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1. Psychometric properties of the Weight Locus of Control Scale (MWLCS): study with Spanish individuals of different anthropometric nutritional status

Author

Cebolla, A., Botella, C., Galiana, L., Fernández-Aranda, F., Toledo, E., Corella, D., Salas-Salvadó, Jordi, Fitó, M., Romaguera, D., Wärnberg, J., Serra-Majem, L. L., Pintó, X., Buil-Cosiales, P., Sorlí, J. V., Díaz-López, A., De la Torre, R., de Mott, M. Fernández, Díaz González, B. V., Corbella, E., Yañez, A., and Baños, R.

Published
2020
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2. JavaScript: Best Practice

Author

James Kolce, Moritz Kroger, Ivan Curic, Samier Saeed, Jeff Mott, M. David Green, Craig Buckler

Published
2018

4. An MRI-based diagnostic framework for early diagnosis of dyslexia

Author

El-Baz, A., Casanova, M., Gimel’farb, G., Mott, M., and Switala, A.

Abstract

Abstract: Purpose: A computer-aided diagnosis (CAD) system for early diagnosis of dyslexia was developed and tested. Dyslexia can severely impair the learning abilities of children so improved diagnostic methods are needed. Neuropathological studies show abnormal anatomy of the cerebral white matter (CWM) in dyslexic brains. We sought to develop an MRI-based macroscopic neuropathological correlate to the minicolumnopathy of dyslexia that relates to cortical connectivity: the gyral window. The brains of dyslexic patients often exhibit decreased gyrifications, so the thickness of gyral CWM for dyslexic subjects is greater than for normal subjects. We developed an MRI-based method for assessment of gyral CWM thickness with automated recognition of abnormal (e.g., dyslexic) brains. Methods: In vivo data was collected from 16 right-handed dyslexic men aged 18–40 years, and a group of 14 controls matched for gender, age, educational level, socioeconomic background, handedness and general intelligence. All the subjects were physically healthy and free of history of neurological diseases and head injury. Images were acquired with the same 1.5T MRI scanner (GE, Milwaukee, WI, USA) with voxel resolution 0.9375  ×  0.9375  ×  1.5 mm using a T1-weighted imaging sequence protocol. The “ground truth” diagnosis to evaluate the classification accuracy for each patient was given by the clinicians. The accuracy of diagnosis/classification of both the training and test subjects was evaluated using the Chi-square test at the three confidence levels—85, 90 and 95%—in order to examine significant differences in the Levy distances. Results: As expected, the 85% confidence level yielded the best results, the system correctly classified 16 out of 16 dyslexic subjects (a 100% accuracy) and 14 out of 14 control subjects (a 100% accuracy). At the 90% confidence level, 16 out of 16 dyslexic subjects were still classified correctly; however, only 13 out of 14 control subjects were correct, bringing the accuracy rate for the control group down to 92.86%. The 95% confidence level obviously gives the smaller accuracy rates for both the groups, namely, 14 out of 16 correct answers for dyslexic subjects (87.5%) and still 13 out of 14 control subjects (92.86%). The classification based on traditional volumetric approach is 7 out of 16 dyslexic subjects (a 43.75% accuracy), and 9 out of 14 control subjects (a 64.29% accuracy) at a 85 confidence interval. These results highlight the advantage of the proposed diagnostic approach. Conclusion: We found that 3D texture analysis of MRI brain scans can accurately discriminate dyslexic and normal subjects in this feasibility trial. Our method for white matter segmentation and classification outperforms volumetric descriptions of brain structures and may be influenced less by age effects and segmentation errors. The proposed approach efficiently extracts quantitative features from 3D shapes of brain structures.

Published
2024
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8. (051) METHAMPHETAMINE-INDUCED VAGINAL LUBRICATION IN RATS AND THE ESTROUS CYCLE.

Author

Mott, M and Goeders, N

Subjects
*ESTRUS, *VAGINA, *LABORATORY rats, *VAGINAL dryness, *SEXUAL excitement
Abstract

