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1. Cellular and antibody response in GMZ2-vaccinated Gabonese volunteers in a controlled human malaria infection trial

Author

Nouatin, Odilon, Ibáñez, Javier, Fendel, Rolf, Ngoa, Ulysse A., Lorenz, Freia-Raphaella, Dejon-Agobé, Jean-Claude, Edoa, Jean Ronald, Flügge, Judith, Brückner, Sina, Esen, Meral, Theisen, Michael, Hoffman, Stephen L., Moutairou, Kabirou, Luty, Adrian J. F., Lell, Bertrand, Kremsner, Peter G., Adegnika, Ayola A., and Mordmüller, Benjamin

Published
2022
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4. Clinical development of a VAR2CSA-based placental malaria vaccine PAMVAC: Quantifying vaccine antigen-specific memory B & T cell activity in Beninese primigravidae

Author

Gbédandé, Komi, Fievet, Nadine, Viwami, Firmine, Ezinmegnon, Sem, Issifou, Saadou, Chippaux, Jean-Philippe, Dossou, Yannelle, Moutairou, Kabirou, Massougbodji, Achille, Ndam, Nicaise, de Jongh, Willem Adriaan, Søgaard, T. Max M., Salanti, Ali, Nielsen, Morten A., Esen, Meral, Mordmüller, Benjamin, Deloron, Philippe, and Luty, Adrian J.F.

Published
2017
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6. High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

Author

d’Almeida, Tania C., Sadissou, Ibrahim, Sagbohan, Mermoz, Milet, Jacqueline, Avokpaho, Euripide, Gineau, Laure, Sabbagh, Audrey, Moutairou, Kabirou, Donadi, Eduardo A., Favier, Benoit, Pennetier, Cédric, Baldet, Thierry, Moiroux, Nicolas, Carosella, Edgardo, Moreau, Philippe, Rouas-Freiss, Nathalie, Cottrell, Gilles, Courtin, David, and Garcia, André

Published
2019
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7. Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

Author

Adamou, Rafiou, Dechavanne, Célia, Sadissou, Ibrahim, d’Almeida, Tania, Bouraima, Aziz, Sonon, Paulin, Amoussa, Roukiyath, Cottrell, Gilles, Le Port, Agnès, Theisen, Michael, Remarque, Edmond J., Longacre, Shirley, Moutairou, Kabirou, Massougbodji, Achille, Luty, Adrian J. F., Nuel, Gregory, Migot-Nabias, Florence, Sanni, Ambaliou, Garcia, André, Milet, Jacqueline, and Courtin, David

Published
2019
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9. Placental Malaria is Associated with Higher LILRB2 Expression in Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During Infancy

Author

Dechavanne, Celia, primary, Nouatin, Odilon, additional, Adamou, Rafiou, additional, Edslev, Sofie, additional, Hansen, Anita, additional, Meurisse, Florian, additional, Sadissou, Ibrahim, additional, Gbaguidi, Erasme, additional, Milet, Jacqueline, additional, Cottrell, Gilles, additional, Gineau, Laure, additional, Sabbagh, Audrey, additional, Massougbodji, Achille, additional, Moutairou, Kabirou, additional, Donadi, Eduardo A., additional, Carosella, Edgardo D., additional, Moreau, Philippe, additional, Remarque, Ed, additional, Theisen, Michael, additional, Rouas-Freiss, Nathalie, additional, Garcia, André, additional, Favier, Benoit, additional, and Courtin, David, additional

Published
2022
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10. Placental malaria is associated with higher LILRB2 expression in monocyte subsets and lower anti-malarial IgG antibodies during infancy

Author

Dechavanne, Celia, Nouatin, Odilon, Adamou, Rafiou, Edslev, Sofie, Hansen, Anita, Meurisse, Florian, Sadissou, Ibrahim, Gbaguidi, Erasme, Milet, Jacqueline, Cottrell, Gilles, Gineau, Laure, Sabbagh, Audrey, Massougbodji, Achille, Moutairou, Kabirou, Donadi, Eduardo A, Carosella, Edgardo D, Moreau, Philippe, Remarque, Ed, Theisen, Michael, Rouas-Freiss, Nathalie, Garcia, André, Favier, Benoit, Courtin, David, Dechavanne, Celia, Nouatin, Odilon, Adamou, Rafiou, Edslev, Sofie, Hansen, Anita, Meurisse, Florian, Sadissou, Ibrahim, Gbaguidi, Erasme, Milet, Jacqueline, Cottrell, Gilles, Gineau, Laure, Sabbagh, Audrey, Massougbodji, Achille, Moutairou, Kabirou, Donadi, Eduardo A, Carosella, Edgardo D, Moreau, Philippe, Remarque, Ed, Theisen, Michael, Rouas-Freiss, Nathalie, Garcia, André, Favier, Benoit, and Courtin, David

Abstract

Background: Placental malaria (PM) is associated with a higher susceptibility of infants to Plasmodium falciparum (Pf) malaria. A hypothesis of immune tolerance has been suggested but no clear explanation has been provided so far. Our goal was to investigate the involvement of inhibitory receptors LILRB1 and LILRB2, known to drive immune evasion upon ligation with pathogen and/or host ligands, in PM-induced immune tolerance.Method: Infants of women with or without PM were enrolled in Allada, southern Benin, and followed-up for 24 months. Antibodies with specificity for five blood stage parasite antigens were quantified by ELISA, and the frequency of immune cell subsets was quantified by flow cytometry. LILRB1 or LILRB2 expression was assessed on cells collected at 18 and 24 months of age.Findings: Infants born to women with PM had a higher risk of developing symptomatic malaria than those born to women without PM (IRR=1.53, p=0.040), and such infants displayed a lower frequency of non-classical monocytes (OR=0.74, p=0.01) that overexpressed LILRB2 (OR=1.36, p=0.002). Moreover, infants born to women with PM had lower levels of cytophilic IgG and higher levels of IL-10 during active infection.Interpretation: Modulation of IgG and IL-10 levels could impair monocyte functions (opsonisation/phagocytosis) in infants born to women with PM, possibly contributing to their higher susceptibility to malaria. The long-lasting effect of PM on infants' monocytes was notable, raising questions about the capacity of ligands such as Rifins or HLA-I molecules to bind to LILRB1 and LILRB2 and to modulate immune responses, and about the reprogramming of neonatal monocytes/macrophages.

