78 results on '"Moskovtchenko JF"'
Search Results
2. O11-7 Étude des bilans pré- et post-transfusionnels à l'hôpital neuro-cardiologique des Hospices Civils de Lyon
- Author
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Garin, L, primary, Augey, L, additional, Vial, J, additional, Renaudier, P, additional, Hirschauer, C, additional, Madjar, JJ, additional, and Moskovtchenko, JF, additional
- Published
- 1998
- Full Text
- View/download PDF
3. Impact de recommandations d'antibiotherapie sur les resistances bacteriennes dans un service de reanimation
- Author
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Coronel, B, primary, Mercatello, A, additional, Lina, G, additional, Dorez, D, additional, M, Blanc-Jouvan, additional, Gallet, D, additional, Bret, M, additional, and Moskovtchenko, JF, additional
- Published
- 1997
- Full Text
- View/download PDF
4. Patients with metastatic renal carcinoma candidate for immunotherapy with cytokines. Analysis of a single institution study on 181 patients
- Author
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Philip, T, primary, Negrier, S, additional, Lasset, C, additional, Coronel, B, additional, Bret, M, additional, Blay, JY, additional, Merrouche, Y, additional, Carrie, C, additional, Kaemmerlen, P, additional, Chauvin, F, additional, Favrot, M, additional, Oskam, R, additional, Tabah, I, additional, Clavel, M, additional, Moskovtchenko, JF, additional, and Mercatello, A, additional
- Published
- 1993
- Full Text
- View/download PDF
5. Intravenous interleukin-2 in patients over 65 with metastatic renal carcinoma
- Author
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Négrier, S, primary, Mercatello, A, additional, Bret, M, additional, Thiesse, P, additional, Blay, JY, additional, Coronel, B, additional, Merrouche, Y, additional, Oskam, R, additional, Franks, CR, additional, Clavel, M, additional, Moskovtchenko, JF, additional, and Philip, T, additional
- Published
- 1992
- Full Text
- View/download PDF
6. In situ decontamination of medical wastes using oxidative agents: a 16-month study in a polyvalent intensive care unit.
- Author
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Coronel B, Duroselle P, Behr H, Moskovtchenko JF, and Freney J
- Subjects
- Prospective Studies, Reproducibility of Results, Decontamination methods, Intensive Care Units, Medical Waste, Oxidants, Ozone, Waste Management methods
- Abstract
Over a 16-month period from September 1997 to December 1998, a prospective study was made of an on-site treatment of medical wastes in a 10-bed intensive care unit. First, the wastes were ground and then, a high concentration of ozone in air was repeatedly injected into the ground wastes. The study analysed the practical application of the system and its microbiological efficiency. Inactivation experiments were made with reference strains of Staphylococcus aureus, Enterococcus hirae, Pseudomonas aeruginosa, Escherichia coli, Mycobacterium smegmatis, Bacillus subtilis var niger, Bacillus stearothermophilus, Candida albicans and Aspergillus niger. Two thousand eight hundred treatment cycles, i.e. 84,000 grindings and 140,000 ozone injections gave a treatment capacity of 50 kg of waste per day with a good staff acceptability. All kinds of medical devices used in an intensive care unit were treated. In untreated ground wastes, the median bacterial load was 105.86 (range 10(2.35)-10(8.05)) cfu/g. After ozone treatment, bacteria and fungi were reduced by a factor of 10(5). Aero-contamination of the ward was unchanged. Computer control allowed all events to be tracked. On-site medical waste treatment appears to be an efficient alternative to the usual centralized collection and treatment., (Copyright 2002 The Hospital Infection Society.)
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- 2002
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7. [The value of anesthesia consultation in relation to the single preanesthetic visit].
- Author
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Blanc-Jouvan M, Mercatello A, Long D, Benoit MP, Khadraoui M, Némoz C, Gaydarova M, Boissel JP, and Moskovtchenko JF
- Subjects
- Analysis of Variance, Anesthesia, General, Female, France, Hospitalization, Humans, Incidence, Length of Stay, Male, Middle Aged, Multivariate Analysis, Ophthalmologic Surgical Procedures, Otorhinolaryngologic Surgical Procedures, Patient Admission, Patient Satisfaction, Prospective Studies, Time Factors, Urologic Surgical Procedures, Anesthesiology, Referral and Consultation
- Abstract
Objective: In France, a preanaesthetic assessment (PAA) several days prior to hospital admission for a scheduled surgical or diagnostic procedure under anaesthesia, associated with a preanaesthetic visit (PAV) the day before, are compulsory. This study aimed at comparing the benefits of PAA with those of a PAV not preceded by a PAA., Study Design: Prospective, controlled, randomized study., Patients: The study included 296 patients undergoing either a urologic, or ophthalmologic, or ENT procedure, randomly allocated either to a PAA (followed by a PAV) group or a PAV (without previous PAA) group., Methods: The main criterion of comparison was the duration of preanaesthetic hospital stay and the secondary criteria were the incidence of procedure postponements and patients' satisfaction respectively., Results: In the PAA group, the preanaesthetic hospital stay was shorter by 0.4 days (P = 0.001). Out of the 19 postponed procedures (7%), the cause of postponement was a medical one in 15 patients: 13 in the PAV group and 2 in the PAA group respectively (P = 0.009). The PAA was not considered as a constraint by most patients., Conclusion: The PAA shortens the duration of preanaesthetic hospital stay and decreases the incidence of procedures postponed for a medical cause.
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- 1999
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8. Acetate-free biofiltration for acute renal failure.
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Bret M, Hurot JM, Mercatello A, Coronel B, Dorez D, Laville M, and Moskovtchenko JF
- Subjects
- Acid-Base Equilibrium, Bicarbonates, Female, Humans, Male, Membranes, Artificial, Middle Aged, Prospective Studies, Renal Dialysis, Weight Loss, Acute Kidney Injury therapy, Hemodiafiltration
- Abstract
The characteristics of acetate-free biofiltration (AFB) are now well documented in patients with chronic renal failure: hemodynamic tolerance, correction of acid-base imbalance, buffer-free dialysate (without acetate) and absence of backfiltration. This hemodialysis technique can be beneficial to patients with acute renal failure (ARF). In our intensive care unit, we prospectively studied 29 patients with isolated ARF or ARF associated with failure of other organs. All eligible patients were randomly assigned to undergo dialysis with bicarbonate hemodialysis (BH) or with (AFB). All used the same high flux biocompatible dialysis membranes. Effectiveness and hemodynamic tolerance of hemodialysis sessions and evolution of patients were analyzed. Correction of metabolic disorders, although better in the AFB group was not statistically different from that in the BH group. Re-equilibration of acid-base balance was also similar, with or without mechanical ventilation. Heparin consumption was significantly higher in the AFB group, with no effect on haemorrhagic complications. Analysis of hypo- and hypertensive episodes, defined as arterial pressure (AP) variations 20% greater than initial pressure, showed no difference in terms of number or degree of AP variation. However, weight loss and the rate of ultrafiltration led to a higher hypotensive risk in the BH group (p < 0.05). Finally, the clinical course and prognosis was similar in both groups. In summary, AFB may be considered as effective a hemodialysis technique as BH in patients with ARF. Weight loss was better tolerated in the AFB group and can be a favorable factor considering the deleterious effect of overhydration in patients admitted to an intensive care unit. This study invites a comparison of longer dialysis session of AFB therapy and continuous hemodiafiltration.
