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2. eXplainable Artificial Intelligence (XAI) in aging clock models

Author

Kalyakulina, Alena, Yusipov, Igor, Moskalev, Alexey, Franceschi, Claudio, and Ivanchenko, Mikhail

Subjects
Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Image and Video Processing, I.2.1, J.3
Abstract

eXplainable Artificial Intelligence (XAI) is a rapidly progressing field of machine learning, aiming to unravel the predictions of complex models. XAI is especially required in sensitive applications, e.g. in health care, when diagnosis, recommendations and treatment choices might rely on the decisions made by artificial intelligence systems. AI approaches have become widely used in aging research as well, in particular, in developing biological clock models and identifying biomarkers of aging and age-related diseases. However, the potential of XAI here awaits to be fully appreciated. We discuss the application of XAI for developing the "aging clocks" and present a comprehensive analysis of the literature categorized by the focus on particular physiological systems.

Published
2023

5. In Silico Screening of Life-Extending Drugs Using Machine Learning and Omics Data

Author

Fedintsev, Alexander, Syromyatnikov, Mikhail, Popov, Vasily, Moskalev, Alexey, Rattan, Suresh I.S., Editor-in-Chief, Barbagallo, Mario, Editorial Board Member, Çakatay, Ufuk, Editorial Board Member, Fraifeld, Vadim E., Editorial Board Member, Fülöp, Tamàs, Editorial Board Member, Gruber, Jan, Editorial Board Member, Jin, Kunlin, Editorial Board Member, Kaul, Sunil, Editorial Board Member, Kaur, Gurcharan, Editorial Board Member, Le Bourg, Eric, Editorial Board Member, Lopez Lluch, Guillermo, Editorial Board Member, Moskalev, Alexey, Editorial Board Member, Nehlin, Jan, Editorial Board Member, Pawelec, Graham, Editorial Board Member, Rizvi, Syed Ibrahim, Editorial Board Member, Sholl, Jonathan, Editorial Board Member, Stambler, Ilia, Editorial Board Member, Szczerbińska, Katarzyna, Editorial Board Member, Trougakos, Ioannis P., Editorial Board Member, Wadhwa, Renu, Editorial Board Member, Wnuk, Maciej, Editorial Board Member, and Zhavoronkov, Alex, editor

Published
2023
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6. Meeting Report: Aging Research and Drug Discovery

Author

Meron, Esther, Thaysen, Maria, Angeli, Suzanne, Antebi, Adam, Barzilai, Nir, Baur, Joseph A, Bekker-Jensen, Simon, Birkisdottir, Maria, Bischof, Evelyne, Bruening, Jens, Brunet, Anne, Buchwalter, Abigail, Cabreiro, Filipe, Cai, Shiqing, Chen, Brian H, Ermolaeva, Maria, Ewald, Collin Y, Ferrucci, Luigi, Florian, Maria Carolina, Fortney, Kristen, Freund, Adam, Georgievskaya, Anastasia, Gladyshev, Vadim N, Glass, David, Golato, Tyler, Gorbunova, Vera, Hoejimakers, Jan, Houtkooper, Riekelt H, Jager, Sibylle, Jaksch, Frank, Janssens, Georges, Jensen, Martin Borch, Kaeberlein, Matt, Karsenty, Gerard, de Keizer, Peter, Kennedy, Brian, Kirkland, James L, Kjaer, Michael, Kroemer, Guido, Lee, Kai-Fu, Lemaitre, Jean-Marc, Liaskos, David, Longo, Valter D, Lu, Yu-Xuan, MacArthur, Michael R, Maier, Andrea B, Manakanatas, Christina, Mitchell, Sarah J, Moskalev, Alexey, Niedernhofer, Laura, Ozerov, Ivan, Partridge, Linda, Passegué, Emmanuelle, Petr, Michael A, Peyer, James, Radenkovic, Dina, Rando, Thomas A, Rattan, Suresh, Riedel, Christian G, Rudolph, Lenhard, Ai, Ruixue, Serrano, Manuel, Schumacher, Björn, Sinclair, David A, Smith, Ryan, Suh, Yousin, Taub, Pam, Trapp, Alexandre, Trendelenburg, Anne-Ulrike, Valenzano, Dario Riccardo, Verburgh, Kris, Verdin, Eric, Vijg, Jan, Westendorp, Rudi GJ, Zonari, Alessandra, Bakula, Daniela, Zhavoronkov, Alex, and Scheibye-Knudsen, Morten

