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Background: Plants are a source of potential anti-infective agents. is a shrub in the family Thymelaeaceae, which has therapeutic effects. The aim of the present study was to evaluate the antimicrobial activity of aqueous, hydroalcoholic and alcoholic extracts of the leaves and stem of on the growth of oral bacteria. Materials and methods: Leaves and stem of were collected from the Zagros Mountains, Lorestan, Iran. They were air dried in the shade. Aqueous, hydroalcoholic and alcoholic extracts of were made by using classic techniques for solvent extraction of plant material. The antimicrobial effects of the extracts were evaluated using the agar disk diffusion method (ADDM) and the minimum inhibitory concentration (MIC). The data were analyzed using Duncan's test and ANOVA. Results: The results showed that the antimicrobial activity depended on the type of extract. The alcoholic extract of had the highest antibacterial activity and the highest effect on . The aqueous extract of the plant had no effect on bacterial growth. Conclusion: On the basis of the current results, the alcoholic extract of might be promising as a natural antimicrobial agent and as a medicine for the prevention and control of the growth of .

Dengue fever, caused by dengue virus, poses a significant global health challenge, particularly in tropical regions where Aedes aegypti serves as the primary vector. The circadian clock in Aedes aegypti governs key behavioral and physiological processes, including activity patterns, feeding behaviors, and susceptibility to dengue virus infection. This article explores the influence of circadian rhythms on the mosquito's ability to transmit dengue virus, emphasizing how the circadian regulation of gene expression, immune responses, and lipid metabolism in the mosquito vector creates temporal windows that affect viral replication efficiency. [ABSTRACT FROM AUTHOR]

Computerized clinical decision-support systems are members of larger sociotechnical systems, composed of human and automated actors, who send, receive, and manipulate artifacts. Sociotechnical consideration is rare in the literature. This makes it difficult to comparatively evaluate the success of CDS implementations, and it may also indicate that sociotechnical context receives inadequate consideration in practice. To facilitate sociotechnical consideration, we developed the Thinking Together model, a flexible diagrammatical means of representing CDS systems as sociotechnical systems. To develop this model, we examined the literature with the lens of Distributed Cognition (DCog) theory. We then present two case studies of vastly different CDSSs, one almost fully automated and the other with minimal automation, to illustrate the flexibility of the Thinking Together model. We show that this model, informed by DCog and the CDS literature, are capable of supporting both research, by enabling comparative evaluation, and practice, by facilitating explicit sociotechnical planning and communication.

Computerized clinical decision-support systems are members of larger sociotechnical systems, composed of human and automated actors, who send, receive, and manipulate artifacts. Sociotechnical consideration is rare in the literature. This makes it difficult to comparatively evaluate the success of CDS implementations, and it may also indicate that sociotechnical context receives inadequate consideration in practice. To facilitate sociotechnical consideration, we developed the Thinking Together model, a flexible diagrammatical means of representing CDS systems as sociotechnical systems. To develop this model, we examined the literature with the lens of Distributed Cognition (DCog) theory. We then present two case studies of vastly different CDSSs, one almost fully automated and the other with minimal automation, to illustrate the flexibility of the Thinking Together model. We show that this model, informed by DCog and the CDS literature, are capable of supporting both research, by enabling comparative evaluation, and practice, by facilitating explicit sociotechnical planning and communication.

The present study aimed to determine the best performance of polymeric materials (RPP and CBR Plus) in various types of fine-grained soil, and the optimal percentage of polymeric materials and curing time such that the best performance in soil stabilisation can be achieved. To this end, the Taguchi and Taguchi-GRA methods were adopted to optimise swelling potential and uniaxial compressive strength (UCS) for each additive. The comparison of optimal states of two materials showed that the CBR Plus has a superior performance compared to RPP in increasing the UCS and reducing the swelling of soil. The best performance in increasing the UCS was obtained for CH specimen with 0.9% treatment with CBR Plus and curing time of 14 days. The best performance of CBR Plus in reducing soil swelling occurs when it is used on the ML soil modified with 0.07% CBR plus at the curing time of 8 days. [ABSTRACT FROM AUTHOR]