Introduction: In an interview-based study performed by our lab of women who use methamphetamine (meth), we previously found that the drug, when delivered intravenously (IV), produces a feeling indistinguishable from an orgasm, which is accompanied by a flushing sensation and the production of excessive vaginal lubrication. We have also reported meth-induced vaginal lubrication in an anesthetized animal model. This production of vaginal transudate was dependent on the dose of meth used and the potent vasodilator nitric oxide. Objective: The objective of the current study was to assess meth-induced vaginal lubrication across different stages of the estrous cycle and following ovariectomy (ovx) in anesthetized rats, and to assess plasma levels of two signaling molecules associated with sexual arousal. Methods: Anesthetized rats, each previously implanted with a chronic indwelling jugular catheter, were anesthetized and given one IV infusion of meth (0.24 mg/kg) and vaginal lubrication was measured. A pre-weighed cotton-tipped swab, inserted into the vaginal canal, collected fluid secreted following the administration of meth. Blood was withdrawn before and at ten and fifteen minutes after meth administration either via the jugular catheter or via a small tail snip to measure plasma levels of estradiol and nitric oxide. Testing was completed at each stage of the estrous cycle as well as before and after ovariectomy. Results: Estradiol and nitric oxide increased following meth infusion similarly across all stages of the estrous cycle. Vaginal lubrication increased more with meth treatment than with saline treatment. This was true across all stages of the estrous cycle and despite ovariectomy. Conclusions: These findings have far-reaching implications for those who suffer from vaginal dryness. The mechanism underlying this phenomenon may present a novel pharmacotherapeutic target to treat vaginal dryness. Since meth still produced vaginal secretions in anesthetized rats, these results suggest that targeting this mechanism may even prove beneficial in post-menopausal women, a patient group likely at highest risk for experiencing vaginal dryness. Disclosure: Any of the authors act as a consultant, employee or shareholder of an industry for: Embera Neuurotherapeutics & JanOne. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Psychometric properties of the Weight Locus of Control Scale (MWLCS): study with Spanish individuals of different anthropometric nutritional status

Author

Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Cebolla, A.; Botella, C.; Galiana, L.; Fernandez-Aranda, F.; Toledo, E.; Corella, D.; Salas-Salvado, Jordi; Fito, M.; Romaguera, D.; Warnberg, J.; Serra-Majem, L. L.; Pinto, X.; Buil-Cosiales, P.; Sorli, J. V.; Diaz-Lopez, A.; De la Torre, R.; de Mott, M. Fernandez; Diaz Gonzalez, B. V.; Corbella, E.; Yanez, A.; Banos, R., Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and Cebolla, A.; Botella, C.; Galiana, L.; Fernandez-Aranda, F.; Toledo, E.; Corella, D.; Salas-Salvado, Jordi; Fito, M.; Romaguera, D.; Warnberg, J.; Serra-Majem, L. L.; Pinto, X.; Buil-Cosiales, P.; Sorli, J. V.; Diaz-Lopez, A.; De la Torre, R.; de Mott, M. Fernandez; Diaz Gonzalez, B. V.; Corbella, E.; Yanez, A.; Banos, R.

Abstract

Introduction The Multidimensional Weight Locus of Control Scale (MWLCS) measures a person's beliefs regarding the locus of control or lack of locus of control over his/her body weight. Purpose We aim to evaluate the factorial structure and psychometric properties of the MWLCS with Spanish normal weight, overweight and obese samples. Methods The research was carried out in two different studies. The first included a sample of 140 normal weight participants, selected out of a 274 sample recruited with an online survey. Study 2 was carried out in a sample of 633 participants recruited from the PREDIMED-Plus study. Out of them, 558 participants fulfilled the weight criteria and were categorized into: overweight (BMI 25 - < 29.99; N = 170), obese class I (BMI 30 - < 34.99; N = 266), and obese class II (BMI 35 - < 39.99; N = 122). Exploratory (EFA) and confirmatory (CFA) factor analyses were used to evaluate the factor structure of the MWLCS, and reliabilities and Spearman's correlations were estimated. Invariance measurement was tested across the three subgroups of weight in Study 2. Results A three-factor structure indicating weight locus of control factors (internal, chance, and powerful others) was supported, both via EFA in the normal weight sample and CFA in the overweight and obese samples. In the normal weight sample, the powerful others dimension was positively related to BMI and the dimensions of the Dutch Eating Behaviors Questionnaire. Additionally, the scale showed evidence of scalar invariance across the groups with different weight conditions. Conclusions This scale seems to be a psychometrically appropriate instrument and its use is highly recommended when designing interventions for overweight or obese individuals.

