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10. The influence of the low-frequency transcutaneous electrical nerve stimulation application moment in vocal quality of dysphonic women.

Author

Moura, Gabriela Campos, Antonetti, Angélica Emygdio da Silva, dos Santos, Ana Paula, Vitor, Jhonatan da Silva, Brasolotto, Alcione Ghedini, Siqueira, Larissa Thaís Donalonso, and Silverio, Kelly Cristina Alves

Subjects
*VOICE disorder treatment, *T-test (Statistics), *RESEARCH funding, *VOICE disorders, *PSYCHOLOGY of women, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *LONGITUDINAL method, *EXPERIMENTAL design, *TRANSCUTANEOUS electrical nerve stimulation, *SPEECH evaluation, *HUMAN voice, *COMPARATIVE studies, PHYSIOLOGICAL aspects of speech
Abstract

Objective: to compare the immediate effects of low-frequency TENS employment on vocal quality in women with behavioral dysphonia before and after vocal exercises. Methodology: 30 women (mean = 31.3 years old), diagnosed with behavioral dysphonia received low-frequency TENS before (TENS + VE Group) and after vocal exercises (VE + TENS Group) with a 1-week washout. They had their sustained vowel/a/and running speech recorded before and after each procedure for auditory-perceptual analysis and acoustic measures. The low-frequency TENS parameters applied were symmetrical biphasic quadratic pulse, 200 µs phase, 10 Hz frequency, intensity on the motor threshold, and the electrodes were positioned on the submandibular and superior fibers of the trapezius muscle region. The vocal exercises: tongue trill, humming, finger kazoo, and water resistance therapy were performed totalizing 20 min. Results: intragroup analysis of sustained vowel/a/showed reduction in both groups of strain parameter and increased the breathiness; only VE + TENS Group increased the instability parameter, decreased fundamental frequency, and increased in SPI values; the running speech analysis showed an increase in the overall degree, roughness, and breathiness parameters. However, in VE + TENS Group, there was a statistically significant decrease in the intensity of the strain and an increase in breathiness. The acoustic measures showed that VE + TENS Group had a higher variation than TENS + VE Group regarding NHR. Conclusion: vocal exercises followed by low-frequency TENS have more immediate positive effects on voice quality than the low-frequency TENS followed by vocal exercises. This is a preliminary immediate effects study, and these effects could be verified through long-term assessments. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Serological and molecular detection of infection with Mycobacterium leprae in Brazilian six banded armadillos (Euphractus sexcinctus)

Author

da Silva Ferreira, Jéssica, de Carvalho, Fernanda Marques, Vidal Pessolani, Maria Cristina, de Paula Antunes, João Marcelo Azevedo, de Medeiros Oliveira, Ilanna Vanessa Pristo, Ferreira Moura, Gabriela Hémylin, Truman, Richard Wayne, Peña, Maria Teresa, Sharma, Rahul, Duthie, Malcolm S., de Paula Souza e Guimarães, Ricardo José, Nogueira Brum Fontes, Amanda, NoelSuffys, Philip, and McIntosh, Douglas

Published
2020
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15. Seroprevalence of Corynebacterium pseudotuberculosis and Toxoplasma gondii in sheep in semi-arid region of Ceara state/Soroprevalencia de Corynebacterium pseudotuberculosis de Toxoplasma gondii em ovinos de regiao semi-arida do estado do Ceara

Author

Moura, Gabriela Hemylin Ferreira, Lelis, Ivana Cristina Nunes Gadelha, Rocha, Celio Souza da, Oliveira, Ilanna Vanessa Pristo de Medeiros, Bezerra, Jose Artur Brilhante, Calabuig, Cecilia Irene Perez, Martins, Patricia Yoshida Faccioli, Pinheiro, Raymundo Rizaldo, Sousa, Maxmiana Mesquita de, Santos, Vanderlan Warlington Souza dos, Abreu, Antonio Rafael Albuquerque, and Antunes, Joao Marcelo Azevedo de Paula

Published
2020
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17. Cardiac involvement in trypanosomiasis in sheep experimentally infected by Trypanosoma vivax (Ziemman, 1905)

Author

Batista, Jael Soares, Araújo Júnior, Hélio Noberto de, Moura, Gabriela Hémylin Ferreira, Góis, Rayr Cezar de Souza, Paiva, Kaliane Alessandra Rodrigues de, Silva, Jardel Bezerra da, Costa, Wirton Peixoto, Menezes, Manuela Costa de, Nunes, Francisco Vitor Aires, Costa, Kizzy Millenn de Freitas Mendonça, and Medeiros, Gerard Vicente Dantas de

