Search

Your search keyword '"Mourits, Marian J. E."' showing total 279 results
Start Over Author "Mourits, Marian J. E."
279 results on '"Mourits, Marian J. E."'

3. Ovarian cancer

Author

Mourits, Marian J. E., Eggink, Florine A., Jalving, Mathilde, de Bruyn, Marco, Bart, Joost, Nijman, Hans W., Steegers, Eric A.P., editor, de Groot, Christianne J.M., editor, Hilders, Carina G.J.M., editor, Hoek, Annemieke, editor, Jaddoe, Vincent W.V., editor, Schoenmakers, Sam, editor, and Zweemer, Ronald P., editor

Published
2024
Full Text
View/download PDF

6. TUBectomy with delayed oophorectomy as an alternative to risk-reducing salpingo-oophorectomy in high-risk women to assess the safety of prevention: the TUBA-WISP II study protocol

Author

Steenbeek, Miranda P, van Bommel, Majke H D, intHout, Joanna, Peterson, Christine B, Simons, Michiel, Roes, Kit C B, Kets, Marleen, Norquist, Barbara M, Swisher, Elizabeth M, Hermens, Rosella P M G, the TUBA-WISP II consortium, Lu, Karen H, de Hullu, Joanne A, Bulten, Johan, Knippenberg, Marjan L, Bogaerts, Joep M A, Slangen, Brigitte F M, Kooreman, Loes, Piek, Jurgen M J, Bosch, Steven, Caroline Vos, M, Sepehrkhouy, Shahrzaf, Piso-Jozwiak, Marta, Ewing-Graham, Patricia C, Gaarenstroom, Katja N, Bosse, Tjalling, Lonkhuijzen, Luc R C W van, Bleeker, Maaike C G, Brood-van Zanten, Monique M A, Tros, Rachel, De Castillo, Alicia Leon l, Mourits, Marian J E, Bart, Joost, Zweemer, Ronald P, Jonges, Trudy G N, Coppus, Sjors F P J, Apperloo, Mirjam J A, Klooster, Astrid, Koopmans, Corine, Brinkhuis, Mariël, Kruse, Arnold-Jan, Kate, Fiebo J C ten, Evert, Janneke S Hoogstad-van, Alcala, Luthy, Dørum, Anne, Davidson, Ben, Nilsen, Elisabeth Berge, Berland, Jannicke, Haug, Ala Jabri, Gløersen, Guro Horni, Stukan, Maciej, Rychlik, Agnieszka, Chrzan, Alicja, Nowosielski, Krzysztof, Karczewska, Weronika Szczęsny, Bojdys-Szyndlar, Monika, Fruscio, Robert, Jaconi, Marta, Marchetti, Claudia, Zannoni, Gian Franco, Housmans, Susanne, Van Rompuy, Anne-Sophie, Fastrez, Maxime, Perrone, Anna M, De Leo, Antonio, Caravia, Santiago Scasso, Kwon, Janice S, Tamussino, Karl, Hickey, Martha, Fox, Stephen, Cantu, David, De Brot, Louise, Neto, Glauco Baiocchi, de los Reyes Oliver Pérez, M, Rådestad, Angelique Flöter, Ataseven, Beyhan, and Harter, Philipp

Published
2023
Full Text
View/download PDF

7. Cancer worry among BRCA1/2 pathogenic variant carriers choosing surgery to prevent tubal/ovarian cancer: course over time and associated factors

Author

van Bommel, Majke H. D., Steenbeek, Miranda P., IntHout, Joanna, Hermens, Rosella P. M. G., Hoogerbrugge, Nicoline, Harmsen, Marline G., van Doorn, Helena C., Mourits, Marian J. E., van Beurden, Marc, Zweemer, Ronald P., Gaarenstroom, Katja N., Slangen, Brigitte F. M., Brood-van Zanten, Monique M. A., Vos, M. Caroline, Piek, Jurgen M., van Lonkhuijzen, Luc R. C. W., Apperloo, Mirjam J. A., Coppus, Sjors F. P. J., Prins, Judith B., Custers, José A. E., and de Hullu, Joanne A.

Published
2022
Full Text
View/download PDF

10. Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy: a multicentre cross-sectional study

Author

MS Gynaecologische Oncologie, Cancer, Genetica Klinische Genetica, Terra, Lara, Heemskerk-Gerritsen, Bernadette A M, Beekman, Maarten J, Engelhardt, Ellen, Mourits, Marian J E, van Doorn, Helena C, de Hullu, Joanna A, Mom, Constantijne H, Slangen, Brigitte F M, Gaarenstroom, Katja N, van Beurden, Marc, Roeters Van Lennep, Jeanine E, van Dorst, Eleonora B L, van der Kolk, Lizet E, Collée, J Margriet, Wevers, Marijke R, Ausems, Margreet G E M, van Engelen, Klaartje, van de Beek, Irma, Berger, Lieke P V, van Asperen, Christi J, Gomez Garcia, Encarna B, Maas, Angela H E M, Hooning, Maartje J, Steensma, Anneke B, van Leeuwen, Flora E, MS Gynaecologische Oncologie, Cancer, Genetica Klinische Genetica, Terra, Lara, Heemskerk-Gerritsen, Bernadette A M, Beekman, Maarten J, Engelhardt, Ellen, Mourits, Marian J E, van Doorn, Helena C, de Hullu, Joanna A, Mom, Constantijne H, Slangen, Brigitte F M, Gaarenstroom, Katja N, van Beurden, Marc, Roeters Van Lennep, Jeanine E, van Dorst, Eleonora B L, van der Kolk, Lizet E, Collée, J Margriet, Wevers, Marijke R, Ausems, Margreet G E M, van Engelen, Klaartje, van de Beek, Irma, Berger, Lieke P V, van Asperen, Christi J, Gomez Garcia, Encarna B, Maas, Angela H E M, Hooning, Maartje J, Steensma, Anneke B, and van Leeuwen, Flora E

Published
2024

11. Ovarian cancer

Author

Mourits, Marian J. E., Eggink, Florine A., Jalving, Mathilde, de Bruyn, Marco, Bart, Joost, Nijman, Hans W., Steegers, Eric A.P., editor, Fauser, Bart C.J.M., editor, Hilders, Carina G.J.M., editor, Jaddoe, Vincent W.V., editor, Massuger, Leon F.A.G., editor, van der Post, Joris A.M., editor, and Schoenmakers, Sam, editor

Published
2019
Full Text
View/download PDF

14. Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

Author

Terra, Lara, Hooning, Maartje J, Heemskerk-Gerritsen, Bernadette A M, van Beurden, Marc, Roeters van Lennep, Jeanine E, van Doorn, Helena C, de Hullu, Joanne A, Mom, Constantijne, van Dorst, Eleonora B L, Mourits, Marian J E, Slangen, Brigitte F M, Gaarenstroom, Katja N, Zillikens, M Carola, Leiner, Tim, van der Kolk, Lizet, Collee, Margriet, Wevers, Marijke, Ausems, Margreet G E M, van Engelen, Klaartje, Berger, Lieke PV, van Asperen, Christi J, Gomez-Garcia, Encarna B, van de Beek, Irma, Rookus, Matti A, Hauptmann, Michael, Bleiker, Eveline M, Schagen, Sanne B, Aaronson, Neil K, Maas, Angela H E M, and van Leeuwen, Flora E

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundBRCA1/2 mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) at 35 to 45 years of age. RRSO substantially decreases ovarian cancer risk, but at the cost of immediate menopause. Knowledge about the potential adverse effects of premenopausal RRSO, such as increased risk of cardiovascular disease, osteoporosis, cognitive dysfunction, and reduced health-related quality of life (HRQoL), is limited. ObjectiveThe aim of this study is to assess the long-term health effects of premenopausal RRSO on cardiovascular disease, bone health, cognitive functioning, urological complaints, sexual functioning, and HRQoL in women with high familial risk of breast or ovarian cancer. MethodsWe will conduct a multicenter cross-sectional study with prospective follow-up, nested in a nationwide cohort of women at high familial risk of breast or ovarian cancer. A total of 500 women who have undergone RRSO before 45 years of age, with a follow-up period of at least 10 years, will be compared with 250 women (frequency matched on current age) who have not undergone RRSO or who have undergone RRSO at over 55 years of age. Participants will complete an online questionnaire on lifestyle, medical history, cardiovascular risk factors, osteoporosis, cognitive function, urological complaints, and HRQoL. A full cardiovascular assessment and assessment of bone mineral density will be performed. Blood samples will be obtained for marker analysis. Cognitive functioning will be assessed objectively with an online neuropsychological test battery. ResultsThis study was approved by the institutional review board in July 2018. In February 2019, we included our first participant. As of November 2020, we had enrolled 364 participants in our study. ConclusionsKnowledge from this study will contribute to counseling women with a high familial risk of breast/ovarian cancer about the long-term health effects of premenopausal RRSO. The results can also be used to offer health recommendations after RRSO. Trial RegistrationClinicalTrials.gov NCT03835793; https://clinicaltrials.gov/ct2/show/NCT03835793. International Registered Report Identifier (IRRID)DERR1-10.2196/24414

Published
2021
Full Text
View/download PDF

15. The association between cancer family history and ovarian cancer risk in BRCA1/2 mutation carriers: can it be explained by the mutation position?

