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338 results on '"Mosnier, I"'

4. Recommandations de la Société française d’ORL et de chirurgie de la face et du cou (SFORL) et de la Société française d’audiologie (SFA) pour la pratique de l’audiométrie vocale dans le bruit chez l’adulte

Author

Joly, C.-A., Reynard, P., Mezzi, K., Bakhos, D., Bergeron, F., Bonnard, D., Borel, S., Bouccara, D., Coez, A., Dejean, F., Del Rio, M., Leclercq, F., Henrion, P., Marx, M., Mom, T., Mosnier, I., Potier, M., Renard, C., Roy, T., Sterkers-Artières, F., Venail, F., Verheyden, P., Veuillet, E., Vincent, C., and Thai-Van, H.

Published
2022
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5. Guidelines of the French Society of Otorhinolaryngology-Head and Neck Surgery (SFORL) and the French Society of Audiology (SFA) for Speech-in-Noise Testing in Adults

Author

Joly, C.-A., Reynard, P., Mezzi, K., Bakhos, D., Bergeron, F., Bonnard, D., Borel, S., Bouccara, D., Coez, A., Dejean, F., Del Rio, M., Leclercq, F., Henrion, P., Marx, M., Mom, T., Mosnier, I., Potier, M., Renard, C., Roy, T., Sterkers-Artières, F., Venail, F., Verheyden, P., Veuillet, E., Vincent, C., and Thai-Van, H.

Published
2022
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8. Implantación coclear en adultos

Author

Lahlou, G., Daoudi, H., Ambert-Dahan, E., Flament, J., Carillo, C., Borel, S., and Mosnier, I.

Abstract

La sordera afecta no sólo a las capacidades de percepción auditiva y de comunicación, sino también a la calidad de vida y a las interacciones sociales. En la actualidad, se ha establecido que debe considerarse el factor de riesgo modificable más importante de la aparición de una demencia. Desde finales de la década de 1980, se ha demostrado la eficacia de la rehabilitación de la audición con el implante coclear, con resultados que han mejorado gracias a la evolución de la técnica quirúrgica, de las tecnologías de procesamiento de la señal y de las prácticas clínicas y a la mejor definición de las indicaciones. En Francia, la actividad de implantación coclear está regulada por la Haute Autorité de Santé y se basa en equipos pluridisciplinarios sometidos a la aprobación de las agencias regionales de salud. En este artículo, se detalla el funcionamiento, las indicaciones y los resultados actuales del implante coclear en adultos.

Published
2024
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13. The French National Cochlear Implant Registry (EPIIC): Cochlear implantation in adults over 65 years old

Author

Mosnier, I., Ferrary, E., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Truy, E., Vincent, C., and Sterkers, O.

Published
2020
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14. The French Cochlear Implant Registry (EPIIC): Cochlear implant candidacy assessment of off-label indications

Author

Quatre, R., Fabre, C., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Tavernier, L., Truy, E., Vincent, C., and Schmerber, S.

Published
2020
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15. The French Cochlear Implant Registry (EPIIC): Perception and language results in infants with cochlear implantation under the age of 24 months

Author

Loundon, N., Simon, F., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Truy, E., Vincent, C., and De Lamaze, A.

Published
2020
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16. The French Cochlear Implant Registry (EPIIC): General indicators

Author

Gauvrit, F., Risoud, M., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.- P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Truy, E., and Vincent, C.

Published
2020
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17. The French National Cochlear Implant Registry (EPIIC): Results, quality of life, questionnaires, academic and professional life

Author

Artières-Sterkers, F., Mondain, M., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Truy, E., Vincent, C., and Uziel, A.

Published
2020
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18. The French National Cochlear Implant Registry (EPIIC): Bilateral cochlear implantation

Author

Puechmaille, M., Lambert, C., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Truy, E., Vincent, C., and Mom, T.

Published
2020
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19. The French Cochlear Implant Registry (EPIIC): Cochlear implantation complications

Author

Parent, V., Codet, M., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Truy, E., Vincent, C., and Godey, B.

