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154 results on '"Mosse, Claudio A."'

1. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2024

Author

Wierda, William G., primary, Brown, Jennifer, additional, Abramson, Jeremy S., additional, Awan, Farrukh, additional, Bilgrami, Syed F., additional, Bociek, Greg, additional, Brander, Danielle, additional, Cortese, Matthew, additional, Cripe, Larry, additional, Davis, Randall S., additional, Eradat, Herbert, additional, Fakhri, Bita, additional, Fletcher, Christopher D., additional, Gaballa, Sameh, additional, Hamid, Muhammad Saad, additional, Hill, Brian, additional, Kaesberg, Paul, additional, Kahl, Brad, additional, Kamdar, Manali, additional, Kipps, Thomas J., additional, Ma, Shuo, additional, Mosse, Claudio, additional, Nakhoda, Shazia, additional, Parikh, Sameer, additional, Schorr, Andrew, additional, Schuster, Stephen, additional, Seshadri, Madhav, additional, Siddiqi, Tanya, additional, Stephens, Deborah M., additional, Thompson, Meghan, additional, Ujjani, Chaitra, additional, Valdez, Riccardo, additional, Wagner-Johnston, Nina, additional, Woyach, Jennifer A., additional, Sundar, Hema, additional, and Dwyer, Mary, additional

Published
2024
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4. Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431

Author

Mast, Kelley J., Taub, Jeffrey W., Alonzo, Todd A., Gamis, Alan S., Mosse, Claudio A., Mathew, Prasad, Berman, Jason N., Wang, Yi-Cheng, Jones, Heath M., Campana, Dario, Coustan-Smith, Elaine, Raimondi, Susana C., Hirsch, Betsy, Hitzler, Johann K., and Head, David R.

Subjects
Dysplasia -- Diagnosis -- Genetic aspects, Down syndrome -- Diagnosis -- Genetic aspects, Cytogenetics -- Comparative analysis -- Genetic aspects -- Reports, Acute myelocytic leukemia -- Genetic aspects -- Diagnosis, Explosions, Displays (Marketing), Myeloid leukemia, Hyperplasia, Diseases, Children, Health
Abstract

* Context.--Detailed diagnostic features of acute myeloid leukemia in Down syndrome are lacking, leading to potential misdiagnoses as standard acute myeloid leukemia occurring in patients with Down syndrome. Objective.--To evaluate diagnostic features of acute myeloid leukemia and myelodysplastic syndrome in patients with Down syndrome. Design.--Diagnostic bone marrow samples from 163 patients enrolled in the Children's Oncology Group study AAML0431 were evaluated by using central morphologic review and institutional immunophenotyping. Results were compared to overall survival, event-free survival, GATA1 mutation status, cytogenetics, and minimal residual disease results. Results.--Sixty myelodysplastic syndrome and 103 acute myeloid leukemia samples were reviewed. Both had distinctive features compared to those of patients without Down syndrome. They showed megakaryocytic and erythroid but little myeloid dysplasia, and marked megakaryocytic hyperplasia with unusual megakaryocyte morphology. In acute myeloid leukemia cases, megakaryoblastic differentiation of blasts was most common (54 of 103, 52%); other cases showed erythroblastic (11 of 103, 11%), mixed erythroid/megakaryoblastic (20 of 103, 19%), or no differentiation (10 of 103, 10%). Myelodysplastic syndrome and acute myeloid leukemia cases had similar event-free survival and overall survival. Leukemic subgroups showed interesting, but not statistically significant, trends for survival and minimal residual disease. Cases with institutional diagnoses of French American British M1-5 morphology showed typical features of Down syndrome disease, with survival approaching that of other cases. Conclusions.--Myelodysplastic syndrome and acute myeloid leukemia in Down syndrome display features that allow discrimination from standard cases of disease. These distinctions are important for treatment decisions, and for understanding disease pathogenesis. We propose specific diagnostic criteria for Down syndrome-related subtypes of acute myeloid leukemia and myelodysplastic syndrome. (Arch Pathol Lab Med. 2020;144:466-472; doi: 10.5858/arpa.2018-0526-OA), Down syndrome (DS) is a common genetic disorder, occurring in approximately 1 in 700 births. (1) The incidence of acute leukemia, both myeloid (AML) and lymphoid (ALL), is markedly increased [...]

