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We report our analysis of MACS J0717.5+3745 using 140 and 268 GHz Bolocam data collected at the Caltech Submillimeter Observatory. We detect extended Sunyaev-Zel'dovich (SZ) effect signal at high significance in both Bolocam bands, and we employ Herschel-SPIRE observations to subtract the signal from dusty background galaxies in the 268 GHz data. We constrain the two-band SZ surface brightness toward two of the sub-clusters of MACS J0717.5+3745: the main sub-cluster (named C), and a sub-cluster identified in spectroscopic optical data to have a line-of-sight velocity of +3200 km s–1 (named B). We determine the surface brightness in two separate ways: via fits of parametric models and via direct integration of the images. For both sub-clusters, we find consistent surface brightnesses from both analysis methods. We constrain spectral templates consisting of relativistically corrected thermal and kinetic SZ signals, using a jointly-derived electron temperature from Chandra and XMM-Newton under the assumption that each sub-cluster is isothermal. The data show no evidence for a kinetic SZ signal toward sub-cluster C, but they do indicate a significant kinetic SZ signal toward sub-cluster B. The model-derived surface brightnesses for sub-cluster B yield a best-fit, line-of-sight velocity of vz = +3450 ± 900 km s–1, with (1 – Prob[vz ⩾ 0]) = 1.3 × 10–5 (4.2σ away from 0 for a Gaussian distribution). The directly integrated sub-cluster B SZ surface brightnesses provide a best-fit vz = +2550 ± 1050 km s–1, with (1 – Prob[vz ⩾ 0]) = 2.2 × 10–3 (2.9σ). [ABSTRACT FROM AUTHOR]

The circumgalactic medium (CGM) is a crucial component of galaxy evolution, but thus far its physical properties are highly unconstrained. As of yet, no cosmological simulation has reached convergence when it comes to constraining the cold and dense gas fraction of the CGM. Such components are also challenging to observe directly, as they require sub-millimetre (sub-mm) instruments with a high sensitivity to extended and mostly diffuse emission. We present a state-of-the-art theoretical effort at modelling the [CII] 158 μm, [CI](1−0) 609 μm, [CI](2−1) 370 μm, CO(3−2) 867 μm, and [OIII] 88 μm line emissions that arise from the interstellar medium (ISM) and CGM of galaxies, with the goal of studying the contribution from different cold (T < 104 K) components of galaxy halos. We used the high-resolution cosmological zoom-in simulation PONOS (mgas = 883.4 M⊙), which represents a typical star-forming galaxy system at z = 6.5, composed of a main disc with stellar mass M* = 2 × 109 M⊙ that is undergoing a major merger. We adopted different modelling approaches based on the photoionisation code CLOUDY. Our fiducial model uses radiative transfer post-processing with RAMSES-RT and KROME (KRAMSES-RT) to create more realistic far-ultraviolet (FUV) radiation fields, which we then compared to other sub-grid modelling approaches adopted in the literature. We find significant differences in the luminosity and in the contribution of different gas phases and galaxy components between the different modelling approaches. [CII] is the least model-dependant gas tracer, while [CI](1−0) and CO(3−2) are very model-sensitive. In all models, we find a significant contribution to the emission of [CII] (up to ∼10%) and [OIII] (up to ∼21%) from the CGM. Our fiducial global radiative transfer (RT) model produces a lower density, T ∼ 104 K tail of [CII] emission that is not seen in the other more simplistic models and that resides entirely in the CGM, ionised by the FUV background and producing the extended halos observed in [CII] at high-z. Notably, [CII] and [OIII] trace different regions of the CGM: [CII] arises from an accreting filament and from the tidal tails connecting the main disc and its merging satellites, while [OIII] traces a puffy halo surrounding the main disc, probably linked to supernova feedback. We discuss our results in the context of sub-mm observations. Using simulated spectra and mock maps, we show that, despite the rather compact angular extent of PONOS's CGM, deep ALMA observations would not detect this component, even in [CII] which is the brightest available tracer. Instead, a next generation single-dish observatory such as the Atacama Large Aperture Submillimeter Telescope (AtLAST) could detect PONOS' CGM in [CII] at a high signal-to-noise ratio, and possibly even in [OIII]. [ABSTRACT FROM AUTHOR]