Published
2020
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20. The French National Cochlear Implant Registry (EPIIC): Cochlear explantation and reimplantation

Author

Hermann, R., Coudert, A., Aubry, K., Bordure, P., Bozorg-Grayeli, A., Deguine, O., Eyermann, C., Franco-Vidal, V., Godey, B., Guevara, N., Karkas, A., Klopp, N., Labrousse, M., Lebreton, J.-P., Lerosey, Y., Lescanne, E., Loundon, N., Marianowski, R., Merklen, F., Mezouaghi, K., Mom, T., Moreau, S., Mosnier, I., Noël-Petroff, N., Parietti-Winkler, C., Piller, P., Poncet, C., Radafy, E., Roman, S., Roux-Vaillard, S., Schmerber, S., Tavernier, L., Vincent, C., and Truy, E.

Published
2020
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30. Développement auditif, plasticité cérébrale, pathologie de privation et réhabilitation

Author

Loundon, N., primary, Le Normand, M.-T., additional, Blanchet, C., additional, Mondain, M., additional, Roman, S., additional, Coez, A., additional, Lazard, D.S., additional, Bakhos, D., additional, Godey, B., additional, Charpiot, A., additional, Barone, P., additional, Deguine, O., additional, Mosnier, I., additional, Belmin, J., additional, Marx, M., additional, Farinetti, A., additional, and Truy, E., additional

Published
2018
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36. Isolated early onset hearing impairment? Diagnosis of syndromic forms by whole genome sequencing.

Author

Marlin, S., Serey Gaut, M., Mosnier, I., Rouillon, I., Parodi, M., Loundon, N., Blanc, P., Jonard, L., and Balogoun, R.

Subjects
SENSORINEURAL hearing loss, CONFERENCES & conventions, GENETIC testing, SEQUENCE analysis
Abstract

Introduction: Clinical geneticists involved in the diagnosis of early onset hearing loss can to encounter young patients with apparently isolated hearing loss or cochleovestibular pathology and a diagnosis of a syndromic form. For example, diagnosis in a young child of Usher syndrome, that associates congenital hearing loss (and vestibular areflexia in the type 1) and later onset retinitis pigmentosa, is not rare in our practice. Material and methods: In France, patients presenting with early onset isolated or syndromic hearing loss have access to diagnostic trio whole genome sequencing through the Plan France Medecine Genomique 2025 sequencing platforms. From 2020 to 2023, almost 500 families have undergone whole genome sequencing for this indication on the SeqOIA platform only. Results: Among patients assessed in the Paris Reference Center for Genetic Deafness and presenting with apparently isolated early onset hearing loss or cochleovestibular pathology, whole genome sequencing identified one patient with Usher syndrome (USH2A) and four patients with very rare syndromic forms. Syndroms identified are Heimler syndrome (PEX6), a Perrault syndrome phenocopy (NARS2), Dystonia Deafness Cerebral Hypomyelination syndrome (BCAP31) and Hypoparathyroidism Deafness Renal syndrome (GATA3). Conclusions: Diagnostic whole genome sequencing enables the diagnosis of ultra rare conditions, which would not have been possible with usual panel sequencing testing strategies. For the patients, the diagnosis of a syndromic form in an apparently isolated presentation allows for better care and genetic counselling but can also be distressing. Indeed, the delay between the result and the manifestation of additional symptoms and the severity of these symptoms can be uncertain. [ABSTRACT FROM AUTHOR]

Published
2024

37. 350 families' whole genome sequencing in early onset hearing loss: the French Reference Centre's experience.

Author

Serey-Gaut, M., Balogoun, R., Roi, M., Achard, S., Loundon, N., Rouillon, I., Parodi, M., Mosnier, I., Lahlou, G., Saint-Jalmes, F., Soufflard, A., Challet, I., Gherbi-Halem, S., Smol, T., Porteret, C., Jonard, L., Blanc, P., and Marlin, S.

