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Objective: to assess the epidemic situation of echinococcosis in the period 2012–2022 in the endemic territories of the Far Eastern Federal District and South of Russia.Materials and methods: based on the data of the annual statistical reporting forms No. 2 "Information on infectious and parasitic diseases", data from the Reference Center for Monitoring Larval Helminthiasis of Rostov Research Institute Microbiology and Parasitology of Rospotrebnadzor, an analysis of the incidence of echinococcosis in the territories of the Far East and South of Russia in the period 2012–2022 was carried out. For seroepidemiological examination of a conditionally healthy population by the ELISA method, the diagnostic kit "Echinococcus-IgG-ELISA-BEST" (JSC "Vector-Best", Novosibirsk) was used.Results: it is shown that the epidemiological situation of echinococcosis is characterized by pronounced territorial unevenness. In the south of Russia, epidemiological problems with echinococcosis persisted in Kalmykia (0.74–2.19 cases per 100,000 population) and in the Astrakhan region (0.60–1.48 cases per 100,000 population). Among the relatively healthy population, the average seropositivity to E.granulosus antigens in the Far East was 5.8%, in the south of Russia — 2,6%. Conclusions: the data obtained indicate an unfavorable epidemiological situation for echinococcosis in a number of regions of the Far East and South of Russia.

The article examines the subject code of the Russian spell tradition using the example of a group of ritual objects of wood origin. This group has received insufficient attention in research, as evidenced by a brief review of the literature. The material for the analysis is the main publications of Russian conspiracies, as well as field materials recorded by the author in the period from 2003 to 2023 in the Omsk Irtysh region. The purpose of this work is to determine the semantic field of a group of wood objects in Russian spells, as well as to identify the relationship between a ritual object and its verbal and symbolic embodiment. The main method of research – historical-typological – allows us to draw typological parallels in order to clarify the boundaries of the semantic field, which includes ritual objects of the group being studied. The article also implements complex and cross-genre approaches. The analysis showed the widespread use of ritual objects of wooden origin in the Russian charm tradition. Objects are included in the text of the conspiracy as independent images and can be used relatively independently of the verbal component of the conspiracy. The semantics of the ritual object is in accordance with the functional and thematic orientation of the spell and is determined by its content. An examination of two objects – a bitch and a sliver – revealed an expansion of their functions and semantic field in in Russian spells of Siberian. This conclusion determines the direction of further research into spells paraphernalia in the aspect of the mutual influence of aboriginal and settler traditions.

Indicators that reflect the transition from unemployment to employment are an important element of the monitoring systems of employment services in EU countries. Monitoring employment trends is a complex task that usually goes beyond quantitative parameters. The correct application and interpretation of the indicators is inseparable from contextual phenomena, and the use of comparative analyses at different scales, e.g. time, territory, makes it possible to increase the informativeness of this indicator. The aim of the paper is to identify, on the basis of the available data, the trends in the transition from unemployed to employment at the national and territorial level, and to forecast possible shirt-term development scenarios for the selected jobplacement indicators. The methodological part of the paper assesses the links between unemployment trends and jobplacement indicators. The methodological approach to the assessment of differentiation of jobplacement indices are described there. On the basis of the data from the customer service units of the national Employment Service, an analysis of the spatial distribution of the transition of the registered unemployed to employment was conducted. The forecast of the indicators was based on short-term historical data from the customer service units and economic context variables. In the face of relatively unfavourable forecasts for the EU economic situation, the paper presents the assumptions for changes in the situation on the Lithuanian labour market in the short term.