In this work, we study the intracluster medium (ICM) of a galaxy cluster at the cosmic noon: JKCS 041 at z  = 1.803. A 28 h long Sunyaev-Zel'dovich (SZ) observation using MUSTANG-2 allows us to detect JKCS 041, even if intrinsically extremely faint compared to other SZ-detected clusters. We found that the SZ peak is offset from the X-ray centre by about 220 kpc in the direction of the brightest cluster galaxy, which we interpret as due to the cluster being observed just after the first passage of a major merger. JKCS 041 has a low central pressure and a low Compton Y compared to local clusters selected by their ICM, likely because the cluster is still in the process of assembly but also in part because of a hard-to-quantify bias in current local ICM-selected samples. JKCS 041 has a 0.5 dex fainter Y signal than another less massive z ∼ 1.8 cluster, exemplifying how much different weak-lensing mass and SZ mass can be at high redshift. The observations we present provide us with the measurement of the most distant resolved pressure profile of a galaxy cluster. Comparison with a library of plausibly descendants shows that JKCS 041 pressure profile will likely increase by about 0.7 dex in the next 10 Gyr at all radii. [ABSTRACT FROM AUTHOR]

Context. Determining when the first galaxies formed remains an outstanding goal of modern observational astronomy. Theory and current stellar population models imply that the first galaxies formed at least at z = 14 − 15. But to date, only one galaxy at z > 13 (GS-z13-0) has been spectroscopically confirmed. Aims. The galaxy 'HD1' was recently proposed to be a z ∼ 13.27 galaxy based on its potential Lyman break and tentative [O III] 88 μm detection with ALMA. We hereby aim to test this scenario with new ALMA Band 4 observations of what would be the [C II] 158 μm emission if HD1 is at z ∼ 13.27. Methods. We carefully analyse the new ALMA Band 4 observations and re-analyse the existing ALMA Band 6 data on the source to determine the proposed redshift. Results. We find a tentative 4σ feature in the Band 4 data that is spatially offset by 1.​​″7 and spectrally offset by 190 km s−1 from the previously reported 3.8σ '[O III] 88 μm' feature. Through various statistical tests, we demonstrate that these tentative features are fully consistent with both being random noise features. Conclusions. We conclude that we are more likely to be recovering noise features than both [O III] 88 μm and [C II] 158 μm emission from a source at z ∼ 13.27. Although we find no credible evidence of a z ∼ 13.27 galaxy, we cannot entirely rule out this scenario. Non-detections are also possible for a z ∼ 13 source with a low interstellar gas-phase metallicity or ionisation parameter and/or high gas density. Moreover, the new continuum and line upper limits provide no strong evidence for or against a lower-redshift scenario. Determining where and exactly what type of galaxy HD1 is, will now likely require JWST/NIRSpec spectroscopy. [ABSTRACT FROM AUTHOR]

Aims. We present the X-ray imaging and spectral analysis of the diffuse emission around the radio galaxy J1140-2629 (the Spiderweb galaxy) at z = 2.16 and of its nuclear emission, based on a deep (700 ks) Chandra observation. Methods. We obtained a robust characterization of the unresolved nuclear emission, and carefully computed the contamination in the surrounding regions due to the wings of the instrument point spread function. Then, we quantified the extended emission within a radius of 12 arcsec. We used the Jansky Very Large Array radio image to identify the regions overlapping the jets, and performed X-ray spectral analysis separately in the jet regions and in the complementary area. Results. We find that the Spiderweb galaxy hosts a mildly absorbed quasar, showing a modest yet significant spectral and flux variability on a timescale of ∼1 year (observed frame). We find that the emission in the jet regions is well described by a power law with a spectral index of Γ ∼ 2 − 2.5, and it is consistent with inverse-Compton upscattering of the cosmic microwave background photons by the relativistic electrons. We also find a roughly symmetric, diffuse emission within a radius of ∼100 kpc centered on the Spiderweb galaxy. This emission, which is not associated with the jets, is significantly softer and consistent with thermal bremsstrahlung from a hot intracluster medium (ICM) with a temperature of kT = 2.0−0.4+0.7 k T = 2. 0 − 0.4 + 0.7 $ kT = 2.0_{-0.4}^{+0.7} $ keV, and a metallicity of Z <  1.6 Z⊙ at 1σ c.l. The average electron density within 100 kpc is ne = (1.51  ±  0.24 ± 0.14) × 10−2 cm−3, corresponding to an upper limit for the total ICM mass of ≤(1.76  ±  0.30  ±  0.17) × 1012 M⊙ (where error bars are 1σ statistical and systematic, respectively). The rest-frame luminosity L0.5 − 10 keV = (2.0 ± 0.5) × 1044 erg s−1 is about a factor of 2 higher than the extrapolated L − T relation for massive clusters, but still consistent within the scatter. If we apply hydrostatic equilibrium to the ICM, we measure a total gravitational mass M(<100 kpc) = (1.5−0.3+0.5) × 1013 M⊙ M (< 100 kpc) = (1. 5 − 0.3 + 0.5) × 10 13 M ⊙ $ M({ and, extrapolating at larger radii, we estimate a total mass M500 = (3.2−0.6+1.1) × 1013 M⊙ M 500 = (3. 2 − 0.6 + 1.1) × 10 13 M ⊙ $ M_{500} = (3.2^{+1.1}_{-0.6})\times 10^{13}\, M_\odot $ within a radius of r500 = (220 ± 30) kpc. Conclusions. We conclude that the Spiderweb protocluster shows significant diffuse emission within a radius of 12 arcsec, whose major contribution is provided by inverse-Compton scattering associated with the radio jets. Outside the jet regions, we also identified thermal emission within a radius of ∼100 kpc, revealing the presence of hot, diffuse baryons that may represent the embryonic virialized halo of the forming cluster. [ABSTRACT FROM AUTHOR]