Subjects
HEARING disorder diagnosis, GENOME-wide association studies, CONFERENCES & conventions, AGE factors in disease, HEARING disorders, SEQUENCE analysis
Abstract

Introduction: Up to recent years, diagnosis of the genetic aetiology of early onset hearing loss (EOHL) relied on targeted gene panel analyses, with a diagnosis rate of about 50%. French clinical geneticists have now access to trio whole genome sequencing (WGS) through the Plan France Medecine Genomique 2025 sequencing platforms for most patients presenting with EOHL. Methods: Testing criteria for WGS differ according to the subgroup of EOHL indications. The strategy is genome-first for syndromic hearing loss (HL), WGS after normal array-CGH for HL associated with malformation(s) and WGS after normal GJB2/GBJ6 and HL gene panel for patients presenting with isolated HL. Results: From 2020 to mid-2024, 350 families assessed in the French Reference Center for genetic HL underwent whole genome sequencing on the SeqOIA platform. The diagnosis yield was 40%. We will present the main genes identified, the diagnostic rate according to subgroups of the EOHL indication, clinical vignettes, along with the advantages and limitations of our strategy. Conclusions: WGS allows for identification of additional causes (class 4 and 5 variants) and candidate genes, but variants interpretation is more complex than exome or gene panel analysis. We show with our four-and-a-half years' experience that WGS is an enticing new tool for patient diagnosis, with its advantages and setbacks. [ABSTRACT FROM AUTHOR]

Published
2024

38. Presbiacusia

Author

Bouccara, D., Ferrary, E., Mosnier, I., Bozorg Grayeli, A., and Sterkers, O.

Published
2006
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46. 3D curved multiplanar cone beam CT reconstruction for intracochlear position assessment of straight electrodes array. A temporal bone and clinical study

Author

De Seta D, Patrizia Mancini, Fy, Russo, Torres R, Mosnier I, Jl, Bensimon, De Seta E, Heymann D, Sterkers O, Bernardeschi D, Nguyen Y, maurice, sandrine, Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition, Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Sense Organs [Rome, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Histology, Temporal bone, Otology, Imaging, Three-Dimensional, bone regeneration, otorhinolaryngologic diseases, Cadaver, Humans, Electrodes, Retrospective Studies, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Cone Beam CT, clectrode position, surface characteristics, hydroxyapatite, Cone-Beam Computed Tomography, Cochlear Implantation, Electrode position, osteoconduction, Cochlear Implants, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Surgery, Computer-Assisted, cochlear implants, cone beam ct, histology, temporal bone, sense organs, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, psychological phenomena and processes
Abstract

