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186 results on '"Mostafa, Nada A."'

8. Nutraceuticals in Cancer Therapy : Challenges and Opportunities

Author

Fayez, Shaimaa, Ayoub, Iriny M., Mostafa, Nada M., Moussa, Ashaimaa Y., Gamal ElDin, Mariam I., El-Shazly, Mohamed, Takayanagi, Takehiko, Section editor, Radhakrishnan, Prakash, Section editor, Günes-Bayir, Ayse, Section editor, Munirathinam, Gnanasekar, Section editor, Munsi, Anjana, Section editor, and Chakraborti, Sajal, editor

Published
2022
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13. Acremochlorin O and Other Prenylated Chlorophenol Antimicrobial Metabolites from the Fungus Acremonium sp. Strain MNA-F-1

Author

Elnaggar, Mohamed S, primary, Mostafa, Nada M, additional, Elissawy, Ahmed M, additional, Phutthacharoen, Kunthida, additional, Eckhardt, Paul, additional, Sandargo, Birthe, additional, van Geelen, Lasse, additional, Ebada, Sherif S, additional, Opatz, Till, additional, Singab, Abdel Nasser B, additional, and Kalscheuer, Rainer, additional

Published
2024
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15. Effects of Rootstock Bunches on the Qualitative Properties and Antioxidant Activity of Seedless Grapes (Vitis vinifera) during Cold Storage with Molecular Docking of the Peptides.

Author

M. Qaoud, EL-Sayed, A. Mostafa, Nada, A. Abdelgawad, Zinab, A. I. Ahmed, Mohamed, A. Abdeen, Habiba, M. E. Hussein, Esraa, S. A. Abd El-Rahman, Amira, M. A. Radwan, Essam, Y. Mohamed, Sayed, A. Hussein, Hebat-Allah, Awad Al-Harbi, Nadi, Mesfir Al-Qahtani, Salem, M. Alqahtani, Mesfer, Mohammed Alzuaibr, Fahad, Alasmari, Abdulrahman, S. Ghazzawy, Hesham, A. A., Lo'ay, A. Abdein, Mohamed, S. Hussein, Azza, and Harbertson, James

Subjects
*COLD storage, *VITIS vinifera, *ENDOENZYMES, *VITAMIN C, *MOLECULAR docking
Abstract

The effect of three rootstocks on the responsiveness of "Superior Seedless" grapes to cold storage was investigated in this study during the growing seasons of 2021 and 2022. The "Superior Seedless" bunches were preserved for 90 days at 4 ± 1°C and 98 ± 2 relative humidity%. The "Superior Seedless" bunch response under cold storage was shown to be influenced by the rootstocks. According to the study, bunches picked from "Superior Seedless" that were grown on the "1103 Paulson" rootstocks performed better in antioxidant enzyme activities (AEAs) than bunches obtained from other rootstocks. Furthermore, during cold storage, the rates of H2O2 and O2−generation decreased more rapidly. However, combined with a low electrolyte leakage percentage (EL%) and malondialdehyde (MDA) accumulation, the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenger concentration increased during the cold storage period. Furthermore, while berry quality traits were harvested from "Superior Seedless" grafted onto "1103 Paulson" rootstock, they were improved compared to other rootstocks. The molecular docking technique is performed to evaluate the binding affinity of antioxidant enzymes with a group of intracellular ligands, including DPPH, MDA, ascorbic acid, and tartaric acid, which show great results with respect to the DPPH compound. Following these findings, it can be concluded that the influence of rootstocks on "Superior Seedless" bunch responses to low cold storage represents a novel potential natural effect of rootstocks on responding bunches of "Superior Seedless" to low cold storage. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia.

Author

El-Nashar, Heba A. S., Sayed, Ahmed M., El-Sherief, Hany A. M., Rateb, Mostafa E., Akil, Lina, Khadra, Ibrahim, Majrashi, Taghreed A., Al-Rashood, Sara T., Binjubair, Faizah A., El Hassab, Mahmoud A., Eldehna, Wagdy M., Abdelmohsen, Usama Ramadan, and Mostafa, Nada M.

