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2. Complex intracranial aneurysms: a DELPHI study to define associated characteristics

Author

Diana, Francesco, Romoli, Michele, Raz, Eytan, Agid, Ronit, Albuquerque, Felipe C., Arthur, Adam S., Beck, Jürgen, Berge, Jerome, Boogaarts, Hieronymus D., Burkhardt, Jan-Karl, Cenzato, Marco, Chapot, René, Charbel, Fady T., Desal, Hubert, Esposito, Giuseppe, Fifi, Johanna T., Florian, Stefan, Gruber, Andreas, Hassan, Ameer E., Jabbour, Pascal, Jadhav, Ashutosh P., Korja, Miikka, Krings, Timo, Lanzino, Giuseppe, Meling, Torstein R., Morcos, Jaques, Mosimann, Pascal J., Nossek, Erez, Pereira, Vitor Mendes, Raabe, Andreas, Regli, Luca, Rohde, Veit, Siddiqui, Adnan H., Tanikawa, Rokuya, Tjoumakaris, Stavropoula I., Tomasello, Alejandro, Vajkoczy, Peter, Valvassori, Luca, Velinov, Nikolay, Walsh, Daniel, Woo, Henry, Xu, Bin, Yoshimura, Shinichi, van Zwam, Wim H., and Peschillo, Simone

Published
2024
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4. Radiological Outcome of Middle Meningeal Artery Embolization in Relation to Chronic Subdural Hematoma Cause and Architecture.

Author

Abdelghafar, Ahmed, Falzon, Andrew, Hendriks, Eef J., Radovanovic, Ivan, Andrade, Hugo, Schaafsma, Joanna D., and Mosimann, Pascal J.

Subjects
SUBDURAL hematoma, COMPUTED tomography, PSEUDOPOTENTIAL method, STATISTICAL correlation, COHORT analysis
Abstract

Background/Objectives: MMAE (middle meningeal artery embolization) has emerged as a potential effective treatment for cSDH (chronic subdural hematoma). In this study, MMAE efficiency with regards to cSDH cause and architecture was explored. The comparability of cSDH thickness and volume as parameters for cSDH pre- and post-MMAE assessment was also analyzed. Methods: In this retrospective cohort study, 52 consecutive cSDH patients treated with MMAE in a single tertiary center were included. The cohort was divided into two group pairs pertaining to cSDH cause (spontaneous or traumatic) and cSDH architecture (non-mature or mature). The radiological outcome was compared in each group before and after MMAE and between each group pair using CT imaging. A correlation analysis between cSDH thickness and volume before and after MMAE was also performed. Results: A statistically significant positive linear association between cSDH thickness and volume at admission and at each follow-up interval (1–3, 3–6, 6–12 months) was noticed. cSDH thickness and volume reduction in each group was statistically significant, except for a traumatic cSDH volume reduction at 6–12 months. There was no statistically significant difference between each group pair in the cSDH thickness and volume reduction difference at all the follow-up intervals. Conclusions: A comparable efficiency of MMAE may be achieved in non-mature and mature as well as in spontaneous and traumatic cSDH, with an advantage for spontaneous cSDH at 6–12 months follow-up compared to traumatic cSDH. Traumatic cSDH may require a relatively long-term follow-up post-MMAE. cSDH thickness and volume, as parameters for pre- and post-MMAE cSDH evaluation, appear similar. [ABSTRACT FROM AUTHOR]

Published
2024
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9. LVIS EVO stent-through-balloon after hydrocoil embolization of intracranial aneurysms: One-year results.