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite-based biomaterials (HA) of different origins (natural or synthetic) or manufacturing process in a sinus lift model in rabbits. The secondary objective was to correlate the findings with the physical and topographical characteristics of the biomaterials. Materials and Methods: Two bovine HA manufactured with different processes (bovine hydroxyapatites [BHA] and cuttlebone hydroxyapatite [CBHA]) and a synthetic hydroxyapatite (SHA) sintered at high temperature were characterised with scanning electronic microscopy (SEM) and the measurement of specific surface area (BET). The materials were implanted in a sinus lift model in rabbits; histological and histomorphometric evaluation using non-decalcified sections was performed at 1, 5 and 12 weeks after implantation. Results: The studied biomaterials displayed a different surface topography. The two natural HA displayed significantly higher bone quantities (P = 0.0017; BHA vs. SHA, P = 0.0018 and CBHA vs. SHA, P = 0.033) at 5 and 12 weeks compared to the synthetic one (SHA). Moreover, the osteoconductivity (bone-to-material contact) was significantly higher in the BHA group compared to the two other groups (P = 0.014; BHA vs. SHA, P = 0.023 and BHA vs. CBHA, P = 0.033). Conclusion: HA-based biomaterials from diverse origins and manufacturing processes displayed different topographical characteristics. This may have influenced different regenerated bone architecture observed; more bone was found with natural HA compared to the synthetic one, and significantly higher bone-to-material contacts were found with BHA., Otology 3D curved multiplanar cone beam CT reconstruction for intracochlear position assessment of straight electrodes array. A temporal bone and clinical study Ricostruzione multiplanare 3D di immagini cone beam per l'idenficazione della posizione degli impianti cocleari. Studio su ossi temporali e pazienti impiantati SUMMARY A retrospective review of post-op cone beam CT (CBCT) of 8 adult patients and 14 fresh temporal bones that underwent cochlear implantation with straight flexible electrodes array was performed to determine if the position of a long and flexible electrodes array within the cochlear scalae could be reliably assessed with CBCT. An oto-radiologist and two otologists examined the images and assessed the electrodes position. The temporal bone specimens underwent histological analysis for confirm the exact position. The position of the electrodes was rated as scala tympani, scala vestibule, or intermediate position for the electrodes at 180°, 360° and for the apical electrode. In the patient group, for the electrodes at 180° all observers agreed for scala tympani position except for 1 evaluation, while a discrepancy in 3 patients both for the 360° and for the apical electrode assessment were found. In five temporal bones the evaluations were in discrepancy for the 180° electrode, while at 360° a disagreement between raters on the scalar positioning was seen in six temporal bones. A higher discrepancy between was found in assessment of the scalar position of the apical electrode (average pairwise agreement 45.4%, Fleiss k = 0.13). A good concordance was found between the histological results and the consensus between raters for the electrodes in the basal turn, while low agreement (Cohen's k 0.31, pairwise agreement 50%) was found in the identification of the apical electrode position confirming the difficulty to correct identify the electrode position in the second cochlear turn in temporal bones. In conclusion, CBCT is a reliable radiologic exam to correctly evaluate the position of a lateral wall flexible array in implanted patients using the proposed imaging reconstruction method, while some artefacts impede exact evaluation of the position of the apical electrode in temporal bone and other radiological techniques should be preferred in ex vivo studies. KEY WORDS: Cone Beam CT • Cochlear implants • Electrode position • Histology • Temporal bone RIASSUNTO Questo studio riporta un'analisi retrospettica delle immagini cone beam CT effettuate su 8 pazienti adulti sottoposti ad impianto cochleare MedEl flex 28 e su 14 ossi temporali impiantati con lo stesso tipo di array portaelettrodi. Lo scopo dello studio é di determinare l'affidabilità della metodica cone beam CT nella valutazione della posizione intracocleare degli elettrodi in impianti che si posizionano lungo la parete laterale del lume co-cleare, quindi non perimodiolari la cui posizione é più facilmente identificabile. Un otoradiologo e due otologi hanno analizzato le immagini e as-segnato la posizione per ciascun elettrodo localizzato nella regione dei 180° e dei 360° del primo giro cocleare e per l'elettrodo apicale scegliendo tra scala timpanica, vestibulare o posizione intermedia L'analisi istologica ha successivamente confermato l'esatta posizione negli ossi temporali. Nel gruppo dei pazienti per l'elettrodo a 180° i tre esperti concordavano sulla posizione in scala timpanica in tutti eccetto un paziente, mentre una discordanza nella valutazione era presente in 3 pazienti per gli elettrodi a 360° e per gli elettrodi apicali. Negli ossi temporali in 5 casi era presente una discordanza per l'elettrodo a 180°, mentre a 360° sei valutazioni erano discordanti tra i valutatori. Una disdcordanza tra le valutazioni più elevata veniva trovata per la la posizione dell'elettrodo apicale (concordanza valutatori 45.4%, Fleiss k = 0,13). Un buon grado di concordanza veniva trovato tra i risultati istologici e le valutazioni tra i valutatori per gli elettrodi localizzati nel giro basale; un grado più basso esisteva per la posizione degli elettrodi apicali (concordanza valutatori 50%, Cohen's k = 0,31) confermando la difficoltà nella corretta valutazione della posizione degli elettrodi nella regione più apicale negli ossi temporali. In conclusione, le immagini cone beam postoperatorie analizzate con la metodica della ricostruzione multiplanare 3D rappresentano una metodica affidabile per lo studio della posizione intracocleare degli elettrodi a posizionamento laterale nei pazienti impiantati. La corretta identificazione del posizionamento dell'elettrodo piu apicale risulta difficile su osso temporale per la presenza di un artefatto più importante o per la minore resistenza delle strutture della parete laterale della coclea (legamento spirale, membrane basilare) nel preparato istologico (osso temporale fresco/congelato) che è responsabile di un maggior numero di traslocazioni dalla rampa timpa-nica alla rampa vestibolare e di localizzazioni intermedie più difficilmente interpretabili.

Published
2016
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