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- 1998
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9. Brain death management: keystone of transplantation activity.
- Author
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Bret M, Coronel B, Vinot O, and Moskovtchenko JF
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- Humans, Brain Death, Organ Transplantation, Tissue Donors
- Published
- 1997
- Full Text
- View/download PDF
10. Cardiac aspergillosis: importance of transesophageal echocardiography.
- Author
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Blanc-Jouvan M, Mercatello A, Duperret S, Coronel B, Bret M, Troncy J, and Moskovtchenko JF
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- Fatal Outcome, Humans, Male, Middle Aged, Abscess diagnostic imaging, Aspergillosis diagnostic imaging, Echocardiography, Transesophageal, Heart Diseases diagnostic imaging
- Published
- 1996
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11. Transesophageal echocardiographic assessment of left ventricular function in brain-dead patients: are marginally acceptable hearts suitable for transplantation?
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Vedrinne JM, Vedrinne C, Coronel B, Mercatello A, Estanove S, and Moskovtchenko JF
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- Adolescent, Adult, Female, Humans, Male, Middle Aged, Prospective Studies, Tissue Donors, Brain Death physiopathology, Echocardiography, Transesophageal, Heart Transplantation, Ventricular Function, Left
- Abstract
Background: The brain-dead donor supply has become one of the criteria limiting the performance of heart transplantation. Conventional screening criteria are too limiting and exclude suitable heart donors. Echocardiography is now widely available and is a reliable tool to assess left ventricular dysfunction in brain-dead donors. Yet few data are available on the degree of left ventricular dysfunction where a transplantation is possible., Methods: Fifty-five potential brain-dead heart donors (age 38 +/- 11 years) were prospectively evaluated by transesophageal echocardiography (TEE) before harvesting. Fractional area change (FAC) was used to assess left ventricular function in potential brain-dead donors. Transplanted hearts were evaluated on the fifth postoperative day. The transplantation was considered a success if the recipient was alive, not retransplanted, without an assistance device or an epinephrine infusion of more than 1 mg/h and showed an ejection fraction above 40%., Results: Of the 55 potential heart donors, 20 exhibited an FAC of less than 50%. Forty hearts were harvested, 36 of which were successfully transplanted. Nine patients had an FAC below 50% (group H2) and 27 had an FAC over 50% (group H1). Four patients died: 2 from hemorrhage (FAC > 50% in donors); 1 from right and one from left ventricular dysfunction (FAC < 50% in donors). The FAC increased significantly from 51 +/- 15% to 57 +/- 11% in 18 hearts that underwent TEE in donors and afterwards in recipients. Overall actuarial survival was 86.2% versus 64.6% at 1 and 2 years in group H1 and group H2, respectively (p = NS)., Conclusions: TEE is useful to assess left ventricular function in potential brain-dead donors. An FAC less than 50% is present in 36% of potential heart donors. Because left ventricular dysfunction is often reversible shortly after transplantation, an FAC below 50% may not necessarily preclude the use of hearts for transplantation.
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- 1996
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12. Hypophysis-thyroid axis disturbances in human brain-dead donors.
- Author
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Colpart JJ, Ramella S, Bret M, Coronel B, Dorez D, Mercatello A, Hadj Aissa A, and Moskovtchenko JF
- Subjects
- Humans, Thyrotropin blood, Thyroxine blood, Triiodothyronine blood, Triiodothyronine, Reverse blood, Brain Death, Pituitary Gland, Anterior metabolism, Thyroid Gland metabolism, Tissue Donors
- Published
- 1996
13. Logistics and management for improvement of multiorgan procurement from potential brain-dead donors.
- Author
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Colpart JJ, Bouttin B, Guillot B, Maillefaud B, Marion A, Saury G, Leone C, Minarro D, and Moskovtchenko JF
- Subjects
- Europe, Hospitals, General, Hospitals, University, Humans, Models, Theoretical, Regional Health Planning, Tissue and Organ Procurement statistics & numerical data, Brain Death, Tissue Donors, Tissue and Organ Procurement organization & administration
- Published
- 1996
14. [Mode of failure of transfusion. Systematic analysis of dysfunctions during 4 months].
- Author
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Renaudier P, Augey L, Vial J, and Moskovtchenko JF
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- Humans, Treatment Failure, Blood Transfusion methods
- Published
- 1995
15. Clinical application of retroviral gene transfer in oncology: results of a French study with tumor-infiltrating lymphocytes transduced with the gene of resistance to neomycin.
- Author
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Merrouche Y, Negrier S, Bain C, Combaret V, Mercatello A, Coronel B, Moskovtchenko JF, Tolstoshev P, Moen R, and Philip T
- Subjects
- Adult, Aged, Blotting, Southern, Cells, Cultured, Cytotoxicity, Immunologic, Female, Genes, Viral, Genetic Therapy, Genetic Vectors, Humans, Interleukin-2 therapeutic use, Lymphocytes, Tumor-Infiltrating immunology, Lymphocytes, Tumor-Infiltrating transplantation, Male, Melanoma secondary, Middle Aged, Polymerase Chain Reaction, Time Factors, Carcinoma, Renal Cell therapy, Drug Resistance genetics, Gene Transfer Techniques, Immunotherapy, Adoptive, Kidney Neoplasms therapy, Melanoma therapy, Neomycin pharmacology, Retroviridae genetics, Transduction, Genetic
- Abstract
Purpose: Adoptive immunotherapy with tumor-infiltrating lymphocytes (TIL) and interleukin-2 (IL-2) has been reported to mediate tumor regression in some human cancers. To define better the biologic characteristics of TIL, especially survival and distribution in vivo, we performed a gene-marker study in patients with advanced malignancies., Patients and Methods: We treated five patients with metastatic melanoma or renal cell carcinoma with adoptive immunotherapy. TIL were genetically modified, before their infusion, using a recombinant retroviral vector that contained the marker gene coding for resistance to neomycin (NeoR)., Results: All of the patients tolerated the treatment well and none of the theoretic safety hazards due to the retroviral gene transduction was observed. The presence of the NeoR gene in TIL was detected by Southern blot analysis, with an efficiency of transduction that ranged from 1% to 26%. With polymerase chain reaction (PCR) analysis, we demonstrated that gene-modified TIL can survive for several months after reinjection, since positive blood samples were observed up to day 260 following reinjection. Eight malignant biopsy specimens were obtained from three patients after cell infusion. TIL were detected in only four of these eight tumor deposits on days 7 and 260., Conclusion: These results confirm the feasibility and safety of using in vitro retroviral gene transduction in human lymphocytes to analyze their in vivo distribution for further therapeutic applications. However, a selective and prolonged retention of TIL at the tumor site was not found in this study.