Author

Teixeira, Natalia, van der Hout, Annemieke, Oosterwijk, Jan C., Vos, Janet R., HEBON, Devilee, Peter, van Engelen, Klaartje, Meijers-Heijboer, Hanne, van der Luijt, Rob B., Kriege, Mieke, Mensenkamp, Arjen R., Rookus, Matti A., van Roozendaal, Kees E., Mourits, Marian J. E., and de Bock, Geertruida H.

Published
2018
Full Text
View/download PDF

16. Urinary incontinence more than 15 years after premenopausal risk‐reducing salpingo‐oophorectomy: a multicentre cross‐sectional study

Author

Terra, Lara, primary, Heemskerk‐Gerritsen, Bernadette A. M., additional, Beekman, Maarten J., additional, Engelhardt, Ellen, additional, Mourits, Marian J. E., additional, van Doorn, Helena C., additional, de Hullu, Joanna A., additional, Mom, Constantijne H., additional, Slangen, Brigitte F. M., additional, Gaarenstroom, Katja N., additional, van Beurden, Marc, additional, Roeters Van Lennep, Jeanine E., additional, van Dorst, Eleonora B. L., additional, van der Kolk, Lizet E., additional, Collée, J. Margriet, additional, Wevers, Marijke R., additional, Ausems, Margreet G .E. M., additional, van Engelen, Klaartje, additional, van de Beek, Irma, additional, Berger, Lieke P. V., additional, van Asperen, Christi J., additional, Gomez Garcia, Encarna B., additional, Maas, Angela H. E. M., additional, Hooning, Maartje J., additional, Steensma, Anneke B., additional, and van Leeuwen, Flora E., additional

Published
2023
Full Text
View/download PDF

18. High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants:Prevalence and Clinical Factors

Author

Stroot, Iris A S, Brouwer, Jan, Bart, Joost, Hollema, Harry, Stommel-Jenner, Denise J, Wagner, Marise M, van Doorn, Helena C, de Hullu, Joanne A, Gaarenstroom, Katja N, Beurden, Marc, van Lonkhuijzen, Luc R C W, Slangen, Brigitte F M, Zweemer, Ronald P, Gómez Garcia, Encarna B, Ausems, Margreet G E M, Boere, Ingrid A, van Engelen, Klaartje, van Asperen, Christi J, Schmidt, Marjanka K, Wevers, Marijke R, de Bock, Geertruida H, Mourits, Marian J E, Stroot, Iris A S, Brouwer, Jan, Bart, Joost, Hollema, Harry, Stommel-Jenner, Denise J, Wagner, Marise M, van Doorn, Helena C, de Hullu, Joanne A, Gaarenstroom, Katja N, Beurden, Marc, van Lonkhuijzen, Luc R C W, Slangen, Brigitte F M, Zweemer, Ronald P, Gómez Garcia, Encarna B, Ausems, Margreet G E M, Boere, Ingrid A, van Engelen, Klaartje, van Asperen, Christi J, Schmidt, Marjanka K, Wevers, Marijke R, de Bock, Geertruida H, and Mourits, Marian J E

Abstract

PURPOSE: To investigate the prevalence of and clinical factors associated with high-grade serous carcinoma (HGSC) at risk-reducing salpingo-oophorectomy (RRSO) in asymptomatic BRCA1/2-pathogenic variant (PV) carriers.PATIENTS AND METHODS: We included BRCA1/2-PV carriers who underwent RRSO between 1995 and 2018 from the Hereditary Breast and Ovarian cancer in the Netherlands study. All pathology reports were screened, and histopathology reviews were performed for RRSO specimens with epithelial abnormalities or where HGSC developed after normal RRSO. We then compared clinical characteristics, including parity and oral contraceptive pill (OCP) use, for women with and without HGSC at RRSO.RESULTS: Of the 2,557 included women, 1,624 had BRCA1, 930 had BRCA2, and three had both BRCA1/2-PV. The median age at RRSO was 43.0 years (range: 25.3-73.8) for BRCA1-PV and 46.8 years (27.6-77.9) for BRCA2-PV carriers. Histopathologic review confirmed 28 of 29 HGSCs and two further HGSCs from among 20 apparently normal RRSO specimens. Thus, 24 (1.5%) BRCA1-PV and 6 (0.6%) BRCA2-PV carriers had HGSC at RRSO, with the fallopian tube identified as the primary site in 73%. The prevalence of HGSC in women who underwent RRSO at the recommended age was 0.4%. Among BRCA1/2-PV carriers, older age at RRSO increased the risk of HGSC and long-term OCP use was protective.CONCLUSION: We detected HGSC in 1.5% (BRCA1-PV) and 0.6% (BRCA2-PV) of RRSO specimens from asymptomatic BRCA1/2-PV carriers. Consistent with the fallopian tube hypothesis, we found most lesions in the fallopian tube. Our results highlight the importance of timely RRSO with total removal and assessment of the fallopian tubes and show the protective effects of long-term OCP.

Published
2023

19. The most efficient and effective BRCA1/2 testing strategy in epithelial ovarian cancer: Tumor-First or Germline-First?

Author

Genetica Klinische Genetica, Cancer, Witjes, Vera M, Ligtenberg, Marjolijn J L, Vos, Janet R, Braspenning, Jozé C C, Ausems, Margreet G E M, Mourits, Marian J E, de Hullu, Joanne A, Adang, Eddy M M, Hoogerbrugge, Nicoline, Genetica Klinische Genetica, Cancer, Witjes, Vera M, Ligtenberg, Marjolijn J L, Vos, Janet R, Braspenning, Jozé C C, Ausems, Margreet G E M, Mourits, Marian J E, de Hullu, Joanne A, Adang, Eddy M M, and Hoogerbrugge, Nicoline

Published
2023

20. Sexual functioning more than 15 years after premenopausal risk-reducing salpingo-oophorectomy

Author

MS Gynaecologische Oncologie, Cancer, Genetica Klinische Genetica, Terra, Lara, Beekman, Maarten J, Engelhardt, Ellen G, Heemskerk-Gerritsen, Bernadette A M, Van Beurden, Marc, Roeters Van Lennep, Jeanine E, Van Doorn, Helena C, De Hullu, Joanne A, Van Dorst, Eleonora B L, Mom, Constantijne H, Slangen, Brigitte F M, Gaarenstroom, Katja N, van der Kolk, Lizet E, Margriet Collée, J, Wevers, Marijke R, Ausems, Margreet G E M, Van Engelen, K, Van De Beek, I, Berger, Lieke P V, Van Asperen, Christi J, Gomez Garcia, Encarna B, Maas, Angela H E M, Hooning, Maartje J, Aaronson, Neil K, Mourits, Marian J E, Van Leeuwen, Flora E, MS Gynaecologische Oncologie, Cancer, Genetica Klinische Genetica, Terra, Lara, Beekman, Maarten J, Engelhardt, Ellen G, Heemskerk-Gerritsen, Bernadette A M, Van Beurden, Marc, Roeters Van Lennep, Jeanine E, Van Doorn, Helena C, De Hullu, Joanne A, Van Dorst, Eleonora B L, Mom, Constantijne H, Slangen, Brigitte F M, Gaarenstroom, Katja N, van der Kolk, Lizet E, Margriet Collée, J, Wevers, Marijke R, Ausems, Margreet G E M, Van Engelen, K, Van De Beek, I, Berger, Lieke P V, Van Asperen, Christi J, Gomez Garcia, Encarna B, Maas, Angela H E M, Hooning, Maartje J, Aaronson, Neil K, Mourits, Marian J E, and Van Leeuwen, Flora E

Published
2023

21. Urinary incontinence more than 15 years after premenopausal risk‐reducing salpingo‐oophorectomy: a multicentre cross‐sectional study.