Author

Mosimann, Pascal J, Yamac, Elif, Wallocha, Marta, Ayad, Ahmed, and Chapot, René

Subjects
*INTRACRANIAL aneurysms, *ANGIOGRAPHY, *ANEURYSMS, *DEATH rate, *DIAGNOSTIC imaging
Abstract

Background and purpose: To evaluate the durability and safety of complete intracranial aneurysm occlusion at one year using the low-profile braided intracranial LVIS EVO stent. Materials and methods: This is a retrospective, monocentric, observational study of unruptured wide-necked intracranial aneurysms treated with the LVIS EVO stent-through-balloon technique after balloon-assisted hydrocoil embolization. Imaging and clinical data were assessed by two blinded independent neuroradiologists and neurologists, respectively. Primary endpoint was complete angiographic occlusion on day 0 and at 12 months. Secondary endpoints included clinical safety using the modified Rankin scale (mRS), ischemic and hemorrhagic adverse events, parent vessel stenosis > 50% or occlusion and retreatment rate. Results: 103 aneurysms in 103 patients were included (53 years-old, 77% women). Mean aneurysm size and neck were 7 and 4 mm, respectively. Complete occlusion was 97% initially and 90% at 12 months, with pending follow up in 17.5% patients. Five patients (5%) with partially stented necks were retreated with a second stent in a T-configuration. Two stents failed to open initially and were immediately retrieved. Asymptomatic parent vessel occlusion and severe in-stent stenosis occurred in 1% and 3%, respectively. The 12-month procedure-related permanent neurological deficit and mortality rates (mRS 3–6) were 2% and 1%, respectively. There was one fatal bleeding but no large ischemic complications. Conclusion: Delivering the LVIS EVO stent through a dual lumen balloon after balloon-assisted hydrocoil embolization yields a high and stable rate of complete aneurysm occlusion at one year with a reasonable immediate and delayed complication rate. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Effect of Pre- and In-Hospital Delay on Reperfusion in Acute Ischemic Stroke Mechanical Thrombectomy

Author

Kaesmacher, Johannes, Maamari, Basel, Meinel, Thomas R., Piechowiak, Eike I., Mosimann, Pascal J., Mordasini, Pasquale, Goeldlin, Martina, Arnold, Marcel, Dobrocky, Tomas, Boeckh-Behrens, Tobias, Berndt, Maria, Michel, Patrik, Requena, Manuel, Benali, Amel, Pierot, Laurent, Mendes Pereira, Vitor, Boulouis, Grégoire, Brehm, Alex, Sporns, Peter B., Ospel, Johanna M., Gralla, Jan, and Fischer, Urs

Published
2020
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14. Effect of Steady and Dynamic Blood Pressure Parameters During Thrombectomy According to the Collateral Status

Author

Maïer, Benjamin, Dargazanli, Cyril, Bourcier, Romain, Kyheng, Maëva, Labreuche, Julien, Mosimann, Pascal J., Puccinelli, Francesco, Taylor, Guillaume, Le Guen, Morgan, Riem, Romuald, Desilles, Jean-Philippe, Boisseau, William, Fahed, Robert, Redjem, Hocine, Smajda, Stanislas, Ciccio, Gabriele, Escalard, Simon, Blanc, Raphaël, Piotin, Michel, Lapergue, Betrand, and Mazighi, Mikael

Published
2020
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15. Proposed achievable levels of dose and impact of dose-reduction systems for thrombectomy in acute ischemic stroke: an international, multicentric, retrospective study in 1096 patients

Author

Guenego, Adrien, Mosimann, Pascal J., Pereira, Vitor Mendes, Nicholson, Patrick, Zuber, Kevin, Lotterie, Jean Albert, Dobrocky, Tomas, Marcellus, David G., Olivot, Jean Marc, Piotin, Michel, Gralla, Jan, Fahed, Robert, Wintermark, Max, Heit, Jeremy J., Cognard, Christophe, and on behalf of the RADON Investigators

Published
2019
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19. Endovascular Stroke Treatment and Risk of Intracranial Hemorrhage in Anticoagulated Patients

