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14 results on '"Mouttham, Lara"'

3. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels

Author

Gomes, Filipe Espinheira, primary, Casanova, Maria Isabel, additional, Mouttham, Lara, additional, Bannasch, Danika L., additional, Park, Sangwan, additional, Kim, Soohyun, additional, Young, Laura J., additional, Daley, Nicole L., additional, Thomasy, Sara M., additional, Castelhano, Marta G., additional, Ledbetter, Eric C., additional, Holmberg, Bradford, additional, Boyd, Ryan, additional, Van Der Woerdt, Alexandra, additional, McDonald, Jessica, additional, and Hayward, Jessica J., additional

Published
2022
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4. Influence of Vitrification Device, Warming Protocol, and Subsequent In Vitro Culture on Structural Integrity of Testicular Fragments from Adult Domestic Cats

Author

Macente, Beatrice Ingrid, primary, Fonseca-Alves, Carlos Eduardo, additional, Magalhães, Georgia Modé, additional, Tavares, Mariana Riboli, additional, Mansano, Cleber Fernando Menegasso, additional, Mouttham, Lara, additional, Apparício, Maricy, additional, Toniollo, Gilson Hélio, additional, and Comizzoli, Pierre, additional

Published
2022
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6. Complex Feline Disease Mapping Using a Dense Genotyping Array

Author

Hernandez, Isabel, primary, Hayward, Jessica J., additional, Brockman, Jeff A., additional, White, Michelle E., additional, Mouttham, Lara, additional, Wilcox, Elizabeth A., additional, Garrison, Susan, additional, Castelhano, Marta G., additional, Loftus, John P., additional, Gomes, Filipe Espinheira, additional, Balkman, Cheryl, additional, Brooks, Marjory B., additional, Fiani, Nadine, additional, Forman, Marnin, additional, Kern, Tom, additional, Kornreich, Bruce, additional, Ledbetter, Eric C., additional, Peralta, Santiago, additional, Struble, Angela M., additional, Caligiuri, Lisa, additional, Corey, Elizabeth, additional, Lin, Lin, additional, Jordan, Julie, additional, Sack, Danny, additional, Boyko, Adam R., additional, Lyons, Leslie A., additional, and Todhunter, Rory J., additional

Published
2022
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7. The TNNT2:c.95‐108G>A variant is common in Maine Coons and shows no association with hypertrophic cardiomyopathy

Author

Schipper, Tom, primary, Ohlsson, Åsa, additional, Longeri, Maria, additional, Hayward, Jessica J., additional, Mouttham, Lara, additional, Ferrari, Paolo, additional, Smets, Pascale, additional, Ljungvall, Ingrid, additional, Häggström, Jens, additional, Stern, Joshua A., additional, Lyons, Leslie A., additional, Peelman, Luc J., additional, and Broeckx, Bart J. G., additional

Published
2022
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8. sj-docx-2-bmi-10.1177_11772719221137217 – Supplemental material for Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank

Author

Mouttham, Lara and Castelhano, Marta G

Subjects
Biochemistry
Abstract

Supplemental material, sj-docx-2-bmi-10.1177_11772719221137217 for Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank by Lara Mouttham and Marta G Castelhano in Biomarker Insights

Published
2022
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9. sj-docx-1-bmi-10.1177_11772719221137217 – Supplemental material for Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank

Author

Mouttham, Lara and Castelhano, Marta G

Subjects
Biochemistry
Abstract

Supplemental material, sj-docx-1-bmi-10.1177_11772719221137217 for Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank by Lara Mouttham and Marta G Castelhano in Biomarker Insights

Published
2022
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10. Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank

Author

Mouttham, Lara, primary, Castelhano, Marta G, additional, Akey, Joshua M, additional, Benton, Brooke, additional, Borenstein, Elhanan, additional, Coleman, Amanda E, additional, Creevy, Kate E, additional, Crowder, Kyle, additional, Dunbar, Matthew D, additional, Ernst, Holley R, additional, Fajt, Virginia R, additional, Fitzpatrick, Annette L, additional, Garrison, Susan J, additional, Herndon, Reba S, additional, Jaramilla, Debra, additional, Jeffery, Unity, additional, Jonlin, Erica C, additional, Kaeberlein, Matt, additional, Karlsson, Elinor K, additional, Kerr, Kathleen F, additional, Levine, Jonathan M, additional, Ma, Jing, additional, McClelland, Robyn L, additional, Prescott, Jena O, additional, Promislow, Daniel EL, additional, Ruple, Audrey, additional, Schwartz, Stephen M, additional, Shrager, Sandi, additional, Snyder-Mackler, Noah, additional, Tinkle, Amanda K, additional, Tolbert, M Katherine, additional, Urfer, Silvan R, additional, and Wilfond, Benjamin S, additional