Lung cancer is one of the most acute types of cancer that cannot be easily treated with current treatments. In this study, Co3O4 nanoparticles were synthesized and functionalized by glucose and conjugated with Lapatinib. Physicochemical properties of the Co3O4@Glu- Lapatinib nanoparticles were characterized by FT-IR, XRD, EDS-mapping, SEM, TEM, DLS, and zeta potential analysis. The viability of the lung cancer and lung fibroblast cells treated with different concentrations of Co3O4@Glu-Lapatinib, Lapatinib and Co3O4 were investigated by MTT assay. The effect of the nanoparticles on cell cycle and cell apoptosis was determined by flow cytometry and Hoechst staining assays. The relative expression of the CASP8, mTOR1, and MAPK1 genes was also quantified using a real-time PCR assay. The synthesized nanoparticles were spherical, with a size of 29–64 nm, zeta potential of 36.8 mV, DLS size of 323 nm, and without elemental impurities. Co3O4@Glu-Lapatinib nanoparticles showed concentration-dependent toxicity on the studied cell lines and were significantly more toxic for the breast cancer cells than breast fibroblast cells with IC50 values of 89 and 178 µg/ml, respectively. Treating cancer cells with Co3O4@Glu-Lapatinib nanoparticles increased cell cycle arrest at the sub-G1 and G0/G1 phases and increased the percentage of apoptotic cells from 0.83 to 88.75%. Furthermore, treating cancer cells with the nanoparticles led to overexpression of the CASP8 and MAPK1 genes by 4.48 and 3.4 folds, respectively, while down-regulated the mTOR1 gene by 0.62 folds. Co3O4@Glu-Lapatinib nanoparticles can exert antiproliferative effects on lung cancer cells through the inhibition of growth signaling factors and activation of apoptogenic mechanisms. [ABSTRACT FROM AUTHOR]

In this article, we want to think about the concept of desire in the philosophy of Deleuze and Guattari, and through it, to understand Deleuze's ontology of the concept of "event". In formulating the concept of "desire", they are looking for an answer to the problem of the chaotic world of contemporary man. A world where for its resilience contemporary man seeks refuge in all kinds of ways of escape. Deleuze and Guattari create a new conceptual system centered on the concept of "desire" in order to answer the why of this situation and draw ways to avoid it. In this text, we tried to analyze the concept of desire from their point of view in connection with the concept of "Apparatus" by Foucault-Agamben and Finally, we should approach a new understanding of the concept of the event as its escape from the relativistic postmodern challenge. An understanding that Deleuze included in the concept of "life power" in his last writing and in this context, he offers us a strange and yet familiar view of "life". [ABSTRACT FROM AUTHOR]

Background: We hypothesize that the poor survival outcomes of end-stage kidney disease (ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and selectivity. The current gold standard criteria using single or several markers show an inability to predict or disclose the treatment effect and disease progression accurately. Methods: We performed an integrated mass spectrometry-based metabolomic and proteomic workflow capable of detecting and quantifying circulating small molecules and proteins in the serum of ESKD patients. Markers linked to cardiovascular disease (CVD) were validated on human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Results: We identified dozens of elevated molecules in the serum of patients compared with healthy controls. Surprisingly, many metabolites, including lipids, remained at an elevated blood concentration despite dialysis. These molecules and their associated physical interaction networks are correlated with clinical complications in chronic kidney disease. This study confirmed two uremic toxins associated with CVD, a major risk for patients with ESKD. Conclusion: The retained molecules and metabolite--protein interaction network address a knowledge gap of candidate uremic toxins associated with clinical complications in patients undergoing dialysis, providing mechanistic insights and potential drug discovery strategies for ESKD. [ABSTRACT FROM AUTHOR]