The purpose of the article was to consider the possibilities of a modern school in the prevention of risky behavior of adolescents. The focus of the research seems relevant due to the fact that the scientific solution meets the urgent needs of the practice of organizing these activities and fills a certain gap in modern research in overcoming risky behaviors of the younger generation. Methods of comparative analysis of psychological and pedagogical scientific sources were used in the preparation of the material, theoretical analysis of monographic and dissertation materials, documentation on the problems of research using generalization, comparison, systematization and modeling was carried out. The article considers a possible field of prevention of risky behavior at school, which lies at the intersection of three components of the environment of an educational organization. These include motivational-value (formation of factors that stimulate subjects of prevention to obtain a predictable positive result), social-subjective (formation of factors that contribute to the formation and development of subjectivity of adolescents in academic, extracurricular, extracurricular work, additional education, self-government, amateur activity), actualization – creative (formation of factors of creative realization of a teenager, aimed at on the formation of the ability to constructive risk) components. As a result, the author came to the conclusion that it is possible to achieve the predicted result of prevention of risky behavior of adolescents using the capabilities of a modern school resulting from the creation and replenishment of its components.

Introduction. Rabbit hemorrhagic disease is an acute highly contagious infection associated with two genotypes of pathogenic Lagovirus. Antibodies to major capsid protein (Vp60) are protective. The aim of the work ‒ is an evaluation of antigenic and immunogenic activity of virus-like particles (VLPs) based on recombinant major capsid proteins of both genotypes of rabbit hemorrhagic disease virus (RHDV) (recVP60-GI1 and recVP60-GI2). Materials and methods. Baculovirus-expressed VLPs were evaluated using electron microscopy and administered to clinically healthy 1.53 month old rabbits in a dose of 50 g. Rabbits were challenged with 103 LD50 of virulent strains Voronezhsky-87 and Tula 21 days post immunization. Serum samples were tested for the presence of RHDV-specific antibodies. Results. VLPs with hemagglutination activity forming VLP 3040 nm in size were obtained in Hi-5 cell culture. Specific antibody titers in rabbits measured by ELISA were 1 : 200 to 1 : 800 on 21th day post immunization with VLPs. Immunogenic activity of recVP60-GI1 VLPs was 90 and 40%, while it was 30 and 100% for recVP60-GI2 VLPs after the challenge with RHDV genotypes 1 and 2 respectively. The immunogenicity of two VLPs in mixture reached 100%. Discussion. VLPs possess hemagglutinating, antigenic and immunogenic activity, suggesting their use as components in substances designed for RHDV specific prophylaxis in rabbits. Results of the control challenge experiment demonstrated the need to include the antigens from both RHDV genotypes in the vaccine. Conclusion. Recombinant proteins recVP60-GI1 and recVP60-GI2 form VLPs that possess hemagglutinating an antigenic activity, and provide 90100% level of protection for animals challenged with RHDV GI1 and GI2 virulent strains.

Few studies have explored the learning opportunities different audiovisual genres may create for vocabulary learning. Even fewer have looked at how learners' viewing experience is affected by individual differences (IDs) in vocabulary size, attention, inhibition, or working memory. Such IDs have been shown to mediate early and long-term vocabulary learning (Gass, Winke, Isbell, & Ahn, 2019; Kam, Liu, & Tseng, 2020; Peters & Webb, 2018). This exploratory study seeks to analyze how vocabulary is acquired under different genres and how this process may be influenced by the IDs mentioned above. Forty-one students of English as a foreign language (EFL) participated in an experiment involving the viewing of four TV genres (sitcom, police procedural, animal documentary, and edutainment). Meaning recognition task was applied at the pretest and posttest, and form recognition at the posttest only. Prior to viewing, students took four cognitive tests related to vocabulary size, attention control, inhibition, and working memory. Results suggest vocabulary size had the largest impact on the participants' performance at pretest and posttest, although its relative weight varied across genres. A nonsignificant or much lesser role was played by working memory, attention, and inhibition. Results are discussed regarding what genre might create the most beneficial conditions for vocabulary learning and how IDs influence such learning.