Published
2022

11. Additional file 1 of Cellular and antibody response in GMZ2-vaccinated Gabonese volunteers in a controlled human malaria infection trial

Author

Nouatin, Odilon, Ibáñez, Javier, Fendel, Rolf, Ngoa, Ulysse A., Lorenz, Freia-Raphaella, Dejon-Agobé, Jean-Claude, Edoa, Jean Ronald, Flügge, Judith, Brückner, Sina, Esen, Meral, Theisen, Michael, Hoffman, Stephen L., Moutairou, Kabirou, Luty, Adrian J. F., Lell, Bertrand, Kremsner, Peter G., Adegnika, Ayola A., and Mordmüller, Benjamin

Abstract

Additional file 1: Figure S1a. Gating strategies for cytokine producing CD4+ T cell identification. Figure S1b. Gating strategy for GMZ2-reactive memory B cell identification. Figure S2. Estimated number of CD4+ T cells producing cytokines on unstimulated, vaccine antigen GMZ2 and Staphylococcal endoterotoxin B (SEB) stimulated cells following immunization. Symbols represent individual samples in unstimulated, GMZ2 stimulated and SEB-stimulated conditions. All time points per volunteer were measured in a single experiment after several optimization tests, and individual volunteers were measured in separate experiments. Red lines represent median values with interquartile range. p value lower than 0.05 is considered significant. Figure S3. Estimated number of B cells with or without GMZ2-reactivity following immunization. Symbols represent individual samples. All time points per volunteer were measured in a single experiment after several optimization tests, and individual volunteers were measured in separate experiments. Red lines represent the median values with interquartile range. p value lower than 0.05 is considered significant. Figure S4. Association between pre/post-immunization GMZ2-specific immune cells and trial outcome. Dot plot graphs show the relation between the estimated number of pre/post-immunization GMZ2 stimulated cytokine producing CD4+ T cells (upper side), the number of and B cells subsets (bottom side) regarding clinical malaria status after CHMI. Monotone increase of parasitemia with symptoms (Malaria) is represented by black spots. Low oscillating parasitemia with no symptoms (Control) plus individuals with neither parasitemia nor symptoms (Protected) are represented by open circles. Comparison of the cell number of GMZ2 stimulated CD4+ T cells, of CD20+ B cells and the GMZ2-specific B subsets was performed using Mann-Whitney (for T cells) or unpaired t-tests (for B cells). Data are from a single experiment after several optimization tests, and individual volunteers were measured in separate experiments. Symbols represent individual samples. Figure S5. Post-immunization cell frequencies and the time to treatment after CHMI. Graphs show the time to first malaria treatment regarding the fraction of specific triple and double positive CD4+ T cells, total B cells and the CD27+/- cluster subsets of GMZ2-specific within CD20+IgG+ B cells (a), or the number of GMZ2-stimulated triple and double positive CD4+ T cells, and the number of total B cells and different GMZ2+B cells (b) at D84. Values above the median are represented in red whereas data below the median are shown in blue. The Log-rank test was used to compare the two curves. p value lower than 0.05 is considered significant. Figure S6. Correlation between the estimated number of B cell phenotypes and the anti-GMZ2 IgG concentration at baseline. The association between the estimated number of CD20+IgG+ B cells, the estimated number of GMZ2-specific B cells and the anti-GMZ2 IgG concentration, was performed on D0 data using Pearson’s correlation after log transformation. Data are from a single experiment after several optimization tests, and individual volunteers were measured in separate experiments. Symbols represent individual samples. A p-value less than 0.05 is considered as statistically significant. Figure S7. B cell phenotypes frequency following immunization regarding vaccine intervention. Frequencies of CD20+IgG positive, CD20+IgG+GMZ2-specific and GMZ2-specific CD27+/- B cells between D0 and D84 are compared for all volunteers regarding vaccine intervention. Vaccinated subjects with Rabies control vaccine are represented with opened squares. GMZ2 vaccinated discriminate vaccinees receiving 100µg GMZ2-Alhydrogel (opened dots), 30µg GMZ2-CAF01 (grey dots), and 100µg GMZ2-CAF01 (black dots). Wilcoxon test following by Bonferroni correction for multiple comparison is performed to test statistical significance. p value below 0.05 is considered statistically significant. Data are from a single experiment after several optimization tests, and individual volunteers were measured in separate experiments. Symbols represent individual samples. Red lines represent the median values with interquartile range. p value lower than 0.05 is considered significant. Table S1. Cox proportional analysis post-immunization

Published
2022
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14. LILRB1 and LILRB2 expression in peripheral blood immune cells at 18 and 24 months of age in infants born from mothers with placental malaria

Author

Dechavanne, Celia, primary, Nouatin, Odilon, additional, Adamou, Rafiou, additional, Edslev, Sofie, additional, Hansen, Anita, additional, Meurisse, Florian, additional, Sadissou, Ibrahim, additional, Gbaguidi, Erasme, additional, Milet, Jacqueline, additional, Cottrell, Gilles, additional, Gineau, Laure, additional, Sabbagh, Audrey, additional, Massougbodji, Achille, additional, Moutairou, Kabirou, additional, Donadi, Eduardo Antonio, additional, Carosella, Edgardo, additional, Moreau, Philippe, additional, Remarque, Ed, additional, Theisen, Michael, additional, Rouas-Freiss, Nathalie, additional, Garcia, Andre, additional, Favier, Benoit, additional, and Courtin, David, additional

Published
2021
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15. Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children