Author

Meinel, Thomas R., Kniepert, Joachim U., Seiffge, David J., Gralla, Jan, Jung, Simon, Auer, Elias, Frey, Sebastién, Goeldlin, Martina, Mordasini, Pasquale, Mosimann, Pascal J., Nogueira, Raul G., Haussen, Diogo C., Rodrigues, Gabriel M., Uphaus, Timo, L’Allinec, Vincent, Krajíčková, Dagmar, Alonso, Angelika, Costalat, Vincent, Hajdu, Steven D., Olivé-Gadea, Marta, Maegerlein, Christian, Pierot, Laurent, Schaafsma, Joanna, Suzuki, Kentaro, Arnold, Marcel, Heldner, Mirjam R., Fischer, Urs, and Kaesmacher, Johannes

Published
2020
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24. Role of Conventional Dynamic Myelography for Detection of High-Flow Cerebrospinal Fluid Leaks

Author

Piechowiak, Eike I., Pospieszny, Katarzyna, Haeni, Levin, Jesse, Christopher M., Peschi, Giovanni, Mosimann, Pascal J., Kaesmacher, Johannes, Mordasini, Pasquale, Raabe, Andreas, Ulrich, Christian T., Beck, Jürgen, Gralla, Jan, and Dobrocky, Tomas

Subjects
Conventional dynamic myelography, Cerebrospinal Fluid Leak, Spontaneous intracranial hypotension, Intracranial Hypotension, Humans, Original Article, CSF leak, Middle Aged, Myelography, Spine, Retrospective Studies
Abstract

Background Spinal imaging is essential to identify and localize cerebrospinal fluid (CSF) leaks in spontaneous intracranial hypotension (SIH) patients when targeted treatment is necessary. Purpose Provide an in-depth presentation of the conventional dynamic myelography (CDM) technique for localizing spinal CSF leaks in SIH patients. Material and Methods Consecutive SIH patients with a CSF leak confirmed on CDM and postmyelography computed tomography (CT) investigated at our institution between 2013 and 2019 were retrospectively analyzed. Intraoperative reports were reviewed to confirm the accuracy of CDM. Results In total, 62 patients (mean age 45 years) were included; 48 with a ventral dural tear, 12 with a meningeal diverticulum, and in 2 patients positive for spinal longitudinal extradural CSF collection the site remained unclear. The leak was identified during the first and the second CDM in 43 and 17 patients, respectively. The use of CDM correctly identified the site of the CSF leak in all but one patient undergoing surgical closure (45/46, 98%). The mean fluoroscopy time was 7.8 min (range 1.8–14.4 min) with a radiation dose for a single examination of 310 mGy (range 28–1237 mGy). Conclusion The CDM procedure has a high accuracy for spinal CSF leak localization including dural tears and spinal nerve diverticula. It is the technique with the highest temporal resolution, is robust to breathing artifacts, allows great flexibility regarding patient positioning, compares favorably to other dynamic examinations with respect to the radiation dose and does not require general anesthesia. For CSF venous fistulas, however, other dynamic examinations, such as digital subtraction myelography, seem more appropriate. Video online The online version of this article contains 4 videos. The article and the videos are online available (10.1007/s00062-020-00943-w). The videos can be found in the article back matter as “Electronic Supplementary Material”.