Subjects
Aging, aging, drug discovery, conference, AI, longevity, Biochemistry and Cell Biology, Physiology, Oncology and Carcinogenesis, Developmental Biology
Abstract

Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and investors in aging research. This year's 8th Annual Aging Research and Drug Discovery (ARDD) meeting was organized as a hybrid meeting from August 30th to September 3rd 2021 with more than 130 attendees participating on-site at the Ceremonial Hall at University of Copenhagen, Denmark, and 1800 engaging online. The conference comprised of presentations from 75 speakers focusing on new research in topics including mechanisms of aging and how these can be modulated as well as the use of AI and new standards of practices within aging research. This year, a longevity workshop was included to build stronger connections with the clinical community.

Published
2022

12. Biomarkers of aging for the identification and evaluation of longevity interventions

Author

Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Justice, Jamie, Belsky, Daniel W., Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A., Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K., Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B., Snyder, Michael P., Sebastiano, Vittorio, and Gladyshev, Vadim N.

Published
2023
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13. ARDD 2020: from aging mechanisms to interventions

Author

Mkrtchyan, Garik V, Abdelmohsen, Kotb, Andreux, Pénélope, Bagdonaite, Ieva, Barzilai, Nir, Brunak, Søren, Cabreiro, Filipe, de Cabo, Rafael, Campisi, Judith, Cuervo, Ana Maria, Demaria, Marco, Ewald, Collin Y, Fang, Evandro Fei, Faragher, Richard, Ferrucci, Luigi, Freund, Adam, Silva-García, Carlos G, Georgievskaya, Anastasia, Gladyshev, Vadim N, Glass, David J, Gorbunova, Vera, de Grey, Aubrey, He, Wei-Wu, Hoeijmakers, Jan, Hoffmann, Eva, Horvath, Steve, Houtkooper, Riekelt H, Jensen, Majken K, Jensen, Martin Borch, Kane, Alice, Kassem, Moustapha, de Keizer, Peter, Kennedy, Brian, Karsenty, Gerard, Lamming, Dudley W, Lee, Kai-Fu, MacAulay, Nanna, Mamoshina, Polina, Mellon, Jim, Molenaars, Marte, Moskalev, Alexey, Mund, Andreas, Niedernhofer, Laura, Osborne, Brenna, Pak, Heidi H, Parkhitko, Andrey, Raimundo, Nuno, Rando, Thomas A, Rasmussen, Lene Juel, Reis, Carolina, Riedel, Christian G, Franco-Romero, Anais, Schumacher, Björn, Sinclair, David A, Suh, Yousin, Taub, Pam R, Toiber, Debra, Treebak, Jonas T, Valenzano, Dario Riccardo, Verdin, Eric, Vijg, Jan, Young, Sergey, Zhang, Lei, Bakula, Daniela, Zhavoronkov, Alex, and Scheibye-Knudsen, Morten

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Clinical Sciences, Biological Sciences, Aging, Prevention, Good Health and Well Being, Artificial Intelligence, Biomedical Research, Cellular Senescence, Congresses as Topic, Drug Discovery, Humans, Life Style, Longevity, Pharmaceutical Preparations, aging, interventions, drug discovery, artificial intelligence, Physiology, Oncology and Carcinogenesis, Developmental Biology
Abstract

Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA.