Author

Sonon, Paulin, primary, Tokplonou, Léonidas, additional, Sadissou, Ibrahim, additional, M'po, Kuumaaté K.G., additional, Glitho, Sonya S.C., additional, Agniwo, Privat, additional, Ibikounlé, Moudachirou, additional, Souza, Andréia S., additional, Massaro, Juliana Doblas, additional, Gonzalez, Daniel, additional, Tchégninougbo, Théophile, additional, Ayitchédji, Aurèle, additional, Massougbodji, Achille, additional, Moreau, Philippe, additional, Garcia, André, additional, Milet, Jacqueline, additional, Sabbagh, Audrey, additional, Mendes-Junior, Celso T., additional, Moutairou, Kabirou A., additional, Castelli, Erick C., additional, Courtin, David, additional, and Donadi, Eduardo A., additional

Published
2021
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16. Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2

Author

Nouatin, Odilon, Mengue, Juliana Boex, Dejon-Agobé, Jean Claude, Fendel, Rolf, Ibáñez, Javier, Ngoa, Ulysse Ateba, Edoa, Jean Ronald, Adégbité, Bayodé Roméo, Honkpéhédji, Yabo Josiane, Zinsou, Jeannot Fréjus, Hounkpatin, Aurore Bouyoukou, Moutairou, Kabirou, Homoet, Andreas, Esen, Meral, Kreidenweiss, Andrea, Hoffman, Stephen L., Theisen, Michael, Luty, Adrian J.F., Lell, Bertrand, Agnandji, Selidji Todagbe, Mombo-Ngoma, Ghyslain, Ramharter, Michael, Kremsner, Peter, Mordmüller, Benjamin, Adegnika, Ayôla Akim, Nouatin, Odilon, Mengue, Juliana Boex, Dejon-Agobé, Jean Claude, Fendel, Rolf, Ibáñez, Javier, Ngoa, Ulysse Ateba, Edoa, Jean Ronald, Adégbité, Bayodé Roméo, Honkpéhédji, Yabo Josiane, Zinsou, Jeannot Fréjus, Hounkpatin, Aurore Bouyoukou, Moutairou, Kabirou, Homoet, Andreas, Esen, Meral, Kreidenweiss, Andrea, Hoffman, Stephen L., Theisen, Michael, Luty, Adrian J.F., Lell, Bertrand, Agnandji, Selidji Todagbe, Mombo-Ngoma, Ghyslain, Ramharter, Michael, Kremsner, Peter, Mordmüller, Benjamin, and Adegnika, Ayôla Akim

Abstract

BACKGROUND: Helminths can modulate the host immune response to Plasmodium falciparum and can therefore affect the risk of clinical malaria. We assessed here the effect of helminth infections on both the immunogenicity and efficacy of the GMZ2 malaria vaccine candidate, a recombinant protein consisting of conserved domains of GLURP and MSP3, two asexual blood-stage antigens of P. falciparum. Controlled human malaria infection (CHMI) was used to assess the efficacy of the vaccine. METHODOLOGY: In a randomized, double-blind Phase I clinical trial, fifty, healthy, lifelong malaria-exposed adult volunteers received three doses of GMZ2 adjuvanted with either Cationic Adjuvant Formulation (CAF) 01 or Alhydrogel, or a control vaccine (Rabies) on days (D) 0, D28 and D56, followed by direct venous inoculation (DVI) of 3,200 P. falciparum sporozoites (PfSPZ Challenge) approximately 13 weeks after last vaccination to assess vaccine efficacy. Participants were followed-up on a daily basis with clinical examinations and thick blood smears to monitor P. falciparum parasitemia for 35 days. Malaria was defined as the presence of P. falciparum parasites in the blood associated with at least one symptom that can be associated to malaria over 35 days following DVI of PfSPZ Challenge. Soil-transmitted helminth (STH) infection was assessed by microscopy and by polymerase chain reaction (PCR) on stool, and Schistosoma infection was assessed by microscopy on urine. Participants were considered as infected if positive for any helminth either by PCR and/or microscopy at D0 and/or at D84 (Helm+) and were classified as mono-infection or co-infection. Total vaccine-specific IgG concentrations assessed on D84 were analysed as immunogenicity outcome. MAIN FINDINGS: The helminth in mono-infection, particularly Schistosoma haematobium and STH were significantly associated with earlier malaria episodes following CHMI, while no association was found in case of coinfection. In further analyses, the

Published
2021

18. Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2

Author

Nouatin, Odilon, primary, Mengue, Juliana Boex, additional, Dejon-Agobé, Jean Claude, additional, Fendel, Rolf, additional, Ibáñez, Javier, additional, Ngoa, Ulysse Ateba, additional, Edoa, Jean Ronald, additional, Adégbité, Bayodé Roméo, additional, Honkpéhédji, Yabo Josiane, additional, Zinsou, Jeannot Fréjus, additional, Hounkpatin, Aurore Bouyoukou, additional, Moutairou, Kabirou, additional, Homoet, Andreas, additional, Esen, Meral, additional, Kreidenweiss, Andrea, additional, Hoffman, Stephen L., additional, Theisen, Michael, additional, Luty, Adrian J. F., additional, Lell, Bertrand, additional, Agnandji, Selidji Todagbe, additional, Mombo-Ngoma, Ghyslain, additional, Ramharter, Michael, additional, Kremsner, Peter, additional, Mordmüller, Benjamin, additional, and Adegnika, Ayôla Akim, additional

Published
2021
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19. Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin

Author

Dechavanne, Celia, Dechavanne, Sebastien, Sadissou, Ibrahim, Lokossou, Adjimon Gatien, Alvarado, Fernanda, Dambrun, Magalie, Moutairou, Kabirou, Courtin, David, Nuel, Gregory, Garcia, Andre, Migot-Nabias, Florence, and King, Christopher L.

