1. Eight nerve in experimental lead poisoning
- Author
-
Moszyński B and Gozdzik-Zolnierkiewicz T
- Subjects
Pathology ,medicine.medical_specialty ,Time Factors ,Guinea Pigs ,Scarpa's ganglion ,Lead poisoning ,Pathogenesis ,otorhinolaryngologic diseases ,medicine ,Animals ,Inner ear ,business.industry ,Histological Techniques ,General Medicine ,Vestibulocochlear Nerve ,medicine.disease ,Lead Poisoning ,medicine.anatomical_structure ,Otorhinolaryngology ,Lead ,Lead acetate ,Anesthesia ,Ear, Inner ,Etiology ,sense organs ,business ,Axonal degeneration ,Demyelinating Diseases - Abstract
Forty healthy guinea pigs were poisoned with repeated peritoneal injections of lead acetate. After 7 weeks the animals were sacrificed and the inner ear with VIII nerve were examined histologically. The lead level in the blood was estimated in all animals after poisoning and in 10 healthy guinea pigs (control group). The sensory cells of the inner ear, the spiral and vestibular ganglion cells appeared to be normal. The VIII nerve in the majority of poisoned animals showed segmental deniyelina-tion and axonal degeneration. Theories on etiology and pathogenesis of the neuropathological changes in lead poisoning are discussed.
- Published
- 1969