Author

Terra, Lara, Heemskerk‐Gerritsen, Bernadette A. M., Beekman, Maarten J., Engelhardt, Ellen, Mourits, Marian J. E., van Doorn, Helena C., de Hullu, Joanna A., Mom, Constantijne H., Slangen, Brigitte F. M., Gaarenstroom, Katja N., van Beurden, Marc, Roeters Van Lennep, Jeanine E., van Dorst, Eleonora B. L., van der Kolk, Lizet E., Collée, J. Margriet, Wevers, Marijke R., Ausems, Margreet G.E. M., van Engelen, Klaartje, van de Beek, Irma, and Berger, Lieke P. V.

Subjects
URINARY incontinence, SALPINGO-oophorectomy, CROSS-sectional method, QUALITY of life, PSYCHOLOGICAL distress
Abstract

Objective: To study the impact of premenopausal risk‐reducing salpingo‐oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later. Design: Cross‐sectional study, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study. Methods: Urinary incontinence was assessed by the urinary distress inventory‐6 (UDI‐6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ‐SF) was used to assess the impact on women's health‐related quality of life (HR‐QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders. Main outcome measures: Differences in UDI‐6 scores and IIQ‐SF scores between women with a premenopausal and a postmenopausal RRSO. Results: Women in the premenopausal RRSO group had slightly higher UDI‐6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non‐significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93–4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2–10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR‐QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46). Conclusions: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Author

O’Mahony, Denise G., Ramus, Susan J., Southey, Melissa C., Meagher, Nicola S., Hadjisavvas, Andreas, John, Esther M., Hamann, Ute, Imyanitov, Evgeny N., Andrulis, Irene L., Sharma, Priyanka, Daly, Mary B., Hake, Christopher R., Weitzel, Jeffrey N., Jakubowska, Anna, Godwin, Andrew K., Arason, Adalgeir, Bane, Anita, Simard, Jacques, Soucy, Penny, Caligo, Maria A., Mai, Phuong L., Claes, Kathleen B. M., Teixeira, Manuel R., Chung, Wendy K., Lazaro, Conxi, Hulick, Peter J., Toland, Amanda E., Pedersen, Inge Sokilde, Mourits, Marian J. E., Neuhausen, Susan L., Vega, Ana, de la Hoya, Miguel, Nevanlinna, Heli, Dhawan, Mallika, Zampiga, Valentina, Danesi, Rita, Varesco, Liliana, Gismondi, Viviana, Vellone, Valerio Gaetano, James, Paul A., Janavičius, Ramūnas, Nikitina-Zake, Liene, Nielsen, Finn Cilius, van Overeem Hansen, Thomas, Pejovic, Tanja, Borg, Ake, Rantala, Johanna, Offit, Kenneth, Montagna, Marco, Nathanson, Katherine L., Domchek, Susan M., Osorio, Ana, García, María J., Karlan, Beth Y., Lesueur, Fabienne, De Fazio, Anna, Bowtell, David, McGuffog, Lesley, Leslie, Goska, Parsons, Michael T., Dörk, Thilo, Speith, Lisa-Marie, dos Santos, Elizabeth Santana, da Costa, Alexandre André B. A., Radice, Paolo, Peterlongo, Paolo, Papi, Laura, Engel, Christoph, Hahnen, Eric, Schmutzler, Rita K., Wappenschmidt, Barbara, Easton, Douglas F., Tischkowitz, Marc, Singer, Christian F., Tan, Yen Yen, Whittemore, Alice S., Sieh, Weiva, Brenton, James D., Yannoukakos, Drakoulis, Fostira, Florentia, Konstantopoulou, Irene, Soukupova, Jana, Vocka, Michal, Chenevix-Trench, Georgia, Pharoah, Paul D. P., Antoniou, Antonis C., Goldgar, David E., Spurdle, Amanda B., and Michailidou, Kyriaki

Abstract

Background: The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) variant classification system. Methods: Data for 10,373 ovarian cancer cases, including carriers and non-carriers of BRCA1 or BRCA2 pathogenic variants, were collected from unpublished international cohorts and consortia and published studies. Likelihood ratios (LR) were calculated for the association of ovarian cancer histology and other characteristics, with BRCA1 and BRCA2 variant pathogenicity. Estimates were aligned to ACMG/AMP code strengths (supporting, moderate, strong). Results: No histological subtype provided informative ACMG/AMP evidence in favour of BRCA1 and BRCA2 variant pathogenicity. Evidence against variant pathogenicity was estimated for the mucinous and clear cell histologies (supporting) and borderline cases (moderate). Refined associations are provided according to tumour grade, invasion and age at diagnosis. Conclusions: We provide detailed estimates for predicting BRCA1 and BRCA2 variant pathogenicity based on ovarian tumour characteristics. This evidence can be combined with other variant information under the ACMG/AMP classification system, to improve classification and carrier clinical management.

Published
2023

25. Colorectal Cancer

Author

Havenga, Klaas, Breukink, Stephanie O., Mourits, Marian J. E., Mulhall, John P., editor, Incrocci, Luca, editor, Goldstein, Irwin, editor, and Rosen, Ray, editor

Published
2011
Full Text
View/download PDF

26. Long‐term effects of premenopausal risk‐reducing salpingo‐oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross‐sectional study

Author

Terra, Lara, primary, Lee Meeuw Kjoe, Philippe R., additional, Agelink Van Rentergem, Joost A., additional, Beekman, Maarten J., additional, Heemskerk‐Gerritsen, Bernadette A. M., additional, Van Beurden, Marc, additional, Roeters Van Lennep, Jeanine E., additional, Van Doorn, Helena C., additional, De Hullu, Joanna A., additional, Mourits, Marian J. E., additional, Van Dorst, Eleonora B. L., additional, Mom, Constantijne H., additional, Slangen, Brigitte F. M., additional, Gaarenstroom, Katja N., additional, van der Kolk, Lizet E., additional, Collée, J. Margriet, additional, Wevers, Marijke R., additional, Ausems, Margreet G. E. M., additional, Van Engelen, Klaartje, additional, Van De Beek, Irma, additional, Berger, Lieke P. V., additional, Van Asperen, Christi J., additional, Gomez Garcia, Encarna B., additional, Maas, Angela H. E. M., additional, Hooning, Maartje J., additional, Van Der Wall, Elsken, additional, Van Leeuwen, Flora E., additional, and Schagen, Sanne B., additional

Published
2023
Full Text
View/download PDF

28. Progression-free survival and overall survival after BRCA1/2-associated epithelial ovarian cancer: A matched cohort study

Author

Heemskerk-Gerritsen, Bernadette A. M., primary, Hollestelle, Antoinette, additional, van Asperen, Christi J., additional, van den Beek, Irma, additional, van Driel, Willemien J., additional, van Engelen, Klaartje, additional, Gómez Garcia, Encarna B., additional, de Hullu, Joanne A., additional, Koudijs, Marco J., additional, Mourits, Marian J. E., additional, Hooning, Maartje J., additional, and Boere, Ingrid A., additional

Published
2022
Full Text
View/download PDF

30. Zo komen we er niet met diversiteit in de UMC’s: Geef leidinggevenden een formele rol om diversiteit te vergroten

Author

Yakar, Derya, Schuit, Stephanie C E, Kahmann, Michiel T G, Kwee, Thomas C, Mourits, Marian J E, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Guided Treatment in Optimal Selected Cancer Patients, Targeted Gynnaecologic Oncology, and Damage and Repair in Cancer Development and Cancer Treatment - 1

Subjects
Male, Academic Medical Centers, Career Mobility, Leadership, Faculty, Medical, Universities, Humans, Female
Abstract

The last years the share of female full professors in Dutch university medical centers (UMC’s) has increased. Yet, there is still a long way to go for equal numbers compared to men and diversity is very much forgotten in this discussion. Sponsorship, which is defined in the business community as the act of supporting, encouraging and protecting a person by a professional in a leadership position, may be effective for increasing diversity in academic hospitals. However, there is little known on how sponsorship should be defined in academia. Qualitative in-depth interviews with the underrepresented groups (e.g., females, people with an immigrant background, more introvert males) may lead to sculpting or defining academic sponsorship in order to create diverse leadership in the UMC’s.