Subjects
Infants -- Analysis, Fc receptors -- Research, Genetic polymorphisms -- Research, Malaria -- Prevention -- Research, Immunoglobulin G -- Research, Biological sciences
Abstract

Background Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps to protect against malaria and other infections in infancy. Recent studies have emphasized the important role of malaria-specific IgG3 in malaria immunity, and its transfer may reduce the risk of malaria in infancy. Human IgGs are actively transferred across the placenta by binding the neonatal Fc receptor (FcRn) expressed within the endosomes of the syncytiotrophoblastic membrane. Histidine at position 435 (H435) provides for optimal Fc-IgG binding. In contrast to other IgG subclasses, IgG3 is highly polymorphic and usually contains an arginine at position 435, which reduces its binding affinity to FcRn in vitro. The reduced binding to FcRn is associated with reduced transplacental transfer and reduced half-life of IgG3 in vivo. Some haplotypes of IgG3 have histidine at position 435. This study examines the hypotheses that the IgG3-H435 variant promotes increased transplacental transfer of malaria-specific antibodies and a prolonged IgG3 half-life in infants and that its presence correlates with protection against clinical malaria during infancy. Methods and findings In Benin, 497 mother-infant pairs were included in a longitudinal birth cohort. Both maternal and cord serum samples were assayed for levels of IgG1 and IgG3 specific for MSP1.sub.19, MSP2 (both allelic families, 3D7 and FC27), MSP3, GLURP (both regions, R0 and R2), and AMA1 antigens of Plasmodium falciparum. Cord:maternal ratios were calculated. The maternal IgG3 gene was sequenced to identify the IgG3-H435 polymorphism. A multivariate logistic regression was used to examine the association between maternal IgG3-H435 polymorphism and transplacental transfer of IgG3, adjusting for hypergammaglobulinemia, maternal malaria, and infant malaria exposure. Twenty-four percent of Beninese women living in an area highly endemic for malaria had the IgG3-H435 allele (377 women homozygous for the IgG3-R435 allele, 117 women heterozygous for the IgG3-R/H alleles, and 3 women homozygous for the IgG3-H435 allele). Women with the IgG3-H435 allele had a 78% (95% CI 17%, 170%, p = 0.007) increased transplacental transfer of GLURP-R2 IgG3 compared to those without the IgG3-H435 allele. Furthermore, in infants born to mothers with the IgG3-H435 variant, a 28% longer IgG3 half-life was noted (95% CI 4%, 59%, p = 0.02) compared to infants born to mothers homozygous for the IgG3-R435 allele. Similar findings were observed for AMA1, MSP2-3D7, MSP3, GLURP-R0, and GLURP-R2 but not for MSP1.sub.19 and MSP2-FC27. Infants born to women with IgG3-H435 had a 32% lower risk of symptomatic malaria during infancy (incidence rate ratio [IRR] = 0.68 [95% CI 0.51, 0.91], p = 0.01) compared to infants born to mothers homozygous for IgG3-R435. We did not find a lower risk of asymptomatic malaria in infants born to women with or without IgG3-H435. Limitations of the study were the inability to determine (i) the actual amount of IgG3-H435 relative to IgG-R435 in serum samples and (ii) the proportion of malaria-specific IgG produced by infants versus acquired from their mothers. Conclusions An arginine-to-histidine replacement at residue 435 in the binding domain of IgG3 to FcRn increases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and is associated with reduced risk of clinical malaria during infancy. The IgG3-H435 allele may be under positive selection, given its relatively high frequency in malaria endemic areas., Author(s): Celia Dechavanne 1,*, Sebastien Dechavanne 1, Ibrahim Sadissou 2,3,4, Adjimon Gatien Lokossou 2,3,5, Fernanda Alvarado 1, Magalie Dambrun 2,3, Kabirou Moutairou 6, David Courtin 2,3, Gregory Nuel 7, Andre [...]

Published
2017
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20. Effect of immune regulatory pathways after immunization with GMZ2 malaria vaccine candidate in healthy lifelong malaria-exposed adults

Author

Nouatin, Odilon, Ateba Ngoa, Ulysse, Ibáñez, Javier, Dejon-Agobe, Jean Claude, Mordmüller, Benjamin, Edoa, Jean Ronald, Mougeni, Fabrice, Brückner, Sina, Bouyoukou Hounkpatin, Aurore, Esen, Meral, Theisen, Michael, Moutairou, Kabirou, Hoffman, Stephen L, Issifou, Saadou, Luty, Adrian J F, Loembe, Marguerite M, Agnandji, Selidji Todagbé, Lell, Bertrand, Kremsner, Peter G, Adegnika, Ayôla Akim, Nouatin, Odilon, Ateba Ngoa, Ulysse, Ibáñez, Javier, Dejon-Agobe, Jean Claude, Mordmüller, Benjamin, Edoa, Jean Ronald, Mougeni, Fabrice, Brückner, Sina, Bouyoukou Hounkpatin, Aurore, Esen, Meral, Theisen, Michael, Moutairou, Kabirou, Hoffman, Stephen L, Issifou, Saadou, Luty, Adrian J F, Loembe, Marguerite M, Agnandji, Selidji Todagbé, Lell, Bertrand, Kremsner, Peter G, and Adegnika, Ayôla Akim

Abstract

BACKGROUND: Despite appreciable immunogenicity in malaria-naive populations, many candidate malaria vaccines are considerably less immunogenic in malaria-exposed populations. This could reflect induction of immune regulatory mechanisms involving Human Leukocyte Antigen G (HLA-G), regulatory T (Treg), and regulatory B (Breg) cells. Here, we addressed the question whether there is correlation between these immune regulatory pathways and both plasmablast frequencies and vaccine-specific IgG concentrations.METHODS: Fifty Gabonese adults with lifelong exposure to Plasmodium spp were randomized to receive three doses of either 30 µg or 100 µg GMZ2-CAF01, or 100 µg GMZ2-alum, or control vaccine (rabies vaccine) at 4-week intervals. Only plasma and peripheral blood mononuclear cells isolated from blood samples collected before (D0) and 28 days after the third vaccination (D84) of 35 participants were used to measure sHLA-G levels and anti-GMZ2 IgG concentrations, and to quantify Treg, Breg and plasmablast cells. Vaccine efficacy was assessed using controlled human malaria infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites (PfSPZ Challenge).RESULTS: The sHLA-G concentration increased from D0 to D84 in all GMZ2 vaccinated participants and in the control group, whereas Treg frequencies increased only in those receiving 30 µg or 100 µg GMZ2-CAF01. The sHLA-G level on D84 was associated with a decrease of the anti-GMZ2 IgG concentration, whereas Treg frequencies on D0 or on D84, and Breg frequency on D84 were associated with lower plasmablast frequencies. Importantly, having a D84:D0 ratio of sHLA-G above the median was associated with an increased risk of P. falciparum infection after sporozoites injection.CONCLUSION: Regulatory immune responses are induced following immunization. Stronger sHLA-G and Treg immune responses may suppress vaccine induced immune responses, and the magnitude of the sHLA-G response increased the

