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342 results on '"Moussa, Madeleine"'

1. The use of Lutetium-177 PSMA radioligand therapy with high dose rate brachytherapy for locally recurrent prostate cancer after previous definitive radiation therapy: a randomized, single-institution, phase I/II study (ROADSTER).

Author

Mendez, Lucas C., Dhar, Aneesh, Laidley, David, Moussa, Madeleine, Gomez, Jose A., Chin, Joseph, Lee, T-Y, Thiessen, Jonathan D., Hoover, Douglas, Surrey, Kathleen, Helou, Joelle, Velker, Vikram, Correa, Rohann J., D’Souza, David, Bayani, Jane, and Bauman, Glenn

Published
2023
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3. Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model.

Author

Relouw, Sydney, Dugbartey, George J., McLeod, Patrick, Knier, Natasha N., Santiesteban, Francisco Martinez, Foster, Paula J., Cadieux-Pitre, Heather-Anne, Hague, Nicole M., Caine, Jenna, Belletti, Kaitlin, Major, Sally, O'Neil, Caroline, Gabril, Manal Y., Moussa, Madeleine, Huynh, Melissa J., Haeryfar, S.M. Mansour, and Sener, Alp

Subjects
INTRAVESICAL administration, MAGNETIC resonance imaging, CANCER diagnosis, BLADDER cancer, HYDROGEN sulfide, CELL survival
Abstract

Present bladder cancer therapies have relatively limited therapeutic impact and account for one of the highest lifetime treatment costs per patient. Therefore, there is an urgent need to explore novel and optimized treatment strategies. The present study investigated the effects of inhibiting endogenous hydrogen sulfide (H2S) production on bladder cell viability and in vivo tumor progression. We targeted the H2S-producing enzyme, cystathionine γ -lyase, in 5637 cells using propargylglycine (H2S inhibitor) and performed cytofluorimetric analysis to evaluate cell viability. We then tested the efficacy of propargylglycine alone or in combination with gemcitabine (conventional chemotherapy) in an intravesical murine model of bladder cancer. Magnetic resonance imaging and immunohistochemical staining for cell proliferation, apoptosis, immune-cell infiltration, and neovascularization were performed to evaluate tumor response. Compared to control conditions or cohorts, propargylglycine administration significantly attenuated bladder cancer cell viability in vitro (p < 0.0001) and tumor growth (p < 0.002) and invasion in vivo. Furthermore, propargylglycine enhanced the anti-cancer effects of gemcitabine, resulting in tumor regression (p < 0.0001). Moreover, propargylglycine induced cleaved PARP-1-activated apoptosis (p < 0.05), as well as intratumoral CD8+ T cell (p < 0.05) and F4/80+ macrophage (p < 0.002) infiltration. Propargylglycine also reduced intratumoral neovascularization (p < 0.0001) and cell proliferation (p < 0.0002). Importantly, the pro-apoptotic and anti-neovascularization effects of gemcitabine were enhanced by propargylglycine co-administration. Our findings suggest that inhibition of endogenous H2S production can be protective against bladder cancer by enhancing the chemotherapeutic action of gemcitabine and may be a novel pharmacological target and approach for improved bladder cancer diagnosis and treatments in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Evaluating the Effects of Kidney Preservation at 10 °C with Hemopure and Sodium Thiosulfate in a Rat Model of Syngeneic Orthotopic Kidney Transplantation.

Author

Abou Taka, Maria, Dugbartey, George J., Richard-Mohamed, Mahms, McLeod, Patrick, Jiang, Jifu, Major, Sally, Arp, Jacqueline, O'Neil, Caroline, Liu, Winnie, Gabril, Manal, Moussa, Madeleine, Luke, Patrick, and Sener, Alp

Subjects
KIDNEY transplantation, ANIMAL disease models, LABORATORY rats, BLOOD urea nitrogen, CHRONIC kidney failure
Abstract