Published
2019
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20. miRNAs in Heart Development and Disease

Author

Lozano-Velasco, Estefania, primary, Inácio, José Manuel, additional, Sousa, Inês, additional, Guimarães, Ana Rita, additional, Franco, Diego, additional, Moura, Gabriela, additional, and Belo, José António, additional

Published
2024
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23. ADENOCARCINOMA MUCINOSO DE APÊNDICE CECAL - RELATO DE CASO

Author

Ilias, Elias Jirjoss, primary, Ketzer, Bernardo Mazzini, additional, Cerqueira, Brunella Silva, additional, Lourencini, Rafael, additional, Kunizaki, Eric Shigueo Boninsenha, additional, Vieites, Luiza, additional, Mendes, Paula Morais Pereira, additional, and Moura, Gabriela Miranda Mariotti de, additional

Published
2020
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25. Epidemiologia e Políticas Públicas de Saúde - Volume 2

Author

Rodrigues, Antonio Bruno do Nascimento, primary, Uchôa, Lucas R, additional, Soares, Thalia M de S, additional, Guimarães, Kayra C, additional, Brandão, Fabricio de Sousa, additional, Lopes, Samara Raquel dos Santos, additional, Almeida, Caroline R de, additional, Silva, Ana Paula Pereira da, additional, Ananias, Lucas, additional, Medeiros, Adam Kelsom Gomes, additional, Santos, José M da S, additional, Amaral, Jéssica Sabrinne Araújo, additional, Silva, Ana Maria Ferreira da, additional, Trindade, Ana Paula Santos, additional, Nascimento, José Italo Silva, additional, Carmo, Laiza de Oliveira do, additional, Santos, Almir Orsano dos, additional, Lazzarotto, Eliana Maria, additional, Momentti, Ana Carolina, additional, Tajra, Fábio Solon, additional, Mendes, Breno Coelho, additional, Aguiar, Bruno Guedes Alcoforado, additional, Costa, Dorcas Lamounier, additional, Batista, Francisca Miriane de Araújo, additional, Silva, Rodrigo Aragão da, additional, Alfredo, Julia Perito, additional, Bigolin, Laura de Lima, additional, Warlet, Luiza Biondi, additional, Alfredo, Camila Perito, additional, Lerro, Lucas, additional, Lerro, Leonardo, additional, Netto, Lana Ferreira Porto Coelho, additional, Moura, Gabriela Vasconcelos de, additional, Suleiman, Nariman Mohamad Abdel Salam, additional, Nobre, Rony Kafer, additional, Carvalho, Kaique Maximo de Oliveira, additional, Gois, Pollyana dos Santos, additional, Santana, Vitória Santos de, additional, Andrade, Ana Paula de Oliveira, additional, Sacramento, Gielson Almeida do, additional, Oliveira, Priscila Mendes Grana, additional, Lira, Kaline Vitória Lima, additional, Rocha, Álvaro Sepúlveda Carvalho, additional, Rocha, Antônio Carlos Guilherme, additional, Santos, Emanuelle Cristine Alves dos, additional, Sousa, José Samuel Teixeira de, additional, Santos, Natália Carvalho de Sousa, additional, Araújo, Telma Maria Evangelista de, additional, Nunes, Karen Lainy dos Reis, additional, Silva, Suzana Fernandes da, additional, Nascimento, Sara Lúcia Portela do, additional, Rocha, Nataly Ramos, additional, Lima, Vitória Assis, additional, Maia, Elayne Silva, additional, Lima, Kaio Filipe Nunes, additional, Cardoso, Thalita Boanerges Miranda, additional, Gonçalves, Lícia de Sousa, additional, Bastos, Larissa do SS, additional, Ferreira, Lucas A, additional, Lima, Alex Ranieri Jerônimo, additional, Moraes, Leonardo Gomes Cavalieri de, additional, Ribeiro, Thaís de Menezes, additional, Amorim, Lidiane Lindinalva Barbosa, additional, Oliveira, Caio alves de, additional, Monteiro, Rayane M M, additional, Santos, Edson Peres dos, additional, Soares, Thalia Maria de Sousa, additional, Galvão, Rubens Francisco Pereira, additional, Amorim, Liliane Barbosa, additional, Santos, Antonio Robson Dos, additional, Vieira, Cleyson Pereira Castro, additional, Borges, Gustavo de Oliveira, additional, Freitas, João Luis Galvão, additional, Ferreira, João Lucas Pereira, additional, Lopes, Lucas Costa, additional, Barros, Yago de Oliveira, additional, Montes, Nadja Janayra Morais, additional, Delcole, Giovanna, additional, Pinto, Natália de Santana, additional, Oliveira, Otávio Augusto Barbosa de, additional, Rodrigues, Rodrigo Ferreira, additional, Toledo, Rodrigo Ruas Floriano de, additional, Moreira, Lyslian J A, additional, Oliveira, Elaine Eugênio de, additional, Addor, Nicolas, additional, Diaz, Melissa, additional, Fernandes, Márcia A, additional, Brito, Cleidiane Maria Sales de, additional, Santos, Gerarlene Ponte Guimarães, additional, Luz, Phellype Kayyaã da, additional, Brandão, Socorro Adriane de S Meneses, additional, Costa, Rayla Maria Pontes Guimarães, additional, Figueiredo, Maria do LF, additional, Gouveia, Márcia Tales de Oliveira, additional, Santos, João Gabriel Ribeiro dos, additional, Fernandes, Márcia Astrês, additional, Pillon, Sandra Cristina, additional, Ibiapina, Aline Rafael de Sousa, additional, Silva, Angela dos Santos, additional, Vieira, Ingrid Raquel