Published
2020

25. HLA‐Cgenetic diversity and evolutionary insights in two samples from Brazil and Benin

Author

Souza, Andreia S., primary, Sonon, Paulin, additional, Paz, Michelle A., additional, Tokplonou, Léonidas, additional, Lima, Thálitta H. A., additional, Porto, Iane O. P., additional, Andrade, Heloisa S., additional, Silva, Nayane dos S. B., additional, Veiga‐Castelli, Luciana C., additional, Oliveira, Maria Luiza G., additional, Sadissou, Ibrahim Abiodoun, additional, Massaro, Juliana Doblas, additional, Moutairou, Kabirou A., additional, Donadi, Eduardo A., additional, Massougbodji, Achille, additional, Garcia, André, additional, Ibikounlé, Moudachirou, additional, Meyer, Diogo, additional, Sabbagh, Audrey, additional, Mendes‐Junior, Celso T., additional, Courtin, David, additional, and Castelli, Erick C., additional

Published
2020
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28. Effect of immune regulatory pathways after immunization with GMZ2 malaria vaccine candidate in healthy lifelong malaria-exposed adults

Author

Nouatin, Odilon, primary, Ateba Ngoa, Ulysse, additional, Ibáñez, Javier, additional, Dejon-Agobe, Jean Claude, additional, Mordmüller, Benjamin, additional, Edoa, Jean Ronald, additional, Mougeni, Fabrice, additional, Brückner, Sina, additional, Bouyoukou Hounkpatin, Aurore, additional, Esen, Meral, additional, Theisen, Michael, additional, Moutairou, Kabirou, additional, Hoffman, Stephen L., additional, Issifou, Saadou, additional, Luty, Adrian J.F., additional, Loembe, Marguerite M., additional, Agnandji, Selidji Todagbé, additional, Lell, Bertrand, additional, Kremsner, Peter G., additional, and Adegnika, Ayôla Akim, additional

Published
2020
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29. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES

Author

Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, 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Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, 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Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, Jennifer, Kestelyn, Evelyne, Uwineza, Mireille, Agaba, Stephen, Delvaux, Therese, Wijgert, Janneke, Gethi, Dickson, Odeny, Lazarus, Tamandjou, Cynthia, Kaindjee-Tjituka, Francina, Brandt, Laura, Cotton, Mark, Nel, Etienne, Preiser, Wolfgang, Andersson, Monique, Adepoju, Abiola, Magana, Musa, Etsetowaghan, Andrew, Chilikwazi, Mutinta, Sutcliffe, Catherine, Thuma, Philip, Sinywimaanzi, Kathy, Matakala, Hellen, Munachoonga, Passwell, Moss, William, Masenza, Issa Sabi, Geisenberger, Otto, Agrea, Peter, Rwegoshora, France, Mahiga, Hellen, Olomi, Willyhelmina, Kroidl, Arne, Kayode, Gbenga, Amoakoh-Coleman, Mary, Ansah, Evelyn, Uthman, Olalekan, Fokam, Joseph, Santoro, Maria-Mercedes, Musolo, Chrissie, Chimbiri, Isabel, Chikwenga, Gloria, Deula, Ruth, Massari, Riccardo, Lungu, Agness, Perno, Carlo-Federico, Ndzengue, Georgia, Loveline, Ngu, Lissom, Abel, Flaurent, Tchouangueu, Sosso, Samuel, Essomba, Claudine, Kpeli, Grace, Otchere, Isaac, Lamelas, Araceli, Buultjens, Andrew, Bulach, Dieter, Baines, Sarah, Seemann, Torsten, Giulieri, Stefano, Nakobu, Zuliehatu, Aboagye, Samuel, Owusu-Mireku, Evelyn, Danso, Emelia, Hauser, Julia, Hinic, Vladimira, Pluschke, Gerd, Stinear, Timothy, Yeboah-Manu, Dorothy, Elshayeb, Ayman, Siddig, Marmar El, Ahmed, Abdel Azim, Hussien, Adil El, Kabwe, Mwila, Tembo, John, Chilukutu, Lophina, Chilufya, Moses, Ngulube, Francis, Lukwesa, Chileshe, Enne, Virve, Wexner, Hannah, Mwananyanda, Lawrence, Hamer, Davidson, Sinyangwe, Sylvester, Ahmed, Yusuf, Klein, Nigel, Maeurer, Markus, Zumla, Ali, Bates, Matthew, Beyala, Landry, Etienne, Guenou, Anthony, Njimbia, Benjamin, Azike, Ateudjieu, Jerome, Chibwe, Bertha, Ojok, David, Tarr, Christine Attia, Perez, Guillermo Martinez, Omeonga, Senga, Kibungu, Fanta, Meyer, Ana, Lansana, Peter, Mayor, Alfredo, Onyango, Peter, Loggerenberg, François Van, Furtado, Tamzin, Boggs, Liam, Segrt, Alexis, Dochez, Carine, Burnett, Rosemary, Mphahlele, M. Jeffrey, Miiro, George, Mbidde, Edward, Peshu, Norbert, Kivaya, Esther, Ngowi, Bernard, Kavishe, Reginald, Maowia, Mukhtar, Sandstrom, Eric, Ayuo, Elizabeth, Mmbaga, Blandina, Leisegang, Cordelia, Thorpe, Marie, Batchilly, Elizabeth, N'Guessan, Jean-Pierre, Kanteh, Dembo, Søfteland, Solrun, Sebitloane, Motshedisi, Vwalika, Bellington, Taylor, Myra, Galappaththi-Arachchige, Hashini, Holmen, Sigve, Gundersen, Svein Gunnar, Ndhlovu, Patricia, Kjetland, Eyrun Floerecke, Kombe, Francis, Toohey, Jacintha, Pienaar, Elizabeth, Kredo, Tamara, Cham, Pa Modou, Abubakar, Ismaela, Dondeh, Bai Lamin, Vischer, Nerina, Pfeiffer, Constanze, Burri, Christian, Musukwa, Kalo, Zürcher, Samuel, Mwandu, Temwani, Bauer, Sophie, Adriko, Moses, Mwaura, Peter, Omolloh, Kevin, Jones, Clarer, Malecela, Mwelecele, Hamidu, Buhari Adamu, Jenner, Tettevi Edward, Asiedu, Larbi John, Osei-Atweneboana, Mike, Afeke, Innocent, Addo, Phyllis, Newman, Mercy, Durnez, Lies, Eddyani, Miriam, Ammisah, Nana, Abas, Mona, Quartey, Maxwell, Ablordey, Anthony, Akinwale, Olaoluwa, Adeneye, Adeniyi, Ezeugwu, Sylvanus, Olukosi, Yetunde, Adewale, Babatunde, Sulyman, Medinat, Mafe, Margaret, Okwuzu, Jane, Gyang, Pam, Nwafor, Timothy, Henry, Uzoma, Musa, Bilkisu, Ujah, Innocent, Agobé, Jean Claude Dejon, Grau-Pujol, Berta, Sacoor, Charfudin, Nhabomba, Augusto, Casellas, Aina, Quintó, Llorenç, Subirà, Carme, Giné, Ricard, Valentín, Antònia, Muñoz, Jose, Nikiema, Marguerite, Ky-Ba, Absatou, Comapore, Kiswendsida Abdou Muller, Traore, Alfred, Sangare, Lassana, Oluremi, Adeolu, Michel, Mandro, Camara, Yaya, Sanneh, Bakary, Cuamba, Inocencia, Gutiérrez, Jose, Lázaro, Carlota, Mejia, Rojelio, Adedeji, Abimbola, Folorunsho, Sola, Demehin, Pelumi, Akinsanya, Bamidele, Cowley, Giovanna, Silva, Eunice Teixeira Da, Nabicassa, Meno, Barros, Pedrozinho Duarte Pereira De, Blif, Milena Mbote, Bailey, Robin, Last, Anna, Mahendradhata, Yodi, Gotuzzo, Eduardo, Nys, Kateljine De, Casteels, Minnes, Nona, Sylvie Kwedi, Lumeka, Kabwende, Todagbe, Agnandji, Djima, Mariam Mama, Ukpong, Morenike, Sagay, Atiene, Khamofu, Hadiza, Torpey, Kwasi, Afiadigwe, Evaristus, Anenih, James, Ezechi, Oliver, Nweneka, Chidi, Idoko, John, Muhumuza, Simon, Katahoire, Anne, Nuwaha, Fred, Olsen, Annette, Okeyo, Seth, Omollo, Raymond, Kimutai, Robert, Ochieng, Michael, Egondi, Thaddaeus, Moonga, Clement, Chileshe, Chisele, Magwende, George, Anumudu, Chiaka, Onile, Olugbenga, Oladele, Victoria, Adebayo, Adewale, Awobode, Henrietta, Oyeyemi, Oyetunde, Odaibo, Alexander, Kabuye, Emily, Lutalo, Tom, Njua-Yafi, Clarisse, Nkuo-Akenji, Theresa, Anchang-Kimbi, Judith, Mugri, Regina, Chi, Hanesh, Tata, Rolland, Njumkeng, Charles, Dodoo, Daniel, Achidi, Eric, Fernandes, José, Bache, Emmanuel B., Matakala, Kalumbu, Searle, Kelly, Greenman, Michelle, and Rainwater-Lovett, Kaitlin