We present resolved thermodynamic profiles out to 500 kpc, about r 500, of the z = 1.75 galaxy cluster IDCS J1426.5+3508 with 40 kpc resolution. Thanks to the combination of Sunyaev–Zel'dovich and X-ray data sets, IDCS J1426.5+3508 becomes the most distant cluster with resolved thermodynamic profiles. These are derived assuming a non-parametric pressure profile and a very flexible model for the electron density profile. The shape of the pressure profile is flatter than the universal pressure profile. The IDCS J1426.5+3508 temperature profile is increasing radially out to 500 kpc. To identify the possible future evolution of IDCS J1426.5+3508 , we compared it with its local descendants that numerical simulations show to be 0.65 ± 0.12 dex more massive. We found no evolution at 30 kpc, indicating a fine tuning between cooling and heating at small radii. At 30 < r < 300 kpc, our observations show that entropy and heat must be deposited with little net gas transfer, while at 500 kpc the gas need to be replaced by a large amount of cold, lower entropy gas, consistent with theoretical expectation of a filamentary gas stream, which brings low entropy gas to 500 kpc and energy at even smaller radii. At r ≳ 400 kpc the polytropic index takes a low value, which indicates the presence of a large amount of non-thermal pressure. Our work also introduces a new definition of the evolutionary rate that uses unscaled radii, unscaled thermodynamic quantities, and different masses at different redshifts to compare ancestors and descendants. It has the advantage of separating cluster evolution, dependence on mass, pseudo-evolution, and returns a number with unique interpretation, unlike other definitions used in literature. [ABSTRACT FROM AUTHOR]

The MeerKAT Exploration of Relics, Giant Halos, and Extragalactic Radio Sources (MERGHERS) survey is a planned project to study a large statistical sample of galaxy clusters with the MeerKAT observatory. Here we present the results of a 16-h pilot project, observed in response to the 2019 MeerKAT Shared Risk proposal call, to test the feasibility of using MeerKAT for a large cluster study using short (0.2–2.1 h) integration times. The pilot focuses on 1.28-GHz observations of 13 massive, low-to-intermediate redshift (0.22 < z < 0.65) clusters from the Sunyaev–Zel'dovich-selected Atacama Cosmology Telescope (ACT) DR5 catalogue that show multiwavelength indications of dynamical disturbance. With a 70 per cent detection rate (9/13 clusters), this pilot study validates our proposed MERGHERS observing strategy and provides twelve detections of diffuse emission, eleven of them new, indicating the strength of MeerKAT for such types of studies. The detections (signal-to-noise ratio ≳ 6) are summarized as follows: two systems host both relic(s) and a giant radio halo, five systems host radio haloes, and two have candidate radio haloes. Power values, k -corrected to 1.4 GHz, assuming a fiducial spectral index of α = −1.3 ± 0.4, are consistent with known radio halo and relic scaling relations. [ABSTRACT FROM AUTHOR]