Published
2020

15. Multidimensional Weight Locus of Control Scale--Spanish Version

Author

Cebolla, A., primary, Botella, C., additional, Galiana, L., additional, Fernández‑Aranda, F., additional, Toledo, E., additional, Corella, D., additional, Salas‑Salvadó, Jordi, additional, Fitó, M., additional, Romaguera, D., additional, Wärnberg, J., additional, Serra‑Majem, L. L., additional, Pintó, X., additional, Buil‑Cosiales, P., additional, Sorlí, J. V., additional, Díaz‑López, A., additional, De la Torre, R., additional, Fernández de Mott, M., additional, Díaz González, B. V., additional, Corbella, E., additional, Yañez, A., additional, and Baños, R., additional

Published
2020
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17. National Scientific Medical Meeting 1994 Abstracts

Author

Carson, K. D., Grimes, S. B., McGinley, J. M., Thornton, M. T., Mulhall, J., Bourke, A. M., McCrory, C., Marsh, B., Hone, R., Phelan, D., White, M., Fabry, J., Hughes, D., Carson, K., Donnelly, M., Shanahan, E., Fitzpatrick, G. J., Bourke, M., Warde, D., Buggy, D., Hughes, N., Taylor, A., Dowd, N., Markham, T., Blunnie, W., Nicholson, G., O’Leary, E., Cunningham, A. J., Dwyer, R., McMechan, S., Cullen, C., Dempsey, G., Wright, G., MacKenzie, G., Anderson, J., Adgey, J., Walsh, M., O’Callaghan, P., Graham, I., O’Hare, J. A., Geoghegan, M., Iman, N., Shah, P., Chander, R., Lavin, F., Daly, K., Johnston, P. W., Imam, Z., Adgey, A. A. J., Rusk, R. A., Richardson, S. G., Hale, A., Kinsella, B. M., FitzGerald, G. A., King, G., Crean, P., Gearty, G., Cawley, T., Docherty, J. R., Geraghty, J., Osborne, H., Upton, J., D’Arcy, G., Stinson, J., Cooke, T., Colgan, M. P., Hall, M., Tyrrell, J., Gaffney, K., Grouden, M., Moore, D. J., Shanik, G., Feely, J., Delanty, N., Reilly, M., Lawson, J. A., Fitzgerald, D. J., Reilly, M. P., McAdam, B. F., Bergin, C., Walshe, M. J., Herity, N. A., Allen, J. D., Silke, B., Singh, H. P., O’Neill, S., Hargrove, M., Coleman, E., Shorten, E., Aherne, T., Kelly, B. E., Hill, D. H., McIlrath, E., Morrow, B. C., Lavery, G. G., Blackwood, B., Fee, J. P. H., Kevin, L., Doran, M., Tansey, D., Boylan, I., McShane, A. J., O’Reilly, G., Tuohy, B., Grainger, P., Larkin, T., Mahady, J., Malone, J., Condon, C., Donoghue, T., O’Leary, J., Lyons, J. F., Tay, Y. K., Tham, S. N., Khoo Tan, H. S., Gibson, G., O’Grady, A., Leader, M., Walshe, J., Carmody, M., Donohoe, J., Murphy, G. M., O’Connor, W., Barnes, L., Watson, R., Darby, C., O’Moore, R., Mulcahy, F., O’Toole, E., O’Briain, D. S., Young, M. M., Buckley, D., Healy, E., Rogers, S., Ni Scannlain, N., McKenna, M. J., McBrinn, Y., Murray, B., Freaney, R., Barrett, E., Razza, Q., Abuaisha, F., Powell, D., Murray, T. M., Powell, A. M., O’Mongain, E., O’Neill, J., Kernan, R. P., O’Connor, P., Clarke, D., Fearon, U., Cunningham, S. K., McKenna, T. J., Hayes, F., Heffernan, A., Sheahan, K., Harper, R., Johnston, G. D., Atkinson, A. B., Sheridan, B., Bell, P. M., Heaney, A. P., Loughrey, G., McCance, D. R., Hadden, D. R., Kennedy, A. L., McNamara, P., O’Shaughnessy, C., Loughrey, H. C., Reid, I., Teahan, S., Caldwell, M., Walsh, T. N., McSweeney, J., Hennessy, T. P., Caldwell, M. T. P., Byrne, P. J., Hennessy, T. P. J., El-Magbri, A. A., Stevens, F. M., O’Sullivan, R., McCarthy, C. F., Laundon, J., Heneghan, M. A., Kearns, M., Goulding, J., Egan, E. L., McMahon, B. P., Hegarty, F., Malone, J. F., Merriman, R., MacMathuna, P., Crowe, J., Lennon, J., White, P., Clarke, E., Prabhakar, M. C., Ryan, E., Graham, D., Yeoh, P. L., Kelly, P., McKeogh, D., O’Keane, C., Kitching, A., Mulligan, E., Gorey, T. F., Mahmud, N., O’Connell, M., Goggins, M., Keeling, P. W. N., Weir, D. G., Kelleher, D., McDonald, G. S. A., Maguire, D., O’Sullivan, G., Harvey, B., Cherukuri, A., McGrath, J. P., Timon, C., Lawlor, P., O’Shea, J., Buckley, M., English, L., Walsh, T., O’Morain, C., Lavelle, S. M., Kanagaratnam, B., Harding, B., Murphy, B., Kavanagh, J., Kerr, D., Lavelle, E., O’Gorman, T., Liston, S., Fitzpatrick, C., Fitzpatrick, P., Turner, M., Murphy, A. W., Cafferty, D., Dowling, J., Bury, G., Kaf Al-Ghazal, S., Zimmermann, E., O’Donoghue, J., McCann, J., Sheehan, C., Boissel, L., Lynch, M., Cryan, B., Fanning, S., O’Meara, D., Fennell, J., Byrne, P. M., Lyons, D., Mulcahy, R., Pooransingh, A., Walsh, J. B., Coakley, D., O’Neill, D., Ryall, N., Connolly, P., Namushi, R., Lawler, M., Locasciulli, A., Bacigalupo, A., Humphries, P., McCann, S. R., Pamphilon, D., Reidy, M., Madden, M., Finch, T., Borton, M., Barnes, C. A., Lawlor, S. E., Gardiner, N., Egan, L. J., Orren, A., Doherty, J., Curran, C., O’Hanlon, D., Kent, P., Kerin, M., Maher, D., Given, H. F., Lynch, S., McManus, R., O’Farrelly, C., Madrigal, L., Feighery, C., O’Donoghue, D., Whelan, C. A., Rea, I. M., Stewart, M., Campbell, P., Alexander, H. D., Crockard, A. D., Morris, T. C. M., Maguire, H., Davidson, F., Kaminski, G. Z., Butler, K., Hillary, I. B., Parfrey, N. A., Crowley, B., McCreary, C., Keane, C., O’Reilly, M., Goh, J., Kennedy, M., Fitzgerald, M., Scott, T., Murphy, S., Hildebrand, J., Holliman, R., Smith, C., Kengasu, K., Riain, U. Ni, Cormican, M., Flynn, J., Glennon, M., Smith, T., Whyte, D., Keane, C. T., Barry, T., Noone, D., Maher, M., Dawson, M., Gilmartin, J. J., Gannon, F., Eljamel, M. S., Allcut, D., Pidgeon, C. N., Phillips, J., Rawluk, D., Young, S., Toland, J., Deveney, A. M., Waddington, J. L., O’Brien, D. P., Hickey, A., Maguire, E., Phillips, J. P., Al-Ansari, N., Cunney, R., Smyth, E., Sharif, S., Eljamel, M., Pidgeon, C., Maguire, E. A., Burke, E. T., Staunton, H., O’Riordan, J. I., Hutchinson, M., Norton, M., McGeeney, B., O’Connor, M., Redmond, J. M. T., Feely, S., Boyle, G., McAuliffe, F., Foley, M., Kelehan, P., Murphy, J., Greene, R. A., Higgins, J., Darling, M., Byrne, P., Kondaveeti, U., Gordon, A. C., Hennelly, B., Woods, T., Harrison, R. F., Geary, M., Sutherst, J. R., Turner, M. J., DeLancey, J. O. L, Donnelly, V. S., O’Connell, P. R., O’Herlihy, C., Barry-Kinsella, C., Sharma, S. C., Drury, L., Lewis, S., Stratton, J., Ni