Lima, additional, Passos, Bruna Victoria da Silva, additional, Oliveira, Douglas Vieira de, additional, Leite, Wellington Macêdo, additional, Lima, Diellison Layson dos Santos, additional, Ramsdorf, Maria Theresa de Alencar, additional, Yoshikawa, Catherine Alexia, additional, Menezes, João Gabriel da Silva, additional, Pereira, Luiz Fernando Benazet de Assunção, additional, Redígulo, Tayná Boldoni, additional, Queiroz, Ana Paula Dossi de Guimarães e, additional, Pedrão, Mariana D, additional, Axer, Mariana O, additional, Gonçalves, Joubert M, additional, Amaral, Letícia L M, additional, Oliveira, Lucas L, additional, Salgado, Lucas S, additional, Porto, Luiza L, additional, Morais, Maria Clara M, additional, Esteves, Raquel D, additional, Carvalho, Thiago L, additional, Soares, Vinícius C, additional, Bossi, Vinícius M, additional, Macedo, Natan L De, additional, Saurini, Thainá M, additional, Freitas, Victor H F, additional, Salgado, Camila S, additional, Costa, Marina Lua Vieira de Abreu, additional, Martins, Thaís Santos, additional, Silva, Fernando José Guedes da, additional, Sales, Jaqueline Carvalho e Silva, additional, Moura, Marcoeli Silva de, additional, Silva, Marla Ariana, additional, Bernini, Daiane Moreira Aguiar, additional, Bernini, Anderson Esteves, additional, Belo, Vinícius Silva, additional, Santos, Regina Consolação dos, additional, Pena, Heber Paulino, additional, Moraes, Juliano Teixeira, additional, Morici, Isabelle Assis, additional, Oliveira, Cíntia Gonçalves, additional, Vasconcelos, Deolane Eustáquia Antunes, additional, Lisboa, Cristiane Rabelo, additional, Diassis, Matheus Alexandre Bezerra, additional, Lima, Ana Victória Mota, additional, Araújo, Helenilda de Sousa, additional, Nobre, Beatriz Gomes, additional, Siqueira, Lucas Sampaio, additional, Pereira, Antonia Vitória Gomes, additional, Santos, Gleice Laisla de Oliveira, additional, Soares, Vitória da Silva, additional, Santos, Vivian Rafaela Almeida, additional, Costa, Natalya Wegila Felix da, additional, Meneses, Ian Alves, additional, Macêdo, Luiz Fernando Reis, additional, Forte, Gustavo Cabral, additional, Alencar, Gisely Torres de, additional, Remaili, Nadine Roiz, additional, Machado, Ana Carolina de Mesquita Netto, additional, Costa, Andressa Ribeiro da, additional, Adjuto, Clara Araújo, additional, Silva, Gabriel Antunes Sousa, additional, Couto, Karinny Guimarães, additional, Garavello, Maria Eugenia Mana, additional, Cardoso, Nicole Nogueira, additional, Nunes, Pedro Augusto Carrijo, additional, Carvalho, Sabrina Oliveira, additional, Abed, Yasser Nader, additional, Santos, Nycolle Santana dos, additional, BEZERRA, LEVI ARAUJO, additional, Vieira, Mikaelly Nunes, additional, Souza, Luiz Carlos Alves de, additional, Marques, Paula Ramalho, additional, Almeida, Adriana Jardim de, additional, Felix, Aline de Oliveira, additional, Pereira, Gabriela Martins, additional, Araujo, Giulia Del Giudice Figueiredo de, additional, Araujo, Lorena Costa, additional, Hyppolito, Rebeca Reginna da Costa, additional, Luz, Paulo Cesar de Moura, additional, Alcântara, Rafaella Silva, additional, Rodrigues, Priscylla Frazão, additional, Lins, Raphaela da Penha, additional, Silva, Tarcísio Rodrigues da, additional, Calheiros, Cláudia Maria Lins, additional, Sander, Renata Cury, additional, Luz, Risocelly dos Santos Andrade, additional, Andrade, Risolene dos Santos, additional, Brito, Mychelangela de Assis, additional, Rocha, Silvana Santiago da, additional, Costa, Ruth Silva Lima da, additional, França, João Vítor da Silva, additional, Conceição, Matilde da Silva, additional, Souza, Christopher Wando da Silva, additional, Ricardo, Nadab Santos, additional, Maia, Nathalia Oliveira Martins, additional, Araújo, Célio Clayson Souza de, additional, Silva, Aldemir Victor de Araújo, additional, Oliveira, Nathan Lima de, additional, Ramos, Sabrina Brito, additional, Ferreira, Luis Felipe da Silva, additional, Oliveira, Matheus Pedrosa De, additional, França, Nathalia Cristina Pereira De, additional, Souza, Thalis Ferreira De, additional, Rodrigues, Stefânia, additional, Luiz, Angel Renaro Ferreira, additional, Moreira, Carla, additional, Lima, Dirce Marisa Lopes de, additional, Oliveira, Vitória de, additional, Souza, Tiago Antonio de, additional, Asìn, Paola Isabel Carrasco, additional, Gerheim, Ester Gomes, additional, Leite, Isabel Cristina Gonçalves, additional, Ribeiro, Luiz C, additional, Scheibe, Victória Machado, additional, Zanatta, Stefanie Flach, additional, Krug, Bruna Reis, additional, Leon, Cristiano De, additional, Cruz, Ludimila Ferreira Sousa, additional, Medeiros, Monayra Amaral, additional, Romanielo, Ana Flávia Resende, additional, Garbelini, Giulia Ugucioni, additional, Antonelli, Laíne Ribeiro, additional, Borges, Daniel Martins, additional, Guimarães, Laura Alves, additional, and Sabino, Barbara Correia Neves, additional

