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Background and purpose: Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) is a natural and safe compound with powerful antioxidant and anti-inflammatory properties. In this study, the ameliorative effects of RA were assayed in folic acid (FA)-induced renal injury by involving the SIRT1/NOX1 pathway. Experimental approach: Thirty-six male C57/BL6 mice were divided into 6 groups (n = 6) including control, vehicle, FA, RA, FA + RA 50, and FA + RA 100. After 10 days, blood urea nitrogen (BUN), creatinine, and oxidative stress were measured. The expression of SIRT1 and NOX1 proteins was evaluated by western blot. Also, histopathological alterations were assayed by H&E and PAS staining methods. Findings/Results: BUN and creatinine were significantly higher in the FA group compared to the control group; however, their levels decreased after RA treatment in both doses. A significant decrease was observed in swelling, necrosis, and desquamation of tubular epithelial cells in the FA + RA 50 and FA + RA 100 groups compared to the FA group. RA in the animals receiving FA increased SIRT1 expression and the levels of GSH and SOD compared to the FA group. RA in the animals receiving FA showed a significant decrease in NOX1 expression and MDA level compared to the FA group. Conclusion and implications: The findings declared that the administration of RA has positive effects against renal damage induced by FA. The effect might result from involvement in the SIRT1/NOX1 pathway and thereby attenuation of oxidative stress.

Objective: This study aimed to evaluate the antimicrobial efficacy of Viola odorata extract, with or without the addition of zinc oxide nanoparticles (ZnO NPs), against Streptococcus mutans.Methods: Two series of V. odorata hydroalcoholic extracts were prepared at concentrations of 25, 50, 100, and 200 mg/ml. Five hundred ppm ZnO NPs were added to 500 ml of the V. odorata extracts in half of the samples. The antibacterial activity of the extracts was then tested using the agar well diffusion method against S. mutans, and the inhibition zones were determined. The control groups were 0.2% chlorhexidine and Salvadora persica mouthwashes. Statistical analysis was performed using an independent-sample t-test, one-way ANOVA, and Duncan's post-hoc test (α=0.05).Results: Adding ZnO NPs significantly improved the inhibition zone of V. odorata extract at all concentrations (P < 0.05). The largest inhibition zone was observed in the 0.2% chlorhexidine mouthwash, significantly greater than all other groups (P < 0.001). The inhibition diameter for S. persica mouthwash was significantly greater than that of all the V. odorata extracts (P < 0.001), except for the group containing 200 mg/ml extract with ZnO NPs (P > 0.05).Conclusions: Adding 500 ppm ZnO NPs enhanced the antibacterial activity of the V. odorata extract. The antibacterial effect of the 200 mg/ml V. odorata extract combined with ZnO NPs was comparable to that of S. persica mouthwash against S. mutans. Given the anti-inflammatory and antibacterial properties of the V. odorata extract, this formulated mouthwash shows potential for improving patients' oral health.

During the last couple of decades, many researchers have been trying to explicate "effective teaching" in higher education. As a result, when one searches the term, a vast amount of papers and research reports pop up in the literature, involving lists of attributes and competencies of effective teachers. But the impressive point is that "effectiveness" has been viewed mostly from a technical vantage point and disciplinary differences have not received proportionate attention. At the same time, some sociologists of science began to view disciplines as tribes and territories who own their exclusive norms, rituals, and values. Hence, this research aims at investigating effective teaching in higher education within the framework of disciplinary culture. Methodologically, the research may be deemed as interpretive ethnography as it aims at representing emically how members of disciplinary cultures perceive and interpret effective teaching. Hence, based on Tony Becher classification of disciplines into civil and rural, two postgraduate classes were selected, namely from Pure Mathematics (involving 15 students to represent civil disciplines) and Education Studies (involving 18 students to represent rural disciplines). To collect data, the researcher deployed non-participant observation for a full semester and informal interviews were also conducted at regular intervals. The field notes and interview protocols were analyzed thematically to produce meaningful categories for results representation. As credibility was of great concern in the research, three strategies were used for this purpose namely member check, peer debriefing and prolonged engagement. Based on the interpretations, members of rural disciplines evaluate teaching as effective when it focuses on classic texts, cares about human and social issues, approaches laymen jargons, emphasizes understanding, appreciates variety of teaching strategies and learning styles, holds a critical stance towards cultural issues, and takes on a lenient approach in marking. On the other side, members of civil disciplines evaluate teaching as effective when it focuses on updated resources, is content-oriented, approaches professional terminology, emphasizes practicality, and takes on a tough stance on marking.