Subjects
ELECTROSPRAY ionization mass spectrometry, MOLECULAR docking, METABOLOMICS, PROTOZOAN diseases, PHENOLIC acids, TRYPANOSOMA brucei, NEOLIGNANS
Abstract

Trypanosomiasis is a protozoan disease transmitted via Trypanosoma brucei. This study aimed to examine the metabolic profile and anti-trypanosomal effect of methanol extract of Thunbergia grandifolia leaves. The liquid chromatography-high resolution electrospray ionisation mass spectrometry (LC-HRESIMS) revealed the identification of fifteen compounds of iridoid, flavonoid, lignan, phenolic acid, and alkaloid classes. The extract displayed a promising inhibitory activity against T. brucei TC 221 with MIC value of 1.90 μg/mL within 72 h. A subsequent in silico analysis of the dereplicated compounds (i.e. inverse docking, molecular dynamic simulation, and absolute binding free energy) suggested both rhodesain and farnesyl diphosphate synthase as probable targets for two compounds among those dereplicated ones in the plant extract (i.e. diphyllin and avacennone B). The absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling of diphyllin and avacennone were calculated accordingly, where both compounds showed acceptable drug-like properties. This study highlighted the antiparasitic potential of T. grandifolia leaves. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Antimalarial and Antileishmanial Flavonoids from Calendula officinalis Flowers.

Author

Al-Huqail, Arwa A., Bekhit, Adnan A., Ullah, Hammad, Ayaz, Muhammad, and Mostafa, Nada M.

Subjects
CALENDULA officinalis, SAPONINS, FLAVONOIDS, SURVIVAL rate, FLAVONOID glycosides, EDIBLE plants, NEGLECTED diseases, FLOWERS, BUCKWHEAT
Abstract

Calendula officinalis L. (Asteraceae), commonly known as English or pot marigold, is an herbaceous plant with edible flowers. In this study, UPLC-ESI-MS/MS analysis was used for tentative identification of compounds in marigold flower methanol extract (MFE). In addition, RP-HPLC-DAD analysis was used to quantify the flavonoids hesperidin and rutin in MFE. The antileishmanial potentials of the crude extract and compounds were evaluated against Leishmania major promastigotes and amastigotes. Further, in vivo 4-day antimalarial testing of the extract and compounds was carried out at doses of 25 mg kg−1 per day using mice infected with ANKA strain of Plasmodium berghei, following standard procedure. Molecular docking studies were carried out to assess the binding mode of flavonoids against the vital targets of L. major, including pteridine reductase 1 and farnesyl diphosphate synthase enzymes. The in silico antimalarial potentials of flavonoids were evaluated against wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase and phosphoethanolamine methyltransferase enzymes. Twenty compounds were tentatively identified by UPLC-ESI-MS/MS analysis of MFE, of which, seven flavonoids, six saponins, three phenolic acids, three fatty acids, and a triterpene glycoside were identified. MFE phytochemical analysis revealed that hesperidin content was 36.17 mg g−1 extract, that is, 9.9-fold their content of rutin (3.65 mg g−1 extract). The method was validated to ensure reproducibility of the results. The tested samples exhibited antileishmanial potentials against L. major promastigotes, with IC50 values of 98.62, 118.86, and 104.74 ng µL−1 for hesperidin, rutin, and MFE, respectively. Likewise, hesperidin showed inhibitory potentials against L. major amastigote with an IC50 value of 108.44 ± 11.2 µM, as compared to miltefosine. The mean survival time, parasitemia, and suppression percentages showed similar results for the three samples against ANKA strain of P. berghei. The docking studies showed good binding affinities of rutin and hesperidin with numerous H-bonding and van der Waals interactions. Marigold flowers are nutraceuticals, presenting important sources of bioactive flavonoids with potential against neglected tropical diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Formulation of Deformable Liponiosomal Hybrid of Repaglinide: In vitro Characterization and Evaluation of the Anti-Diabetic Effect