Published
2020
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27. Study of the Epigenetic Signals in the Human Genome

Author

Ferreira, Susana, Afreixo, Vera, Moura, Gabriela, Tavares, Ana, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Fdez-Riverola, Florentino, editor, Mohamad, Mohd Saberi, editor, Rocha, Miguel, editor, De Paz, Juan F., editor, and Pinto, Tiago, editor

Published
2017
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30. Genetic predisposition for low functional status in COPD

Author

Marçalo, Rui, primary, Rodrigues, Guilherme, additional, Pinheiro, Miguel, additional, Neto, Sonya, additional, Marques, Sofia L., additional, Simão, Paula, additional, Martins, Vitória, additional, Andrade, Lília, additional, Mendes, Maria Aurora, additional, Afreixo, Vera, additional, Moura, Gabriela, additional, and Marques, Alda, additional

Published
2023
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32. Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction

Author

Inácio, José M., primary, Cristo, Fernando, additional, Pinheiro, Miguel, additional, Vasques-Nóvoa, Francisco, additional, Saraiva, Francisca, additional, Nunes, Mafalda M., additional, Rosas, Graça, additional, Reis, Andreia, additional, Coimbra, Rita, additional, Oliveira, José Luís, additional, Moura, Gabriela, additional, Leite-Moreira, Adelino, additional, and Belo, José António, additional

Published
2023
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34. tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Tavares, Joana F, Davis, Nick K, Poim, Ana, Reis, Andreia, Kellner, Stefanie, Sousa, Inês, Soares, Ana R, Moura, Gabriela MR, Dedon, Peter C, Santos, Manuel, Massachusetts Institute of Technology. Department of Biological Engineering, Tavares, Joana F, Davis, Nick K, Poim, Ana, Reis, Andreia, Kellner, Stefanie, Sousa, Inês, Soares, Ana R, Moura, Gabriela MR, Dedon, Peter C, and Santos, Manuel