Published
2022

31. Healthcare professionals’ perspectives on implementation of universal tumor DNA testing in ovarian cancer patients: multidisciplinary focus groups

Author

Witjes, Vera M., primary, Braspenning, Jozé C. C., additional, Hoogerbrugge, Nicoline, additional, Smolders, Yvonne H. C. M., additional, Hermkens, Dorien M. A., additional, Mourits, Marian J. E., additional, Ligtenberg, Marjolijn J. L., additional, Ausems, Margreet G. E. M., additional, and de Hullu, Joanne A., additional

Published
2022
Full Text
View/download PDF

33. Cancer worry among BRCA1/2 pathogenic variant carriers choosing surgery to prevent tubal/ovarian cancer: course over time and associated factors

Author

MS Gynaecologische Oncologie, Cancer, van Bommel, Majke H. D., Steenbeek, Miranda P., IntHout, Joanna, Hermens, Rosella P. M. G., Hoogerbrugge, Nicoline, Harmsen, Marline G., van Doorn, Helena C., Mourits, Marian J. E., van Beurden, Marc, Zweemer, Ronald P., Gaarenstroom, Katja N., Slangen, Brigitte F. M., Brood-van Zanten, Monique M. A., Vos, M. Caroline, Piek, Jurgen M., van Lonkhuijzen, Luc R. C. W., Apperloo, Mirjam J. A., Coppus, Sjors F. P. J., Prins, Judith B., Custers, Jose A. E., de Hullu, Joanne A., MS Gynaecologische Oncologie, Cancer, van Bommel, Majke H. D., Steenbeek, Miranda P., IntHout, Joanna, Hermens, Rosella P. M. G., Hoogerbrugge, Nicoline, Harmsen, Marline G., van Doorn, Helena C., Mourits, Marian J. E., van Beurden, Marc, Zweemer, Ronald P., Gaarenstroom, Katja N., Slangen, Brigitte F. M., Brood-van Zanten, Monique M. A., Vos, M. Caroline, Piek, Jurgen M., van Lonkhuijzen, Luc R. C. W., Apperloo, Mirjam J. A., Coppus, Sjors F. P. J., Prins, Judith B., Custers, Jose A. E., and de Hullu, Joanne A.

Published
2022

34. Experiences of patients and health care professionals on the quality of telephone follow-up care during the COVID-19 pandemic: a large qualitative study in a multidisciplinary academic setting

Author

van Erkel, Famke M, primary, Pet, Myrthe J, additional, Bossink, Elles HM, additional, van de Graaf, Cathy F M, additional, Hodes, Marije T J, additional, van Ogtrop, Sonja N, additional, Mourits, Marian J E, additional, Welker, Gera A, additional, Halmos, Gyorgy B, additional, van Leeuwen, Barbara, additional, Racz, Emoke, additional, Reyners, Anna K L, additional, van Munster, Barbara C, additional, and van der Zaag-Loonen, Hester J, additional

Published
2022
Full Text
View/download PDF

35. Oral Contraceptive Use in BRCA1 and BRCA2 Mutation Carriers: Absolute Cancer Risks and Benefits

Author

Schrijver, Lieske H, primary, Mooij, Thea M, additional, Pijpe, Anouk, additional, Sonke, Gabe S, additional, Mourits, Marian J E, additional, Andrieu, Nadine, additional, Antoniou, Antonis C, additional, Easton, Douglas F, additional, Engel, Christoph, additional, Goldgar, David, additional, John, Esther M, additional, Kast, Karin, additional, Milne, Roger L, additional, Olsson, Håkan, additional, Phillips, Kelly-Anne, additional, Terry, Mary Beth, additional, Hopper, John L, additional, van Leeuwen, Flora E, additional, and Rookus, Matti A, additional

Published
2022
Full Text
View/download PDF

36. Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers

Author

Steenbeek, Miranda P., primary, Harmsen, Marline G., additional, Hoogerbrugge, Nicoline, additional, de Jong, Marieke Arts, additional, Maas, Angela H. E. M., additional, Prins, Judith B., additional, Bulten, Johan, additional, Teerenstra, Steven, additional, van Bommel, Majke H. D., additional, van Doorn, Helena C., additional, Mourits, Marian J. E., additional, van Beurden, Marc, additional, Zweemer, Ronald P., additional, Gaarenstroom, Katja N., additional, Slangen, Brigitte F. M., additional, Brood-van Zanten, Monique M. A., additional, Vos, M. Caroline, additional, Piek, Jurgen M. J., additional, van Lonkhuijzen, Luc R. C. W., additional, Apperloo, Mirjam J. A., additional, Coppus, Sjors F. P. J., additional, Massuger, Leon F. A. G., additional, IntHout, Joanna, additional, Hermens, Rosella P. M. G., additional, and de Hullu, Joanne A., additional