The paper is devoted to the task of searching for mentions of green practices in social media texts. The relevance of this task is dictated by the need to expand existing knowledge about the use of green practices in society and the spread of existing green practices. This paper uses a text corpus consisting of the texts published on the environmental communities of the VKontakte social network. The corpus is equipped with an expert markup of the mention of nine types of green practices. As part of this work, a semi-automatic approach is proposed to the collection of additional texts to reduce the class imbalance in the corpus. The approach includes the following steps: detecting the most frequent words for each practice type; automatic collecting texts in social media that contain the detected frequent words; expert verification and filtering of collected texts. The four machine learning models are compared to find the mentions of green practices on the two variants of the corpus: original and augmented using the proposed approach. Among the listed models, the highest averaged F1-score (81.32%) was achieved by Conversational RuBERT fine-tuned on the augmented corpus. Conversational RuBERT model was chosen for the implementation of the application prototype. The main function of the prototype is to detect the presence of the mention of nine types of green practices in the text. The prototype is implemented in the form of the Telegram chatbot.

Introduction. Treatment of patients with brain metastases is an important problem that should be considered in the framework of combination approach. Introduction of new techniques of drug therapy as well as radiotherapy and neurosurgical treatment allows to significantly increase patient survival. Effective drug therapy and local control of brain metastases are of utmost importance in prediction of overall survival and patient quality of life.Aim. To investigate the prognostic factors for overall survival and intracranial progression (local recurrences, distant metastases) in patients with brain metastases of renal cancer after neurosurgical resection.Materials and methods. Retrospective analysis of the treatment results of 114 patients with metastatic brain lesions due to renal cancer who underwent neurosurgical resection (NSR) at the N. N. Blokhin National medical Research Center of Oncology was performed. Clinical data of 102 (89.5 %) of 114 patients for whom data on survival was available were evaluated. Among them, 80 (78.4 %) of patients died, 22 (21.5 %) are under observation. Extracranial disease status at the time of NSR was known in 82 (71.9 %) patients: 45 (54.8 %) patients had extracranial metastases, and 37 (45.1 %) did not. Total resection of brain metastases with perifocal and perivascular zones was performed in 92 (90.1 %) patients; in other cases, fragmental lesion resection was performed.Results. median overall survival after NSR was 13.8 months (95 % confidence interval 10.3–18.6). per study data, factors affecting overall survival of patients with brain metastases of renal cancer after neurosurgical resection were presence / absence of extracranial metastases and patient’s functional status. Local recurrences in the postoperative cavity after NSR were observed in 24 (21 %) of 114 patients. median time of local recurrence was not achieved. Statistically significant factor of high risk of recurrence in the postoperative cavity was presence of lesions with maximal diameter ≥2 cm. Development of new (distant) metastases was observed in 31 (27.2 %) of 114 patients. median survival without distant metastases in patients with brain metastases after NSR was not achieved. frequencies of distant metastases at 6, 12 and 24 months were 15.5; 24.1 and 35.8 % respectively. per multifactor analysis, factors affecting development of distant metastases in the brain after NSR are multiple metastatic brain lesions and presence of extracranial metastases.Conclusion. Neurosurgical resection in patients with cerebral metastases of renal cancer in the total group leads to median overall survival of 13.8 months. predictors of better overall survival are absence of extracranial metastases and high functional status.

The prevalence of cognitive impairment in patients with multiple sclerosis is 40 to 65%. Improvement of cognitive-oriented therapy and search for its new techniques is considered to be promising for slowing the progression or for recovery of cognitive functions. It is related to low efficacy of medical treatment, preserved neuroplasticity in most patients with multiple sclerosis, positive results of studies on selected cognitive rehabilitation techniques in other nervous system disorders. The spectrum of techniques for cognitive training varies from technically feasible methods using a sheet of paper and a pen to the most advanced ones, such as the use of immersive virtual reality. The effectiveness of cognitive rehabilitation in patients with multiple sclerosis with virtual reality technologies has not been studied in large-scale randomized placebo-controlled studies.