Published
2020
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11. NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022

Author

Wierda, William G., primary, Brown, Jennifer, additional, Abramson, Jeremy S., additional, Awan, Farrukh, additional, Bilgrami, Syed F., additional, Bociek, Greg, additional, Brander, Danielle, additional, Chanan-Khan, Asher A., additional, Coutre, Steve E., additional, Davis, Randall S., additional, Eradat, Herbert, additional, Fletcher, Christopher D., additional, Gaballa, Sameh, additional, Ghobadi, Armin, additional, Hamid, Muhammad Saad, additional, Hernandez-Ilizaliturri, Francisco, additional, Hill, Brian, additional, Kaesberg, Paul, additional, Kamdar, Manali, additional, Kaplan, Lawrence D., additional, Khan, Nadia, additional, Kipps, Thomas J., additional, Ma, Shuo, additional, Mato, Anthony, additional, Mosse, Claudio, additional, Schuster, Stephen, additional, Siddiqi, Tanya, additional, Stephens, Deborah M., additional, Ujjani, Chaitra, additional, Wagner-Johnston, Nina, additional, Woyach, Jennifer A., additional, Ye, J. Christine, additional, Dwyer, Mary A., additional, and Sundar, Hema, additional

Published
2022
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20. Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease

Author

Whartenby, Katharine A., Calabresi, Peter A., McCadden, Erin, Nguyen, Bao, Kardian, David, Wang, Tianhong, Mosse, Claudio, Pardoll, Drew M., and Small, Donald

Subjects
Antigens -- Research, Autoimmune diseases -- Research, Dendritic cells -- Research, Science and technology
Abstract

Autoimmune diseases often result from inappropriate or unregulated activation of autoreactive T cells. Traditional approaches to treatment of autoimmune diseases through immunosuppression have focused on direct inhibition of T cells. In the present study, we examined the targeted inhibition of antigen-presenting cells as a means to downregulate immune responses and treat autoimmune disease. Dendritic cells (DCs) are the central antigen-presenting cells for the initiation of T cell responses, including autoreactive ones. A large portion of DCs are derived from hematopoietic progenitors that express FLT3 receptor (CD135), and stimulation of the receptor via FLT3 ligand either in vivo or in vitro is known to drive expansion and differentiation of these progenitors toward a DC phenotype. We hypothesized that inhibition of FLT3 signaling would thus produce an inhibition of DC-induced stimulation of T cells, thereby inhibiting autoimmune responses. To this end, we used small-molecule tyrosine kinase inhibitors targeted against FLT3 and examined the effects on DCs and their role in the promulgation of autoimmune disease. Results of our studies show that inhibition of FLT3 signaling induces apoptosis in both mouse and human DCs, and thus is a potential target for immune suppression. Furthermore, targeted inhibition of FLT3 significantly improved the course of established disease in a model for multiple sclerosis, experimental autoimmune encephalomyelitis, suggesting a potential avenue for treating autoimmune disease. autoimmune disease | FLT3 ligand

Published
2005

25. Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431

Author

Mast, Kelley J., primary, Taub, Jeffrey W., additional, Alonzo, Todd A., additional, Gamis, Alan S., additional, Mosse, Claudio A., additional, Mathew, Prasad, additional, Berman, Jason N., additional, Wang, Yi-Cheng, additional, Jones, Heath M., additional, Campana, Dario, additional, Coustan-Smith, Elaine, additional, Raimondi, Susana C., additional, Hirsch, Betsy, additional, Hitzler, Johann K., additional, and Head, David R., additional

Published
2019
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26. NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019