- Published
- 1995
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16. Itraconazole concentrations during continuous haemodiafiltration.
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Coronel B, Persat F, Dorez D, Moskovtchenko JF, Peins MA, and Mercatello A
- Subjects
- Humans, Itraconazole analogs & derivatives, Male, Middle Aged, Acute Kidney Injury therapy, Hemodiafiltration methods, Itraconazole blood
- Published
- 1994
- Full Text
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17. [Can hydroxyethylamidon be used during intensive care of brain-dead organ donors?].
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Coronel B, Laurent V, Mercatello A, Bret M, Colon S, Colpart JJ, and Moskovtchenko JF
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- Adult, Albumins administration & dosage, Albumins pharmacology, Blood Coagulation Tests, Clinical Protocols, Female, Hemodynamics drug effects, Humans, Hydroxyethyl Starch Derivatives pharmacology, Kidney Transplantation, Male, Middle Aged, Brain Death, Critical Care, Hydroxyethyl Starch Derivatives administration & dosage, Tissue Donors
- Abstract
In France, most of the kidney grafts are obtained from brain dead organ donors. Brain death induces numerous changes, especially in haemodynamic status, requiring the infusion of large volumes of fluid. The aim of this study was to evaluate the effect of hydroxyethyl starch (HES) on the organ donors and the kidney graft function in recipients. We compared two groups of brain dead organ donors and the kidney grafts, differing by the infused solutions: either a combination of HES (Elohes, Biosedra) and 4% human albumin solutions (HES group), or albumin alone in the control group (Albumin group). In the two groups, sex-ratio, age, cause of brain death and duration of therapy were similar. Fluid requirements were identical in the two groups: respectively 2,211 +/- 1,512 mL in the Albumin group vs 2,452 +/- 1,094 mL in the HES group (p = 0.17). However, the volume of albumin was significantly decreased in the HES group: 711 +/- 822 mL (p = 0.0001). Therefore the cost was lower in the latter: 638 +/- 633 vs 1766 +/- 788 FF. The coagulation status was not significantly different between the two groups. Amylasemia was higher in the HES group, but the difference was not significant. In the Albumin group, urinary output increased, but not significantly and creatinemia was decreased: 113.9 +/- 62 vs 131.5 +/- 44 mumol.L-1 (p < 0.05). The two groups of recipients were also similar for sex-ratio, age, kind of graft, cause of the chronic renal failure and ischaemia times.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1994
- Full Text
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18. Treatment of acute respiratory failure with non-invasive intermittent positive pressure ventilation in haematological patients.
- Author
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Tognet E, Mercatello A, Polo P, Coronel B, Bret M, Archimbaud E, and Moskovtchenko JF
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- Acute Disease, Adolescent, Adult, Aged, Carbon Dioxide blood, Female, Humans, Intermittent Positive-Pressure Ventilation adverse effects, Male, Middle Aged, Outcome Assessment, Health Care, Partial Pressure, Prospective Studies, Respiratory Insufficiency etiology, Time Factors, Intermittent Positive-Pressure Ventilation methods, Leukemia complications, Respiratory Insufficiency therapy
- Abstract
Objective: The aim of this study was to assess whether non-invasive positive pressure ventilation delivered intermittently (Ni-IPPV) by means of a facial or nasal mask is beneficial in haematological patients suffering from acute respiratory failure., Design: Prospective, open, non-randomised study., Setting: University Hospital, medical intensive care unit., Patients and Method: Eighteen haematological patients with acute respiratory failure which occurred before, during or just after therapeutic aplasia were ventilated with Ni-IPPV delivered via an individual nasal mask or a standard facial mask. Non-invasive ventilation was achieved until weaning (success (S)) or intubation (failure (F))., Results: Twelve patients were ultimately intubated and died (F group). Seven needed intubation within 3 hours following admission because of the inability of Ni-IPPV to provide adequate ventilation in six patients and after cardiac arrest, probably related to cardiac aspergillosis in one patient. Six patients were not intubated and were discharged alive (S group). Of 11 patients who received Ni-IPPV for more than 3 hours, the respiratory rate decreased significantly (p < 0.05) from 33 +/- 7 breaths/min to 24 +/- 5 breaths/min with Ni-IPPV and the PaO2 increased significantly from 6.6 +/- 1.7 kPa upon admission to 17.7 +/- 5.5 kPa during Ni-IPPV. Mean daily ventilation was 12 +/- 7 hours for a mean duration of 5.5 +/- 4.4 days. Pressure support was used in nine patients and appeared the most efficient ventilation mode of non-invasive ventilation. The duration per day of Ni-IPPV was shorter and PaCO2 values during Ni-IPPV were lower in the S group than in the F group., Conclusions: This technique is able to provide adequate ventilatory support for many haematological patients and allows avoidance of ventilation in some.
- Published
- 1994
19. [Immunotherapy of metastatic kidney cancer].
- Author
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Négrier S, Mercatello A, Coronel B, Merrouche Y, Bret M, Blay JY, Thiesse P, Clavel M, Moskovtchenko JF, and Philip T
- Subjects
- Humans, Kidney Neoplasms therapy, Interferon-alpha therapeutic use, Interleukin-2 therapeutic use, Kidney Neoplasms pathology, Neoplasm Metastasis pathology
- Abstract
Interleukin 2 (IL2), like Interferon alpha (IFN), is active in metastatic renal cancer, considered to be a chemoresistant cancer. 20 to 30% of objective responses, including 5 to 10% of complete remissions are reported with various protocols of IL2 administration. The considerable toxicity is now well controlled, allowing treatments to be administered in standard wards or even on an outpatient basis by subcutaneous injection. IFN, generally given as long-term treatment, achieved average response rates of between 15 and 20%. Although IL2 and IFN have been granted Product Marketing Authorization in France, the modalities of optimal administration, the place of the combination of IL2-Interferon alpha and the factors predictive of response to treatment still remain unclear.