This study was undertaken to analyze the effectiveness of cytological diagnostics of endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total of 25 endocervical adenocarcinomas, including endocervical adenocarcinomas in situ, were diagnosed using cytological methods over a year. Liquid-based cytology ensured better detection of glandular differentiation signs than conventional cytology. After molecular testing for human papillomavirus (HPV), we performed retrospective analysis of cytological characteristics of all endocervical adenocarcinomas (n = 15).We identified specific cellular characteristics of HPV-associated typical and mucinous adenocarcinomas. We also observed 1 case of non-HPV-related clear-cell and 1 case of non-HPV-related mesonephral adenocarcinoma.Our findings suggest that endocervical adenocarcinomas are a heterogeneous group of tumors. Endocervical adenocarcinomas accounted for 10.7 % of all primary cervical carcinomas (n = 214). Eighty percent of all endocervical adenocarcinomas were HPV-related, whereas the remaining 20 % were HPV-negative. We found no cytological differences between invasive endocervical adenocarcinomas and adenocarcinomas in situ.Mutations detected in some of the patients are an important diagnostic criterion that specifies whether the tumor is rare.

The degradation of polylactide (PLA) films of different structures under conditions of controlled composting has been studied. We have demonstrated that PLA underwent degradation within one month in a substrate that simulated standard industrial composting. Regardless of the initial structure of the samples, the number-average molecular weight (Mn) decreased to 4 kDa while the degree of crystallinity increased to about 70% after 21 days of composting. Addition of an inoculant to the standard substrate resulted in the accelerated degradation of the PLA samples for one week due to an abiotic hydrolysis. These findings have confirmed that industrial composting could solve the problem of plastic disposal at least for PLA.

While the population is ageing fast in Lithuania the possible ways of adaptation of older people in labour market should be analysed thoroughly. A small private company operating in the sector of electric installation was selected as a case. Analysis was aimed to reveal the main sector-specific enterprise-level factors for participation in labour market after the official retirement age. Paper presents both employee’s and employer’s perspectives on sustainable employment. The case study presents the experience of the 72 years old electrician and the employer’s undertakings to encourage older workers to continue their careers. The data from the micro-level are analysed within the socio-economic context of the country. The case study shows that a long career is probable when both the business and the employees benefit from it, and the employee’s health condition is satisfying. From the employer’s perspective, the benefits derived from the employment of the high-skilled, experienced, and reliable workers; and from the older employee’s perspective, such aspects as self-realisation and favourable conditions at the workplace have a great value.

Retrospective analysis of the usage of fine needle aspiration breast cytolology has been represented in the present work. The potentialities of cytological diagnostics according to Yokohama system with characteristics of C1–C5 categories were estimated. The results of cytological conclusions of 4778 patients with breast lesions who had been examined in the Altay oncological dispensary during the year were studied. Fine needle aspiration breast cytology was used of outpatients in 89.6 % cases. The largest number of patients with pathological changes in the breast was noted in category C2 with benign processes (75.7 % of all cases). Difficult cases for cytological study, where the method could not guarantee the accuracy of the diagnosis, belong to the C3 and C4 categories (1.9 % of all cases). The cytological conclusion recommended the compulsory usage of the core biopsy. Malignant tumors were identified in 853 (19.9 %) patients with an indication of the histological type of tumors.Thus, the cytological technique (as a part of Triple test) should be chosen for outpatients with breast diseases using the Yokohama writing system (C1–C5 categories) of fine needle aspiration cytology.

Budget mobilization and improvements in the quality of tax administration are always among the top priorities for fiscal authorities. During periods of instability the role of tax compliance and budget execution increases even more. Times like these require quick analysis and adaptation of the tax system to changing economic conditions, and do not always allow conventional scientific approaches to be used in the analysis of tax collection. Fiscal authorities are faced with the need to create relatively simple tools for assessing that would allow one to analyze revenues with a minimum set of data and to assess the efficiency of the tax authorities taking into account changes in the macroeconomic environment. The integral index of collection presented in this work can help solve this problem. The essence of the approach is to analyze the coherence of two dynamics: actual tax receipts and their proxy tax base. The methodical advantages of the proposed indicator are its relative simplicity and versatility. It is applicable for most of the tax and non-tax payments and can be used both independently and in conjunction with other indicators of tax collection completeness. The above makes the index a convenient tool for quick analysis at different stages of the budget process—it can be useful not only for ex-post understanding of trends in budget revenues execution and tax administration dynamics, but also for improving the accuracy of budget forecasts ex-ante.