Published
2020

25. Mechanical thrombectomy for acute ischemic stroke in COVID-19 patients: multicenter experience in 111 cases

Author

Styczen, Hanna, Maus, Volker, Goertz, Lukas, Koehrmann, Martin, Kleinschnitz, Christoph, Fischer, Sebastian, Moehlenbruch, Markus, Muehlen, Iris, Kallmuenzer, Bernd, Dorn, Franziska, Lakghomi, Asadeh, Gawlitza, Matthias, Kaiser, Daniel, Klisch, Joachim, Lobsien, Donald, Rohde, Stefan, Ellrichmann, Gisa, Behme, Daniel, Thormann, Maximilian, Flottmann, Fabian, Winkelmeier, Laurens, Gizewski, Elke R., Mayer-Suess, Lukas, Boeckh-Behrens, Tobias, Riederer, Isabelle, Klingebiel, Randolf, Berger, Bjoern, Schlunz-Hendann, Martin, Grieb, Dominik, Khanafer, Ali, de Rochemont, Richard du Mesnil, Arendt, Christophe, Altenbernd, Jens, Schlump, Jan-Ulrich, Ringelstein, Adrian, Sanio, Vivian Jean Marcel, Loehr, Christian, Dahlke, Agnes Maria, Brockmann, Carolin, Reder, Sebastian, Sure, Ulrich, Li, Yan, Muehl-Benninghaus, Ruben, Rodt, Thomas, Kallenberg, Kai, Durutya, Alexandru, Elsharkawy, Mohamed, Stracke, Paul, Schumann, Mathias Gerhard, Bock, Alexander, Nikoubashman, Omid, Wiesmann, Martin, Henkes, Hans, Mosimann, Pascal J., Chapot, Rene, Forsting, Michael, Deuschl, Cornelius, Styczen, Hanna, Maus, Volker, Goertz, Lukas, Koehrmann, Martin, Kleinschnitz, Christoph, Fischer, Sebastian, Moehlenbruch, Markus, Muehlen, Iris, Kallmuenzer, Bernd, Dorn, Franziska, Lakghomi, Asadeh, Gawlitza, Matthias, Kaiser, Daniel, Klisch, Joachim, Lobsien, Donald, Rohde, Stefan, Ellrichmann, Gisa, Behme, Daniel, Thormann, Maximilian, Flottmann, Fabian, Winkelmeier, Laurens, Gizewski, Elke R., Mayer-Suess, Lukas, Boeckh-Behrens, Tobias, Riederer, Isabelle, Klingebiel, Randolf, Berger, Bjoern, Schlunz-Hendann, Martin, Grieb, Dominik, Khanafer, Ali, de Rochemont, Richard du Mesnil, Arendt, Christophe, Altenbernd, Jens, Schlump, Jan-Ulrich, Ringelstein, Adrian, Sanio, Vivian Jean Marcel, Loehr, Christian, Dahlke, Agnes Maria, Brockmann, Carolin, Reder, Sebastian, Sure, Ulrich, Li, Yan, Muehl-Benninghaus, Ruben, Rodt, Thomas, Kallenberg, Kai, Durutya, Alexandru, Elsharkawy, Mohamed, Stracke, Paul, Schumann, Mathias Gerhard, Bock, Alexander, Nikoubashman, Omid, Wiesmann, Martin, Henkes, Hans, Mosimann, Pascal J., Chapot, Rene, Forsting, Michael, and Deuschl, Cornelius

Abstract

Background Data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in patients with COVID-19 is limited. Addressing this subject, we report our multicenter experience. Methods A retrospective cohort study was performed of consecutive acute stroke patients with COVID-19 infection treated with MT at 26 tertiary care centers between January 2020 and November 2021. Baseline demographics, angiographic outcome and clinical outcome evaluated by the modified Rankin Scale (mRS) at discharge and 90 days were noted. Results We identified 111 out of 11 365 (1%) patients with acute or subsided COVID-19 infection who underwent MT due to LVO. Cardioembolic events were the most common etiology for LVO (38.7%). Median baseline National Institutes of Health Stroke Scale score and Alberta Stroke Program Early CT Score were 16 (IQR 11.5-20) and 9 (IQR 7-10), respectively. Successful reperfusion (mTICI >= 2b) was achieved in 97/111 (87.4%) patients and 46/111 (41.4%) patients were reperfused completely. The procedure-related complication rate was 12.6% (14/111). Functional independence was achieved in 20/108 (18.5%) patients at discharge and 14/66 (21.2%) at 90 days follow-up. The in-hospital mortality rate was 30.6% (33/108). In the subgroup analysis, patients with severe acute COVID-19 infection requiring intubation had a mortality rate twice as high as patients with mild or moderate acute COVID-19 infection. Acute respiratory failure requiring ventilation and time interval from symptom onset to groin puncture were independent predictors for an unfavorable outcome in a logistic regression analysis. Conclusion Our study showed a poor clinical outcome and high mortality, especially in patients with severe acute COVID-19 infection undergoing MT due to LVO.