Scanaill, S., Stuart, B., Hickey, K., Coulter-Smith, S., Moloney, A., Robson, M. S., Murphy, M., Keane, D., Stronge, J., Boylan, P., Gonsalves, R., Blankson, S., McGuinness, E., Sheppard, B., Bonnar, J., MacDonagh-White, C. M., Kelleher, C. C., Newell, J., White, O., Young, Y., Hallahan, C., Carroll, K., Tipton, K., McDermott, E. W., Reynolds, J. V., Nolan, N., McCann, A., Rafferty, R., Sweeney, P., Carney, D., O’Higgins, N. J., Duffy, M. J., Grimes, H., Gallagher, S., O’Hanlon, D. M., Strattan, J., Lenehan, P., Robson, M., Cusack, Y. A., O’Riordain, D., Mercer, P. M., Smyth, P. P. A., Gallagher, H. J., Moule, B., Cooke, T. G., McArdle, C. S., Burke, C., Vance, A., Saidtéar, C., Early, A., Eustace, P., Maguire, L., Cullinane, A. B. P., Prosser, E. S., Coca-Prados, M., Harvey, B. J., Saidléar, C., Orwa, S., Fitzsimons, R. B., Bradley, O., Hogan, M., Zimmerman, L., Wang, J., Kuliszewski, M., Liu, J., Post, M., Premkumar, Conran, M. J., Nolan, G., Duff, D., Oslizlok, P., Denham, B., O’Connell, P. A, Birthistle, K., Hitchcock, R., Carrington, D., Calvert, S., Holmes, K., Smith, D. F., Hetherton, A. M., Mott, M. G., Oakhill, A., Foreman, N., Foot, A., Dixon, J., Walsh, S., Mortimer, G., O’Sullivan, C., Kilgallen, C. M., Sweeney, E. C., Brayden, D. J., Kelly, J. G., McCormack, P. M. E., Hayes, C., Johnson, Z., Dack, P., Hosseini, J., O’Connell, T., Hemeryck, L., Condren, L., McCormack, P., McAdam, B., Lawson, J., Keimowitz, R., O’Leary, A., Pilkington, R., Adebayo, G. I., Gaffney, P., McGettigan, P., McManus, J., O’Shea, B., Wen, Y., Killalea, S., Golden, J., Swanwick, G., Clare, A. W., Mulvany, F., Byrne, M., O’Callaghan, E., Byrne, H., Cannon, N., Kinsella, T., Cassidy, B., Shepard, N., Horgan, R., Larkin, C., Cotter, D., Coffey, V. P., Sham, P. C., Murray, L. H., Lane, A., Kinsella, A., Murphy, P., Colgan, K., Sloan, D., Gilligan, P., McEnri, J., Ennis, J. T., Stack, J., Corcoran, E., Walsh, D., Thornton, L., Temperley, I., Lawlor, E., Tobin, A., Hillary, I., Nelson, H. G., Martin, M., Ryan, F. M., Christie, M. A., Murray, D., Keane, E., Holmes, E., Hollyer, J., Strangeways, J., Foster, P., Stanwell-Smith, R., Griffin, E., Conlon, T., Hayes, E., Clarke, T., Fogarty, J., Moloney, A. C., Killeen, P., Farrell, S., Clancy, L., Hynes, M., Conlon, C., Foley-Nolan, C., Shelley, E., Collins, C., McNamara, E., Hayes, B., Creamer, E., LaFoy, M., Costigan, P., Al fnAnsari, N., Cunney, R. J., Smyth, E. G., Johnson, H., McQuoid, G., Gilmer, B., Browne, G., Keogh, J. A. B., Jefferson, A, Smith, M., Hennessy, S., Burke, C. M., Sreenan, S., Power, C. K., Pathmakanthan, S., Poulter, L. W., Chan, A., Sheehan, M., Maguire, M., O’Connor, C. M., FitzGerald, M. X., Southey, A., Costello, C. M., McQuaid, K., Urbach, V., Thomas, S., Horwitz, E. R., Mulherin, D., FitzGerald, O., Bresnihan, B., Kirk, G., Veale, D. J., Belch, J. J. F., Mofidi, A., Mofidi, R., Quigley, C., McLaren, M., Veale, D., D’Arrigo, C., Couto, J. Candal, Woof, J., Greer, M., Cree, I., Belch, J., Hone, S., Fenton, J., Hamilton, S., and McShane, D.