- Published
- 1993
20. Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma.
- Author
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Blay JY, Negrier S, Combaret V, Attali S, Goillot E, Merrouche Y, Mercatello A, Ravault A, Tourani JM, and Moskovtchenko JF
- Subjects
- Adult, Aged, Carcinoma, Renal Cell mortality, Carcinoma, Renal Cell secondary, Carcinoma, Renal Cell therapy, Female, Humans, Interleukin-2 therapeutic use, Kidney Neoplasms mortality, Kidney Neoplasms therapy, Male, Middle Aged, Prognosis, Survival Analysis, C-Reactive Protein analysis, Carcinoma, Renal Cell blood, Interleukin-6 blood, Kidney Neoplasms blood
- Abstract
Interleukin (IL) 6 was measured in the serum of 138 patients with metastatic renal carcinoma before the initiation of IL-2 treatment. IL-6 was detectable in 66 patients with renal cancer (48%) and in only 8 of 70 normal adults (11%). Serum C reactive protein (CRP) and IL-6 levels are correlated, suggesting that IL-6 is involved in CRP increase in these patients. The interval between diagnosis of the primary tumor and metastasis was shorter in patients with a detectable serum IL-6 and/or serum CRP level greater than 50 mg/liter. Serum IL-6 and CRP levels were higher in subgroups of patients previously defined as having a poor life expectancy according to the Eastern Cooperative Oncology Group criteria. Pretreatment concentrations of IL-6 and CRP were higher in patients who experienced progressive disease after IL-2 treatment. Patients with detectable IL-6 had a shorter survival from the beginning of IL-2 treatment than patients without circulating IL-6 (median, 8 versus 16 months). Similarly, the median survival from the beginning of IL-2 therapy of patients with CRP levels greater than 50 mg/liter was 6 months, compared to 16 months in those with CRP levels below this threshold. None of the 21 patients with serum IL-6 concentrations greater than 300 pg/ml achieved response to any of the three IL-2 regimens. This subgroup has a median survival of 5 months after IL-2 treatment and consisted of 15% of the patients in our series. These results indicate that serum IL-6 and CRP levels are adverse prognosis factors in patients with metastatic renal cell carcinoma. Serum IL-6 level could help in the selection or stratification of the patients in future IL-2 trials.
- Published
- 1992
21. [Treatment of cancer of the kidney with interleukin 2 in adults, the Lyon experience].
- Author
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Negrier S, Mercatello A, Coronel B, Ravaud A, Merrouche Y, Bret M, Lanier F, Moskovtchenko JF, and Philip T
- Subjects
- Drug Therapy, Combination, France, Humans, Infusions, Intravenous, Injections, Subcutaneous, Interferon-alpha administration & dosage, Kidney Neoplasms mortality, Kidney Neoplasms secondary, Interferon-alpha therapeutic use, Interleukin-2 therapeutic use, Kidney Neoplasms therapy
- Abstract
Like interferon-alpha, interleukin 2 (IL2) is active on metastatic kidney cancers, which are regarded as chemoresistant tumors. Out of 20 to 30% objective responses, 5 to 10% complete remissions are reported with various IL2 delivery schedules. The considerable toxicity is well mastered at present, thus allowing treatment in non-intensive care departments, or even in an ambulatory mode for subcutaneous administration. Even though Interleukin 2 has been authorized for sale in France, optimal mode of administration, the role of the IL2-interferon-alpha combination or the predictive factors of response to treatment still raise many questions.
- Published
- 1992
22. [Propofol versus etomidate in short-time urologic surgery].
- Author
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Baude C, Long D, Chabrol B, and Moskovtchenko JF
- Subjects
- Adult, Age Factors, Aged, Alfentanil administration & dosage, Anesthesia, Intravenous methods, Drug Evaluation, Hemodynamics drug effects, Humans, Middle Aged, Urologic Diseases surgery, Etomidate administration & dosage, Propofol administration & dosage
- Abstract
Thirty patients, scheduled for short urological surgical procedures and ranked ASA 1 or 2, were randomly assigned to two homogenous groups. In group P, they were given a 2 mg.kg-1 bolus of propofol and 10 micrograms.kg-1 of alfentanil, followed by a continuous infusion of propofol (5 mg.kg-1.h-1) and 5 micrograms.kg-1 doses of alfentanil. In group E, they were given a 0.3 mg.kg-1 bolus of etomidate, followed by an infusion (1.5 mg.kg-1.h-1). The doses of alfentanil were the same as in group P. Further doses of either propofol (0.5 mg.kg-1) or etomidate (0.2 mg.kg-1) were used should anaesthesia prove not to be deep enough. The patients were not intubated, and breathed spontaneously. Surgery lasted a mean of 18.3 +/- 11.8 min (group P) and 18.8 +/- 9.4 min (group E). The following parameters were studied: the amount of each agent required for maintenance of anaesthesia, the duration of apnoea at induction, the quality of anaesthesia and of muscle relaxation, adverse effects (coughing, trismus, restlessness, nausea, vomiting), the time required for recovery, and its quality. In group P, there was a 27% decrease in arterial pressure, without any tachycardia or hypoxia, together with a quick recovery of excellent quality. On the other hand, in group E, there was little or no haemodynamic alteration, but there often was a trismus at induction. Hypoxia also occurred during induction with etomidate, being severe enough in one case to require tracheal intubation and artificial ventilation. The reasons for this hypoxia seemed to be the apnoea and the trismus, which tends to hinder assisted ventilation.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1992
- Full Text
- View/download PDF
23. [Acute respiratory insufficiency in sickle cell disease].