Published
2020

16. Nutritional Regulation of Aging and Longevity

Author

Moskalev, Alexey, Rattan, Suresh I.S., Series Editor, Barbagallo, Mario, Editorial Board Member, Çakatay, Ufuk, Editorial Board Member, Fraifeld, Vadim E., Editorial Board Member, Fülöp, Tamàs, Editorial Board Member, Gruber, Jan, Editorial Board Member, Jin, Kunlin, Editorial Board Member, Kaul, Sunil, Editorial Board Member, Kaur, Gurcharan, Editorial Board Member, Le Bourg, Eric, Editorial Board Member, Lopez Lluch, Guillermo, Editorial Board Member, Moskalev, Alexey, Editorial Board Member, Nehlin, Jan, Editorial Board Member, Pawelec, Graham, Editorial Board Member, Rizvi, Syed Ibrahim, Editorial Board Member, Sholl, Jonathan, Editorial Board Member, Stambler, Ilia, Editorial Board Member, Szczerbińska, Katarzyna, Editorial Board Member, Trougakos, Ioannis P., Editorial Board Member, Wadhwa, Renu, Editorial Board Member, Wnuk, Maciej, Editorial Board Member, and Rattan, Suresh I. S., editor

Published
2021
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17. Matrisome Transcriptome Dynamics during Tissue Aging

Author

Guvatova, Zulfiya G., primary, Kobelyatskaya, Anastasiya A., additional, Kudasheva, Eveline R., additional, Pudova, Elena A., additional, Bulavkina, Elizaveta V., additional, Churov, Alexey V., additional, Tkacheva, Olga N., additional, and Moskalev, Alexey A., additional

Published
2024
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20. Aging and drug discovery

Author

Bakula, Daniela, Aliper, Alexander M, Mamoshina, Polina, Petr, Michael A, Teklu, Amanuel, Baur, Joseph A, Campisi, Judith, Ewald, Collin Y, Georgievskaya, Anastasia, Gladyshev, Vadim N, Kovalchuk, Olga, Lamming, Dudley W, Luijsterburg, Martijn S, Martín-Montalvo, Alejandro, Maudsley, Stuart, Mkrtchyan, Garik V, Moskalev, Alexey, Olshansky, S Jay, Ozerov, Ivan V, Pickett, Alexander, Ristow, Michael, Zhavoronkov, Alex, and Scheibye-Knudsen, Morten

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Clinical Sciences, Biological Sciences, Aging, Good Health and Well Being, aging, drug discovery, Biochemistry and cell biology, Clinical sciences
Abstract

Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

Published
2018

21. Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions

Author

Shaposhnikov, Mikhail V., Guvatova, Zulfiya G., Zemskaya, Nadezhda V., Koval, Liubov A., Schegoleva, Eugenia V., Gorbunova, Anastasia A., Golubev, Denis A., Pakshina, Natalya R., Ulyasheva, Natalia S., Solovev, Ilya A., Bobrovskikh, Margarita A., Gruntenko, Nataly E., Menshanov, Petr N., Krasnov, George S., Kudryavseva, Anna V., and Moskalev, Alexey A.

Published
2022
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22. Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Author

Zhu, Rongjia, Yan, Tingdong, Feng, Yingmei, Liu, Yan, Cao, Hongcui, Peng, Gongxin, Yang, Yanlei, Xu, Zhen, Liu, Jingqi, Hou, Wei, Wang, Xiaoyue, Li, Zhe, Deng, Luchan, Wang, Shihua, Li, Jing, Han, Qin, Li, Hongling, Shan, Guangliang, Cao, Yinghao, An, Xingyan, Yan, Jianshe, Zhang, Zhonghui, Li, Huafei, Qu, Xuebin, Zhu, Jiaqi, Zhou, Shumin, Wang, Jiao, Zhang, Fengchun, Gao, Jinming, Jin, Ronghua, Xu, Dayong, Ma, Yan-Qing, Huang, Tao, Peng, Shuang, Zheng, Zhi, Stambler, Ilia, Gilson, Eric, Lim, Lee Wei, Moskalev, Alexey, Cano, Antonio, Chakrabarti, Sasanka, Ulfhake, Brun, Su, Huanxing, Xu, Haoying, Xu, Sihuan, Wei, Feng, Brown-Borg, Holly M., Min, Kyung-Jin, Ellison-Hughes, Georgina, Caruso, Calogero, Jin, Kunlin, and Zhao, Robert Chunhua