Pulses of near-fault earthquakes are very effective in the seismic response of the Triple Friction Pendulum Isolator (TFPI). In previous studies, the effect of original bi-directional pulses components on the isolated tall buildings by TFPI was neglected. Also, the effect of changing the design parameters of TFPI on preventing seismic disaster in this type of building is unknown. For this reason, a 10 stories moment steel structure mounted on TFPI was designed. Then, the seven pairs of bidirectional near-fault earthquake records without and with removal pulses were applied to the isolated structure. The results show that the seismic responses on the base level decrease by reducing the velocity pulse amplitude (AP) and increasing the velocity pulse period (TP), also if the period of the isolators (TM) is being higher than TP, the seismic responses on the upper floors reduce. Moreover, Increasing the geometrical dimensions of the TFPI can significantly reduce the seismic effect of near-fault earthquake with pulses.

In the matter of inheritance division among nephews and nieces, most فقها (jurists) uphold the rule of "Tafadol" and consider the inheritance share of males to be twice that of females. However, according to Ayatollah Khouei's view, in the absence of a specific proof, one should refer to the principle of equality, and the arguments for the rule of "Tafadol" are not capable of being extended beyond their specific cases. The main question is what are the jurisprudential foundations of Ayatollah Khouei's view in this regard? Considering that no specific basis has been found for his view, an attempt has been made to argue based on Ayatollah Khouei's jurisprudential principles, such as the invalidity of consensus) based on a single hadith, the invalidity) and non-determinative nature) of practical fame, the invalidity of the narrations of the book "Fiqh al-Ridha" and "Da'a'im al-Islam", and the non-universality) of the rule of "Tafadol". In addition to rejecting the major premise of the validity) of consensus based on a single hadith, he also raises a minor premise objection and rejects the very existence of consensus in this matter.

Solving mathematical equations faster and more efficiently has been a Holy Grail for centuries for scientists and engineers across all disciplines. While electronic digital circuits have revolutionized equation solving in recent decades, it has become apparent that performance gains from brute-force approaches of compute-solvers are quickly saturating over time. Instead, paradigms that leverage the universes’ natural tendency to minimize a system’s free energy, such as annealers or Ising Machines, are being sought after due to favorable complexity scaling. Here, we introduce a programmable analog solver leveraging the formal mathematical equivalence between Maxwell’s equations and photonic circuitry. It features a mesh network of nanophotonic beams to find solutions to partial differential equations. As an example, we designed, fabricated, and demonstrated a novel application-specific photonic integrated circuit comprised of electro-optically reconfigurable nodes and experimentally validated 90 % accuracy with respect to a commercial solver. Finally, we tested this photonic integrated chip performance by simulating thermal diffusion on a spacecraft’s heat shield during re-entry to a planet’s atmosphere. The programmable light-circuitry presented herein offers a facile route for solving complex problems and thus will have profound potential applications across many scientific and engineering fields.

The basic pillar of therapeutic simulation is the cells that are provided to scientists to combine and create a simulated embryo. These cells are not capable of planting in the laboratory environment but must be provided by the applicant to the researchers to produce simulated embryo for extracting stem cells. One of the challenges of using the therapeutic simulation process is how scientists reach the above base cells. It also raises the necessity of extracting stem cells from the resulting embryo, the issue of the owners of the decision -making authority towards the embryo. Another challenge is the conscious consent of the cell owners and the role of satisfaction in the owners of the embryo. The evaluation in the present article indicates that non -identification or restriction of decision -making authority to their cell owners and encloses the transfer of basic cells to scientists based on purely kind -hearted donation, benefiting from this modern technology and its valuable achievements with limitations. It makes a lot. In contrast, recognizing cell owners' decision -making authority over those cells and accepting monetary mechanisms and predicting the possibility of paying for cell owners while considering the necessity of their consent in the transfer process, not only increases the motivations of cell donation to simulate therapy. It will also promote the increasing development of scientific processes related to therapeutic simulation, which will be the source of the discovery of the treatment of many illnesses.