Author

Wierda, William G., primary, Byrd, John C., additional, Abramson, Jeremy S., additional, Bilgrami, Syed F., additional, Bociek, Greg, additional, Brander, Danielle, additional, Brown, Jennifer, additional, Chanan-Khan, Asher A., additional, Chavez, Julio C., additional, Coutre, Steve E., additional, Davis, Randall S., additional, Fletcher, Christopher D., additional, Hill, Brian, additional, Kahl, Brad S., additional, Kamdar, Manali, additional, Kaplan, Lawrence D., additional, Khan, Nadia, additional, Kipps, Thomas J., additional, Ma, Shuo, additional, Malek, Sami, additional, Mato, Anthony, additional, Mosse, Claudio, additional, Neppalli, Vishala T., additional, Shadman, Mazyar, additional, Siddiqi, Tanya, additional, Stephens, Deborah, additional, Wagner, Nina, additional, Dwyer, Mary A., additional, and Sundar, Hema, additional

Published
2019
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28. Prospective trial of minimal residual disease assessment by multiparametric flow cytometry for multiple myeloma in the era of bortezomib-based chemotherapy

Author

Clark, C. Amos, primary, Mosse, Claudio A., additional, Chen, Heidi, additional, Byrne, Michael, additional, Chinratanalab, Wichai, additional, Engelhardt, Brian G., additional, Goodman, Stacey A., additional, Harrell, Shelton L., additional, Kassim, Adetola A., additional, Savani, Bipin N., additional, Sengsayadeth, Salyka, additional, Jagasia, Madan, additional, and Cornell, R. Frank, additional

Published
2018
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31. Prospective Trial of Minimal Residual Disease Assessment by Multiparametric Flow Cytometry for Multiple Myeloma in the Era of Bortezomib-Based Chemotherapy

Author

Cornell, Robert F., primary, Mosse, Claudio A., additional, Chen, Heidi, additional, Byrne, Michael T., additional, Chinratanalab, Wichai, additional, Engelhardt, Brian G., additional, Goodman, Stacey, additional, Kassim, Adetola A., additional, Savani, Bipin N., additional, Sengsayadeth, Salyka, additional, Jagasia, Madan, additional, and Clark, Charles Amos, additional

Published
2018
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32. Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis

Author

Rosado, Flavia G. Nunes, Stratton, Charles W., and Mosse, Claudio A.

Subjects
Bacteria -- Health aspects, Pediatrics -- Health aspects, Lymphadenitis -- Diagnosis -- Health aspects, Bacterial infections -- Diagnosis -- Health aspects, Infection -- Diagnosis -- Health aspects, Health
Abstract

* Context.--Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. Objective.--To assess and compare the histopathologic and epidemiologic features of common and uncommon pediatric bacterial lymphadenitis. Design.--We searched our database for surgical specimens that had a positive identification of bacteria during an 8-year period. The chart was reviewed to assess the pathogen identified and epidemiologic data. The archival tissue sections were reviewed and the histopathologic findings described for each pathogen. Results.--The review of 368 pediatric lymph node biopsies identified 33 cases with a bacterial infection. These comprised 21 cases of Mycobacterium avium complex (60%), 1 of Mycobacterium fortuitum (3%), 7 of Bartonella henselae (20%), 2 of Yersinia enterocolitica (7%), 1 of Francisella tularensis (3%) and 1 of Streptococcus pyogenes (3%). Conclusions.--Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report. (Arch Pathol Lab Med. 2011; 135:1490-1493; doi: 10.5858/arpa.2010-0581-OA), Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Excisional biopsies are routinely performed to obtain lymph node material for appropriate laboratory studies as well [...]