Kidney transplantation is preferred for end-stage renal disease. The current gold standard for kidney preservation is static cold storage (SCS) at 4 °C. However, SCS contributes to renal graft damage through ischemia–reperfusion injury (IRI). We previously reported renal graft protection after SCS with a hydrogen sulfide donor, sodium thiosulfate (STS), at 4 °C. Therefore, this study aims to investigate whether SCS at 10 °C with STS and Hemopure (blood substitute), will provide similar protection. Using in vitro model of IRI, we subjected rat renal proximal tubular epithelial cells to hypoxia–reoxygenation for 24 h at 10 °C with or without STS and measured cell viability. In vivo, we preserved 36 donor kidneys of Lewis rats for 24 h in a preservation solution at 10 °C supplemented with STS, Hemopure, or both followed by transplantation. Tissue damage and recipient graft function parameters, including serum creatinine, blood urea nitrogen, urine osmolality, and glomerular filtration rate (GFR), were evaluated. STS-treated proximal tubular epithelial cells exhibited enhanced viability at 10 °C compared with untreated control cells (p < 0.05). Also, STS and Hemopure improved renal graft function compared with control grafts (p < 0.05) in the early time period after the transplant, but long-term function did not reach significance. Overall, renal graft preservation at 10 °C with STS and Hemopure supplementation has the potential to enhance graft function and reduce kidney damage, suggesting a novel approach to reducing IRI and post-transplant complications. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Data from Neoadjuvant Cabazitaxel plus Abiraterone/Leuprolide Acetate in Patients with High-Risk Prostate Cancer: ACDC-RP Phase II Trial

Author

Fleshner, Neil E., primary, Sayyid, Rashid K., primary, Hansen, Aaron R., primary, Chin, Joseph L.K., primary, Fernandes, Ricardo, primary, Winquist, Eric, primary, van der Kwast, Theodorus, primary, Sweet, Joan, primary, Lajkosz, Katherine, primary, Kenk, Miran, primary, Hersey, Karen, primary, Veloso, Rosette, primary, Berlin, Doron, primary, Herrera-Caceres, Jaime O., primary, Sridhar, Srikala, primary, Moussa, Madeleine, primary, Finelli, Antonio, primary, Hamilton, Robert J., primary, Kulkarni, Girish S., primary, Zlotta, Alexandre R., primary, and Joshua, Anthony M., primary

Published
2023
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12. Supplementary Tables 1-2 from Neoadjuvant Cabazitaxel plus Abiraterone/Leuprolide Acetate in Patients with High-Risk Prostate Cancer: ACDC-RP Phase II Trial

Author

Fleshner, Neil E., primary, Sayyid, Rashid K., primary, Hansen, Aaron R., primary, Chin, Joseph L.K., primary, Fernandes, Ricardo, primary, Winquist, Eric, primary, van der Kwast, Theodorus, primary, Sweet, Joan, primary, Lajkosz, Katherine, primary, Kenk, Miran, primary, Hersey, Karen, primary, Veloso, Rosette, primary, Berlin, Doron, primary, Herrera-Caceres, Jaime O., primary, Sridhar, Srikala, primary, Moussa, Madeleine, primary, Finelli, Antonio, primary, Hamilton, Robert J., primary, Kulkarni, Girish S., primary, Zlotta, Alexandre R., primary, and Joshua, Anthony M., primary

Published
2023
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13. Supplementary Material 1 from Neoadjuvant Cabazitaxel plus Abiraterone/Leuprolide Acetate in Patients with High-Risk Prostate Cancer: ACDC-RP Phase II Trial

Author

Fleshner, Neil E., primary, Sayyid, Rashid K., primary, Hansen, Aaron R., primary, Chin, Joseph L.K., primary, Fernandes, Ricardo, primary, Winquist, Eric, primary, van der Kwast, Theodorus, primary, Sweet, Joan, primary, Lajkosz, Katherine, primary, Kenk, Miran, primary, Hersey, Karen, primary, Veloso, Rosette, primary, Berlin, Doron, primary, Herrera-Caceres, Jaime O., primary, Sridhar, Srikala, primary, Moussa, Madeleine, primary, Finelli, Antonio, primary, Hamilton, Robert J., primary, Kulkarni, Girish S., primary, Zlotta, Alexandre R., primary, and Joshua, Anthony M., primary