Published
2022

26. Mechanical thrombectomy for acute ischemic stroke in COVID-19 patients: multicenter experience in 111 cases

Author

Styczen, Hanna, primary, Maus, Volker, additional, Goertz, Lukas, additional, Köhrmann, Martin, additional, Kleinschnitz, Christoph, additional, Fischer, Sebastian, additional, Möhlenbruch, Markus, additional, Mühlen, Iris, additional, Kallmünzer, Bernd, additional, Dorn, Franziska, additional, Lakghomi, Asadeh, additional, Gawlitza, Matthias, additional, Kaiser, Daniel, additional, Klisch, Joachim, additional, Lobsien, Donald, additional, Rohde, Stefan, additional, Ellrichmann, Gisa, additional, Behme, Daniel, additional, Thormann, Maximilian, additional, Flottmann, Fabian, additional, Winkelmeier, Laurens, additional, Gizewski, Elke R, additional, Mayer-Suess, Lukas, additional, Boeckh-Behrens, Tobias, additional, Riederer, Isabelle, additional, Klingebiel, Randolf, additional, Berger, Björn, additional, Schlunz-Hendann, Martin, additional, Grieb, Dominik, additional, Khanafer, Ali, additional, du Mesnil de Rochemont, Richard, additional, Arendt, Christophe, additional, Altenbernd, Jens, additional, Schlump, Jan-Ulrich, additional, Ringelstein, Adrian, additional, Sanio, Vivian Jean Marcel, additional, Loehr, Christian, additional, Dahlke, Agnes Maria, additional, Brockmann, Carolin, additional, Reder, Sebastian, additional, Sure, Ulrich, additional, Li, Yan, additional, Mühl-Benninghaus, Ruben, additional, Rodt, Thomas, additional, Kallenberg, Kai, additional, Durutya, Alexandru, additional, Elsharkawy, Mohamed, additional, Stracke, Paul, additional, Schumann, Mathias Gerhard, additional, Bock, Alexander, additional, Nikoubashman, Omid, additional, Wiesmann, Martin, additional, Henkes, Hans, additional, Mosimann, Pascal J, additional, Chapot, René, additional, Forsting, Michael, additional, and Deuschl, Cornelius, additional

Published
2022
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27. Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy : a systematic review and meta-analysis of observational data

Author

Kaesmacher, Johannes, Meinel, Thomas Raphael, Kurmann, Christoph, Zaidat, Osama O., Castonguay, Alicia C., Zaidi, Syed F., Mueller-Kronast, Nils, Kappelhof, Manon, Dippel, Diederik W. J., Soudant, Marc, Bracard, Serge, Hill, Michael D., Goyal, Mayank, Strbian, Daniel, Heiferman, Daniel M., Ashley, William, Anadani, Mohammad, Spiotta, Alejandro M., Dobrocky, Tomas, Piechowiak, Eike, Arnold, Marcel, Goeldlin, Martina, Seiffge, David, Mosimann, Pascal J., Mordasini, Pasquale, Gralla, Jan, Fischer, Urs, Neurologian yksikkö, and HUS Neurocenter

Subjects
VESSEL OCCLUSION STROKES, THROMBOLYSIS, TENECTEPLASE, FEASIBILITY, thrombectomy, ENDOVASCULAR TREATMENT, MANAGEMENT, 3112 Neurosciences, REPERFUSION, ACUTE ISCHEMIC-STROKE, HEMORRHAGIC TRANSFORMATION, stroke, 3124 Neurology and psychiatry
Abstract