Published
2021
Full Text
View/download PDF

37. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Author

Coignard, Juliette, Lush, Michael, Beesley, Jonathan, O’Mara, Tracy A., Dennis, Joe, Tyrer, Jonathan P., Barnes, Daniel R., McGuffog, Lesley, Leslie, Goska, Bolla, Manjeet K., Adank, Muriel A., Agata, Simona, Ahearn, Thomas, Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J., Arun, Banu K., Augustinsson, Annelie, Azzollini, Jacopo, Barrowdale, Daniel, Baynes, Caroline, Becher, Heko, Bermisheva, Marina, Bernstein, Leslie, Białkowska, Katarzyna, Blomqvist, Carl, Bojesen, Stig E., Bonanni, Bernardo, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Burwinkel, Barbara, Buys, Saundra S., Caldés, Trinidad, Caligo, Maria A., Campa, Daniele, Carter, Brian D., Castelao, Jose E., Chang-Claude, Jenny, Chanock, Stephen J., Chung, Wendy K., Claes, Kathleen B. M., Clarke, Christine L., Bertrand, Ophélie, Caputo, Sandrine, Dupré, Anaïs, le Mentec, Marine, Belotti, Muriel, Birot, Anne-Marie, Buecher, Bruno, Fourme, Emmanuelle, Gauthier-Villars, Marion, Golmard, Lisa, Houdayer, Claude, Moncoutier, Virginie, de Pauw, Antoine, Saule, Claire, Sinilnikova, Olga, Mazoyer, Sylvie, Damiola, Francesca, Barjhoux, Laure, Verny-Pierre, Carole, Léone, M. lanie, Boutry-Kryza, Nadia, Calender, Alain, Giraud, Sophie, Caron, Olivier, Guillaud-Bataille, Marine, Bressac-de-Paillerets, Brigitte, Bignon, Yves- Jean, Uhrhammer, Nancy, Lasset, Christine, Bonadona, Valérie, Berthet, Pascaline, Vaur, Dominique, Castera, Laurent, Noguchi, Tetsuro, Popovici, Cornel, Sobol, Hagay, Bourdon, Violaine, Remenieras, Audrey, Noguès, Catherine, Coupier, Isabelle, Pujol, Pascal, Dumont, Aurélie, Révillion, Françoise, Adenis, Claude, Muller, Danièle, Barouk-Simonet, Emmanuelle, Bonnet, Françoise, Bubien, Virginie, Sevenet, Nicolas, Longy, Michel, Toulas, Christine, Guimbaud, Rosine, Gladieff, Laurence, Feillel, Viviane, Leroux, Dominique, Dreyfus, H. lène, Rebischung, Christine, Peysselon, Magalie, Coron, Fanny, Faivre, Laurence, Baurand, Amandine, Jacquot, Caroline, Bertolone, Geoffrey, Lizard, Sarab, Prieur, Fabienne, Lebrun, Marine, Kientz, Caroline, Ferrer, Sandra Fert, Mari, V. ronique, Vénat-Bouvet, Laurence, Delnatte, Capucine, Bézieau, Stéphane, Mortemousque, Isabelle, Coulet, Florence, Colas, Chrystelle, Soubrier, Florent, Warcoin, Mathilde, Sokolowska, Johanna, Bronner, Myriam, Collonge-Rame, Marie-Agnès, Damette, Alexandre, Gesta, Paul, Lallaoui, Hakima, Chiesa, Jean, Molina-Gomes, Denise, Ingster, Olivier, Gregory, Helen, Miedzybrodzka, Zosia, Morrison, Patrick J., Ong, Kai-ren, Donaldson, Alan, Rogers, Mark T., Kennedy, M. John, Porteous, Mary E., Brewer, Carole, Davidson, Rosemarie, Izatt, Louise, Brady, Angela, Barwell, Julian, Adlard, Julian, Foo, Claire, Lalloo, Fiona, Side, Lucy E., Eason, Jacqueline, Henderson, Alex, Walker, Lisa, Eeles, Rosalind A., Cook, Jackie, Snape, Katie, Eccles, Diana, Murray, Alex, McCann, Emma, Collée, J. Margriet, Conroy, Don M., Czene, Kamila, Daly, Mary B., Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M., Dörk, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M., Dwek, Miriam, Eccles, Diana M., Eliassen, A. Heather, Engel, Christoph, Eriksson, Mikael, Evans, D. Gareth, Fasching, Peter A., Flyger, Henrik, Fostira, Florentia, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gago-Dominguez, Manuela, Gapstur, Susan M., Garber, Judy, Garcia-Barberan, Vanesa, García-Closas, Montserrat, García-Sáenz, José A., Gaudet, Mia M., Gayther, Simon A., Gehrig, Andrea, Georgoulias, Vassilios, Giles, Graham G., Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., González-Neira, Anna, Greene, Mark H., Guénel, Pascal, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A., Hart, Steven N., He, Wei, Hogervorst, Frans B. L., Hollestelle, Antoinette, Hopper, John L., Horcasitas, Darling J., Hulick, Peter J., Hunter, David J., Imyanitov, Evgeny N., Fox, Stephen, Campbell, Ian, Spurdle, Amanda, Webb, Penny, de Fazio, Anna, Tassell, Margaret, Kirk, Judy, Lindeman, Geoff, Price, Melanie, Southey, Melissa, Milne, Roger, Deb, Sid, Bowtell, David, van der Hout, Annemieke H., van den Ouweland, Ans M. W., Mensenkamp, Arjen R., van Deurzen, Carolien H. M., Kets, Carolien M., Seynaeve, Caroline, van Asperen, Christi J., Aalfs, Cora M., Gómez Garcia, Encarna B., van Leeuwen, Flora E., de Bock, G. H., Meijers-Heijboer, Hanne E. J., Obdeijn, Inge M., Gille, J. J. P., Oosterwijk, Jan C., Wijnen, Juul T., van der Kolk, Lizet E., Hooning, Maartje J., Ausems, Margreet G. E. M., Mourits, Marian J. E., Blok, Marinus J., Rookus, Matti A., van der Luijt, Rob B., van Cronenburg, T. C. T. E. F., van der Pol, Carmen C., Russell, Nicola S., Siesling, Sabine, Overbeek, Lucy, Wijnands, R., de Lange, Judith L., Clarke, Christine, Graham, Dinny, Sachchithananthan, Mythily, Marsh, Deborah, Scott, Rodney, Baxter, Robert, Yip, Desmond, Carpenter, Jane, Davis, Alison, Pathmanathan, Nirmala, Simpson, Peter, Jager, Agnes, Jakubowska, Anna, James, Paul A., Jensen, Uffe Birk, John, Esther M., Jones, Michael E., Kaaks, Rudolf, Kapoor, Pooja Middha, Karlan, Beth Y., Keeman, Renske, Khusnutdinova, Elza, Kiiski, Johanna I., Ko, Yon-Dschun, Kosma, Veli-Matti, Kraft, Peter, Kurian, Allison W., Laitman, Yael, Lambrechts, Diether, le Marchand, Loic, Lester, Jenny, Lesueur, Fabienne, Lindstrom, Tricia, Lopez-Fernández, Adria, Loud, Jennifer T., Luccarini, Craig, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Martens, John W. M., Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Milne, Roger L., Montagna, Marco, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Nielsen, Finn C., O’Brien, Katie M., Olopade, Olufunmilayo I., Olson, Janet E., Olsson, H. kan, Osorio, Ana, Ottini, Laura, Park-Simon, Tjoung-Won, Parsons, Michael T., Pedersen, Inge Sokilde, Peshkin, Beth, Peterlongo, Paolo, Peto, Julian, Pharoah, Paul D. P., Phillips, Kelly-Anne, Polley, Eric C., Poppe, Bruce, Presneau, Nadege, Pujana, Miquel Angel, Punie, Kevin, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad U., Rennert, Gad, Rennert, Hedy S., Robson, Mark, Romero, Atocha, Rossing, Maria, Saloustros, Emmanouil, Sandler, Dale P., Santella, Regina, Scheuner, Maren T., Schmidt, Marjanka K., Schmidt, Gunnar, Scott, Christopher, Sharma, Priyanka, Soucy, Penny, Southey, Melissa C., Spinelli, John J., Steinsnyder, Zoe, Stone, Jennifer, Stoppa-Lyonnet, Dominique, Swerdlow, Anthony, Tamimi, Rulla M., Tapper, William J., Taylor, Jack A., Terry, Mary Beth, Teulé, Alex, Thull, Darcy L., Tischkowitz, Marc, Toland, Amanda E., Torres, Diana, Trainer, Alison H., Truong, Thérèse, Tung, Nadine, Vachon, Celine M., Vega, Ana, Vijai, Joseph, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R., Weitzel, Jeffrey N., Wendt, Camilla, Wolk, Alicja, Yadav, Siddhartha, Yang, Xiaohong R., Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Park, Sue K., Thomassen, Mads, Offit, Kenneth, Schmutzler, Rita K., Couch, Fergus J., Simard, Jacques, Chenevix-Trench, Georgia, Easton, Douglas F., Andrieu, Nadine, Antoniou, Antonis C., German Cancer Research Center, National Health and Medical Research Council (Australia), United States of Department of Health & Human Services, National Institute for Health Research (Reino Unido), French National Cancer Institute, Ligue Nationale Contre le Cancer (Francia), Cancer Research UK (Reino Unido), Unión Europea. Comisión Europea, Canadian Institutes of Health Research, Cancer Council New South Wales (Australia), KWF Kankerbestrijding, Instituto de Salud Carlos III, Xunta de Galicia (España), Ministerio de Sanidad, Política Social e Igualdad (España), Helmholtz Association, California Breast Cancer Research Program, Federal Ministry of Education & Research (Alemania), Government of Netherlands, Russian Foundation for Basic Research, O’Mara, Tracy A. [0000-0002-5436-3232], Dennis, Joe [0000-0003-4591-1214], Tyrer, Jonathan P. [0000-0003-3724-4757], Barnes, Daniel R. [0000-0002-3781-7570], Leslie, Goska [0000-0001-5756-6222], Ahearn, Thomas [0000-0003-0771-7752], Andrulis, Irene L. [0000-0002-4226-6435], Arndt, Volker [0000-0001-9320-8684], Azzollini, Jacopo [0000-0002-9364-9778], Barrowdale, Daniel [0000-0003-1661-3939], Becher, Heko [0000-0002-8808-6667], Bernstein, Leslie [0000-0002-7692-6518], Bojesen, Stig E. [0000-0002-4061-4133], Bonanni, Bernardo [0000-0003-3589-2128], Brauch, Hiltrud [0000-0001-7531-2736], Caldés, Trinidad [0000-0002-1038-5392], Chanock, Stephen J. [0000-0002-2324-3393], Chung, Wendy K. [0000-0003-3438-5685], Claes, Kathleen B. M. [0000-0003-0841-7372], Collée, J. Margriet [0000-0002-9272-9346], Devilee, Peter [0000-0002-8023-2009], Dörk, Thilo [0000-0002-9458-0282], Dunning, Alison M. [0000-0001-6651-7166], Dwek, Miriam [0000-0001-7184-2932], Eliassen, A. Heather [0000-0002-3961-6609], Fritschi, Lin [0000-0002-7692-3560], García-Closas, Montserrat [0000-0003-1033-2650], García-Sáenz, José A. [0000-0001-6880-0301], Gayther, Simon A. [0000-0001-7937-5443], Giles, Graham G. [0000-0003-4946-9099], Greene, Mark H. [0000-0003-1852-9239], Guénel, Pascal [0000-0002-8359-518X], Håkansson, Niclas [0000-0001-7673-5554], Hart, Steven N. [0000-0001-7714-2734], He, Wei [0000-0003-0161-3274], Hollestelle, Antoinette [0000-0003-1166-1966], Hulick, Peter J. [0000-0001-8397-4078], Jakubowska, Anna [0000-0002-5650-0501], James, Paul A. [0000-0002-4361-4657], Jensen, Uffe Birk [0000-0002-6205-6355], Jones, Michael E. [0000-0001-7479-3451], Kapoor, Pooja Middha [0000-0001-5503-8215], Keeman, Renske [0000-0002-5452-9933], Kraft, Peter [0000-0002-4472-8103], Kurian, Allison W. [0000-0002-6175-9470], Lambrechts, Diether [0000-0002-3429-302X], Lesueur, Fabienne [0000-0001-7404-4549], Martens, John W. M. [0000-0002-3428-3366], Miller, Austin [0000-0001-9739-8462], Milne, Roger L. [0000-0001-5764-7268], Nathanson, Katherine L. [0000-0002-6740-0901], Nevanlinna, Heli [0000-0002-0916-2976], Olopade, Olufunmilayo I. [0000-0002-9936-1599], Olson, Janet E. [0000-0003-4944-7789], Ottini, Laura [0000-0001-8030-0449], Parsons, Michael T. [0000-0003-3242-8477], Pedersen, Inge Sokilde [0000-0002-9902-8040], Peshkin, Beth [0000-0002-2997-4701], Peterlongo, Paolo [0000-0001-6951-6855], Peto, Julian [0000-0002-1685-8912], Pharoah, Paul D. P. [0000-0001-8494-732X], Punie, Kevin [0000-0002-1162-7963], Radice, Paolo [0000-0001-6298-4111], Rennert, Gad [0000-0002-8512-068X], Robson, Mark [0000-0002-3109-1692], Romero, Atocha [0000-0002-1634-7397], Saloustros, Emmanouil [0000-0002-0485-0120], Sandler, Dale P. [0000-0002-6776-0018], Schmidt, Marjanka K. [0000-0002-2228-429X], Scott, Christopher [0000-0003-1340-0647], Stone, Jennifer [0000-0001-5077-0124], Toland, Amanda E. [0000-0002-0271-1792], Truong, Thérèse [0000-0002-2943-6786], Vachon, Celine M. [0000-0002-1962-9322], Vega, Ana [0000-0002-7416-5137], Vijai, Joseph [0000-0002-7933-151X], Weitzel, Jeffrey N. [0000-0001-6714-092X], Wolk, Alicja [0000-0001-7387-6845], Yadav, Siddhartha [0000-0003-4630-9903], Yannoukakos, Drakoulis [0000-0001-7509-3510], Ziogas, Argyrios [0000-0003-4529-3727], Zorn, Kristin K. [0000-0003-2143-8979], Park, Sue K. [0000-0001-5002-9707], Simard, Jacques [0000-0001-6906-3390], Easton, Douglas F. [0000-0003-2444-3247], Apollo - University of Cambridge Repository, Becher, Heiko [0000-0002-8808-6667], RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Polikliniek (9), Klinische Genetica, German Cancer Research Center (DKFZ), National Health and Medical Research Council of Australia, United States Department of Health & Human Services National Institutes of Health (NIH) - USA, National Institute for Health Research (NIHR), Institut National du Cancer (INCA) France, Ligue nationale contre le cancer, Cancer Research UK, European Commision, Canadian Institutes of Health Research (CIHR), Cancer Council New South Wales, Accion Estrategica de Salud del Instituto de Salud Carlos III FIS Intrasalud, Xunta de Galicia, Fomento de la Investigacion Clinica Independiente, Ministerio de Sanidad, Servicios Sociales e Igualdad, Spain, Fondo de Investigacion Sanitario, California Breast Cancer Research Fund, Federal Ministry of Education & Research (BMBF), Netherlands Government, Russian Foundation for Basic Research (RFBR), O'Mara, Tracy A [0000-0002-5436-3232], Tyrer, Jonathan P [0000-0003-3724-4757], Barnes, Daniel R [0000-0002-3781-7570], Andrulis, Irene L [0000-0002-4226-6435], Bojesen, Stig E [0000-0002-4061-4133], Chanock, Stephen J [0000-0002-2324-3393], Chung, Wendy K [0000-0003-3438-5685], Claes, Kathleen BM [0000-0003-0841-7372], Collée, J Margriet [0000-0002-9272-9346], Dunning, Alison M [0000-0001-6651-7166], Eliassen, A Heather [0000-0002-3961-6609], García-Sáenz, José A [0000-0001-6880-0301], Gayther, Simon A [0000-0001-7937-5443], Giles, Graham G [0000-0003-4946-9099], Greene, Mark H [0000-0003-1852-9239], Hart, Steven N [0000-0001-7714-2734], Hulick, Peter J [0000-0001-8397-4078], James, Paul A [0000-0002-4361-4657], Jones, Michael E [0000-0001-7479-3451], Kurian, Allison W [0000-0002-6175-9470], Martens, John WM [0000-0002-3428-3366], Milne, Roger L [0000-0001-5764-7268], Nathanson, Katherine L [0000-0002-6740-0901], Olopade, Olufunmilayo I [0000-0002-9936-1599], Olson, Janet E [0000-0003-4944-7789], Parsons, Michael T [0000-0003-3242-8477], Pharoah, Paul DP [0000-0001-8494-732X], Sandler, Dale P [0000-0002-6776-0018], Schmidt, Marjanka K [0000-0002-2228-429X], Toland, Amanda E [0000-0002-0271-1792], Vachon, Celine M [0000-0002-1962-9322], Weitzel, Jeffrey N [0000-0001-6714-092X], Zorn, Kristin K [0000-0003-2143-8979], Park, Sue K [0000-0001-5002-9707], Easton, Douglas F [0000-0003-2444-3247], HUS Comprehensive Cancer Center, Department of Oncology, Clinicum, INDIVIDRUG - Individualized Drug Therapy, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Institut Català de la Salut, [Coignard J] Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France. Institut Curie Paris, Paris, France. Mines ParisTech Fontainebleau, Paris, France. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. PSL University Paris, Paris, France. Paris Sud University, Orsay, France. [Lush M, Dennis J] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [Beesley J, O'Mara TA] Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. [Tyrer JP] Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge, Cambridge, UK. [Diez O] Oncogenetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Àrea de Genètica Clínica i Molecular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Lopez-Fernández A] High Risk and Cancer Prevention Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Life Course Epidemiology (LCE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Human Genetics, ARD - Amsterdam Reproduction and Development, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, CCA - Cancer biology and immunology, Clinical Genetics, Medical Oncology, Pathology, and Radiology & Nuclear Medicine