- Author
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Dorez D, Marrast AM, Lepape A, Mercatello A, Banssillon V, and Moskovtchenko JF
- Subjects
- Acute Disease, Adult, Bronchoalveolar Lavage Fluid chemistry, Humans, Male, Middle Aged, Pulmonary Edema diagnosis, Anemia, Sickle Cell complications, Pulmonary Edema etiology, Respiratory Insufficiency etiology
- Abstract
Two cases are reported of acute respiratory failure occurring during sickling crises. In the first one, the crisis was characterised by priapism, and in the other one, by abdominal pain. The different causes of these respiratory effects are discussed: infection, fat embolism, pulmonary infarct, haemodynamic pulmonary oedema, as was probably the case in the first patient, or non haemodynamic pulmonary oedema due to sickling, as during conventional treatment of a sickling crisis (oxygen, antibiotics, blood transfusion, cytapheresis). Invasive investigations may contribute to keeping up the clinical picture, because of hypoxic sickling. The water equilibrium of these patients must be monitored with great care. Worsening of the patient's condition despite 48 h of correct treatment must lead to the search for a specific cause.
- Published
- 1992
- Full Text
- View/download PDF
24. Torulopsis glabrata peritonitis in a chronic hemodialyzed patient.
- Author
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Dhedin N, Coronel B, Gruner L, Fouque D, Laville M, Mercatello A, and Moskovtchenko JF
- Subjects
- Humans, Male, Middle Aged, Candidiasis etiology, Peritonitis etiology, Renal Dialysis adverse effects
- Published
- 1992
- Full Text
- View/download PDF
25. [Analysis of changes in serum levels of TNF, IL-1 and IL-6 during administration of IL-2. Correlation with clinical response to treatment].
- Author
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Blay JY, Négrier S, Combaret V, Merrouche Y, Mercatello A, Moskovtchenko JF, Philip T, and Favrot M
- Subjects
- Adenocarcinoma drug therapy, Adenocarcinoma secondary, Dose-Response Relationship, Drug, Humans, Interferon-alpha therapeutic use, Kidney Neoplasms drug therapy, Kidney Neoplasms secondary, Treatment Outcome, Interleukin-1 analysis, Interleukin-2 therapeutic use, Interleukin-6 analysis, Tumor Necrosis Factor-alpha analysis
- Abstract
We have investigated the serum concentrations of TNF, IL-1 and IL-6 in 49 patients with metastatic renal carcinoma receiving interleukin 2 (IL-2) or a combination of IL-2 and interferon alpha (IFN). Our results demonstrate that IL-2 and/or IFN induce an increase of serum concentrations of IL-1 and TNF in 95% and 75% of the patients respectively. Serum IL-6 levels increase in 44% of the patients. Serum concentrations of IL-1 and TNF remain elevated 48 hours after the end of IL-2 infusion. IL-1 and TNF levels are higher in patients receiving a combination of IL-2 and IFN. TNF and IL-1 levels in serum are significantly higher in responders to IL-2 treatment 48 hours after the end of IL-2 infusion. These two biological criteria enable a subgroup of patients with a very low response rate to IL-2 to be defined. The persistent increase of these cytokines in serum indicates a persistent activation of the immune system lasting after the end of IL-2 treatment which could be involved in the antitumor response.
- Published
- 1992
26. 99mTc-HMPAO cerebral scintigraphy in the diagnosis of brain death.
- Author
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Yatim A, Mercatello A, Coronel B, Bret M, Colpart JJ, Moskovtchenko JF, and Peyrin JO
- Subjects
- Brain Death physiopathology, Electroencephalography, Humans, Radionuclide Imaging, Technetium Tc 99m Exametazime, Technetium Tc 99m Pentetate, Brain diagnostic imaging, Brain Death diagnostic imaging, Organotechnetium Compounds, Oximes
- Published
- 1991
27. Acute renal failure with preserved renal plasma flow induced by cancer immunotherapy.
- Author
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Mercatello A, Hadj-Aïssa A, Négrier S, Allaouchiche B, Coronel B, Tognet E, Bret M, Favrot M, Pozet N, and Moskovtchenko JF
- Subjects
- Acute Kidney Injury physiopathology, Carcinoma, Renal Cell physiopathology, Carcinoma, Renal Cell secondary, Female, Glomerular Filtration Rate, Humans, Interferon Type I adverse effects, Interleukin-2 adverse effects, Kidney Neoplasms physiopathology, Male, Middle Aged, Recombinant Proteins, Renal Circulation, Acute Kidney Injury etiology, Carcinoma, Renal Cell therapy, Immunotherapy adverse effects, Kidney Neoplasms therapy
- Abstract
Adoptive immunotherapy in patients with advanced cancer produces significant regression of metastatic disease in selected patients, but it is complicated by severe side effects. Prevention of these complications is still limited because their precise mechanisms remain unknown. For this reason we have investigated renal function and hemodynamic parameters in 16 patients with renal cell carcinoma before and during treatment with a combination of high doses of both recombinant interleukin-2 (rIL2) and recombinant alpha-interferon. After patients had received three injections of combined immunotherapy, there was a decrease in mean blood pressure (-20%), glomerular filtration rate (-25%), urine output (-50%), and fractional sodium excretion (-0.8%). This was associated with an increase in heart rate (+30%), plasma creatinine level (+30%), fractional potassium excretion (+14%) and microalbuminuria (+130%). However, renal plasma flow remained constant. The increment in microalbuminuria may reflect an alteration of glomerular capillary permeability. The reduction in GFR may be accounted either for a decrease in efferent to afferent arteriolar resistance ratio, leading to a decrease in glomerular capillary pressure, or for a decrease in ultrafiltration coefficient, or both. Nonsteroidal antiinflammatory drugs, such as ketoprofen, used to minimize side effects, could considerably worsen renal function and should be avoided in patients treated by rIL2. Our results bring new insights into the pathogenesis of functional acute renal failure and provide a rational basis for the use of vasopressors in the treatment of cytokine-induced acute renal failure.
- Published
- 1991
- Full Text
- View/download PDF
28. [Cerebral aspergillosis in immunocompromised patients].