We present the first high-resolution 230–470 MHz map of the Perseus cluster obtained with the Karl G. Jansky Very Large Array. The high dynamic range and resolution achieved have allowed the identification of previously unknown structures in this nearby galaxy cluster. New hints of sub-structures appear in the inner radio lobes of the brightest cluster galaxy NGC 1275. The spurs of radio emission extending into the outer X-ray cavities, inflated by past nuclear outbursts, are seen for the first time at these frequencies, consistent with spectral aging. Beyond NGC 1275, we also analyse complex radio sources harboured in the cluster. Two new distinct, narrowly collimated jets are visible in IC 310, consistent with a highly projected narrow-angle tail radio galaxy infalling into the cluster. We show how this is in agreement with its blazar-like behaviour, implying that blazars and bent-jet radio galaxies are not mutually exclusive. We report the presence of filamentary structures across the entire tail of NGC 1265, including two new pairs of long filaments in the faintest bent extension of the tail. Such filaments have been seen in other cluster radio sources such as relics and radio lobes, indicating that there may be a fundamental connection between all these radio structures. We resolve the very narrow and straight tail of CR 15 without indication of double jets, so that the interpretation of such head–tail sources is yet unclear. Finally, we note that only the brightest western parts of the mini-halo remain, near NGC 1272 and its bent double jets. [ABSTRACT FROM AUTHOR]

We present the results of deep Chandra and XMM–Newton X-ray imaging and spatially resolved spectroscopy of Abell 2256, a nearby (z  = 0.058) galaxy cluster experiencing multiple mergers and displaying a rich radio morphology dominated by a large relic. The X-ray data reveal three subclusters: (i) the 'main cluster'; (ii) the remnant of an older merger in the east of the cluster with an ∼600 kpc-long tail; (iii) a bright, bullet-like, low-entropy infalling system, with a large line-of-sight velocity component. The low-entropy system displays a 250 kpc-long cold front with a break and an intriguing surface brightness decrement. Interestingly, the infalling gas is not co-spatial with bright galaxies and the radio-loud brightest cluster galaxy of the infalling group appears dissociated from the low-entropy plasma by ∼50 kpc in projection, to the south of the eastern edge of the cold front. Assuming that the dark matter follows the galaxy distribution, we predict that it is also significantly offset from the low-entropy gas. Part of the low-frequency radio emission near the cold front might be revived by magnetic field amplification due to differential gas motions. Using analytical models and numerical simulations, we investigate the possibility that the supersonic infall of the subcluster generates a large-scale shock along our line of sight, which can be detected in the X-ray temperature map but is not associated with any clear features in the surface brightness distribution. [ABSTRACT FROM AUTHOR]

Context. The study of dust emission at millimeter wavelengths is important to shed light on the dust properties and physical structure of pre-stellar cores, the initial conditions in the process of star and planet formation. Aims. Using two new continuum facilities, AzTEC at the Large Millimeter Telescope Alfonso Serrano and MUSTANG-2 at the Green Bank Observatory, we aim to detect changes in the optical properties of dust grains as a function of radius for the well-known pre-stellar core L1544. Methods. We determined the emission profiles at 1.1 and 3.3 mm and examine whether they can be reproduced in terms of the current best physical models for L1544. We also made use of various tools to determine the radial distributions of the density, temperature, and dust opacity in a self-consistent manner. Results. We find that our observations cannot be reproduced without invoking opacity variations. New temperature and density profiles, as well as opacity variations across the core, have been derived with the new data. The opacity changes are consistent with the expected variations between uncoagulated bare grains, toward the outer regions of the core, and grains with thick ice mantles, toward the core center. A simple analytical grain growth model predicts the presence of grains of ~3–4 μm within the central 2000 au for the new density profile. [ABSTRACT FROM AUTHOR]

Aims: Extragalactic observations of water emission can provide valuable insight into the excitation of the interstellar medium. In particular they allow us to investigate the excitation mechanisms in obscured nuclei, that is, whether an active galactic nucleus or a starburst dominates. Methods: We use subarcsecond resolution observations to tackle the nature of the water emission in Arp 220. ALMA Band 5 science verification observations of the 183 GHz H2O313-220 line, in conjunction with new ALMA Band 7 H2O515-422 data at 325 GHz, and supplementary 22 GHz H2O616-523 VLA observations, are used to better constrain the parameter space in the excitation modeling of the water lines. Results: We detect 183 GHz H2O and 325 GHz water emission toward the two compact nuclei at the center of Arp 220, being brighter in Arp 220West. The emission at these two frequencies is compared to previous single-dish data and does not show evidence of variability. The 183 and 325 GHz lines show similar spectra and kinematics, but the 22 GHz profile is significantly different in both nuclei due to a blend with an NH3 absorption line. Conclusions: Our findings suggest that the most likely scenario to cause the observed water emission in Arp 220 is a large number of independent masers originating from numerous star-forming regions. [ABSTRACT FROM AUTHOR]