Published
1994
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18. Model-driven systems development

Author

Balmelli, L., Brown, D., Cantor, M., and Mott, M.

Subjects
System development -- Analysis, Systems engineering -- Analysis
Published
2006

21. Psychometric properties of the Weight Locus of Control Scale (MWLCS): study with Spanish individuals of different anthropometric nutritional status

Author

Cebolla, A., primary, Botella, C., additional, Galiana, L., additional, Fernández-Aranda, F., additional, Toledo, E., additional, Corella, D., additional, Salas-Salvadó, Jordi, additional, Fitó, M., additional, Romaguera, D., additional, Wärnberg, J., additional, Serra-Majem, L. L., additional, Pintó, X., additional, Buil-Cosiales, P., additional, Sorlí, J. V., additional, Díaz-López, A., additional, De la Torre, R., additional, de Mott, M. Fernández, additional, Díaz González, B. V., additional, Corbella, E., additional, Yañez, A., additional, and Baños, R., additional

Published
2019
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25. Do visual evoked potentials detect neural damage in children treated for cancer?

Author

Verity, C.M., Morgan, Hilary, Mott, M., and Oakhill, A.

Subjects
Radiotherapy -- Complications, Brain damage -- Evaluation, Methotrexate -- Adverse and side effects, Visual evoked response -- Measurement, Visual evoked response -- Evaluation, Chemotherapy -- Complications, Lymphoblastic leukemia in children -- Care and treatment, Health
Abstract

Radiation and chemotherapy (with methotrexate) can reduce the incidence of central nervous system relapse among children with acute lymphoblastic leukemia (ALL), a malignancy of the blood cells characterized by the formation of immature, incompetent cells. However, these treatments can also damage cells of the nervous system (neurons). One tool that has been suggested for the early detection of neurotoxicity during treatment of ALL is the visual evoked potential (VEP), a recording of the brain's electrical response to visual stimuli. Recordings are made by means of scalp electrodes, a noninvasive procedure. The ability of VEPs to identify incipient neural damage was tested by studying several groups of pediatric ALL patients. The groups consisted of one prospective group (six children) of ALL patients, enrolled in the study at the time of diagnosis, and three follow-up groups; 23 patients who had been treated with cranial irradiation (CI) and methotrexate; 11 patients who had medulloblastoma (a kind of brain tumor) and received a higher dose of CI, but no methotrexate; and four osteosarcoma (bone tumor) patients who had been treated with methotrexate, but no CI. A control group was formed of 34 siblings of the treated children. VEPs were recorded for all children to both flash stimuli and pattern-reversal stimuli (where a change in pattern causes a change in the evoked response). Results showed that differences between the groups in VEP amplitude and latency did exist, but most children had values within a normal range. A discussion of other research results is provided. Overall, the findings did not support the use of VEPs to detect damage to the visual system. It is recommended that children undergoing treatment for cancer should be protected from unnecessary testing. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

37. The Childhood Lymphomas

Author

Mott, M. G., Herfarth, Ch., editor, Senn, H. J., editor, Baum, M., editor, von Essen, C., editor, Diehl, V., editor, Hitzig, W., editor, Rajewsky, M. F., editor, Thomas, C., editor, and Duncan, William, editor

Published
1983
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42. Exposure to power frequency electric fields and the risk of childhood cancer in the UK

Author

Skinner, J, Mee, TJ, Blackwell, RP, Maslanyj, MP, Simpson, J, Allen, SG, Day, NE, Cheng, KK, Gilman, E, Williams, D, Cartwright, R, Craft, A, Birch, JM, Eden, OB, McKinney, PA, Deacon, J, Peto, J, Beral, V, Roman, E, Elwood, P, Alexander, FE, Mott, M, Chilvers, CE, Muir, K, Doll, R, Taylor, CM, Greaves, M, Goodhead, D, Fry, FA, Adams, G, and Law, G

Subjects
Male, Cancer Research, Pediatrics, medicine.medical_specialty, Adolescent, Epidemiology, Childhood cancer, Population, Child Welfare, Pilot Projects, electric fields, Risk Assessment, Central Nervous System Neoplasms, Electromagnetic Fields, Neoplasms, Odds Ratio, Medicine, childhood cancer, Humans, education, Child, education.field_of_study, Leukemia, business.industry, Incidence (epidemiology), Incidence, Case-control study, Infant, Newborn, Infant, Environmental exposure, Odds ratio, Environmental Exposure, Confidence interval, United Kingdom, Oncology, Case-Control Studies, Child, Preschool, leukaemia, Housing, Female, Risk assessment, business
Abstract

The United Kingdom Childhood Cancer Study, a population-based case–control study covering the whole of Great Britain, incorporated a pilot study measuring electric fields. Measurements were made in the homes of 473 children who were diagnosed with a malignant neoplasm between 1992 and 1996 and who were aged 0–14 at diagnosis, together with 453 controls matched on age, sex and geographical location. Exposure assessments comprised resultant spot measurements in the child's bedroom and the family living-room. Temporal stability of bedroom fields was investigated through continuous logging of the 48-h vertical component at the child's bedside supported by repeat spot measurements. The principal exposure metric used was the mean of the pillow and bed centre measurements. For the 273 cases and 276 controls with fully validated measures, comparing those with a measured electric field exposure ⩾20 V m−1 to those in a reference category of exposure