- Author
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Preckel MP, Mercatello A, Tognet E, Devaux Y, Archimbaud E, Fiere D, and Moskovtchenko JF
- Subjects
- Adult, Amphotericin B therapeutic use, Aspergillosis cerebrospinal fluid, Aspergillosis diagnostic imaging, Aspergillosis drug therapy, Brain Diseases cerebrospinal fluid, Brain Diseases diagnostic imaging, Brain Diseases drug therapy, Bronchoalveolar Lavage Fluid, Female, Humans, Male, Middle Aged, Prognosis, Tomography, X-Ray Computed, Aspergillosis etiology, Brain Diseases etiology, Immunologic Deficiency Syndromes complications
- Abstract
Three cases of central nervous system (CNS) aspergillosis in immunocompromised patients are reported. All three had neurological symptoms with normal cerebrospinal fluid (CSF). The CT scan showed poorly defined low density lesions which were not enhanced by contrast medium. They also had pulmonary signs and fever despite antibiotic treatment. Aspergillus fumigatus was isolated from bronchoalveolar lavage fluid. Antifungal therapy was started promptly, associating amphotericin B, itraconazole and flucytosine. Unfortunately, they died within 2 days to 2 weeks after admission in the intensive care unit. Postmortem examinations revealed disseminated aspergillosis with colonization of brain, lung, heart and kidney. The CT scan signs were quite different from those seen with the more usual bacterial ring lesions. In immunocompromised patients, the agents responsible for producing these findings are Aspergillus, Nocardia, Cryptococcus, Toxoplasma and Mycobacterium tuberculosis. Signs involving organs other than the CNS, and an examination of the CSF, should provide elements for establishing a differential diagnosis. Early antifungal treatment is the only chance of survival. Recrudescent fever and pulmonary signs occurring in neutropenic patients after antibacterial antibiotic treatment has been started are sufficient criteria for empirically starting amphotericin B administration unless clinical judgement dictates otherwise.
- Published
- 1991
- Full Text
- View/download PDF
29. Microalbuminuria is acutely increased during anesthesia and surgery.
- Author
-
Mercatello A, Hadj-Aïssa A, Chery C, Sagnard P, Pozet N, Tissot E, Boulez J, and Moskovtchenko JF
- Subjects
- Adult, Aged, Albuminuria physiopathology, Albuminuria urine, Capillary Permeability physiology, Female, Humans, Kidney Glomerulus blood supply, Kidney Glomerulus physiopathology, Male, Middle Aged, Albuminuria etiology, Anesthesia adverse effects, Intraoperative Complications etiology
- Abstract
Microalbuminuria is known to increase in various diseases with potential repercussion on the kidneys and indicates an increase in glomerular intracapillary pressure or changes in permeability characteristics. In this study, we measured whether albumin excretion is affected in patients undergoing anesthesia and surgery, which are both known to induce dramatic changes in renal function and in the release of vasoactive substances such as catecholamines, vasopressin, angiotensin, and prostaglandins. Seven patients with normal renal function and physiological microalbuminuria prior to surgery were studied. Urine samples were collected before anesthesia, just before the beginning of surgery, and thereafter 30 min following incision, and 30 min after the end of surgery. Anesthesia induced a significant increase in microalbuminuria, which further increased during surgery. After the end of surgical procedure, microalbuminuria decreased but remained significantly higher than control. This phenomenon may be due to an increase in intracapillary glomerular pressure and/or an alteration in glomerular permeability induced by a direct effect of drugs, or to the action of vasoactive substances on the glomerular structure.
- Published
- 1991
- Full Text
- View/download PDF
30. [Postoperative analgesia for nephrectomy].
- Author
-
Baude C, Long D, Chabrol B, and Moskovtchenko JF
- Subjects
- Acetaminophen administration & dosage, Acetaminophen analogs & derivatives, Adult, Analgesia, Epidural, Bupivacaine administration & dosage, Buprenorphine administration & dosage, Drug Administration Schedule, Female, Humans, Injections, Intravenous, Male, Meperidine administration & dosage, Middle Aged, Pleura, Analgesics administration & dosage, Nephrectomy, Pain, Postoperative drug therapy
- Abstract
The aim of this study of post-nephrectomy acute pain in 30 patients was to compare three methods of postoperative analgesia and determine which one could be the most satisfactory. Ten patients received epidural analgesia with pethidine (400 mg.24 h-1 for 48 hrs). Ten other patients received intrapleural analgesia with bupivacaine (0.2 mg.kg-1.h-1 of 0.5% bupivacaine with 1/200,000 epinephrine). The ten remaining patients received systemic IV analgesia (2 g of propacetamol every 6 hrs and 0.15 mg of buprenorphine every 6 hrs). According to results of pain evaluation score (VAS) epidural analgesia with pethidine (VAS less than 2.5) appeared to be the best tested analgesic method. IV systemic analgesia (VAS less than 5) was less effective. Intrapleural bupivacaine (VAS greater than 5) was ineffective but apparently not toxic (serum concentration less than 1,200 ng.ml-1).
- Published
- 1991
31. [Value of the combination of propofol-alfentanil and vecuronium for the anesthesia of laparoscopy in ambulatory patients].
- Author
-
Bagou G, Laplace MC, Coronel B, Prud'hon MC, Clement HJ, Muguet D, and Moskovtchenko JF
- Subjects
- Adult, Anesthesia, General methods, Blood Pressure drug effects, Drug Combinations, Female, Heart Rate drug effects, Humans, Alfentanil, Ambulatory Surgical Procedures, Laparoscopy, Propofol, Vecuronium Bromide
- Abstract
Laparoscopy without an important surgical act was executed in twenty patients. Anaesthetic protocol associated propofol, alfentanil and vecuronium. This protocol meet conditions for ambulatory patients. Only three were not suited to leave hospital six hours after coelioscopy.
- Published
- 1991
32. [Organization of organ transplantation in France].
- Author
-
Colpart JJ, Noury D, Cochat P, Kormann P, and Moskovtchenko JF
- Subjects
- Child, Europe, France, Humans, Organization and Administration, Tissue and Organ Procurement, Organ Transplantation legislation & jurisprudence, Organ Transplantation statistics & numerical data
- Abstract
France was in tenth position in the field of kidney transplant in Europe in 1982, and is currently at the top of western countries for all transplant activities (per million inhabitants). Cyclosporin A was certainly a favourable factor for liver, heart and lung transplantations. Nevertheless the transplantation activity in France is twice than of Great Britain or Germany for those transplant specialties and the percentage of renal transplantations from living related donors is very low in France: 2.7% versus 30% in others. These data depend on a specific French organization which involves: a presume consent law; an emergency policy with mobile medical rescue teams and polyvalent intensive care units; a three level France Transplant organization: national, regional and local; hospital physicians as regional transplant coordinators who are independent from transplant teams; waiting list telematic computer system which promotes priorities: high emergencies, high-sensitized and pediatric recipients.
- Published
- 1991
33. [Peroperative septic shock during a percutaneous nephrolithotomy].
- Author
-
Baude C, Long D, Chabrol B, Wherlin P, and Moskovtchenko JF
- Subjects
- Adult, Humans, Male, Intraoperative Complications, Nephrostomy, Percutaneous, Shock, Septic etiology
- Published
- 1990
34. [Antibiotic prophylaxis with cefotiam in transurethral resection of the prostate].