Subjects
0301 basic medicine, Linkage disequilibrium, endocrine system diseases, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], 45/43, General Physics and Astronomy, Genome-wide association study, Linkage Disequilibrium, Breast cancer, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Risk Factors, Genotype, breast neoplasms, Medicine and Health Sciences, 631/208/68, skin and connective tissue diseases, Cancer genetics, adult, alleles, BRCA1 protein, BRCA2 protein, female, genetic predisposition to disease, genome-wide association study, genotype, humans, linkage disequilibrium, middle aged, mutation, quantitative trait loci, risk factors, polymorphism, single nucleotide, HEBON Investigators, Genetics, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], education.field_of_study, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Multidisciplinary, Otros calificadores::Otros calificadores::/genética [Otros calificadores], BRCA1 Protein, Genetic Predisposition to Disease/genetics, article, Single Nucleotide, Middle Aged, BRCA2 Protein/genetics, 3. Good health, Mama - Càncer - Factors de risc, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Genome-Wide Association Study/methods, Medical genetics, Female, Medical Genetics, 692/499, Adult, medicine.medical_specialty, 45/61, Science, 3122 Cancers, Population, Quantitative Trait Loci, Genetic Phenomena::Genetic Variation::Mutation [PHENOMENA AND PROCESSES], ABCTB Investigators, 631/67/2324, Breast Neoplasms, Biology, Breast Neoplasms/genetics, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Càncer de mama, GEMO Study Collaborators, 03 medical and health sciences, Cancer epidemiology, SDG 3 - Good Health and Well-being, Other subheadings::Other subheadings::/genetics [Other subheadings], medicine, Humans, Genetic Predisposition to Disease, Allele, Polymorphism, education, EMBRACE Collaborators, fenómenos genéticos::variación genética::mutación [FENÓMENOS Y PROCESOS], Alleles, Medicinsk genetik, BRCA2 Protein, Mutació (Biologia), General Chemistry, 631/67/1347, Genotype frequency, 030104 developmental biology, Mutation, Mama - Càncer - Aspectes genètics, BRCA1 Protein/genetics, 3111 Biomedicine, KConFab Investigators, Quantitative Trait Loci/genetics, Genètica, Genome-Wide Association Study
Abstract

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P, Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Published
2021
Full Text
View/download PDF

44. PREsurgery thoughts – thoughts on prehabilitation in oncologic gynecologic surgery, a qualitative template analysis in older adults and their healthcare professionals.