Author

Abdelwahab,Ali, Abdelmohymen,Alshimaa, Mostafa,Nada, Magdy,Galal, Mazyed,Eman, Abdelwahab,Ali, Abdelmohymen,Alshimaa, Mostafa,Nada, Magdy,Galal, and Mazyed,Eman

Abstract

Ali F Abdelwahab,1 Alshimaa M Abdelmohymen,2 Nada M Mostafa,2 Galal Magdy,3 Eman A Mazyed4 1Department of Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt; 4Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptCorrespondence: Eman A Mazyed, Tel +20 100 3484508, Email eman_mazyad@pharm.kfs.edu.egPurpose: The current study sought to create novel deformable liponiosomal hybrids (LNHs) as a viable RPG delivery system. Repaglinide (RPG) is an effective anti-hyperglycemic drug. However, its limited solubility may limit its therapeutic applicability. LNHs are a potential liposome-niosome combination. Using phospholipids and non-ionic surfactants together improves their functionality in regulating drug release and increasing their permeability and stability.Materials and Methods: The development of RPG-loaded LNHs was performed using the reverse ethanol injection method based on the 23 factorial design to explore the potential of various variables on the encapsulation efficiency (EE%) and % RPG released after 12 h (Q12h). Further in vitro characterization tests and in vivo study were also performed on the optimal RPG-loaded LNHs.Results: After investigating how the examined independent factors could affect significantly both the EE % and Q12h, F7 was selected as the optimal liponiosomal formulation. F7 showed 87.07 ± 2.27 EE% and 94.32 ± 1.25 Q12h. F7 demonstrated higher permeability and stability than the corresponding liposomes and niosomes. Furthermore, F7 demonstrated greater hypoglycemic efficacy and bioavailability than pure RPG.Conclusion: The combination of liponiosomes and niosomes in the form of LNHs has the potential to be an effective nano-drug delivery vehicle for RPG.Keywords: repagli

Published
2023

32. The genus Schinus (Anacardiaceae): a review on phytochemicals and biological aspects

Author

El-Nashar, Heba A. S., Mostafa, Nada M., El-Ghffar, Eman A. Abd, Eldahshan, Omayma A., and Singab, Abdel Nasser B.

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

The genus Schinus belongs to family ‘Anacardiaceae’ and includes about 29 species originating from South America, distributed to Peru, Chile, Argentina, Brazil and Paraguay and cultivated in Egypt. Traditionally, Schinus plants are used to alleviate several and diverse diseases including rheumatism, hypertension, ulcers, gastric distress, menstrual disorders, gonorrhea, bronchitis, gingivitis, conjunctivitis, dysentery, wounds, urinary tract, and eye infections. Several phytochemical studies on the Schinus plants revealed presence of diverse bioactive compounds such as flavonoids, bioflavonoids, phenolic acids, tannins, catechins, terpenoids and essential oils. Besides, some Schinus species and their isolated active compounds showed important biological activities such as antibacterial, antifungal, insecticidal, antiparasitic, analgesic, cytotoxic, antitumor, antioxidant, antihypertensive, anti-inflammatory, antimycobacterial, anti-Parkinson, anti-allergic, antiviral, wound healing, chemoprotective, anthelmintic and hepatoprotective. This review attempts to summarize the phytochemical profile and biological activities of Schinus species that could guide researchers to undertake further investigation.

Published
2021

35. Mechanistic Wound Healing and Antioxidant Potential of Moringa oleifera Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular Docking, and In Vivo Studies

Author

Shady, Nourhan Hisham, primary, Mostafa, Nada M., additional, Fayez, Shaimaa, additional, Abdel-Rahman, Islam M., additional, Maher, Sherif A., additional, Zayed, Ahmed, additional, Saber, Entesar Ali, additional, Khowdiary, Manal M., additional, Elrehany, Mahmoud A., additional, Alzubaidi, Mubarak A., additional, Altemani, Faisal H., additional, Shawky, Ahmed M., additional, and Abdelmohsen, Usama Ramadan, additional