Abstract Background and Aim Due to the concern about the side effects of chemical drugs and their ineffectiveness, the use of natural compounds as alternatives or complementary therapies has received increasing attention. The purpose of this study was to investigate the effect of Nigella sativa oil on the outcome of missed abortion. Methods In this double‐blind clinical trial, 70 nulliparous pregnant women referred to Hajar Hospital and Imam Ali clinics of Shahrekord and had missed abortion before the 12‐week gestational age were selected and randomly divided into two interventions and control groups. The intervention group received 5 g of Nigella sativa oil alone daily for up to 3 days and the control group received a placebo. In case of nonresponse, 3 days after the last dose of medication or placebo, 800 μg of misoprostol (vaginal) were used. Data were analyzed by SPSS software. The chi‐square test, Fisher's exact test, independent t‐test and paired t‐test were used for analytical statistics. Results According to the results, 18 cases (51.4%) in the intervention group and seven cases (20%) in the control group showed complete evacuation of uterine contents which had a significant difference (p

Background and Objectives: This study aims to investigate whether a relationship is observed between spiritual health and health literacy among female teenagers, especially in terms of their attitudes toward breast self-examination. Methods: This study was a cross-sectional survey. Using multi-stage cluster sampling, 600 female students in grades 10 and 11 were chosen. A standard health literacy questionnaire created by Montazeri et al. and a 20-item spiritual health questionnaire created by Paloutzian and Ellison were used. Data were analyzed using SPSS software, version 22. Results: Most respondents had moderate health literacy and spiritual health with a positive and significant correlation (r=0.32). Health literacy has also been linked to maternal education and lower social class affiliation. Spiritual health was shown to be the vital variable in explaining health literacy in the regression. Conclusion: The research results showed the importance of spiritual health in health literacy and attitude towards health and preventive behaviors. Policymakers should give much more importance to spiritual health, especially in existential and non-ritual religious forms, in designing preventive interventions.

Background and Objectives: Nonalcoholic steatohepatitis is a severe liver disease characterized by excess lipid accumulation (steatosis) and inflammation in the liver. Endoplasmic reticulum stress is considered one of the crucial factors in nonalcoholic steatohepatitis pathophysiology. Rosmarinic acid is a herbal medicine with antioxidant and anti-inflammatory properties. This study aimed to evaluate the effect of rosmarinic acid on reducing the endoplasmic reticulum stress induced by nonalcoholic steatohepatitis in male Swiss-type mice. Methods: The study animals were grouped into four: Saline, rosmarinic acid, nonalcoholic steatohepatitis, and nonalcoholic steatohepatitis-rosmarinic acid. Nonalcoholic steatohepatitis was induced by a diet without methionine-choline for 8 weeks, and rosmarinic acid was injected intraperitoneally daily for 8 weeks in mice. After 8 weeks, the animals were killed, and their liver samples were obtained. Real-time PCR was used for molecular studies. Data analyses were performed by one-way analysis of variance and Tukey's post hoc test. Results: Findings of this study showed that rosmarinic acid alleviated mRNA levels of GRP78, IRE-1, and PERK while increasing the Apo B expression. Conclusion: The results suggest that rosmarinic acid ameliorates endoplasmic reticulum stress parameters, upregulates Apo B expression as a key factor in triglyceride exit from the liver, and thereby improves nonalcoholic steatohepatitis in male Swiss-type mice.

Background and Objectives: Melanoma is the most aggressive and fatal type of skin cancer caused by the uncontrolled proliferation of melanocytes. The ineffectiveness of existing therapies has encouraged researchers to use herbal medicines. Amygdalin is a natural cyanogenic glycoside that is found in fruits and seeds of different plants and has antiproliferative, antioxidant, and immune-regulating activities. In this study, we aim to evaluate the effect of amygdalin against murine melanoma cancer cell line and normal human fibroblast cells. Methods: The murine melanoma cancer cell line (B16F10) and human foreskin fibroblasts (HFF) cells were exposed to different concentrations of amygdalin and dacarbazine (a standard anticancer drug) for 24 and 48 hours. The half-maximal inhibitory concentration (IC50) of amygdalin was obtained using the MTT assay and analyzed in GraphPad Prism and Excel applications. Results: Amygdalin had a high cytotoxic effect on the melanoma cell line within 48 hours of exposure, which is comparable to the cytotoxicity of dacarbazine at the same time. Amygdalin had no cytotoxic effect on HFF cells, while dacarbazine caused a high toxicity on HFF cells. Conclusion: Amygdalin, by inhibiting the proliferation of cancer cells in a dose-dependent manner, may prevent the adverse effects of chemical drugs on healthy cells and can be an appropriate treatment option for melanoma.