Background Achieving the best possible reperfusion is a key determinant of clinical outcome after mechanical thrombectomy (MT). However, data on the safety and efficacy of intra-arterial (IA) fibrinolytics as an adjunct to MT with the intention to improve reperfusion are sparse. Methods We performed a PROSPERO-registered (CRD42020149124) systematic review and meta-analysis accessing MEDLINE, PubMed, and Embase from January 1, 2000 to January 1, 2020. A random-effect estimate (Mantel-Haenszel) was computed and summary OR with 95% CI were used as a measure of added IA fibrinolytics versus control on the risk of symptomatic intracranial hemorrhage (sICH) and secondary endpoints (modified Rankin Scale

Published
2021

32. Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy:A systematic review and meta-analysis of observational data

Author

Kaesmacher, Johannes, Meinel, Thomas Raphael, Kurmann, Christoph, Zaidat, Osama O., Castonguay, Alicia C., Zaidi, Syed F., Mueller-Kronast, Nils, Kappelhof, Manon, DIppel, DIederik W.J., Soudant, Marc, Bracard, Serge, Hill, Michael D., Goyal, Mayank, Strbian, Daniel, Heiferman, Daniel M., Ashley, William, Anadani, Mohammad, Spiotta, Alejandro M., Dobrocky, Tomas, Piechowiak, Eike I., Arnold, Marcel, Goeldlin, Martina, Seiffge, David, Mosimann, Pascal J., Mordasini, Pasquale, Gralla, Jan, Fischer, Urs, Kaesmacher, Johannes, Meinel, Thomas Raphael, Kurmann, Christoph, Zaidat, Osama O., Castonguay, Alicia C., Zaidi, Syed F., Mueller-Kronast, Nils, Kappelhof, Manon, DIppel, DIederik W.J., Soudant, Marc, Bracard, Serge, Hill, Michael D., Goyal, Mayank, Strbian, Daniel, Heiferman, Daniel M., Ashley, William, Anadani, Mohammad, Spiotta, Alejandro M., Dobrocky, Tomas, Piechowiak, Eike I., Arnold, Marcel, Goeldlin, Martina, Seiffge, David, Mosimann, Pascal J., Mordasini, Pasquale, Gralla, Jan, and Fischer, Urs

Abstract

Background Achieving the best possible reperfusion is a key determinant of clinical outcome after mechanical thrombectomy (MT). However, data on the safety and efficacy of intra-arterial (IA) fibrinolytics as an adjunct to MT with the intention to improve reperfusion are sparse. Methods We performed a PROSPERO-registered (CRD42020149124) systematic review and meta-analysis accessing MEDLINE, PubMed, and Embase from January 1, 2000 to January 1, 2020. A random-effect estimate (Mantel-Haenszel) was computed and summary OR with 95% CI were used as a measure of added IA fibrinolytics versus control on the risk of symptomatic intracranial hemorrhage (sICH) and secondary endpoints (modified Rankin Scale ≤2, mortality at 90 days). Results The search identified six observational cohort studies and three observational datasets of MT randomized-controlled trial data reporting on IA fibrinolytics with MT as compared with MT alone, including 2797 patients (405 with additional IA fibrinolytics (100 urokinase (uPA), 305 tissue plasminogen activator (tPA)) and 2392 patients without IA fibrinolytics). Of 405 MT patients treated with additional IA fibrinolytics, 209 (51.6%) received prior intravenous tPA. We did not observe an increased risk of sICH after administration of IA fibrinolytics as adjunct to MT (OR 1.06, 95% CI 0.64 to 1.76), nor excess mortality (0.81, 95% CI 0.60 to 1.08). Although the mode of reporting was heterogeneous, some studies observed improved reperfusion after IA fibrinolytics. Conclusion The quality of evidence regarding peri-interventional administration of IA fibrinolytics in MT is low and limited to observational data. In highly selected patients, no increase in sICH was observed, but there is large uncertainty.