Abstract

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Protein synthesis rate and accuracy are tightly controlled by the cell and are essential for proteome homoeostasis (proteostasis); however, the full picture of how mRNA translational factors maintain protein synthesis accuracy and co-translational protein folding are far from being fully understood. To address this question, we evaluated the role of 70 yeast tRNA-modifying enzyme genes on protein aggregation and used mass spectrometry to identify the aggregated proteins. We show that modification of uridine at anticodon position 34 (U34) by the tRNA-modifying enzymes Elp1, Elp3, Sml3 and Trm9 is critical for proteostasis, the mitochondrial tRNA-modifying enzyme Slm3 plays a fundamental role in general proteostasis and that stress response proteins whose genes are enriched in codons decoded by tRNAs lacking mcm5U34, mcm5s2U34, ncm5U34, ncm5Um34, modifications are overrepresented in protein aggregates of the ELP1, SLM3 and TRM9 KO strains. Increased rates of amino acid misincorporation were also detected in these strains at protein sites that specifically mapped to the codons sites that are decoded by the hypomodified tRNAs, demonstrating that U34 tRNA modifications safeguard the proteome from translational errors, protein misfolding and proteotoxic stress.

Published
2023

36. Vesicular stomatitis due to Indiana III (Alagoas/VSIV-3) is endemic in Brazilian state of Ceara/Estomatite vesicular causada pelo subtipo Indiana III (Alagoas/VVI-3) e endemica no estado do Ceara, Brasil

Author

Rocha, Celio Souza da, Oliveira, Ilanna Vanessa Pristo de Medeiros, Moura, Gabriela Hemylin Ferreira, Bezerra, Jose Artur Brilhante, Rondon, Fernanda Cristina Macedo, Vasconcelos, David Caldas, Almeida, Monica Marcos de, Cortez, Annira Aquino, Calabuig, Cecilia, and Antunes, Joao Marcelo Azevedo de Paula

Published
2020
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37. Brazilian food biodiversity: a richness invisible on our plates

Author

Gomes, Sávio, primary, Chaves, Viviany, additional, de Carvalho, Aline, additional, Silva, Elenilma da, additional, Neto, Elias de Menezes, additional, Moura, Gabriela, additional, Chaves, Leonardo, additional, Alves, Rômulo, additional, de Albuquerque, Ulysses, additional, Pereira, Fillipe, additional, and Jacob, Michelle, additional

Published
2023
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40. Biorreator osmótico anaeróbio acoplado à destilação com membranas como alternativa para a concentração e recuperação de nutrientes no tratamento de esgotos domésticos

Author

Arcanjo, Gemima Santos, primary, Santos, Carolina Rodrigues dos, additional, Cavalcante, Bárbara Fernandes, additional, Moura, Gabriela de Alcântara, additional, Ricci, Bárbara Caroline, additional, Mounteer, Ann Honor, additional, and Amaral, Míriam Cristina Santos, additional

Published
2023
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41. Occurrence of Apicomplexa protozoa in wild birds in the Northeast region of Brazil

Author

Moura, Gabriela Hémylin Ferreira, primary, Nascimento, Gleyce Silva do, additional, Oliveira, Pollyanne Raysa Fernandes de, additional, Santana, Vanessa Silva, additional, Shimabukuro, Ayko, additional, Valença, Yuri Marinho, additional, Calabuig, Cecilia, additional, Melo, Renata Pimentel Bandeira de, additional, and Mota, Rinaldo Aparecido, additional

Published
2023
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43. Analysing the Evolution of Repetitive Strands in Genomes

Author

Lousado, José P., Oliveira, José Luis, Moura, Gabriela R., Santos, Manuel A. S., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Omatu, Sigeru, editor, Rocha, Miguel P., editor, Bravo, José, editor, Fernández, Florentino, editor, Corchado, Emilio, editor, Bustillo, Andrés, editor, and Corchado, Juan M., editor

Published
2009
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44. Characterization of the Cultivable Microbiota Components of Marine Bioaerosols in the North Tropical Atlantic.