Subjects
Abstracts of Poster Presentations, Abstracts of Oral Presentations, Author Index, Abstracts of Presentations in Plenary Sessions, Article, Abstracts of the Eighth Edctp Forum, 6–9 November 2016
Published
2017

32. High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

Author

d'Almeida, Tania C., Sadissou, Ibrahim, Sagbohan, Mermoz, Milet, Jacqueline, Avokpaho, Euripide, Gineau, Laure, Sabbagh, Audrey, Moutairou, Kabirou, Donadi, Eduardo A., Favier, Benoit, Pennetier, Cédric, Baldet, Thierry, Moiroux, Nicolas, Carosella, Edgardo, Moreau, Philippe, Rouas-Freiss, Nathalie, Cottrell, Gilles, Courtin, David, Garcia, André, d'Almeida, Tania C., Sadissou, Ibrahim, Sagbohan, Mermoz, Milet, Jacqueline, Avokpaho, Euripide, Gineau, Laure, Sabbagh, Audrey, Moutairou, Kabirou, Donadi, Eduardo A., Favier, Benoit, Pennetier, Cédric, Baldet, Thierry, Moiroux, Nicolas, Carosella, Edgardo, Moreau, Philippe, Rouas-Freiss, Nathalie, Cottrell, Gilles, Courtin, David, and Garcia, André

Abstract

Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR = 1.02, 95%CI [1.01–1.03], p = 0.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.

Published
2019

33. P047 HLA-G and HLA-E variable sites are associated with susceptibility to P. falciparum malaria in beninese toffin children

Author

Sonon, Paulin, primary, Tokplonou, Léonidas, additional, Sadissou, Ibrahim, additional, M’po, Kuumaaté K., additional, Glitho, Sonya S., additional, Ibikounlé, Moudachirou, additional, da Paz, Michelle Almeida, additional, Massaro, Juliana Doblas, additional, Gonzalez, Daniel, additional, Massougbodji, Achille, additional, Moreau, Philippe, additional, Garcia, André, additional, Milet, Jacqueline, additional, Sabbagh, Audrey, additional, Mendes-Junior, Celso T., additional, Moutairou, Kabirou A., additional, Castelli, Erick C., additional, Courtin, David, additional, and Donadi, Eduardo A., additional

Published
2019
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34. HLA-G expression during hookworm infection in pregnant women