Published
2021

33. Association of reperfusion success and emboli in new territories with long term mortality after mechanical thrombectomy

Author

Beyeler, Morin, primary, Weber, Loris, additional, Kurmann, Christoph C, additional, Piechowiak, Eike Immo I, additional, Mosimann, Pascal J, additional, Zibold, Felix, additional, Meinel, Thomas Raphael, additional, Branca, Mattia, additional, Goeldlin, Martina, additional, Pilgram-Pastor, Sara M, additional, Grunder, Lorenz, additional, Arnold, Marcel, additional, Seiffge, David, additional, Meier, Raphael, additional, Heldner, Mirjam R, additional, Dobrocky, Tomas, additional, Mordasini, Pasquale, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2021
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35. Is Intracerebral Hemorrhage a Time-Dependent Phenomenon After Successful Combined Intravenous and Intra-Arterial Therapy?

Author

Mosimann, Pascal J., Sirimarco, Gaia, Meseguer, Elena, Serfaty, Jean-Michel, Laissy, Jean-Pierre, Labreuche, Julien, Lapergue, Bertrand, Gonzalez-Valcarcel, Jaime, Lavallée, Philippa C., Cabrejo, Lucie, Guidoux, Celine, Klein, Isabelle F., Olivot, Jean-Marc, Schouman-Claeys, Elisabeth, Amarenco, Pierre, and Mazighi, Mikael

Published
2013
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36. Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data

Author

Kaesmacher, Johannes, primary, Meinel, Thomas Raphael, additional, Kurmann, Christoph, additional, Zaidat, Osama O, additional, Castonguay, Alicia C, additional, Zaidi, Syed F, additional, Mueller-Kronast, Nils, additional, Kappelhof, Manon, additional, Dippel, Diederik W J, additional, Soudant, Marc, additional, Bracard, Serge, additional, Hill, Michael D, additional, Goyal, Mayank, additional, Strbian, Daniel, additional, Heiferman, Daniel M, additional, Ashley, William, additional, Anadani, Mohammad, additional, Spiotta, Alejandro M, additional, Dobrocky, Tomas, additional, Piechowiak, Eike I, additional, Arnold, Marcel, additional, Goeldlin, Martina, additional, Seiffge, David, additional, Mosimann, Pascal J, additional, Mordasini, Pasquale, additional, Gralla, Jan, additional, and Fischer, Urs, additional

Published
2021
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37. Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Author

Poupart, Oriane, primary, Conti, Riccardo, additional, Schmocker, Andreas, additional, Pancaldi, Lucio, additional, Moser, Christophe, additional, Nuss, Katja M., additional, Sakar, Mahmut S., additional, Dobrocky, Tomas, additional, Grützmacher, Hansjörg, additional, Mosimann, Pascal J., additional, and Pioletti, Dominique P., additional

Published
2021
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40. Impact of pre-stroke dependency on outcome after endovascular therapy in acute ischemic stroke

Author

Oesch, Lisa, primary, Arnold, Marcel, additional, Bernasconi, Corrado, additional, Kaesmacher, Johannes, additional, Fischer, Urs, additional, Mosimann, Pascal J., additional, Jung, Simon, additional, Meinel, Thomas, additional, Goeldlin, Martina, additional, Heldner, Mirjam, additional, Volbers, Bastian, additional, Gralla, Jan, additional, and Sarikaya, Hakan, additional

Published
2020
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44. Safety and Efficacy of Intra-arterial Urokinase After Failed, Unsuccessful, or Incomplete Mechanical Thrombectomy in Anterior Circulation Large-Vessel Occlusion Stroke

Author

Kaesmacher, Johannes, primary, Bellwald, Sebastian, additional, Dobrocky, Tomas, additional, Meinel, Thomas R., additional, Piechowiak, Eike I., additional, Goeldlin, Martina, additional, Kurmann, Christoph C., additional, Heldner, Mirjam R., additional, Jung, Simon, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Mosimann, Pascal J., additional, Schroth, Gerhard, additional, Mattle, Heinrich P., additional, Gralla, Jan, additional, and Fischer, Urs, additional

Published
2020
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45. Association of reperfusion success and emboli in new territories with long term mortality after mechanical thrombectomy.