Fluoride is currently accessible in various forms, including water, toothpaste, mouth rinses, and professional fluoride therapy at dental clinics. A body of data supports the use of systemic and topical fluoride from various sources to prevent dental caries. Fluoride ions are absorbed by the enamel before tooth eruption and produce fluorohydroxyapatite, which is more resistant to acid attack than hydroxyapatite crystals [1]. Fluoride ions also aid in the early caries lesion remineralization process. As a result of the two mechanisms outlined above, fluoride strengthens enamel teeth against organic acids and dental caries.

Introduction Introduction: Mayonnaise is one types of sauces that has always been loved and preferred by consumers because of its unique texture and taste. Sauce is a semi-solid or liquid food ingredients that consists of emulsifying edible vegetable oils (at least 66%) in a liquid phase including vinegar, water, lemon juice, and egg yolk (Bortnowska and Makiewiewicz, 2006). According to the National Standard of Iran (No. 2454), if the amount of fat in mayonnaise is reduced by at least 25% (from 66% of fat), it is considered reduced fat mayonnaise, and if it is reduced by 50% in fat, mayonnaise is considered low-fat. (National Standard of Iran 2454, 1394). Fibers are edible parts of plants or similar carbohydrates that cannot be absorbed in the gut and only irritate the gut. Dietary fiber contains polysaccharides, oligosaccharides, lignin and related plant materials. Dietary fiber intake can reduce the risk of cardiovascular disease, high blood pressure, diabetes, obesity, cancer and some gastrointestinal disorders. They can alter tissue properties, eliminate hydration, stabilize high-fat foods and emulsions, and improve shelf life (Zhang et al., 2017). Barley (Avena sativa L.) is an important crop with about 21 million tons annually production worldwide. The seed has been used to raise public awareness about the health benefits of beta-glucan, which helps lower blood cholesterol and glucose levels. Protein is the second most abundant element (12 to 20%) in barley after starch, which contains organic amino acids, due to its high lysine content because globulins make up 70 to 80% of total barley protein. Alcohol-soluble prolamins, on the other hand, are the main storage proteins in other cereals (Nito et al., 2015). Materials and Methods In this study, nitrate, ethanol, methanol, chloroform, ethylene glycol and acetic acid were prepared from Merck Company (Germany) and sunflower oil from Rana Company, vinegar from Somayeh Company, salt from Aali Company, sugar from Pardis Company, mustard from Bijan Company and Barley Malt Pulp was prepared from Behnoosh Company. Chemical extraction method was used to extract fiber. (Salehifar and Fadai Noghani, 2013). To prepare the mayonnaise samples, the powder ingredients including salt, mustard and sugar, vinegar and water were first mixed well and uniformly with a mixer (IKA WERK, Germany). Then, according to the formulation, the fiber extracted from barley malt pulp was gradually added to the above mixture, which was stirring, and the eggs were added to the mixture and mixed thoroughly to obtain a uniform composition. At this stage, the oil was added dropwise with continuous pouring. Finally, the samples of mayonnaise prepared were kept at refrigerator for further analysis. In all samples, the amount of sugar (11.5 g), white vinegar (23.1 g), eggs (39.45 g), salt (4.50 g), water (24.6 g) was constant (Bostani et al., 2011). In this study, in order to reduce the amount of oil, it was replaced with fiber extracted from barley malt pulp at five levels of 0, 5, 10, 15 and 20% (w / w). Results and Discussion The effect of replacing different percentages of fibers extracted from barley malt pulp with fat at levels (5, 10, 15 and 20%) on physicochemical properties (fat, fiber, ash, viscosity and colorimetry (L*) a*, b*) and sensory characteristics (taste, smell, color, texture and general acceptance) were determined using analysis of variance at 5% probability level. Various properties of low-fat mayonnaise showed that as the percentage of barley malt fiber increased, the amount of fat, radiance and yellowness in low-fat mayonnaise treatments (P 0.05) as well as protein content. In the treatments, which was statistically significant (P> 0.05), the results of sensory evaluation of mayonnaise samples showed that the addition of fiber extracted from barley malt pulp resulted in a significant reduction in taste, texture, color and the general acceptance of mayonnaise samples (P 0.05), so that the treatment containing 20% barley malt fiber had the lowest sensory score (taste). Smell, texture, color, acceptance k Li) and treatments containing 5 and 10% barley malt fiber received the highest sensory scores (taste, odor, texture, color, general acceptance) from the panelists. Conclusion According to the results, treatment 3 (containing 10% barley malt fiber) was introduced as the best treatment in the present study.