We discuss the design and measured performance of a titanium nitride (TiN) mesh absorber we are developing for controlling optical crosstalk in horn-coupled lumped-element kinetic inductance detector (LEKID) arrays for millimeter wavelengths. This absorber was added to the fused silica anti-reflection coating attached to previously characterized, 20-element prototype arrays of LEKIDs fabricated from thin-film aluminum on silicon substrates. To test the TiN crosstalk absorber, we compared the measured response and noise properties of LEKID arrays with and without the TiN mesh. For this test, the LEKIDs were illuminated with an adjustable, incoherent electronic millimeter-wave source. Our measurements show that the optical crosstalk in the LEKID array with the TiN absorber is reduced by 66 % on average, so the approach is effective and a viable candidate for future kilo-pixel arrays. [ABSTRACT FROM AUTHOR]

MUSTANG-2 is a 90 GHz feedhorn-coupled, microwave SQUID-multiplexed TES bolometer array in the final stages of development for operation on the 100-m Robert C. Byrd Green Bank Telescope. We present the camera design and report the performance during the first season of observation, in which 64 of the available 215 pixels in the focal plane were populated. We highlight the microwave multiplexing readout technology, which is envisioned as a path to read out the next generation of large pixel-count cryogenic focal planes. In this regard, MUSTANG2 is a pathfinder for this multiplexing technology. We present noise spectra which show no detector noise degradation when read out with microwave SQUID multiplexing, and we present first light images of Jupiter and M87, which demonstrate the end-to-end system performance. [ABSTRACT FROM AUTHOR]

We report photon-noise limited performance of horn-coupled, aluminum lumped-element kinetic inductance detectors at millimeter wavelengths. The detectors are illuminated by a millimeterwave source that uses an active multiplier chain to produce radiation between 140 and 160 GHz. We feed the multiplier with either amplified broadband noise or a continuous-wave tone from a microwave signal generator. We demonstrate that the detector response over a 40 dB range of source power is well-described by a simple model that considers the number of quasiparticles. The detector noise-equivalent power (NEP) is dominated by photon noise when the absorbed power is greater than approximately 1 pW, which corresponds to NEP ≈ 2 × 10–17WHz–1/2, referenced to absorbed power. At higher source power levels, we observe the relationships between noise and power expected from the photon statistics of the source signal: NEP ∝ P for broadband (chaotic) illumination and NEP ∝ P1/2 for continuous-wave (coherent) illumination. [ABSTRACT FROM AUTHOR]

We discuss the design, fabrication, and testing of prototype horn-coupled, lumped-element kinetic inductance detectors (LEKIDs) designed for cosmic microwave background studies. The LEKIDs are made from a thin aluminum film deposited on a silicon wafer and patterned using standard photolithographic techniques at STAR Cryoelectronics, a commercial device foundry.We fabricated 20-element arrays, optimized for a spectral band centered on 150 GHz, to test the sensitivity and yield of the devices as well as the multiplexing scheme. We characterized the detectors in two configurations. First, the detectors were tested in a dark environment with the horn apertures covered, and second, the horn apertures were pointed towards a beam-filling cryogenic blackbody load. These tests show that the multiplexing scheme is robust and scalable, the yield across multiple LEKID arrays is 91%, and the measured noise-equivalent temperatures for a 4 K optical load are in the range 26 ± 6μK√s. [ABSTRACT FROM AUTHOR]

This paper describes MUSTANG 2, a 338 element focal plane array that is being built for the Green Bank Telescope. Each element consists of a profiled feedhorn coupled to two transition edge sensor bolometers, one for each polarization. Initial deployment will be with 32 detectors, but once fully populated, MUSTANG 2 will be capable of mapping a $$8'\times 8'$$ area to $$23~\upmu $$ Jy in 1 h with good image fidelity on angular scales from $$9''$$ to $$6'$$ . As well as an instrument overview, the choice of bandpass and the design of the feeds, detectors and readout are given. [ABSTRACT FROM AUTHOR]