Published
2011
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34. In the Era of Bortezomib-Based Chemotherapy the Presence of Minimal Residual Disease Predicts Progression Free Survival after Autologous Hematopoietic Cell Transplant

Author

Cornell, Robert F, primary, Jones, Jade E, additional, Mosse, Claudio A., additional, Chen, Heidi, additional, Dugger, Laura, additional, Goorha, Salil, additional, Chinratanalab, Wichai, additional, Engelhardt, Brian, additional, Goodman, Stacey A., additional, Greer, John P, additional, Lacy, Shelton, additional, Kassim, Adetola A., additional, McDonagh, Kevin, additional, Savani, Bipin N., additional, Sengsayadeth, Salyka, additional, and Jagasia, Madan, additional

Published
2015
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38. Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach

Author

Seegmiller, Adam C., primary, Kim, Annette S., additional, Mosse, Claudio A., additional, Levy, Mia A., additional, Thompson, Mary Ann, additional, Kressin, Megan K., additional, Jagasia, Madan H., additional, Strickland, Stephen A., additional, Reddy, Nishitha M., additional, Marx, Edward R., additional, Sinkfield, Kristy J., additional, Pollard, Herschel N., additional, Plummer, W. Dale, additional, Dupont, William D., additional, Shultz, Edward K., additional, Dittus, Robert S., additional, Stead, William W., additional, Santoro, Samuel A., additional, and Zutter, Mary M., additional

Published
2013
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40. Minimal residual disease (MRD) status pre- and post- high-dose therapy/autologous stem (HDC/ASCT) cell transplantation for multiple myeloma (MM) in the era of novel agents.

Author

Kassim, Adetola, primary, McDuffie, Jeremy Scott, additional, Mosse, Claudio A, additional, Savani, Bipin N., additional, Greer, John P., additional, Oluwole, Olalekan O., additional, Goodman, Stacey, additional, Engelhardt, Brian G., additional, Chinratanalab, Wichai, additional, Kim, Annette S, additional, and Jagasia, Madan H., additional

Published
2013
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42. Inter-reader variability in follicular lymphoma grading: Conventional and digital reading

Author

Lozanski, Gerard, primary, Pennell, Michael, additional, Shana'ah, Arwa, additional, Zhao, Weiqiang, additional, Gewirtz, Amy, additional, Racke, Frederick, additional, Hsi, Eric, additional, Simpson, Sabrina, additional, Mosse, Claudio, additional, Alam, Shadia, additional, Swierczynski, Sharon, additional, Hasserjian, Robert P., additional, and Gurcan, Metin N., additional

Published
2013
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45. Evidence-Based, Patient-Specific Guidelines Provide Efficient and Cost-Effective Molecular and Cytogenetic Testing in Hematologic Malignancy

Author

Seegmiller, Adam C., primary, Kim, Annette S., additional, Mosse, Claudio A., additional, Levy, Mia A., additional, Thompson, Mary Ann, additional, Kressin, Megan K., additional, Jagasia, Madan H., additional, Strickland, Stephen A., additional, Reddy, Nishitha M., additional, Sinkfield, Kristy J., additional, Santoro, Samuel A., additional, and Zutter, Mary M., additional

Published
2011
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47. Innovative Analyses Support a Role for DNA Damage and an Aberrant Cell Cycle in Myelodysplastic Syndrome Pathogenesis

Author

Head, David R., primary, Jacobberger, James W., additional, Mosse, Claudio, additional, Jagasia, Madan, additional, Dupont, William, additional, Goodman, Stacey, additional, Flye, Leanne, additional, Shinar, Andrew, additional, McClintock-Treep, Sara, additional, Stelzer, Greg, additional, Briggs, Robert, additional, and Shults, Keith, additional

Published
2011
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48. Quantitative Assessment of Myeloid Nuclear Differentiation Antigen Distinguishes Myelodysplastic Syndrome From Normal Bone Marrow

Author

McClintock-Treep, Sara A., primary, Briggs, Robert C., additional, Shults, Keith E., additional, Flye-Blakemore, Leanne A., additional, Mosse, Claudio A., additional, Jagasia, Madan H., additional, Shinar, Andrew A., additional, Dupont, William D., additional, Stelzer, Greg T., additional, and Head, David R., additional

Published
2011
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