Optical real-time data processing is advancing fields like tensor algebra acceleration, cryptography, and digital holography. This technology offers advantages such as reduced complexity through optical fast Fourier transform and passive dot-product multiplication. In this study, the proposed Reconfigurable Complex Convolution Module (RCCM) is capable of independently modulating both phase and amplitude over two million pixels. This research is relevant for applications in optical computing, hardware acceleration, encryption, and machine learning, where precise signal modulation is crucial. We demonstrate simultaneous amplitude and phase modulation of an optical two-dimensional signal in a thin lens’s Fourier plane. Utilizing two spatial light modulators (SLMs) in a Michelson interferometer placed in the focal plane of two Fourier lenses, our system enables full modulation in a 4F system’s Fourier domain. This setup addresses challenges like SLMs’ non-linear inter-pixel crosstalk and variable modulation efficiency. The integration of these technologies in the RCCM contributes to the advancement of optical computing and related fields.

Key Clinical Message Although gastro‐pleural fistulas after bariatric surgeries are rare, they are life‐threatening complications that should be suspected in patients who present with gastrointestinal or respiratory symptoms after bariatric surgery. Abstract Previous studies showed an incidence rate of 0.2%–0.37% for gastro‐pleural fistulas after bariatric surgery. We report a 56‐year‐old female with a rare presentation of gastro‐pleural fistula after Roux‐en‐Y gastric bypass, simultaneous fistula of the gastric pouch, and remnant to the pleural space.

Objective(s): The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum results in a state known as “ER stress”. It can affect the fate of proteins and play a crucial role in the pathogenesis of several diseases. In this study, we investigated the protective effect of chlorogenic acid (CA) on the inflammation and apoptosis of tunicamycin-induced ER stress in mice.Materials and Methods: We categorized mice into six groups: Saline, Vehicle, CA, TM, CA 20-TM, and CA 50-TM. The mice received CA (20 or 50 mg/kg) before intraperitoneal tunicamycin injection. After 72 hr of treatment, serum biochemical analysis, histopathological alterations, protein and/or mRNA levels of steatosis, and inflammatory and apoptotic markers were investigated by ELISA and/or RT-PCR. Results: We found that 20 mg/kg CA decreased mRNA levels of Grp78, Ire-1, and Perk. Moreover, CA supplementation prevented TM-induced liver injury through changes in lipid accumulation and lipogenesis markers of steatosis (Srebp-1c, Ppar-α, and Fas), and exerted an inhibitory effect on inflammatory (NF-κB, Tnf-α, and Il-6) and apoptotic markers (caspase 3, p53, Bax, and Bcl2), of liver tissue in ER stress mice. Conclusion: These data suggest that CA ameliorates hepatic apoptosis and inflammation by reducing NF-κB and Caspase 3 as related key factors between inflammation and apoptosis.

Background: The purpose of this study was to investigate the efficacy and safety of Jollab monzej (JMZ), a Traditional Persian compound medicine, on multiple sclerosis-related fatigue (MSRF). Methods: We did a double-blind randomized controlled phase3 clinical trial on the JMZ syrup in fifty-six relapsing-remitting MS (RRMS) patients aged 18-55 years with moderate to severe fatigue using the Expanded Disability Status Scale (EDSS) score ≤ 6. We randomly assigned (1;1) participants to the JMZ syrup or placebo syrup groups treated for one month. Participants, investigators, and assessors were unaware of the assignments. The primary outcome was changes in the fatigue score on the Fatigue Severity Scale (FSS), at baseline and one month after treatment using the intention-to-treat (ITT) analysis. The secondary outcomes were changes in the score of Visual Analogue Scale (VAS), Beck Depression Inventory (BDI), and Pittsburgh Sleep Quality Index (PSQI). Outcomes were measured at baseline, one month after treatment, and 2-week follow-up. Safety was detected in all participants. Results: We randomly assigned 56 participants to the JMZ group (n=28) and placebo group (n=28). Fatigue scores significantly changed in both groups; however, the JMZ group had a greater reduction in FSS score in the ITT analysis. The adjusted mean difference was 8.80 (Confidence interval (CI) 95%, 2.90-14.70, P = 0.00). The mean difference of VAS, BDI, and global PSQI scores were statistically significant (P=0.01, P₌0.00, P₌0.01; respectively). Regarding safety, mild adverse events (AEs) were reported. Conclusion: The results of our study revealed that the administration of JMZ syrup alleviated MSRF and also could improve depression and sleep disorders.

