.quotation_subject ,Immunology ,Population ,Developing country ,Fertility ,Acquired immunodeficiency syndrome (AIDS) ,GROSSESSE ,Epidemiology ,INFECTION ,medicine ,Immunology and Allergy ,education ,media_common ,ANALYSE STATISTIQUE ,Estimation ,education.field_of_study ,METHODE D'ANALYSE ,business.industry ,SIDA ,medicine.disease ,PREVALENCE ,Sexual intercourse ,Infectious Diseases ,FEMME ,Serostatus ,business ,VIH-1 ,Demography - Abstract
Especially in developing countries HIV prevalence estimates in the general population are based upon the prevalence observed through sentinel surveillance in antenatal centers. Pregnant women are therefore considered to be representative of all women of childbearing age. However HIV-1 prevalence in the general population may be underestimated when based upon such surveillance because studies have shown that HIV infection may impair female fertility causing HIV-infected women to visit antenatal centers less often than do other women. Prevalences assessed at antenatal centers therefore need to be adjusted. Nicoll et al.s method of adjusting by estimating a summary relative inclusion ratio (RIR) was applied to Abidjan Cote dIvoire. The RIR was used upon data on female fertility by HIV status for 5483 pregnant women who agreed to be tested for HIV between 1995 and 1997 in 3 antenatal centers in Yopougon district and found to be readily applicable in African countries although it is important to consider the age structure of the population in antenatal centers and to stratify that adjustment by age. The only data needed for such an adjustment are age number of live births HIV serostatus for women entering the sentinel center and if possible age at first sexual intercourse and the age structure of the community considered.
- Published
- 1999
49. Impaired fertility in HIV-1-infected pregnant women : a clinic-based survey in Abidjan, Côte d'Ivoire, 1997
- Author
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Msellati P, Noba, Desgrées du Loû A, Ida Viho, R. Ramon, Christiane Welffens-Ekra, Dabis F, and Angèle Yao
- Subjects
Adult ,medicine.medical_specialty ,media_common.quotation_subject ,Immunology ,Population ,FECONDITE ,HIV Infections ,Fertility ,Acquired immunodeficiency syndrome (AIDS) ,Pregnancy ,Epidemiology ,Humans ,Immunology and Allergy ,Medicine ,Pregnancy Complications, Infectious ,education ,media_common ,Gynecology ,education.field_of_study ,business.industry ,Obstetrics ,SIDA ,Hazard ratio ,virus diseases ,ETUDE D'IMPACT ,medicine.disease ,Confidence interval ,Cote d'Ivoire ,Infectious Diseases ,FEMME ,HIV-1 ,ENQUETE ,Marital status ,Female ,business - Abstract
The reproductive histories of 1201 consecutive women attending a prenatal clinic in Abidjan Ivory Coast in 1997 were investigated to determine whether HIV-infected women become pregnant less often than HIV-negative women. This issue is important because if HIV-positive women have fewer pregnancies or more miscarriages than other women then women who visit antenatal clinics are not representative of all women of childbearing age and HIV prevalence is underestimated at these centers. All women were unaware of their HIV status at study entry. 169 women (14.3%) were HIV-positive but it was not possible to determine whether the pregnancies occurred before or after infection. The mean age at first coitus was 16 years among HIV-positive and 17 years among HIV-negative women. The mean number of pregnancies was higher among HIV-positive women under 20 years of age than HIV-negative women of this age (2.1 vs. 1.7) but this trend was reversed from age 25 years onward (4.2 vs. 4.7). The interval between the last two pregnancies was longer among HIV-infected women than uninfected women (36.4 vs. 33 months). The gap was greatest among women 25-29 years of age (51.8 vs. 35.7 months). In multivariate analysis after adjustment for age last pregnancy outcome duration of postpartum amenorrhea use of contraceptives during this interval marital status and educational level HIV infection significantly delayed the occurrence of the current pregnancy (Cox model hazard ratio 0.83; 95% confidence interval 0.69-0.99). Since HIV infection appears to compromise physiologic ability to become pregnant HIV prevalence assessed at antenatal centers should be adjusted for the fertility differences between HIV-positive and HIV-negative women.
- Published
- 1999
50. Prevention of mother-to-child transmission of HIV in Africa : uptake of pregnant women in a clinical trial in Abidjan, Côte d'Ivoire
- Author
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R. Ramon, Msellati P, C Welffens Ekra, Dabis F, Valentin Noba, Ida Viho, and Laurent Mandelbrot
- Subjects
medicine.medical_specialty ,Pediatrics ,TRANSMISSION ,ZIDOVUDINE ,Immunology ,Population ,ESSAI CLINIQUE ,Developing country ,TRAITEMENT MEDICAL ,Zidovudine ,Acquired immunodeficiency syndrome (AIDS) ,GROSSESSE ,medicine ,Immunology and Allergy ,SANTE PUBLIQUE ,education ,education.field_of_study ,Pregnancy ,Obstetrics ,business.industry ,Transmission (medicine) ,SIDA ,virus diseases ,medicine.disease ,PREVALENCE ,Clinical trial ,Infectious Diseases ,Clinical research ,business ,VIH-1 ,VIH-2 ,medicine.drug - Abstract
Before implementation of a tolerance and efficacy trial of zidovudine (ZDV) in Abidjan Ivory Coast the acceptability of HIV screening was probed among women attending the Yopougon Health Center for their first prenatal visit in 1996-97. Of the 2219 prenatal clients who were eligible for AZT 395 (17.8%) refused HIV testing--primarily because of fear of the result. Of the 1824 women who consented to testing 279 (15.3%) were HIV-positive (249 for HIV-1 21 for HIV-2 and 9 with dual reactions). 204 HIV-positive women returned for their test result. Of these women 3 refused the confirmation test and 29 were lost to follow-up after the second test leaving 172 women for pre-inclusion. However 101 of these women were subsequently excluded for reasons including return visit too late in pregnancy for AZT planned delivery outside of Abidjan change of mind and loss to follow-up before formal inclusion. Thus only 71 women received the trial treatment. The only significant difference between these 71 women and those who did not complete the selection process was that the former women were older (mean age 26 years) than the latter (mean age 24 years). The finding that it was necessary to perform HIV tests in 1824 women to recruit 71 women for a clinical trial of ZDV indicates a need for IEC campaigns aimed at women of childbearing age about maternal-child HIV transmission and its prevention.
- Published
- 1998
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