- Author
-
Baude C, Wehrlin P, Long D, Chabrol B, Salas M, and Moskovtchenko JF
- Subjects
- Aged, Anti-Infective Agents, Urinary, Humans, Male, Middle Aged, Postoperative Complications prevention & control, Urinary Tract Infections prevention & control, Cefotiam therapeutic use, Premedication, Prostatectomy, Urethra surgery
- Abstract
Unlabelled: Over a period of 7 months, 50 patients underwent a trans-urethral resection of the prostate (TURP), this intervention is classified as "clear-contamined". The antibiotic prophylactic protocol, the subject of this study, was the following: cefotiam 2 g IV with the induction of anesthesia, 1 g 3 hours later and 1 g IV with the removal of the urethral catheter., Results: there were 3 early post-operative urinary tract infections, one of these patients was symptomatic, at the time of removal of the urethral catheter. Most of these infections were due to Enterococcus faecalis bacteria. There was 4 late post-operative symptomatic urinary tract infections at days 15, 20, 50, and 120 respectively. All these late infections were due to Streptococcus faecalis. In total, there was a 10% rate of urinary tract infections in the critical 30 days period following the TURP. All the blood cultures were negative. These results lead us to conclude that the short term preventive treatment using the cefotiam, cephalosporin which has a strong prostatic tissue penetration, reduces the rate of post TURP urinary tract infections.
- Published
- 1990
35. Prospective effect of norepinephrine infusion in acute renal insufficiency induced by interleukin 2 therapy.
- Author
-
Allaouchiche B, Mercatello A, Tognet E, Négrier S, Moskovtchenko JF, Franks CR, and Philip T
- Subjects
- Acute Kidney Injury prevention & control, Blood Pressure, Combined Modality Therapy, Creatinine metabolism, Dopamine therapeutic use, Humans, Infusions, Intravenous, Interferon alpha-2, Interferon-alpha therapeutic use, Interleukin-2 therapeutic use, Norepinephrine administration & dosage, Recombinant Proteins adverse effects, Recombinant Proteins therapeutic use, Acute Kidney Injury chemically induced, Interleukin-2 adverse effects, Kidney Neoplasms therapy, Norepinephrine therapeutic use
- Published
- 1990
- Full Text
- View/download PDF
36. [Hemodialysis during extracorporeal circulation. Valve replacement in dialyzed patients with chronic renal insufficiency. 4 case reports].
- Author
-
Neidecker J, Amouroux C, Hamandjian I, Barral F, Mikaeloff P, Champsaur G, Moskovtchenko JF, and Estanove S
- Subjects
- Adult, Electrolytes blood, Female, Hematocrit, Humans, Kidney Failure, Chronic therapy, Male, Middle Aged, Urea blood, Aortic Valve Insufficiency surgery, Aortic Valve Stenosis surgery, Extracorporeal Circulation methods, Heart Valve Prosthesis, Renal Dialysis methods
- Published
- 1983
37. [Development of renal function after induction of anesthesia].
- Author
-
Mercatello A, Mongin-Long D, Chabrol B, Baude C, Wehrlin P, Hadj Aissa A, Pozet N, Dubernard JM, and Moskovtchenko JF
- Subjects
- Adult, Aged, Humans, Kidney drug effects, Kidney Function Tests, Male, Middle Aged, Renal Circulation drug effects, Anesthesia, Kidney physiology
- Published
- 1989
38. [Pseudo-late onset cutaneous parphyria in haemodialysis patients. Clinical and histological features. 9 cases (author's transl)].
- Author
-
Thivolet J, Euvrard S, Perrot H, Moskovtchenko JF, Claudy A, and Ortonne JP
- Subjects
- Adult, Humans, Male, Middle Aged, Porphyrias pathology, Seasons, Porphyrias etiology, Renal Dialysis adverse effects
- Abstract
In the context of a study of cutaneous problems seen in chronic renal failure patients on intermittent haemodialysis, the authors noted bullous eruptions very similar to late onset cutaneous porphyria. The bullae occur during the summer and are situated on exposed areas, in particular the head and neck. There is skin fragility and the bullae are transient, giving place to erosions and later to atrophic scarring. Even pseudo-miliary cysts have been observed. Histology reveals a sub-epidermal bulla, the basis of which consists of spiky papillary dermis. Immunofluorescence show immunoglobulin deposits in the vessels and basal membrane. All porphyrin measurements are negative. This disorder may be due to the presence of a non-porphyrinogenic photo-sensitising substance, found in certain types of plastic tubing.
- Published
- 1977
39. [Study of the criteria of evaluation of the exercise capacity of the chronic hemodialyzed subject].
- Author
-
Mallié JP, Moskovtchenko JF, Quard S, and Traeger J
- Subjects
- Adult, Blood Gas Analysis, Exercise Test, Heart Rate, Hematocrit, Hemoglobins analysis, Humans, Hydrogen-Ion Concentration, Kidney Failure, Chronic physiopathology, Lactates blood, Male, Middle Aged, Oxygen blood, Oxygen Consumption, Respiration, Urea blood, Disability Evaluation, Kidney Failure, Chronic rehabilitation, Physical Exertion, Renal Dialysis, Work Capacity Evaluation
- Abstract
Direct measurement methods (or the forecast related to indirect measurements) of the maximal oxygen uptake are reviewed. 15 patients suffering from renal failure, performed a total of 28 exercises. One can draw the conclusion that the maximum VO2 is inferior in these subjects to the values usually determined in normal healthy subjects of the same age. This decrease can be significantly correlated with the haematocrit. Comparison between direct measurement methods of the maximal oxygen uptake and indirect methods allowing its forecast from the heart rate, shows that only direct methods are to be used in these patients.
- Published
- 1975
40. [Repetitive hemodialysis using a single venipuncture].
- Author
-
Ducret F, Cognet JB, Moskovtchenko JF, and Traeger J
- Subjects
- Humans, Time Factors, Bloodletting, Renal Dialysis methods
- Published
- 1977
41. [Acute normovolemic hemodilution in total hip prosthesis interventions].
- Author
-
Broisin F, Dardet R, Tauty-Spiers C, Bagou G, and Moskovtchenko JF
- Subjects
- Adult, Aged, Aged, 80 and over, Hematocrit, Humans, Intraoperative Period, Middle Aged, Retrospective Studies, Blood Transfusion, Hemodilution methods, Hip Prosthesis
- Published
- 1987
42. [5 protocols for intravenous anesthesia of short duration].