IntroductionEfforts have always been made to protect valuable compounds of medicine, food and aromatics materials that are highly sensitive to environmental conditions by the encapsulation method. encapsulation of flavors, in addition to its protection, allows the aromatic substance to be released in a long time, and the time and place of its release can be controlled. To design these protection systems requires detailed information on encapsulation and release methods, the nature of walls and aromatic materials (Gunning et al.,1999). For encapsulation of sensitive compounds such as lipophilic materials, it is necessary to produce an emulsion of the desired substance in wall materials such as proteins, polysaccharides or a mixture of them. The important factors in encapsulation are the molecular weight, chemical properties and polarity of the core materials, the properties of the materials of the walls, and finally, the methods used to produce microcapsules. (Jafari et al., 2008).The aim of this study was to produce and evaluate the properties of two and six layer multilayer microcapsules containing limonene using soy protein isolate and starch modified by spray drying. The release of encapsulated limonene was investigated under artificial oral conditions under different stress conditions. The results of this study can be used to predict the release rate of the encapsulated flavors and their release conditions.Materials and MethodsSolution preparation: The solution of SPI (0-3%) was prepared by methods of Huang et al. (2012). The OSA starch stock solution (0-2%) was prepared by methods of Nilsson and Bergens (2007).Emulsion’s preparation: the primary emulsion of the optimum SPI and secondary emulsion of optimum OSA starch concentration prepared by the method of Noshad et al (2015).Microcapsule production: To prepare the Microcapsules, a laboratory spray dryer was used. 180±5 ᵒC, inlet air temperature, 25 (ml/min) feed rate, and 90±10 ᵒC outlet air temperature were used. Six layer microcapsules was also prepared in the same conditions (Ansarifar et al., 2017)The micro structure, morphology and release of limonene were evaluated and finally by Zero order, First order, Higuchi, and Korsemeyer- peppas models were used to the fitting of experimental data.Limonene release: To investigate the release of the encapsulated limonene, the release of these microcapsules (two and six layer) at 37 ° C and pH = 6.8, as well as frequent chewing (0, 50 and 100 rpm) were examined. For the apply of shear stress, an oral simulator was designed and developed by the Department of Food Science and Technology of Ferdowsi University of Mashhad was used. Results and DiscusionThe results of particle size changes of the initial emulsion formed with different levels of soy protein isolate showed that the particle size decreased with increasing the concentration of this protein to 1.5% and then it was increased. The results of zeta potential showed that with increasing the concentration of soy protein isolate to 1.5%, the zeta potential of the samples increased and with more than 1.5%, it did not have much effect on the zeta potential of the samples, which indicates that concentrate of 1.5% soy protein isolate has a good ability to cover surface of limonene particles. Similarly, 1.2% of OSA starch was determined for the secondary layer.SEM images of the microcapsules showed that in the two-layer wall microcapsules have cavities, cracks and shrinkage. In the starting of drying, the rate of moisture lost is high and on the other hand, the wall is not strong enough to withstand the stresses caused by the exit of moisture from the walls, so the microcapsule has cavities. In six-layer microcapsules, a smooth, non-cracked surface was observed, which can be attributed to the wall strength due to the increase in the number of layers. Fourier transform infrared spectroscopic (FTIR) test showed that the outer surface of the microcapsules was covered by OSA starch in two and six layer microcapsules.The release profile of encapsulated limonene showed that the release rate in two layer samples was faster than six layer samples. Also, with increasing shear rate, the amount of release increased. The results of experimental models fitting showed that the first-order model had the best description for releasing limonene from two- and six-layer samples in different conditions. Calculation of diffusion coefficient showed that six-layer microcapsules have a lower diffusion coefficient than two-layer microcapsules, which leads to a decrease in the release rate of limonene.Conclusion The results of this study showed that the layer-by-layer method could be used to produce limonene microcapsules. Soy protein isolate and modified starch can cover limonene droplets well. SEM images showed that the structure of six-layer microcapsules is free of cracks and cavities and has a more uniform surface than two-layer microcapsules. To investigate the mechanism of limonene release from two- and six-layer microcapsules, different kinetic models were used to fit the experimental release data. The results showed that the release of these microcapsules occurred based on the diffusion mechanism and Fick's law, which is the main mechanism of mass transfer in the release process. Also, the results showed that the six-layer microcapsules had a lower diffusion coefficient than the two-layer microcapsules and the release rate was lower in the two-layer microcapsule; This is due to the repetitive coating of soy protein isolate and modified starch around the microcapsules and the increase in wall thickness.