Search

Your search keyword '"Moure, Ricardo"' showing total 9 results
Start Over Author "Moure, Ricardo"
9 results on '"Moure, Ricardo"'

4. The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Author

Quesada-López, Tania, Cereijo, Rubén, Turatsinze, Jean-Valery, Planavila, Anna, Cairó, Montserrat, Gavaldà-Navarro, Aleix, Peyrou, Marion, Moure, Ricardo, Iglesias, Roser, Giralt, Marta, Eizirik, Decio L., and Villarroya, Francesc

Subjects
Mice, Knockout, Physique, Adipose Tissue, White, Science, Astronomie, p38 Mitogen-Activated Protein Kinases, Article, Receptors, G-Protein-Coupled, Up-Regulation, Cold Temperature, Fibroblast Growth Factors, Technologie de l'environnement, contrôle de la pollution, Methylamines, Mice, Adipose Tissue, Brown, Eicosapentaenoic Acid, Gene Expression Regulation, Fatty Acids, Omega-3, Adipocytes, Chimie, Animals, Propionates, Cells, Cultured, Body Temperature Regulation
Abstract

The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose tissue are important components of energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation. Using RNA-seq to analyse mouse BAT transcriptome, we find that the gene encoding GPR120 is induced by thermogenic activation. We further show that GPR120 activation induces BAT activity and promotes the browning of white fat in mice, whereas GRP120-null mice show impaired cold-induced browning. Omega-3 polyunsaturated fatty acids induce brown and beige adipocyte differentiation and thermogenic activation, and these effects require GPR120. GPR120 activation induces the release of fibroblast growth factor-21 (FGF21) by brown and beige adipocytes, and increases blood FGF21 levels. The effects of GPR120 activation on BAT activation and browning are impaired in FGF21-null mice and cells. Thus, the lipid sensor GPR120 activates brown fat via a mechanism that involves induction of FGF21., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

8. Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System

Author

Moure, Ricardo, primary, Domingo, Pere, additional, Villarroya, Joan, additional, Gasa, Laura, additional, Gallego-Escuredo, José M., additional, Quesada-López, Tania, additional, Morón-Ros, Samantha, additional, Maroto, Alberto F., additional, Mateo, Gracia M., additional, Domingo, Joan C., additional, Villarroya, Francesc, additional, and Giralt, Marta, additional

Published
2018
Full Text
View/download PDF

9. The Molecular Signature of HIV-1-Associated Lipomatosis Reveals Differential Involvement of Brown and Beige/Brite Adipocyte Cell Lineages

Author

Cereijo, Rubén, primary, Gallego-Escuredo, José Miguel, additional, Moure, Ricardo, additional, Villarroya, Joan, additional, Domingo, Joan Carles, additional, Fontdevila, Joan, additional, Martínez, Esteban, additional, Gutiérrez, Maria del Mar, additional, Mateo, María Gracia, additional, Giralt, Marta, additional, Domingo, Pere, additional, and Villarroya, Francesc, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results