Published
2002

43. The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionising radiation: 2: gamma radiation

Author

Cartwright, RA, Law, G, Roman, E, Gilman, E, Eden, OB, Mott, M, Muir, K, Goodhead, D, Kendall, G, Cheng, KK, Day, N, Craft, A, Birch, JM, McKinney, PA, Peto, J, Beral, V, Elwood, P, Alexander, FE, Chilvers, CED, Doll, R, Taylor, GM, Greaves, M, Goodhead, DT, Fry, FA, Adams, G, Skinner, J, Williams, D, Deacon, J, Simpson, J, and Investigat, UKCCS

Subjects
non-Hodgkin's lymphoma, gamma dose rate, Cancer Research, medicine.medical_specialty, acute lymphoblastic leukaemia, Epidemiology, chemistry.chemical_element, Radon, Radiation, Radiation Dosage, Malignancy, Ionizing radiation, Radiation, Ionizing, Environmental health, medicine, childhood cancer, Humans, Medical physics, Child, radon interactions, central nervous system tumours, Geography, Gamma ray, Case-control study, Cancer, Environmental Exposure, Environmental exposure, medicine.disease, United Kingdom, Oncology, chemistry, Gamma Rays, Air Pollution, Indoor, Case-Control Studies, Housing, Regression Analysis
Abstract

This article reports measurements of household levels of gamma and cosmic rays at the addresses of children with cancer at the time of diagnosis and six months before, and of similar data at the addresses of control children. There is no indication of increased risk with increasing dose rates either in matched or unmatched analyses, with or without adjustment for deprivation. Sub-division by diagnostic group did not reveal any association with any specific types of malignancy. Studies of the relationship between household gamma rays and radon concentration show no evidence of any interactions. British Journal of Cancer (2002) 86, 1727–1731. doi:10.1038/sj.bjc.6600277 www.bjcancer.com © 2002 Cancer Research UK

Published
2002

44. Childhood cancer and residential proximity to power lines

Author

Cheng, KK, Day, NE, Cartwright, R, Craft, A, Birch, JM, Eden, OB, McKinney, PA, Peto, J, Beral, V, Roman, E, Elwood, P, Alexander, FE, Chilvers, CED, Doll, R, Greaves, M, Goodhead, D, Fry, FA, Adams, G, Gilman, E, Skinner, J, Williams, D, Deacon, J, Mott, M, Muir, K, Law, G, Simpson, J, and Investigat, UKCCS

Subjects
Cancer Research, medicine.medical_specialty, Pediatrics, Electric Wiring, Adolescent, Childhood cancer, Population, magnetic fields, Malignancy, Central Nervous System Neoplasms, Electric Power Supplies, Electromagnetic Fields, Neoplasms, Epidemiology, childhood cancer, Humans, Medicine, Child, education, education.field_of_study, business.industry, Infant, Newborn, Case-control study, Infant, Cancer, Regular Article, Environmental Exposure, Environmental exposure, Odds ratio, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, United Kingdom, Oncology, Case-Control Studies, Child, Preschool, leukaemia, power lines, business
Abstract

In the United Kingdom Childhood Cancer Study, a population-based case–control study covering the whole of England, Scotland and Wales, measured power-frequency magnetic fields were not found to be associated with risk for any malignancy. To examine further the risk associated with residential proximity to electricity supply equipment, distances to high-voltage lines, underground cables, substations and distribution circuits were collected for 3380 cases and 3390 controls. Magnetic field exposure from this equipment was calculated using distance, load and other circuit information. There was no evidence that either proximity to electrical installations or the magnetic field levels they produce in the UK is associated with increased risk of childhood leukaemia or any other cancer. Odds ratios of 0.73 (95% CI = 0.42–1.26) for acute lymphoblastic leukaemia, 0.75 (95% CI = 0.45–1.25) for all leukaemias, 1.08 (95% CI = 0.56–2.09) for central nervous system cancers and 0.92 (95% CI = 0.64–1.34) for all malignancies were obtained for residence within 50 m of an overhead line. When individuals with a calculated magnetic field exposure ≥ 0.2 μT were compared to those in a reference category of exposure

Published
2000

48. (006) Methamphetamine-Induced Vaginal Lubrication.