Recycling post‐consumer carpet waste is a critical consideration for decreasing the environmental hazard of non‐biodegradable plastics. Therefore, the manufacturing of activated carbon fibres (ACFs) from post‐consumer carpet waste treated with KOH was modelled and optimized by the response surface methodology (RSM). The simultaneous effects of carbonization rate, pyrolysis temperature, and activation time on the performance of carpet waste‐based ACFs were studied. Box–Behnken design (BBD) was applied to study the influence of three significant processing parameters on the carbon yield and iodine adsorption of synthesized ACFs. The RSM analysis established that pyrolysis temperature was the most important parameter affecting the ACFs' performance. The optimum settings that led to the production of high carbon yield and iodine adsorption of ACFs were a carbonization rate of 5.4°C/min, pyrolysis temperature of 705.7°C, and activation time of 83 min. The carbon yield and iodine adsorption under the above conditions were obtained at 49.8 ± 0.9 wt.% and 1351 ± 45 mg/g, respectively. BBD has been established to be a powerful approach in modelling and optimization to achieve high‐quality of iodine adsorbents from carpet wastes. [ABSTRACT FROM AUTHOR]

Background: We hypothesize that the poor survival outcomes of end-stage kidney disease (ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and selectivity. The current gold standard criteria using single or several markers show an inability to predict or disclose the treatment effect and disease progression accurately. Methods: We performed an integrated mass spectrometry-based metabolomic and proteomic workflow capable of detecting and quantifying circulating small molecules and proteins in the serum of ESKD patients. Markers linked to cardiovascular disease (CVD) were validated on human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Results: We identified dozens of elevated molecules in the serum of patients compared with healthy controls. Surprisingly, many metabolites, including lipids, remained at an elevated blood concentration despite dialysis. These molecules and their associated physical interaction networks are correlated with clinical complications in chronic kidney disease. This study confirmed two uremic toxins associated with CVD, a major risk for patients with ESKD. Conclusion: The retained molecules and metabolite–protein interaction network address a knowledge gap of candidate uremic toxins associated with clinical complications in patients undergoing dialysis, providing mechanistic insights and potential drug discovery strategies for ESKD. [ABSTRACT FROM AUTHOR]

The findings revealed that the addition of nanoalginate and lime had distinct effects on various soil properties. Specifically, the liquid limit (LL) and plastic limit (PL) decreased when sodium nanoalginate and lime were added, while the plasticity index (PI) and shrinkage limit (SL) increased. Furthermore, the soil classification was altered when sodium alginate and lime were introduced to the control soil. Regarding the standard Proctor test, it was observed that adding sodium nanoalginate increased the maximum dry density and reduced the optimal moisture content, whereas lime had the opposite effect by decreasing the maximum dry density and increasing the optimal moisture content. The free swelling and swelling pressure tests indicated that the incorporation of sodium nanoalginate and lime reduced both free swelling and swelling pressure. The most significant reduction was observed in the sample containing 7% sodium nanoalginate and 5% lime. Additionally, the study highlighted the influence of processing time, showing that an increase in the curing time led to a decrease in free swelling and swelling pressure in samples mixed with 3% sodium nanoalginate and lime. The XRD test showed that adding sodium nanoalginate reduced primary minerals, forming SAH, while lime reduced quartz and calcite, creating CSH. Overall, the results suggest that sodium nanoalginate can be a more environmentally friendly alternative to lime for soil stabilization projects. [ABSTRACT FROM AUTHOR]

The nanocomposites NiO‐ZnO‐CdO/reduced graphene oxide (N‐Z‐C/rGO) were prepared using the reflux method. These nanocomposites were characterized using various techniques, including infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), electron dispersive spectroscopy (EDS), induced coupled plasma emission spectroscopy (ICP), and X‐ray diffraction (XRD). The application of the synthesized nanocomposites was investigated in two fields: the removal of azo dyes and the oxidation of certain organic compounds. To explore the use of this compound as an adsorbent, the removal of methylene blue (MB) and rhodamine B (RhB) dyes was studied. Under optimal conditions, the adsorbent absorbed MB with 98 % efficiency in 15 minutes and RhB with 96 % efficiency in 30 minutes. In the second part of the study, the performance of the nanocomposite in the oxidation of benzyl alcohol and styrene was examined. Optimal conditions for oxidizing benzyl alcohol used tert‐butyl hydroperoxide(TBHP) and acetonitrile, achieving 83 % efficiency and 92 % selectivity for benzoic acid in 6 hours. α‐methyl styrene oxidation used chloroform and TBHP, reaching 97 % efficiency and 90 % selectivity for acetophenone in 4 hours. [ABSTRACT FROM AUTHOR]