Published
2023
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14. Neoadjuvant Cabazitaxel plus Abiraterone/Leuprolide Acetate in Patients with High-Risk Prostate Cancer: ACDC-RP Phase II Trial

Author

Fleshner, Neil E., primary, Sayyid, Rashid K., additional, Hansen, Aaron R., additional, Chin, Joseph L.K., additional, Fernandes, Ricardo, additional, Winquist, Eric, additional, van der Kwast, Theodorus, additional, Sweet, Joan, additional, Lajkosz, Katherine, additional, Kenk, Miran, additional, Hersey, Karen, additional, Veloso, Rosette, additional, Berlin, Doron, additional, Herrera-Caceres, Jaime O., additional, Sridhar, Srikala, additional, Moussa, Madeleine, additional, Finelli, Antonio, additional, Hamilton, Robert J., additional, Kulkarni, Girish S., additional, Zlotta, Alexandre R., additional, and Joshua, Anthony M., additional

Published
2023
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15. Prostate Cancer: Improved Tissue Characterization by Temporal Modeling of Radio-Frequency Ultrasound Echo Data

Author

Nahlawi, Layan, Imani, Farhad, Gaed, Mena, Gomez, Jose A., Moussa, Madeleine, Gibson, Eli, Fenster, Aaron, Ward, Aaron D., Abolmaesumi, Purang, Shatkay, Hagit, Mousavi, Parvin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ourselin, Sebastien, editor, Joskowicz, Leo, editor, Sabuncu, Mert R., editor, Unal, Gozde, editor, and Wells, William, editor

Published
2016
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19. Supplementary Figure Legends 1-6 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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20. Supplementary Movie 1 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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21. Supplementary Figure 2 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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22. Data from A New Three-Dimensional Ultrasound Microimaging Technology for Preclinical Studies Using a Transgenic Prostate Cancer Mouse Model

Author

Wirtzfeld, Lauren A., primary, Wu, Guojun, primary, Bygrave, Michael, primary, Yamasaki, Yasuto, primary, Sakai, Hideki, primary, Moussa, Madeleine, primary, Izawa, Jonathan I., primary, Downey, Dónal B., primary, Greenberg, Norman M., primary, Fenster, Aaron, primary, Xuan, Jim W., primary, and Lacefield, James C., primary

Published
2023
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23. Supplementary Figure 3 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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24. Supplementary Figure 4 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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25. Supplementary Figure 1 from A New Three-Dimensional Ultrasound Microimaging Technology for Preclinical Studies Using a Transgenic Prostate Cancer Mouse Model

Author

Wirtzfeld, Lauren A., primary, Wu, Guojun, primary, Bygrave, Michael, primary, Yamasaki, Yasuto, primary, Sakai, Hideki, primary, Moussa, Madeleine, primary, Izawa, Jonathan I., primary, Downey, Dónal B., primary, Greenberg, Norman M., primary, Fenster, Aaron, primary, Xuan, Jim W., primary, and Lacefield, James C., primary

Published
2023
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26. Supplementary Procedures from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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27. Supplementary Figure 3 from A New Three-Dimensional Ultrasound Microimaging Technology for Preclinical Studies Using a Transgenic Prostate Cancer Mouse Model

Author

Wirtzfeld, Lauren A., primary, Wu, Guojun, primary, Bygrave, Michael, primary, Yamasaki, Yasuto, primary, Sakai, Hideki, primary, Moussa, Madeleine, primary, Izawa, Jonathan I., primary, Downey, Dónal B., primary, Greenberg, Norman M., primary, Fenster, Aaron, primary, Xuan, Jim W., primary, and Lacefield, James C., primary

Published
2023
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28. Supplementary Figure 5 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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29. Supplementary Figure 2 from A New Three-Dimensional Ultrasound Microimaging Technology for Preclinical Studies Using a Transgenic Prostate Cancer Mouse Model

Author

Wirtzfeld, Lauren A., primary, Wu, Guojun, primary, Bygrave, Michael, primary, Yamasaki, Yasuto, primary, Sakai, Hideki, primary, Moussa, Madeleine, primary, Izawa, Jonathan I., primary, Downey, Dónal B., primary, Greenberg, Norman M., primary, Fenster, Aaron, primary, Xuan, Jim W., primary, and Lacefield, James C., primary

