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2. Use of a Multiplex PCR Assay To Assess the Presence of Treponema pallidum in Mucocutaneous Ulcerations in Patients with Suspected Syphilis

Author

Grange, P. A., primary, Jary, A., additional, Isnard, C., additional, Burrel, S., additional, Boutolleau, D., additional, Touati, A., additional, Bébéar, C., additional, Saule, J., additional, Martinet, P., additional, Robert, J.-L., additional, Moulene, D., additional, Vermersch-Langlin, A., additional, Benhaddou, N., additional, Janier, M., additional, and Dupin, N., additional

Published
2021
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3. Surveillance de la résistance génomique aux antibiotiques de Treponema pallidum subs pallidum des cas de syphilis précoce en France

Author

Sanchez, A., primary, Mayslich, C., additional, Malet, I., additional, Grange, P.-A., additional, Janier, M., additional, Saule, J., additional, Martinet, P., additional, Robert, J.-L., additional, Moulene, D., additional, Truchetet, F., additional, Pinault, A.-L., additional, Vermersch-Langlin, A., additional, Benhaddou, N., additional, Chanal, J., additional, and Dupin, N., additional

Published
2020
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4. Surveillance of Antibiotic Resistance Genes in Treponema Pallidum Subspecies Pallidum from Patients with Early Syphilis in France

Author

Sanchez, A, primary, Mayslich, C, additional, Malet, I, additional, Grange, P, additional, Janier, M, additional, Saule, J, additional, Martinet, P, additional, Robert, J, additional, Moulene, D, additional, Truchetet, F, additional, Pinault, A, additional, Vermersch-Langlin, A, additional, Benhaddou, N, additional, Chanal, J, additional, and Dupin, N, additional

Published
2020
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5. CONDYDAV : étude observationnelle multicentrique des patients présentant des condylomes dans les dispensaires antivénériens en France

Author

Chanal, J., Fouéré, S., Yassir-Oria, F., Spenatto, N., Bouscarat, F., Picot, E., Martinet, P., Vernay-Vaisse, C., Pelletier, F., Courtieu, C., Baclet, V., Bernier, C., Aymar-Moulene, D., Dupuis-Fourdan, F., Passeron, A., Bara-Passot, C., Pinault, A.-L., Misery, L., Janier, M., and Dupin, N.

Abstract

Les condylomes sont un des premiers motifs de consultation dans les centres de maladies sexuellement transmissibles (MST). Depuis 2007, la vaccination contre les papillomavirus humains (PVH) est autorisée en France. L’objectif de notre étude était de déterminer la prévalence des condylomes et le profil clinique et épidémiologique des patients avec condylomes consultant dans des centres de MST.

Published
2024
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6. Use of a Multiplex PCR Assay To Assess the Presence of Treponema pallidumin Mucocutaneous Ulcerations in Patients with Suspected Syphilis

Author

Grange, P. A., Jary, A., Isnard, C., Burrel, S., Boutolleau, D., Touati, A., Bébéar, C., Saule, J., Martinet, P., Robert, J.-L., Moulene, D., Vermersch-Langlin, A., Benhaddou, N., Janier, M., and Dupin, N.

Abstract

We evaluated the utility of the commercial Allplex genital ulcer real-time PCR multiplex assay for detecting Treponema pallidum(TPA), herpes simplex virus 1 (HSV-1) and 2 (HSV-2), and Chlamydia trachomatisserovar L (lymphogranuloma venereum [LGV]) DNA in mucosal and genital ulcers in the context of suspected syphilis. In total, 374 documented genital and mucosal ulcers from patients with and without syphilis presenting at several sexually transmitted infection (STI) centers in France from October 2010 to December 2016 were analyzed at the National Reference Center (CNR) for Bacterial STIs at Cochin Hospital in Paris. TPA detection results were compared with the final diagnosis based on a combination of clinical examination, serological results, and in-house nested PCR (nPCR).

Published
2021
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7. Surveillance de la résistance génomique aux antibiotiques de Treponema pallidum subs pallidumdes cas de syphilis précoce en France

Author

Sanchez, A., Mayslich, C., Malet, I., Grange, P.-A., Janier, M., Saule, J., Martinet, P., Robert, J.-L., Moulene, D., Truchetet, F., Pinault, A.-L., Vermersch-Langlin, A., Benhaddou, N., Chanal, J., and Dupin, N.

Abstract

La syphilis reste un problème de santé publique dans la plupart des pays occidentaux et le nombre de cas a augmenté depuis 2000. La benzathine pénicilline G (BPG) est le traitement de référence de la syphilis précoce, mais les ruptures de stock récentes renforcent la nécessité de valider des traitements alternatifs. Le but de cette étude était d’évaluer la présence des marqueurs génomiques de la résistance de Treponema pallidum subs pallidum(TPA) aux macrolides et à la doxycycline en France.

Published
2020
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