1. [Efficacy and safety of combined treatment of prostatic adenoma with 5-alpha reductase and alpha-adrenoblockers].
- Author
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Tkachuk VN, Al'-Shukri SKh, Tkachuk IN, and Mosoian MS
- Subjects
- Adrenergic alpha-Antagonists adverse effects, Aged, Drug Therapy, Combination, Enzyme Inhibitors, Finasteride adverse effects, Humans, Male, Quality of Life, Remission Induction, Sulfonamides adverse effects, Tamsulosin, Time Factors, 5-alpha Reductase Inhibitors, Adrenergic alpha-Antagonists administration & dosage, Finasteride administration & dosage, Prostatic Hyperplasia drug therapy, Sulfonamides administration & dosage
- Abstract
Pharmacotherapy of prostatic adenoma is based in present-day practice primarily on two basic groups of medicines--inhibitors of 5alpha-reductase and blockers of alphal-adrenoreceptors. Our trial included 98 patients with prostatic adenoma aged 59-79 years given combined treatment with finasteride (inhibitor of 5alpha-reductase) made in Hungary (prosteride, Gedeon Richter) and an uroselective blocker of alpha1-adrenoreceptors sonisin (Gedeon Richter, Hungary). Prosteride was given for 12 months, sonisine--for the first 6 months of combined treatment. Positive results were achieved in 97 (99%) of 98 patients. After 12-month combined treatment symptoms of the disease reduced by IPSS from 17.9 +/- 1.8 to 3.9 +/- 0.9 points, Qmax rose from 8.8 +/- 0.3 to 14.6 +/- 0.3, residual urine volume diminished from 91.7 +/- 8.5 to 31.7 +/- 4.4, the size of the prostate reduced from 72.4 +/- 2.9 to 50.6 +/- 3.7, quality of life improved 2-fold. Combined administration of finasteride (prosteride) and alpha1-adrenoblocker tamsulosine (sonisine) meet three principles of pharmacotherapy of prostatic adenoma: prevents progression of the disease and surgical treatment, relieves symptoms and improves quality of life.
- Published
- 2009