Published
2023
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30. Supplementary Figure 6 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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34. Ultrasound-Based Characterization of Prostate Cancer: An in vivo Clinical Feasibility Study

Author

Imani, Farhad, Abolmaesumi, Purang, Gibson, Eli, Khojaste, Amir, Gaed, Mena, Moussa, Madeleine, Gomez, Jose A., Romagnoli, Cesare, Siemens, D. Robert, Leviridge, Michael, Chang, Silvia, Fenster, Aaron, Ward, Aaron D., Mousavi, Parvin, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Mori, Kensaku, editor, Sakuma, Ichiro, editor, Sato, Yoshinobu, editor, Barillot, Christian, editor, and Navab, Nassir, editor

Published
2013
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35. Validation of Direct Registration of Whole-Mount Prostate Digital Histopathology to ex vivo MR Images

Author

Gibson, Eli, Crukley, Cathie, Gomez, José, Moussa, Madeleine, Chin, Joseph L., Bauman, Glenn, Fenster, Aaron, Ward, Aaron D., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Madabhushi, Anant, editor, Dowling, Jason, editor, Huisman, Henkjan, editor, and Barratt, Dean, editor

Published
2011
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38. Short-Duration Dynamic [18F]DCFPyL PET and CT Perfusion Imaging to Localize Dominant Intraprostatic Lesions in Prostate Cancer: Validation Against Digital Histopathology and Comparison to [18F]DCFPyL PET/MR at 120 Minutes

Author

Yang, Dae-Myoung, primary, Alfano, Ryan, additional, Bauman, Glenn, additional, Thiessen, Jonathan D, additional, Chin, Joseph, additional, Pautler, Stephen, additional, Moussa, Madeleine, additional, Gomez, Jose A, additional, Rachinsky, Irina, additional, Gaed, Mena, additional, Chung, Kevin J, additional, Ward, Aaron, additional, and Lee, Ting-Yim, additional

Published
2021
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40. Ultrasound-Based Characterization of Prostate Cancer: An in vivo Clinical Feasibility Study

Author

Imani, Farhad, primary, Abolmaesumi, Purang, additional, Gibson, Eli, additional, Khojaste, Amir, additional, Gaed, Mena, additional, Moussa, Madeleine, additional, Gomez, Jose A., additional, Romagnoli, Cesare, additional, Siemens, D. Robert, additional, Leviridge, Michael, additional, Chang, Silvia, additional, Fenster, Aaron, additional, Ward, Aaron D., additional, and Mousavi, Parvin, additional

Published
2013
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43. Histologic validation of auto-contoured dominant intraprostatic lesions on [18F] DCFPyL PSMA-PET imaging

Author

Alfano, Ryan, primary, Bauman, Glenn S., additional, Liu, Wei, additional, Thiessen, Jonathan D., additional, Rachinsky, Irina, additional, Pavlosky, William, additional, Butler, John, additional, Gaed, Mena, additional, Moussa, Madeleine, additional, Gomez, Jose A., additional, Chin, Joseph L., additional, Pautler, Stephen, additional, and Ward, Aaron D., additional

Published
2020
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48. 79: Multi-Parametric Magnetic Resonance Imaging of Multi-Focal Prostate Cancer Unmasks Intra-Prostatic Genomic Heterogeneity and Novel Radio-Genomic Correlates: Results of the Smarter Prostate Interventions and Therapeutics (Spirit) Study

Author

Correa, Rohann J.M., primary, Aref-Eshghi, Erfan, additional, Alfano, Ryan, additional, Sadikovic, Bekim, additional, Ward, Aaron D., additional, Boutros, Paul C., additional, Bartlett, John M.S., additional, Kassam, Zahra, additional, Chin, Joseph L., additional, Pautler, Stephen E., additional, Gaed, Mena, additional, Gómez, José A., additional, Moussa, Madeleine, additional, and Bauman, Glenn S., additional

Published
2020
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