- Author
-
Prud'hon MC, Clément HJ, Muguet D, Bagou G, and Moskovtchenko JF
- Subjects
- Adolescent, Adult, Aged, Anesthesia, Inhalation, Clinical Protocols, Female, Humans, Middle Aged, Nitrous Oxide, Preanesthetic Medication, Time Factors, Anesthesia, Intravenous methods, Barbiturates
- Published
- 1988
43. [Medicolegal obstacles in organ procurement. Effect of legislation in France and Europe].
- Author
-
Colpart JJ, Vedrinne J, Revillard M, Moskovtchenko JF, Vialte P, and Traeger J
- Subjects
- Europe, France, Humans, Legislation, Medical, Tissue and Organ Procurement legislation & jurisprudence
- Published
- 1986
44. [Subtotal parathyroidectomy for hyperparathyroidism secondary to chronic renal insufficiency (author's transl)].
- Author
-
Saubier EC, Back D, Moskovtchenko JF, and Traeger J
- Subjects
- Adolescent, Adult, Female, Follow-Up Studies, Humans, Hyperparathyroidism, Secondary etiology, Male, Middle Aged, Hyperparathyroidism, Secondary surgery, Kidney Failure, Chronic complications, Parathyroid Glands surgery
- Published
- 1981
45. [Survival of patients in acute renal failure: effect of nutrition and its associated complications].
- Author
-
Laville M, Islam S, Zanettini MC, Deteix P, Finaz de Villaine J, Gaussorgues P, Moskovtchenko JF, and Traeger J
- Subjects
- Acute Kidney Injury complications, Acute Kidney Injury diet therapy, Adolescent, Adult, Age Factors, Aged, Child, Dietary Proteins therapeutic use, Energy Intake, Female, Humans, Male, Middle Aged, Prealbumin analysis, Prognosis, Retrospective Studies, Transferrin analysis, Acute Kidney Injury mortality, Nutritional Physiological Phenomena
- Abstract
A retrospective study of 150 patients with acute renal failure (ARF) was conducted to assess the influence of both protein and caloric intake and non-renal complications on the prognosis, as well as the predictive value of plasma protein levels. The majority of ARF had occurred in medical or surgical settings (46% and 32.7%, respectively). Nutritional data were available from 94 patients, fed either by parenteral or enteral routes, or both. The mean caloric intake was higher (29 kcal/kg/day) in patients who recovered than in those who did not (24 kcal/kg/day, p less than 0.01). A caloric intake above 35 kcal/kg/day resulted in an improved survival, independently of either patients' age or non-renal complications. Serum prealbumin and transferrin levels were higher in surviving patients than in those who died, 0.25 vs 0.16 g/l (p less than 0.001) and 1.7 vs 1.4 g/l (p less than 0.01), respectively. Nutritional support in ARF could be adapted according to the variations of these serum markers. Its influence on survival should be assessed with regard to the associated prognosis factors.
- Published
- 1985
46. Myocardiotoxicity of 5 fluorouracil.
- Author
-
Coronel B, Madonna O, Mercatello A, Caillette A, and Moskovtchenko JF
- Subjects
- Adult, Fluorouracil therapeutic use, Humans, Laryngeal Neoplasms drug therapy, Male, Cardiomyopathy, Dilated chemically induced, Fluorouracil adverse effects
- Abstract
We report a case of specific myocardiotoxicity due to 5 F.U. not previously described in man. A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U. and cis-platinum. Dopamine was necessary to maintain blood pressure. Two-D echocardiography and a right heart catheterisation confirmed the alteration of myocardial contractility. After 2 weeks a complete cardiac recovery occurred.
- Published
- 1988
- Full Text
- View/download PDF
47. [Vitamin and trace element balance during extremely prolonged parenteral nutrition].
- Author
-
Lévy A, Colpart JJ, Moussa M, Chabal J, Forest G, Gelabert D, and Moskovtchenko JF
- Subjects
- Adolescent, Colon surgery, Duodenum surgery, Enteritis complications, Enteritis pathology, Humans, Jejunum surgery, Kidney Neoplasms complications, Liposarcoma complications, Long-Term Care, Male, Necrosis, Nutritional Requirements, Postoperative Care, Enteritis surgery, Kidney Neoplasms surgery, Liposarcoma surgery, Parenteral Nutrition, Total, Trace Elements analysis, Vitamins analysis
- Published
- 1985
48. [Pregnancy in a woman undergoing continuous hemodialysis].
- Author
-
Clément HJ, Prud'hon MC, Gaucherand P, Rudigoz RC, Bagou G, Muguet D, and Moskovtchenko JF
- Subjects
- Adult, Female, Humans, Pregnancy, Kidney Failure, Chronic therapy, Pregnancy Complications, Renal Dialysis
- Published
- 1988
49. [Auricular adynamia due to hyperkalemia].
- Author
-
Bernheim J, Beruard M, Zech P, Cognet JB, and Moskovtchenko JF
- Subjects
- Adult, Aged, Arrhythmias, Cardiac physiopathology, Bradycardia complications, Coronary Disease etiology, Electrocardiography, Female, Humans, Hyperkalemia therapy, Kidney Failure, Chronic complications, Male, Middle Aged, Postoperative Complications, Renal Dialysis, Arrhythmias, Cardiac etiology, Heart Atria, Hyperkalemia complications
- Abstract
Auricular asystoly (A.A.) was the electrocardiographic pattern of 6 patients admitted for electrolytic disorders secondary to either renal failure or inadequate treatment. A rapid increase of blood potassium was the unique commun abnormality found to explain the dysrhytmia. Bradycardia (between 25 and 55 beats/mn) was present in each case with or without clinical symptoms. Temporary prophylactic pace maker insertion was performed in 4/7 patients. Recovery appeared after dialysis treatment in 6 cases, medical treatment in one, sinus rhythm being present in 6 and chronic atrial fibrillation in one. Prognosis of A.A. due to hyperkaliemia is good when hydroelectrolytic disorders are rapidly corrected. Follow up of blood electrolytes and electrocardiogram must be regular to prevent reccurencies.
- Published
- 1975
50. [Classification of corticoids].
- Author
-
Moskovtchenko JF and Cognet JB
- Subjects
- Glucocorticoids classification, Humans, Mineralocorticoids classification, Adrenal Cortex Hormones classification
- Abstract
A pharmacological classification of corticoids can be carried out, based on the ratio of their glucocorticoid and mineralocorticoid activities. Their large number is due to the fact that they are practically all synthetic, and that minimal modifications in their structure gives rise to new drugs with variable gluco and mineralocorticoid activity.
- Published
- 1976
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