Published
2021
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24. Introduction

Author

Moskalev, Alexey, Rattan, Suresh I.S., Series Editor, and Moskalev, Alexey, editor

Published
2019
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27. Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex

Author

Golubev, Denis, primary, Platonova, Elena, additional, Zemskaya, Nadezhda, additional, Shevchenko, Oksana, additional, Shaposhnikov, Mikhail, additional, Nekrasova, Polina, additional, Patov, Sergey, additional, Ibragimova, Umida, additional, Valuisky, Nikita, additional, Borisov, Alexander, additional, Zhukova, Xenia, additional, Sorokina, Svetlana, additional, Litvinov, Roman, additional, and Moskalev, Alexey, additional

Published
2023
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29. Decelerated Epigenetic Aging in Long Livers

Author

Guvatova, Zulfiya G., primary, Kobelyatskaya, Anastasiya A., additional, Pudova, Elena A., additional, Tarasova, Irina V., additional, Kudryavtseva, Anna V., additional, Tkacheva, Olga N., additional, Strazhesko, Irina D., additional, and Moskalev, Alexey A., additional

Published
2023
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30. Antioxidant Properties and Geroprotective Potential of Wheat Bran Extracts with Increased Content of Anthocyanins

Author

Mikhailova, Daria V., primary, Shevchenko, Oksana G., additional, Golubev, Denis A., additional, Platonova, Elena Y., additional, Zemskaya, Nadezhda V., additional, Shoeva, Olesya Yu., additional, Gordeeva, Elena I., additional, Patov, Sergey A., additional, Shaposhnikov, Mikhail V., additional, Khlestkina, Elena K., additional, and Moskalev, Alexey, additional

Published
2023
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34. Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity

Author

Golubev, Denis, primary, Platonova, Elena, additional, Zemskaya, Nadezhda, additional, Shevchenko, Oksana, additional, Shaposhnikov, Mikhail, additional, Nekrasova, Polina, additional, Patov, Sergey, additional, Ibragimova, Umida, additional, Valuisky, Nikita, additional, Borisov, Alexander, additional, Zhukova, Xenia, additional, Sorokina, Svetlana, additional, Litvinov, Roman, additional, and Moskalev, Alexey, additional

Published
2023
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36. The use of therapeutic plasmapheresis in preventive and sports medicine

Author

Gilmutdinova Ilmira, Kudryashova Irina, Kostromina Elena, Yafarova Inessa, Gilmutdinov Rinat, Kaverina Irina, Isaev Andrey, and Moskalev Alexey

Subjects
Microbiology, QR1-502, Physiology, QP1-981, Zoology, QL1-991
Abstract

Maintenance of active longevity, preservation of physical activity, and prevention of decreased mobility associated with injury or age of patients are among the most urgent tasks for modern healthcare. The suppression of pathological processes and activation of defense systems at the cellular and organismal levels are the main routes for solving these problems. Several initial anti-aging therapy approaches are detoxification, rheocorrection, and immunocorrection. In these areas, methods of extracorporeal hemocorrection, in particular, therapeutic plasmapheresis, are effective. This study aimed to evaluate the effectiveness of hardware plasmapheresis with albumin compensation by assessing the dynamics of circulating age-related biomarker levels in randomly selected patients. Twenty human subjects of both sexes aged 40–55 years with an increase in one or more aging-related biomarkers participated in this study. The patients were randomly divided into two groups with ten people each. Patients from Group 1 underwent therapeutic plasmapheresis with albumin replacement (four procedures with a 2-day interval). Patients from Group 2 were offered plasmapheresis treatment with saline replacement. The levels of aging-related biomarkers were determined in the blood of patients before and 30 days after starting treatment. Preliminary data showed that plasmapheresis with albumin replacement in randomly selected male and female patients was accompanied by normalization of the selected aging biomarkers. Thirty days after the start of the plasmapheresis treatment, a decrease in both biological and phenotypic age was determined. Further studies are needed to investigate the effects of nutritional factors on aging biomarkers with and without plasmapheresis treatment. Based on the obtained results, recommendations will be made on the use of plasmapheresis in preventive and sports medicine. The use of this method will help reduce the biological age of patients and, as a result, reduce the risks of developing age-related diseases and disabilities and contribute to prolonging life and improving its quality.