The stratospheric kinetic inductance polarimeter is a proposed balloon-borne experiment designed to study the cosmic microwave background, the cosmic infrared background and Galactic dust emission by observing 1,133 deg $$^2$$ of sky in the Northern Hemisphere with launches from Kiruna, Sweden. The instrument contains 2,317 single-polarization, horn-coupled, aluminum lumped-element kinetic inductance detectors ( Lekids). The Lekids will be maintained at 100 mK with an adiabatic demagnetization refrigerator. The polarimeter operates in two configurations, one sensitive to a spectral band centered on 150 GHz and the other sensitive to 260 and 350 GHz bands. The detector readout system is based on the ROACH-1 board, and the detectors will be biased below 300 MHz. The detector array is fed by an F/2.4 crossed-Dragone telescope with a 500 mm aperture yielding a 15 arcmin FWHM beam at 150 GHz. To minimize detector loading and maximize sensitivity, the entire optical system will be cooled to 1 K. Linearly polarized sky signals will be modulated with a metal-mesh half-wave plate that is mounted at the telescope aperture and rotated by a superconducting magnetic bearing. The observation program consists of at least two, 5-day flights beginning with the 150 GHz observations. [ABSTRACT FROM AUTHOR]

We describe Sunyaev-Zel'dovich (SZ) effect measurements and analysis of the intracluster medium (ICM) pressure profiles of a set of 45 massive galaxy clusters imaged using Bolocam at the Caltech Submillimeter Observatory.We deproject the average pressure profile of our sample into 13 logarithmically spaced radial bins between 0.07R500 and 3.5R500, and we find that a generalized Navarro, Frenk, and White (gNFW) profile describes our data with sufficient goodness-of-fit and best-fit parameters (C500, α, β, γ , P0 = 1.18, 0.86, 3.67, 0.67, 4.29). We use X-ray data to define cool-core and disturbed subsamples of clusters, and we constrain the average pressure profiles of each of these subsamples. We find that, given the precision of our data, the average pressure profiles of disturbed and cool-core clusters are consistent with one another at R ≳ 0.15R500, with cool-core systems showing indications of higher pressure at R ≲ 0.15R500. In addition, for the first time, we place simultaneous constraints on the mass scaling of cluster pressure profiles, their ensemblemean profile, and their radius-dependent intrinsic scatter between 0.1R500 and 2.0R500. The scatter among profiles is minimized at radii between ≲0.2R500 and ≲0.5R500, with a value of ≲20%. These results for the intrinsic scatter are largely consistent with previous analyses, most of which have relied heavily on X-ray derived pressures of clusters at significantly lower masses and redshifts compared to our sample. Therefore, our data provide further evidence that cluster pressure profiles are largely universal with scatter of ≲20%-40% about the universal profile over a wide range of masses and redshifts. [ABSTRACT FROM AUTHOR]

Background: Treatment of gonorrhea is complicated by widespread resistance of Neisseria gonorrhoeae to antimicrobial agents of choice, including decreased susceptibility to ciprofloxacin.Goal: To demonstrate the efficacy and safety of gatifloxacin, a novel 8-methoxy fluoroquinolone antibiotic, compared with ofloxacin in treating patients with uncomplicated gonococcal infection.Study Design: In a double-blind, randomized (2:2:1), controlled trial, 340 men and 388 women with uncomplicated gonorrhea who were 16 years or older received a single oral dose of gatifloxacin (400 mg or 600 mg) or ofloxacin (400 mg). Primary analysis of efficacy was based on bacteriologic eradication from sites of infection. Secondary analyses examined clinical response and adverse event profiles.Results: Bacteriologic eradication rates for gatifloxacin in evaluable men with urethral gonorrhea were 99% (400 mg) and 100% (600 mg) versus 100% for ofloxacin (n = 117, 122, and 55, respectively; P = ns). Eradication rates in evaluable women with endocervical gonorrhea were 99% for both 400 mg and 600 mg gatifloxacin versus 100% for ofloxacin (n = 101, 104, and 55, respectively; P = ns). Eradication rates were 100% for both rectal (n = 43) and pharyngeal (n = 31) infection across all treatment groups. All three drug regimens were well tolerated and exhibited similar clinical response profiles.Conclusion: Gatifloxacin is safe and effective as a single 400-mg or 600-mg dose for the treatment of uncomplicated gonorrhea. Similar efficacy rates were observed with the 400-mg and 600-mg doses. A single 400-mg dose can be recommended for treatment of uncomplicated gonorrhea. [ABSTRACT FROM AUTHOR]