Author

van der Zanden, Vera, van der Zaag-Loonen, Hester J., Paarlberg, K. Marieke, Meijer, Wouter J., Mourits, Marian J. E., and van Munster, Barbara C.

Subjects
CANCER patient psychology, RESEARCH, OCCUPATIONAL roles, FRAIL elderly, BIOPSYCHOSOCIAL model, ATTITUDES of medical personnel, RESEARCH methodology, MEDICAL personnel, INTERVIEWING, MEDICAL screening, HUMAN services programs, GYNECOLOGIC surgery, PATIENTS' attitudes, QUALITATIVE research, PSYCHOSOCIAL factors, RESEARCH funding, NURSES, PREHABILITATION, THEMATIC analysis, SUPERVISION of employees, FEMALE reproductive organ tumors, REHABILITATION, OLD age
Abstract

This study aimed to reveal information that can be used for composing a prehabilitation program tailored to elderly gynecological oncological patients and is applicable to healthcare professionals. We investigated possible content and indications for prehabilitation, and what potential barriers might exist. Because of the primary exploratory study aim, inductive thematic template analysis on semi-structured interviews with gynecologic oncological patients aged ≥60 years and healthcare professionals were used. 16 patients and 20 healthcare professionals were interviewed. Three themes important for prehabilitation were found: (1) "Motivation," (2) "Practical issues and facilitators," and (3) "Patient-related factors." A short time interval between diagnosis and surgery was reported as a potential barrier for prehabilitation. Given components for a tailor-made prehabilitation program are: (1) The first contact with a nurse who screens the patients, gives tailor-made advice on prehabilitation and keeps patients motivated and supports them mentally; (2) If patients are referred to a more extensive/supervised program, this should preferably be arranged close to a patients' home. Based on our findings, an outline of a patient-tailored prehabilitation program was developed. The main important themes for prehabilitation were "Motivation," "Practical issues and facilitators," and "Patient-related factors." Patients and healthcare professionals are positive about prehabilitation. Main themes for designing a prehabilitation program are "Motivation," "Practical issues and facilitators," and "Patient-related factors." Nursing staff can play a key role in prehabilitation. It is important to screen patients for specific impairments to obtain a tailor-made prehabilitation program. For some patients, general advice on prehabilitation might be sufficient, while others may need more supervision. The time interval between diagnosis and surgery is often short and is perceived as a potentially significant barrier for an effective prehabilitation program. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

45. Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers: an international cohort study

Author

Schrijver, Lieske H., Antoniou, Antonis C., Olsson, Hakan, Mooij, Thea M., Roos-Blom, Marie-Jose, Azarang, Leyla, Adlard, Julian, Ahmed, Munaza, Barrowdale, Daniel, Davidson, Rosemarie, Donaldson, Alan, Eeles, Ros, Evans, D. Gareth, Frost, Debra, Henderson, Alex, Izatt, Louise, Ong, Kai-Ren, Bonadona, Valerie, Coupier, Isabelle, Faivre, Laurence, Fricker, Jean-Pierre, Gesta, Paul, van Engelen, Klaartje, Jager, Agnes, Menko, Fred H., Mourits, Marian J. E., Singer, Christian F., Tan, Yen Y., Foretova, Lenka, Navratilova, Marie, Schmutzler, Rita K., Ellberg, Carolina, Gerdes, Anne-Marie, Caldes, Trinidad, Simard, Jacques, Olah, Edith, Jakubowska, Anna, Rantala, Johanna, Osorio, Ana, Hopper, John L., Phillips, Kelly-Anne, Milne, Roger L., Terry, Mary Beth, Nogues, Catherine, Engel, Christoph, Kast, Karin, Goldgar, David E., van Leeuwen, Flora E., Easton, Douglas F., Andrieu, Nadine, Rookus, Matti A., Schrijver, Lieske H., Antoniou, Antonis C., Olsson, Hakan, Mooij, Thea M., Roos-Blom, Marie-Jose, Azarang, Leyla, Adlard, Julian, Ahmed, Munaza, Barrowdale, Daniel, Davidson, Rosemarie, Donaldson, Alan, Eeles, Ros, Evans, D. Gareth, Frost, Debra, Henderson, Alex, Izatt, Louise, Ong, Kai-Ren, Bonadona, Valerie, Coupier, Isabelle, Faivre, Laurence, Fricker, Jean-Pierre, Gesta, Paul, van Engelen, Klaartje, Jager, Agnes, Menko, Fred H., Mourits, Marian J. E., Singer, Christian F., Tan, Yen Y., Foretova, Lenka, Navratilova, Marie, Schmutzler, Rita K., Ellberg, Carolina, Gerdes, Anne-Marie, Caldes, Trinidad, Simard, Jacques, Olah, Edith, Jakubowska, Anna, Rantala, Johanna, Osorio, Ana, Hopper, John L., Phillips, Kelly-Anne, Milne, Roger L., Terry, Mary Beth, Nogues, Catherine, Engel, Christoph, Kast, Karin, Goldgar, David E., van Leeuwen, Flora E., Easton, Douglas F., Andrieu, Nadine, and Rookus, Matti A.

Abstract

Obstetrical complications, often referred to as the great obstetrical syndromes, are among the most common global causes of mortality and morbidity in young women and their infants. However, treatments for these syndromes are underdeveloped compared with other fields of medicine and are urgently needed. This current paucity of treatments for obstetrical complications is a reflection of the challenges of drug development in pregnancy. The appetite of pharmaceutical companies to invest in research for obstetrical syndromes is generally reduced by concerns for maternal, fetal, and infant safety, poor definition, and high-risk regulatory paths toward product approval. Notably, drug candidates require large investments for development with an unguaranteed return on investment. Furthermore, the discovery of promising drug candidates is hampered by a poor understanding of the pathophysiology of obstetrical syndromes and their uniqueness to human pregnancies. This limits translational extrapolation and de-risking strategies in preclinical studies, as available for other medical areas, compounded with limited fetal safety monitoring to capture early prenatal adverse reactions. In addition, the ethical review committees are reluctant to approve the inclusion of pregnant women in trials, and in the absence of regulatory guidance in obstetrics, clinical development programs are subject to unpredictable regulatory paths. To develop effective and safe drugs for pregnancy complications, substantial commitment, and investment in research for innovative therapies are needed in parallel with the creation of an enabling ethical, legislative, and guidance framework. Solutions are proposed to enable stakeholders to work with a common set of expectations to facilitate progress in this medical discipline. Addressing this significant unmet need to advance maternal and possibly perinatal health requires the involvement of all stakeholders and specifically patients, couples, and cli-nicians