Published
2022
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40. Transcriptomic Analysis of the Effect of Torin-2 on the Central Nervous System of Drosophila melanogaster

Author

Vershinina, Yulia S., primary, Krasnov, George S., additional, Garbuz, David G., additional, Shaposhnikov, Mikhail V., additional, Fedorova, Maria S., additional, Pudova, Elena A., additional, Katunina, Irina V., additional, Kornev, Alexey B., additional, Zemskaya, Nadezhda V., additional, Kudryavtsev, Alexander A., additional, Bulavkina, Elizaveta V., additional, Matveeva, Anna A., additional, Ulyasheva, Natalia S., additional, Guvatova, Zulfiya G., additional, Anurov, Artemiy A., additional, Moskalev, Alexey A., additional, and Kudryavtseva, Anna V., additional

Published
2023
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45. List of Contributors

Author

Adwan-Shekhidem, Huda, primary, Atzmon, Gil, additional, Benayoun, Bérénice A., additional, Bowman, John D., additional, Braun, Kim V.E., additional, Cacabelos, Ramón, additional, Caiafa, Paola, additional, Cao, Xiaohua, additional, Choudhury, Mahua, additional, Chowdhury, Rajiv, additional, Ciccarone, Fabio, additional, Cunliffe, Vincent T., additional, Dang, Weiwei, additional, Dong, Xiao, additional, Eachus, Helen, additional, Franco, Oscar H., additional, Gravina, Silvia, additional, Koliada, Alexander K., additional, Kovalchuk, Igor, additional, Kranjc, Tilen, additional, Kudryavtseva, Anna, additional, Kumar, Vineet, additional, Langley-Evans, Simon C., additional, Loenen, Wil A.M., additional, Lovšin, Nika, additional, Lushchak, Oleh V., additional, Marc, Janja, additional, Meruvu, Sunitha, additional, Mills, Ken I., additional, Mitnitski, Arnold B., additional, Moskalev, Alexey, additional, Muhlhausler, Beverly S., additional, Muka, Taulant, additional, Nano, Jana, additional, O’Sullivan, Justin M., additional, Ostanek, Barbara, additional, Portilla, Eliana, additional, Raj, Ken, additional, Rea, Irene M., additional, Reynolds, Clare M., additional, Schumacher, Axel, additional, Seaborne, Robert A., additional, Segovia, Stephanie A., additional, Shaposhnikov, Mikhail, additional, Sharples, Adam P., additional, Solovev, Ilya, additional, Stewart, Claire E., additional, Teijido, Oscar, additional, Troup, Jenna, additional, Ucar, Duygu, additional, Vaiserman, Alexander M., additional, Verma, Mukesh, additional, Vickers, Mark H., additional, Vijg, Jan, additional, Voortman, Trudy, additional, Xu, Xiangru, additional, Zampieri, Michele, additional, and Zupan, Janja, additional

Published
2018
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47. The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma

Author

Fedorova, Maria S., Krasnov, George S., Lukyanova, Elena N., Zaretsky, Andrew R., Dmitriev, Alexey A., Melnikova, Nataliya V., Moskalev, Alexey A., Kharitonov, Sergey L., Pudova, Elena A., Guvatova, Zulfiya G., Kobelyatskaya, Anastasiya A., Ishina, Irina A., Slavnova, Elena N., Lipatova, Anastasia V., Chernichenko, Maria A., Sidorov, Dmitry V., Popov, Anatoly Y., Kiseleva, Marina V., Kaprin, Andrey D., Snezhkina, Anastasiya V., and Kudryavtseva, Anna V.

Published
2019
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