Search

Background: Pre-eclampsia (PE) is associated with a high rate of maternal and perinatal morbidity and mortality, so its prediction has a tremendous impact on its management. Objectives: To evaluate the role of uterine artery Doppler indices in the prediction of pre-eclampsia during the first trimester of pregnancy. Patients and methods: During the early stages of their pregnancies, 60 expectant mothers received early pregnancy care at South Valley University Hospital between weeks 9 and 11. Assessments included clinical exams, medical history, lab tests, abdominal ultrasound, and uterine artery Doppler scans at 9, 11, and 18 weeks. Results: The mean age of patients was 24.8 ± 3.4 years, with a mean body mass index (BMI) of 24 ± 2.3 kg/m2. There were 13 patients (23.6%) with PE; out of them, 9 patients had a severe form of PE, and 42 patients (76.4%) had no PE. Doppler flow study of the uterine artery at 9–11 and 18 weeks showed statistically significant (p-value

Background: Missed Abortion is non-viable intrauterine pregnancy with either an empty gestational sac or a gestational sac contains an embryo without fetal heart activity. Objectives: The aim of this study was to compare effect of misoprostol with clomiphene citrate, misoprostol with letrozole and misoprostol alone in terminating first trimester missed abortion. Patients and methods: This randomized clinical trial was included patients with missed abortion attending to our outpatient clinic at South Valley University Hospital, Department of Obstetrics and Gynecology. Fifteen patients were excluded during the follow-up period; hence, 37 patients per group were included in the final analysis. They divided into three groups: Interventional group (A): received 5mg letrozole ; Group (B): received 100 mg clomiphene citrate and Group (C): Control group received calcium carbonate . Then all patients received two doses of 800 microgram misoprostol orally. Results: As regard outcome among the three studied groups. The results showed that 21.6% cases in group (A) showed failure in management with six cases needed surgical evacuation and two cases completed treatment on misoprostol, 32.4% cases in group(B) showed failure in management with ten cases needed surgical evacuation and two cases completed treatment on misoprostol and 37.8% cases in group(C) showed failure in management with ten cases needed surgical evacuation and four cases completed treatment on misoprostol. Conclusion: Letrozole pre-treatment with misoprostol increases efficacy of misoprostol in induction of complete abortion of non-viable first trimester pregnancy with no evident side effects.

Background: Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine and metabolic conditions in premenopausal women. Objectives: The goal of this study was to see the efficacy of Letrozole in conjunction with clomiphene citrate versus Letrozole alone in inducing ovulation in PCOS patients. Patients and methods: This was a randomized clinical trial (RCT) done on a total of 200 patients who came to South Valley University, Obstetrics and Gynecology clinics, after receiving the ethical committee permission and signed informed consent from all participants. Results: Regarding all treatment outcomes, there were no statistically substantial difference among the two groups as regards the following parameters: ovulation, mature follicle number, endometrial thickness, OHSS, single pregnancy, clinical pregnancy, multiple pregnancy and miscarriage, P>0.05. Conclusion: this research showed that in terms of infertility therapy in women with PCOS, the combination of letrozole and CC was linked to"Although there is absolute difference between the two groups in favor of the combined use of letrozole plus clomiphene citrate, this difference is not statistically significant". These new findings indicate that this combined therapy might be a low-risk, low-cost infertility treatments.