Published
2022
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11. Complex feline disease mapping using a dense genotyping array

Author

Hernandez, Isabel, primary, Hayward, Jessica J., additional, Brockman, Jeff A., additional, White, Michelle E., additional, Mouttham, Lara, additional, Wilcox, Elizabeth A., additional, Garrison, Susan, additional, Castelhano, Marta G., additional, Loftus, John P., additional, Gomes, Filipe Espinheira, additional, Balkman, Cheryl, additional, Brooks, Marjory B., additional, Fiani, Nadine, additional, Forman, Marnin, additional, Kern, Tom, additional, Kornreich, Bruce, additional, Ledbetter, Eric, additional, Peralta, Santiago, additional, Struble, Angela M., additional, Caligiuri, Lisa, additional, Corey, Elizabeth, additional, Lin, Lin, additional, Jordan, Julie, additional, Sack, Danny, additional, Boyko, Adam R., additional, Lyons, Leslie A., additional, and Todhunter, Rory J., additional

Published
2021
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13. Influence of Vitrification Device, Warming Protocol, and Subsequent In VitroCulture on Structural Integrity of Testicular Fragments from Adult Domestic Cats

Author

Macente, Beatrice Ingrid, Fonseca-Alves, Carlos Eduardo, Magalhães, Georgia Modé, Tavares, Mariana Riboli, Mansano, Cleber Fernando Menegasso, Mouttham, Lara, Apparício, Maricy, Toniollo, Gilson Hélio, and Comizzoli, Pierre

Abstract

The objective of the study was to evaluate the integrity of cat testicular tissues after vitrification with different devices followed by different warming conditions. The influence of vitroculture for 24 hours after warming also was examined. Testicular tissues from adult domestic cats were dissected in small fragments that were vitrified using Cryotop®or threaded on fine needles, warmed (directly at 37°C or with a preliminary 10 seconds exposure to 50°C), and/or cultured in vitrofor an additional 24 hours. For each treatment group, tissues were assessed based on histology, apoptosis, and sperm DNA integrity. Results showed that fragments of testicular tissues were efficiently cryopreserved (maintaining the quality of all cell types) with vitrification with Cryotop followed by direct warming at 37°C, and additional culture of 24 hours at 38.5°C. These encouraging results are paving the road to optimize preservation protocols and use them for systematic banking of tissues from genetically valuable felids.

Published
2022
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14. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels.

Author

Espinheira Gomes, Filipe, Isabel Casanova, Maria, Mouttham, Lara, Bannasch, Danika L., Sangwan Park, Soohyun Kim, Young, Laura J., Daley, Nicole L., Thomasy, Sara M., Castelhano, Marta G., Ledbetter, Eric C., Holmberg, Bradford, Boyd, Ryan, Van Der Woerdt, Alexandra, McDonald, Jessica, and Hayward, Jessica J.

Subjects
*GENOME-wide association studies, *LOCUS (Genetics), *SINGLE nucleotide polymorphisms, *GLAUCOMA, *OPEN-angle glaucoma
Abstract

OBJECTIVE To identify genetic associations with primary glaucoma (PG) in American Cocker Spaniels using a genome-wide association study (GWAS). ANIMALS A nationwide ambidirectional case–control cohort study was performed in American Cocker Spaniels that had an ophthalmic examination performed by a veterinarian. Ninety-four dogs with PG (cases) and 111 dogs without glaucoma (controls) met phenotypic criteria and had a blood sample collected after receiving informed owner consent. PROCEDURES Genomic DNA was extracted from whole blood samples and genotyped (CanineHD BeadChip, Illumina Inc). A case–control GWAS using a linear mixed model was performed, and 3 significance thresholds were calculated (1) using a Bonferroni correction on all single nucleotide polymorphisms (SNPs) included in the GWAS, (2) using a Bonferroni correction on only the unlinked SNPs from a pruned data set, and (3) using 10,000 random phenotype permutations. RESULTS Following genotype data quality control, 89 cases and 93 controls were included in the GWAS. We identified an association on canine chromosome (CFA10); however, it did not reach statistical significance. Potential candidate genes within the surrounding linkage disequilibrium interval include coiled-coil domain containing 85A (CCDC85A) and extracellular growth factor containing fibulin extracellular matrix protein 1 (EFEMP1). CLINICAL RELEVANCE Primary glaucoma in the American Cocker Spaniel is a complex heterogeneous disease that may be influenced by a locus on CFA10. The candidate genes CCDC85A and EFEMP1 within the identified linkage disequilibrium interval have been shown to be involved in human open-angle glaucoma. [ABSTRACT FROM AUTHOR]

Published
2022
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