Published
2022
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41. Effect of Titanium and Vanadium on Antioxidants Content and Productivity of Red Cabbage

Author

Doklega, Samar M. A., primary, El-Ezz, Sally F. Abo, additional, Mostafa, Nada A., additional, Dessoky, Eldessoky S., additional, Abdulmajeed, Awatif M., additional, Darwish, Doaa Bahaa Eldin, additional, Alzuaibr, Fahad Mohammed, additional, El-Yazied, Ahmed Abou, additional, El-Mogy, Mohamed M., additional, Mahmoud, Samy F., additional, M. Taha, Noura, additional, and Abd El-Hady, Mahmoud A. M., additional

Published
2022
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42. Cyclodepsipeptides: Isolation from Endophytic Fungi of Sarcophyton ehrenbergi and Verification of Their Larvicidal Activity via In-Vitro and In-Silico Studies

Author

Singab, Abdel Nasser B., primary, Mostafa, Nada M., additional, Elkhawas, Yasmin A., additional, Al-Sayed, Eman, additional, Bishr, Mokhtar M., additional, Elissawy, Ahmed M., additional, Elnaggar, Mohamed S., additional, Fawzy, Iten M., additional, Salama, Osama M., additional, Tsai, Yi-Hong, additional, and Chang, Fang-Rong, additional

Published
2022
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44. Perspectives, Attitudes, and Willingness to Participate Toward Biobank Research of the Public in the Arab Region

Author

Ahram, Mamoun, primary, Abdelgawad, Fatma, additional, ElHafeez, Samar Abd, additional, Abdelhafiz, Ahmed, additional, Ibrahim, Maha, additional, Mostafa, Nada, additional, Elgamri, Alya, additional, Mohammed, Zeinab, additional, Elsebaie, Eman, additional, Gamel, Ehsan, additional, Shahouri, Manal, additional, El-Rhazi, Karima, additional, Adarmouch, Latifa, additional, and Silverman, Henry, additional

Published
2022
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47. UPLC-ESI-MS/MS profiling and hepatoprotective activities of Stevia leaves extract, butanol fraction and stevioside against radiation-induced toxicity in rats

Author

Abdallah, Sherien H., Mostafa, Nada M., Mohamed, Marwa Abd El Hameed, Nada, Ahmed S., and Singab, Abdel Nasser B.

Subjects
Flavonoids, Plant Extracts, Butanols, Organic Chemistry, Plant Science, Biochemistry, Glutathione, Analytical Chemistry, Rats, Plant Leaves, 1-Butanol, Glucosides, Tandem Mass Spectrometry, Animals, Stevia, Diterpenes, Kaurane, Radiation Injuries
Abstract

Stevioside is the major component of Stevia rebaudiana (Bertoni) leaves, family Asteraceae. UPLC-ESI-MS/MS analyses of leaves total methanol extract (TEx) and standardized butanol fraction (BF, 113.5 mg stevioside/g) were performed herein, revealing steviol glycosides, caffeoylquinic acid derivatives, flavonoids, and sesquiterpenoids. Their hepatoprotective activities against radiation-induced toxicity were evaluated compared to pure stevioside. Rats pretreatment with stevioside, TEx, and BF orally for 7 days before subjection to 6.5 Gy whole-body-gamma-irradiation reversed histopathological damages; improved liver functions and restored depleted antioxidants. ALT and reduced-glutathione levels showed insignificant changes, compared to control, by (5.22%, 3.20%, 24.90%) and (−0.47%, −3.95%, −2.63%), respectively. Glutathione-S-transferase, catalase, and MDA levels were significantly ameliorated. Liver tissue molecular profiling showed reduction in elevated TNF-α by 23.83%, 29.06%, 28.34%, respectively, and in NF-kB and COX-2 expression levels via immunohistochemical study. BF showed better hepatoprotective activity than TEx which may be attributed to higher stevioside, flavonoids, and caffeoylquinic acid derivatives content.

Published
2021

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