Author

Avokpaho, Euripide, primary, d’Almeida, Tania C., additional, Sadissou, Ibrahim, additional, Tokplonou, Léonidas, additional, Adamou, Rafiou, additional, Sonon, Paulin, additional, Milet, Jacqueline, additional, Cottrell, Gilles, additional, Mondière, Amandine, additional, Massougbodji, Achille, additional, Moutairou, Kabirou, additional, Donadi, Eduardo A., additional, Teixeira Mendes Junior, Celso, additional, Favier, Benoit, additional, Carosella, Edgardo, additional, Moreau, Philippe, additional, Rouas-Freiss, Nathalie, additional, Garcia, André, additional, and Courtin, David, additional

Published
2019
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35. Pancreatic beta cells persistently infected with coxsackievirus B4 are targets of NK cell-mediated cytolytic activity

Author

Nekoua, Magloire Pandoua, primary, Bertin, Antoine, additional, Sane, Famara, additional, Alidjinou, Enagnon Kazali, additional, Lobert, Delphine, additional, Trauet, Jacques, additional, Hober, Christine, additional, Engelmann, Ilka, additional, Moutairou, Kabirou, additional, Yessoufou, Akadiri, additional, and Hober, Didier, additional

Published
2019
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36. Hla‐C genetic diversity and evolutionary insights in two samples from Brazil and Benin.

Author

Souza, Andreia S., Sonon, Paulin, Paz, Michelle A., Tokplonou, Léonidas, Lima, Thálitta H. A., Porto, Iane O. P., Andrade, Heloisa S., Silva, Nayane dos S. B., Veiga‐Castelli, Luciana C., Oliveira, Maria Luiza G., Sadissou, Ibrahim Abiodoun, Massaro, Juliana Doblas, Moutairou, Kabirou A., Donadi, Eduardo A., Massougbodji, Achille, Garcia, André, Ibikounlé, Moudachirou, Meyer, Diogo, Sabbagh, Audrey, and Mendes‐Junior, Celso T.

Subjects
CYTOTOXIC T cells, KILLER cells, HLA histocompatibility antigens, LINKAGE disequilibrium, CELL membranes
Abstract

Human leukocyte antigen‐C (HLA‐C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA‐C has a dual function because it also interacts with Killer‐cell immunoglobulin‐like receptors (KIR) receptors expressed in natural killer and T cells, modulating their activity. The structure and diversity of the HLA‐C regulatory regions, as well as the relationship among variants along the HLA‐C locus, are poorly addressed, and few population‐based studies explored the HLA‐C variability in the entire gene in different population samples. Here we present a molecular and bioinformatics method to evaluate the entire HLA‐C diversity, including regulatory sequences. Then, we applied this method to survey the HLA‐C diversity in two population samples with different demographic histories, one highly admixed from Brazil with major European contribution, and one from Benin with major African contribution. The HLA‐C promoter and 3′UTR were very polymorphic with the presence of few, but highly divergent haplotypes. These segments also present conserved sequences that are shared among different primate species. Nucleotide diversity was higher in other segments rather than exons 2 and 3, particularly around exon 5 and the second half of the 3′UTR region. We detected evidence of balancing selection on the entire HLA‐C locus and positive selection in the HLA‐C leader peptide, for both populations. HLA‐C motifs previously associated with KIR interaction and expression regulation are similar between both populations. Each allele group is associated with specific regulatory sequences, reflecting the high linkage disequilibrium along the entire HLA‐C locus in both populations. [ABSTRACT FROM AUTHOR]

Published
2020
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37. HLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample

Author

Sonon, Paulin, primary, Sadissou, Ibrahim, additional, Tokplonou, Léonidas, additional, M'po, Kuumaaté K.G., additional, Glitho, Sonya S.C., additional, Agniwo, Privat, additional, Ibikounlé, Moudachirou, additional, Massaro, Juliana Doblas, additional, Massougbodji, Achille, additional, Moreau, Philippe, additional, Sabbagh, Audrey, additional, Mendes-Junior, Celso T., additional, Moutairou, Kabirou A., additional, Castelli, Erick C., additional, Courtin, David, additional, and Donadi, Eduardo A., additional

Published
2018
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38. Experimental huts trial of the efficacy of pyrethroids/piperonyl butoxide (PBO) net treatments for controlling multi-resistant populations of Anopheles funestus s.s. in Kpomè, Southern Benin

Author

Akoton, Romaric, primary, Tchigossou, Genevieve M., additional, Djègbè, Innocent, additional, Yessoufou, Akadiri, additional, Atoyebi, Michael Seun, additional, Tossou, Eric, additional, Zeukeng, Francis, additional, Boko, Pelagie, additional, Irving, Helen, additional, Adéoti, Razack, additional, Riveron, Jacob, additional, Wondji, Charles S., additional, Moutairou, Kabirou, additional, and Djouaka, Rousseau, additional

Published
2018
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40. CLINICAL DEVELOPMENT OF A VAR2CSA-BASED PLACENTAL MALARIA VACCINE PLACMALVAC:QUANTIFYING VACCINE ANTIGEN-SPECIFIC MEMORY B & T CELL ACTIVITY IN BENINESE PRIMIGRAVIDAE

Author

Gbedande, Komi, Fievet, Nadine, Ezinmegnon, Sem, Viwami, Firmine, Issifou, Saadou, Dossou, Yannelle, Chippaux, Jean-Philippe, Moutairou, Kabirou, Massougbodji, Achille, Ndam, Nicaise Tuikue, Salanti, Ali, Mordmueller, Benjamin, Deloron, Philippe, Luty, Adrian J. F., Gbedande, Komi, Fievet, Nadine, Ezinmegnon, Sem, Viwami, Firmine, Issifou, Saadou, Dossou, Yannelle, Chippaux, Jean-Philippe, Moutairou, Kabirou, Massougbodji, Achille, Ndam, Nicaise Tuikue, Salanti, Ali, Mordmueller, Benjamin, Deloron, Philippe, and Luty, Adrian J. F.