Author

Moura, Gabriela Cristina Chagas, Ayres, Yasmin Marques, Brito, Anna Luisa de Carvalho, Júnior, Edmilson Ferreira de Souza, Rocha, Rafael dos Santos, De Sousa, Paulo Miguel Vieira, Ferreira, Antônio Geraldo, Sousa, Oscarina Viana de, and Veleda, Doris

Subjects
*MICROBIOLOGICAL aerosols, *MARINE fungi, *MARINE bacteria, *OCEAN temperature, *OCEAN-atmosphere interaction, *ENTEROBACTERIACEAE
Abstract

Microorganisms are key to balancing marine ecosystems and have complex interactions at the ocean–atmosphere interface, affecting global climate and human health. This research investigated the diversity of cultivable bacteria and fungi in marine bioaerosols in the North Tropical Atlantic Ocean. Using the technique of spontaneous sedimentation in selective culture media, samples were collected during oceanographic expeditions. After isolation and purification, microbial strains were identified by phenotypic and genetic analyses. Fungi isolated included Acrophialophora, Aspergillus, Chrysosporium, Cladosporium, Fonsecaea, Mucor, Rhodotorula, Schizophyllum, Stemphylium, Candida, Curvularia, Cystobasidium, Exophiala, Neotestudina, Penicillium, Pestalotiopsis, and Preussia. The bacterial isolates belonged to the Bacillota, Pseudomonadota, Enterobacteriaceae family, Bacillus genus, and Serratia liquefaciens groups. About 40% of bacteria and 42% of fungi were identified as potential human pathogens, suggesting a relationship between human actions and the microbiota present in bioaerosols on the high seas. Sea surface temperature (SST) and wind speed influenced microorganisms. More studies and analyses in different scenarios should be conducted considering environmental and climate variables in order to deepen knowledge and generate information on the subject, so that standards can be established, and quality parameters determined. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Evaluation of the Potential of Brazilian Red Propolis in the Acceleration of Healing in Surgical Wounds

Author

Negri Giuseppina, Iberê Alves Freitas Carlos, E. P. Jara Carmen, Cesar Batista de Morais Marcos, Dantas de Medeiros Gerard Vicente, Salatino Antonio, Soares Batista Jael, Hémylin Ferreira Moura Gabriela, Costa de Menezes Manuela, da Silva Teófilo Tiago, Hugo Rodrigues Victor, Almeida Viana Geysa, and Peixoto Costa Wirton

Subjects
Acceleration, Complementary and alternative medicine, business.industry, Drug Discovery, Dentistry, Medicine, Surgical wound, Propolis, business
Abstract

Background : The use of red propolis has antimicrobial, anti-inflammatory, antioxidant activity results, and provides local conditions that optimize events involved in the healing process, accelerating tissue repair. Objective: To evaluate the chemical composition, antioxidant activity, cytotoxic effects, and healing potential of Red Propolis Hydroethanolic Extract (RPHE) on the surgical wounds of cats submitted ovarisalpingohisterectomy. Methods: Chemical analyses of RPHE were carried out using HPLC-DADESI-MS/MS. Antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrilhydrazyl) method, and cytotoxicity was evaluated using the MTT colorimetric method. The healing effect of the extract was evaluated in 60 domestic cats (Felis catus) divided into three groups: GI: treated with topical application RPHE; GII: received topical application of commercial rifamycin-based solution, and GIII: treated with topical application of 0.9% NaCl physiological solution. Surgical wounds were evaluated for clinical, macroscopic, and histological aspects. Results: The RPHE showed 26 flavonoids and high antioxidant activity. Propolis extract had no cytotoxic effect on any of the cell lines tested. High cell viability percentages were observed, ranging from 80.0% to 94.4% for L929 fibroblasts and 78.0% to 91.5% keratinocytes (Hacat). Red propolis had a positive influence on the healing of wounds in cats submitted to ovarisalpingohisterectomy because it promoted less intense inflammatory response, rapid closure of the wound, early deposition of collagen and reepithelization. Conclusion: The RPHE presented rich in flavanoids, high antioxidant activity, did not exert cytotoxic effect and promoted the acceleration of healing of surgical wounds.

Published
2021
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48. Assessment of the stability of a procedure for variables selection in high dimensionality data: an application to genomic data - Alzheimer’s disease

Author

Rodrigues, Leonor Carvalho, Cabral, Jorge, Tavares, Ana Helena, Enes, Vera, Pinheiro, Miguel, Moura, Gabriela, and Afreixo, Vera

Subjects
Akaike’s information criterion, Single nucleotide polymorphisms, Alzheimer’s disease, Stability, Least absolute shrinkage and selection operator
Abstract

Journal of Statistics on Health Decision, vol. 4 n.º 1 (2022): Special Issue - Statistics on Health Decision Making: Real World Data

Published
2022

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