Author

Mott, M and Goeders, N

Subjects
*VAGINA, *VAGINAL dryness, *VAGINAL medication, *LABORATORY rats, *PELVIS, *IMPLANTABLE catheters
Abstract

Introduction: Vaginal dryness is a frequent complaint, especially in post-menopausal women. The physiology underlying the production of vaginal lubrication in response to arousing stimuli is established; however, no current pharmacological agents successfully target mechanisms within this physiology. Previous research from our lab has demonstrated that female methamphetamine (meth) users experience the immediate production of excessive vaginal lubrication, accompanied by a warmth or flushing sensation spreading from the chest areas to the pelvic region, when using the drug intravenously (IV). The physiological source of this previously undescribed effect of meth could present a potential mechanism to enhance a woman's natural production of vaginal lubrication, providing a potentially life-changing option to patients experiencing vaginal dryness. Objectives: The purpose of the current study was to determine if vaginal lubrication induced by IV meth use reported in a previous study from our lab occurs in rats, and if this effect is dose-dependent. This study also sought to begin to uncover the mechanism behind this phenomenon. Methods: Adult female Wistar rats (n=8) were implanted with chronic indwelling jugular catheters and allowed at least one week to recover from surgery. Rats anesthetized with isoflurane gas were intravenously infused with one of seven doses of meth ranging from 0.015-0.96 mg/kg meth or saline IV via the implanted catheter. Pre-weighed cotton-tipped swabs inserted into the vaginal canal collected fluid secreted following drug administration. The change in weight of the swab was taken as the weight of fluid produced. Consequent studies examined several signaling molecules in plasma known to have an influence on vaginal lubrication, including the steroid hormones estradiol, progesterone and testosterone, as well as the gaseous vasodilator nitric oxide. These molecules were measured at time points up to 60 minutes after meth administration. Results: As hypothesized, meth increased vaginal lubrication in a dose-dependent manner. Doses of 0.06 and 0.24 mg/kg of meth induced significant increases in vaginal lubrication compared to saline. Further, compared to pre-meth levels, significant increases in estradiol were seen at two and 15 minutes after meth administration. Significant increases in progesterone, testosterone and nitric oxide were seen ten minutes after meth administration. Conclusions: This study has far-reaching implications since the majority of women will experience vaginal dryness at least once, if not recurrently. The underlying mechanism of meth-induced vaginal lubrication, when elucidated, may provide a pharmacological target in treating not only meth use disorder, but also the millions of women suffering from vaginal dryness. Disclosure: No. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Prevalence of Child and Adult Sexual Abuse and Risk Taking Practices Among HIV Serodiscordant African-American Couples

Author

El-Bassel, N, Wingood, G, Wyatt, GE, III, JJB, Pequegnat, W, Landis, JR, Bellamy, S, Gilbert, L, Remien, RH, Witte, S, Wu, E, DiClemente, R, Myers, H, Jemmott, LS, Metzger, D, Brown, T, Greene, Q, Helker, C, Robinson, N, Allen-Taylor, L, Appleby, D, Crowley, E, Ankoma, A, Ashton, D, Goddard, DA, Daniel, T, Henderson, T, Rivkin, I, Green, CM, Cheraquit, RD, Gray, D, Hakim, L, Sarfo, B, Saunders, K, Simmons, D, Wilson, K, Braxton, ND, Camp, C, Conner, A, Gibson, J, Harmon, A, Latham, T, Pennick-Walters, T, Rucker, K, Steinback, S, Williams, P, Williams, R, Williams, S, Chancy, K, Levels, F, Thomas, N, Bennett, R, Bryson, S, Curtis, S, Jones, M, Jones, P, Moore, M, Patterson, C, Penn, M, Samuel, A, Shine, R, Stevenson, R, Tate, R, Taylor, M, Wroton, C, Griffith, D, Johnson, P, Matthews, L, Mendoza, R, Winkle, A, Daugherty, J, Er, D, Felix, L, Hailemeskal, M, Howard, T, Hoyte, T, Smith, J, Smith, L, DeMorst, L, Regan, R, Rogers, E, Carter, K, Collier, C, Croom, M, Samuel, D, Sosa, J, Taylor, B, Bryan, TS, Robinson-Simpson, L, Loeb, T, Williams, J, Gueits, L, Bayer, C, Caliendo, A, Freeman, S, Ingersoll, J, Maslankowski, L, McGee-Smith, D, Moorer, P, Mott, M, Woodard, B, Bannerman, C, Blake, W, Bratts, T, Copeland, O, De Jesus-Sosa, D, Faly, A, Hsu, J, Irobunda, H, Johnson, S, Napoleon, F, Williams, K, Combs, S, MacDonald, M, Roy, L, White, D, Woods, P, Wyatt, C, and Prevention, NIMHMHIVSTD

Subjects
Serodiscordant, Adult sexual abuse, HIV, African-American couples, Sexual re-victimization, Child sexual abuse
Published
2010

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