Published
2021

46. Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Author

Seppala, Toni T., Dominguez-Valentin, Mev, Crosbie, Emma J., Engel, Christoph, Aretz, Stefan, Macrae, Finlay, Winship, Ingrid, Capella, Gabriel, Thomas, Huw, Hovig, Eivind, Nielsen, Maartje, Sijmons, Rolf H., Bertario, Lucio, Bonanni, Bernardo, Tibiletti, Maria G., Cavestro, Giulia M., Mints, Miriam, Gluck, Nathan, Katz, Lior, Heinimann, Karl, Vaccaro, Carlos A., Green, Kate, Lalloo, Fiona, Hill, James, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Strauss, Hans-Georg, Tecklenburg, Johanna, Holinski-Feder, Elke, Steinke-Lange, Verena, Mecklin, Jukka-Pekka, Plazzer, John-Paul, Pineda, Marta, Navarro, Matilde, Vida, Joan B., Kariv, Revital, Rosner, Guy, Pinero, Tamara A., Pavicic, Walter, Kalfayan, Pablo, Ten Broeke, Sanne W., Jenkins, Mark A., Sunde, Lone, Bernstein, Inge, Burn, John, Greenblatt, Marc, Cappel, Wouter H. de Vos Tot Nederveen, Della Valle, Adriana, Lopez-Koestner, Francisco, Alvarez, Karin, Buettner, Reinhard, Goergens, Heike, Morak, Monika, Holzapfel, Stefanie, Hueneburg, Robert, Doeberitz, Magnus von Knebel, Loeffler, Markus, Redler, Silke, Weitz, Jurgen, Pylvaenaeinen, Kirsi, Renkonen-Sinisalo, Laura, Lepisto, Anna, Hopper, John L., Win, Aung K., Lindor, Noralane M., Gallinger, Steven, Marchand, Loic Le, Newcomb, Polly A., Figueiredo, Jane C., Thibodeau, Stephen N., Therkildsen, Christina, Wadt, Karin A. W., Mourits, Marian J. E., Ketabi, Zohreh, Denton, Oliver G., Rodland, Einar A., Vasen, Hans, Neffa, Florencia, Esperon, Patricia, Tjandra, Douglas, Moeslein, Gabriela, Rokkones, Erik, Sampson, Julian R., Evans, D. G., Moller, Pal, Seppala, Toni T., Dominguez-Valentin, Mev, Crosbie, Emma J., Engel, Christoph, Aretz, Stefan, Macrae, Finlay, Winship, Ingrid, Capella, Gabriel, Thomas, Huw, Hovig, Eivind, Nielsen, Maartje, Sijmons, Rolf H., Bertario, Lucio, Bonanni, Bernardo, Tibiletti, Maria G., Cavestro, Giulia M., Mints, Miriam, Gluck, Nathan, Katz, Lior, Heinimann, Karl, Vaccaro, Carlos A., Green, Kate, Lalloo, Fiona, Hill, James, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Strauss, Hans-Georg, Tecklenburg, Johanna, Holinski-Feder, Elke, Steinke-Lange, Verena, Mecklin, Jukka-Pekka, Plazzer, John-Paul, Pineda, Marta, Navarro, Matilde, Vida, Joan B., Kariv, Revital, Rosner, Guy, Pinero, Tamara A., Pavicic, Walter, Kalfayan, Pablo, Ten Broeke, Sanne W., Jenkins, Mark A., Sunde, Lone, Bernstein, Inge, Burn, John, Greenblatt, Marc, Cappel, Wouter H. de Vos Tot Nederveen, Della Valle, Adriana, Lopez-Koestner, Francisco, Alvarez, Karin, Buettner, Reinhard, Goergens, Heike, Morak, Monika, Holzapfel, Stefanie, Hueneburg, Robert, Doeberitz, Magnus von Knebel, Loeffler, Markus, Redler, Silke, Weitz, Jurgen, Pylvaenaeinen, Kirsi, Renkonen-Sinisalo, Laura, Lepisto, Anna, Hopper, John L., Win, Aung K., Lindor, Noralane M., Gallinger, Steven, Marchand, Loic Le, Newcomb, Polly A., Figueiredo, Jane C., Thibodeau, Stephen N., Therkildsen, Christina, Wadt, Karin A. W., Mourits, Marian J. E., Ketabi, Zohreh, Denton, Oliver G., Rodland, Einar A., Vasen, Hans, Neffa, Florencia, Esperon, Patricia, Tjandra, Douglas, Moeslein, Gabriela, Rokkones, Erik, Sampson, Julian R., Evans, D. G., and Moller, Pal

Abstract

Purpose: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. Results: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. Conclusion: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene-and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syn-drome to improve outcomes. (C) 2021 The Author(s). Published by Elsevier Ltd.

Published
2021

47. Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers: A Nonrandomized Controlled Trial

Author

MS Gynaecologische Oncologie, Cancer, Steenbeek, Miranda P., Harmsen, Marline G., Hoogerbrugge, Nicoline, Arts de Jong, Marieke, Maas, Angela H.E.M., Prins, Judith B, Bulten, Johan, Teerenstra, Steven, van Bommel, Majke H.D., van Doorn, Helena C, Mourits, Marian J E, van Beurden, Marc, Zweemer, Ronald P, Gaarenstroom, Katja N, Slangen, Brigitte F M, Brood-van Zanten, Monique M A, Vos, M Caroline, Piek, Jurgen M J, van Lonkhuijzen, Luc R C W, Apperloo, Mirjam J A, Coppus, Sjors F P J, Massuger, Leon F A G, IntHout, Joanna, Hermens, Rosella P M G, de Hullu, Joanne A., MS Gynaecologische Oncologie, Cancer, Steenbeek, Miranda P., Harmsen, Marline G., Hoogerbrugge, Nicoline, Arts de Jong, Marieke, Maas, Angela H.E.M., Prins, Judith B, Bulten, Johan, Teerenstra, Steven, van Bommel, Majke H.D., van Doorn, Helena C, Mourits, Marian J E, van Beurden, Marc, Zweemer, Ronald P, Gaarenstroom, Katja N, Slangen, Brigitte F M, Brood-van Zanten, Monique M A, Vos, M Caroline, Piek, Jurgen M J, van Lonkhuijzen, Luc R C W, Apperloo, Mirjam J A, Coppus, Sjors F P J, Massuger, Leon F A G, IntHout, Joanna, Hermens, Rosella P M G, and de Hullu, Joanne A.

Published
2021

48. Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

Author

MS Gynaecologische Oncologie, Cancer, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, Genetica Klinische Genetica, Terra, Lara, Hooning, Maartje J, Heemskerk-Gerritsen, Bernadette A M, van Beurden, Marc, Roeters van Lennep, Jeanine E, van Doorn, Helena C, de Hullu, Joanne A, Mom, Constantijne, van Dorst, Eleonora B L, Mourits, Marian J E, Slangen, Brigitte F M, Gaarenstroom, Katja N, Zillikens, M Carola, Leiner, Tim, van der Kolk, Lizet, Collee, Margriet, Wevers, Marijke, Ausems, Margreet G E M, van Engelen, Klaartje, Berger, Lieke Pv, van Asperen, Christi J, Gomez-Garcia, Encarna B, van de Beek, Irma, Rookus, Matti A, Hauptmann, Michael, Bleiker, Eveline M, Schagen, Sanne B, Aaronson, Neil K, Maas, Angela H E M, van Leeuwen, Flora E, MS Gynaecologische Oncologie, Cancer, Researchgr. Cardiovasculaire Radiologie, Circulatory Health, Genetica Klinische Genetica, Terra, Lara, Hooning, Maartje J, Heemskerk-Gerritsen, Bernadette A M, van Beurden, Marc, Roeters van Lennep, Jeanine E, van Doorn, Helena C, de Hullu, Joanne A, Mom, Constantijne, van Dorst, Eleonora B L, Mourits, Marian J E, Slangen, Brigitte F M, Gaarenstroom, Katja N, Zillikens, M Carola, Leiner, Tim, van der Kolk, Lizet, Collee, Margriet, Wevers, Marijke, Ausems, Margreet G E M, van Engelen, Klaartje, Berger, Lieke Pv, van Asperen, Christi J, Gomez-Garcia, Encarna B, van de Beek, Irma, Rookus, Matti A, Hauptmann, Michael, Bleiker, Eveline M, Schagen, Sanne B, Aaronson, Neil K, Maas, Angela H E M, and van Leeuwen, Flora E

Published
2021

49. Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.

Author

Steenbeek, Miranda P, van Bommel, Majke H D, Bulten, Johan, Hulsmann, Julia A, Bogaerts, Joep, Garcia, Christine, Cun, Han T, Lu, Karen H, van Beekhuizen, Heleen J, Minig, Lucas, Gaarenstroom, Katja N, Nobbenhuis, Marielle, Krajc, Mateja, Rudaitis, Vilius, Norquist, Barbara M, Swisher, Elizabeth M, Mourits, Marian J E, Massuger, Leon F A G, Hoogerbrugge, Nicoline, and Hermens, Rosella P M G

Published
2022
Full Text
View/download PDF

50. Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study) (Preprint)

Author

Terra, Lara, primary, Hooning, Maartje J, additional, Heemskerk-Gerritsen, Bernadette A M, additional, van Beurden, Marc, additional, Roeters van Lennep, Jeanine E, additional, van Doorn, Helena C, additional, de Hullu, Joanne A, additional, Mom, Constantijne, additional, van Dorst, Eleonora B L, additional, Mourits, Marian J E, additional, Slangen, Brigitte F M, additional, Gaarenstroom, Katja N, additional, Zillikens, M Carola, additional, Leiner, Tim, additional, van der Kolk, Lizet, additional, Collee, Margriet, additional, Wevers, Marijke, additional, Ausems, Margreet G E M, additional, van Engelen, Klaartje, additional, Berger, Lieke PV, additional, van Asperen, Christi J, additional, Gomez-Garcia, Encarna B, additional, van de Beek, Irma, additional, Rookus, Matti A, additional, Hauptmann, Michael, additional, Bleiker, Eveline M, additional, Schagen, Sanne B, additional, Aaronson, Neil K, additional, Maas, Angela H E M, additional, and van Leeuwen, Flora E, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results