Published
2017

41. Infections with Plasmodium falciparum during pregnancy affect VAR2CSA DBL-5 domain-specific T cell cytokine responses

Author

Gbédandé, Komi, Cottrell, Gilles, Vianou, Bertin, Ibitokou, Samad, Fernando, Aurax, Troye-Blomberg, Marita, Salanti, Ali, Moutairou, Kabirou, Massougbodji, Achille, Ndam, Nicaise Tuikue, Deloron, Philippe, Luty, Adrian J. F., and Fievet, Nadine

Subjects
Infectious Diseases, Pregnancy, Research, parasitic diseases, T cells, Cytokines, Parasitology, VAR2CSA, Malaria
Abstract

Background Current knowledge of human immunological responses to pregnancy-associated malaria-specific Plasmodium falciparum protein VAR2CSA concerns almost exclusively B cell-driven antibody-mediated activity. Knowledge of VAR2CSA-specific T cell-mediated activity is minimal by comparison, with only a single published report of a study investigating VAR2CSA-derived peptide-specific T cell responses. The study described here represents an attempt to redress this balance. Methods Within the framework of a cohort study of 1037 pregnant Beninese, sub-groups were selected on the basis of the documented presence/absence of infection with P. falciparum and conducted detailed immunological assessments both at inclusion into the study and at delivery. Peripheral blood mononuclear cells were isolated, stimulated in vitro, and VAR2CSA DBL-5 domain-specific, IFN-γ-secreting T-cell frequencies and cytokine responses were quantified using flow cytometric techniques. Multivariate analyses were used to determine primarily whether the T cell-mediated DBL5-specific activity measured was associated with infection by P. falciparum adjusted for gravidity, anaemia and other cofactors. Results Infections with P. falciparum detected at inclusion were associated with enhanced non-specific TNF responses, whilst diminished non-specific and DBL-5-specific IL-10 responses were associated with infections detected at delivery. Infections during pregnancy led to enhanced non-specific and DBL-5-specific IFN-γ responses detectable at delivery but to concomitantly lower DBL-5-specific CD8+ IFN-γ responses. Prospective assessments indicated that non-specific pro-inflammatory responses detectable at inclusion in the study were associated with the occurrence of infections subsequently during pregnancy. Conclusions The findings represent a first step in elucidating the quantity and quality of cellular immunological responses to VAR2CSA, which will help in the development of the primary vaccine candidate for prevention of pregnancy-associated malaria. Electronic supplementary material The online version of this article (doi:10.1186/s12936-016-1525-x) contains supplementary material, which is available to authorized users.

Published
2016
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42. Effectiveness effects of three medicinal plants in diabetic pregnancy

Author

Fachinan, Rufine, Nekoua, Magloire, Hichami , Aziz, Moutairou , Kabirou, Khan , Naim, Yessoufou , Akadiri, Université d'Abomey Calavi, Lipides - Nutrition - Cancer (U866) ( LNC ), and Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA )

Subjects
Treatment, Medicinal plants, Pregnancy, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Herbs
Abstract

IF 4.066; International audience

Published
2016
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44. Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight

Author

d’Almeida, Tania C., primary, Sadissou, Ibrahim, additional, Milet, Jacqueline, additional, Cottrell, Gilles, additional, Mondière, Amandine, additional, Avokpaho, Euripide, additional, Gineau, Laure, additional, Sabbagh, Audrey, additional, Massougbodji, Achille, additional, Moutairou, Kabirou, additional, Donadi, Eduardo A., additional, Favier, Benoit, additional, Carosella, Edgardo, additional, Moreau, Philippe, additional, Rouas-Freiss, Nathalie, additional, Courtin, David, additional, and Garcia, André, additional

Published
2017
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45. SOLUBLE HLA-G LEVEL EFFECT ON GMZ2 SPECIFIC IgG PRODUCTION AFTER IMMUNISATION

Author

Nouatin, Odilon, primary, Ngoa, Ulysse Ateba, additional, Dejon, Jean Claude, additional, Edoa, Jean R, additional, Homoet, Andreas, additional, Engelhon, Julie Englhon, additional, Massinga-Louembe, Marguerite, additional, Esen, Meral, additional, Theisen, Michael, additional, Sim, Kim Lee, additional, Richie, Thomas, additional, Luty, Adrian Jf, additional, Moutairou, Kabirou, additional, Hoffman, Stephen, additional, Kremsner, Peter, additional, Lell, Bertrand, additional, Mordmüller, Benjamin, additional, and Adegnika, Ayola, additional

Published
2017
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48. Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Author

Yessoufou, Akadiri, Nekoua, Magloire P., Gbankoto, Adam, Mashalla, Yohana, and Moutairou, Kabirou

Subjects
Article Subject
Abstract

Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly being used to prevent cardiovascular diseases, including diabetes and obesity. In this paper, we report data on the observed effects of omega-3 PUFA on major metabolic disorders and immune system disruption during gestational diabetes and their consequences on macrosomia. While controversies still exist about omega-3 PUFA effects on antioxidant status regarding the level of omega-3 PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious proinflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. Based on the available evidence, international nutritional and food agencies recommend administration of omega-3 PUFA as triglyceride-lowering agents, for the prevention of cardiovascular disease risk and during human pregnancy and lactation. Furthermore, studies targeting humans are still required to explore application of the fatty acids as supplement in the management of gestational diabetes and inflammatory and immune diseases.

Published
2015
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49. Acquisition of natural humoral immunity to P. falciparum in early life in Benin:impact of clinical, environmental and host factors

Author

Dechavanne, Célia, Sadissou, Ibrahim, Bouraima, Aziz, Ahouangninou, Claude, Amoussa, Roukiyath, Milet, Jacqueline, Moutairou, Kabirou, Massougbodji, Achille, Theisen, Michael, Remarque, Edmond J, Courtin, David, Nuel, Gregory, Migot-Nabias, Florence, Garcia, André, Dechavanne, Célia, Sadissou, Ibrahim, Bouraima, Aziz, Ahouangninou, Claude, Amoussa, Roukiyath, Milet, Jacqueline, Moutairou, Kabirou, Massougbodji, Achille, Theisen, Michael, Remarque, Edmond J, Courtin, David, Nuel, Gregory, Migot-Nabias, Florence, and Garcia, André

Abstract

To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

Published
2016

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