Author

Beyeler, Morin, Weber, Loris, Kurmann, Christoph C., Piechowiak, Eike Immo I., Mosimann, Pascal J., Zibold, Felix, Meinel, Thomas Raphael, Branca, Mattia, Goeldlin, Martina, Pilgram-Pastor, Sara M., Grunder, Lorenz, Arnold, Marcel, Seiffge, David, Meier, Raphael, Heldner, Mirjam R., Dobrocky, Tomas, Mordasini, Pasquale, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Subjects
CEREBRAL embolism & thrombosis, CONFIDENCE intervals, ISCHEMIC stroke, REGRESSION analysis, VEIN surgery, TREATMENT effectiveness, THROMBECTOMY, STROKE patients, REPERFUSION, PROPORTIONAL hazards models
Abstract

Background The degree of reperfusion is the most important modifiable predictor of 3 month functional outcome and mortality in ischemic stroke patients treated with mechanical thrombectomy. Whether the beneficial effect of reperfusion also leads to a reduction in long term mortality is unknown. Methods Patients undergoing mechanical thrombectomy between January 2010 and December 2018 were included. The post-thrombectomy degree of reperfusion and emboli in new territories were core laboratory adjudicated. Reperfusion was evaluated according to the expanded Thrombolysis in Cerebral Infarction (eTICI) scale. Vital status was obtained from the Swiss population register. Adjusted hazard ratios (aHRs) using time split Cox regression models were calculated. Subgroup analyses were performed in patients with borderline indications. Results Our study included 1264 patients (median follow-up per patient 2.5 years). Patients with successful reperfusion had longer survival times, attributable to a lower hazard of death within 0-90 days and for >90 days to 2 years (aHR 0.34, 95% CI 0.26 to 0.46; aHR 0.37, 95% CI 0.22 to 0.62). This association was homogeneous across all predefined subgroups (p for interaction >0.05). Among patients with successful reperfusion, a significant difference in the hazard of death was observed between eTICI2b50 and eTICI3 (aHR 0.51, 95% CI 0.33 to 0.79). Emboli in new territories were present in 5% of patients, and were associated with increased mortality (aHR 2.3, 95% CI 1.11 to 4.86). Conclusion Successful, and ideally complete, reperfusion without emboli in new territories is associated with a reduction in long term mortality in patients treated with mechanical thrombectomy, and this was evident across several subgroups. [ABSTRACT FROM AUTHOR]

Published
2022
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46. ONLINE_SUPPLEMENT – Supplemental material for Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry

Author

Meinel, Thomas Raphael, Kaesmacher, Johannes, Mordasini, Pasquale, Mosimann, Pascal J., Jung, Simon, Arnold, Marcel, Heldner, Mirjam Rachel, Michel, Patrik, Hajdu, Steven D., Ribo, Marc, Requena, Manuel, Maegerlein, Christian, Friedrich, Benjamin, Costalat, Vincent, Benali, Amel, Pierot, Laurent, Gawlitza, Matthias, Schaafsma, Joanna, Vitor Mendes Pereira, Gralla, Jan, and Fischer, Urs

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, ONLINE_SUPPLEMENT for Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry by Thomas Raphael Meinel, Johannes Kaesmacher, Pasquale Mordasini, Pascal J. Mosimann, Simon Jung, Marcel Arnold, Mirjam Rachel Heldner, Patrik Michel, Steven D. Hajdu, Marc Ribo, Manuel Requena, Christian Maegerlein, Benjamin Friedrich, Vincent Costalat, Amel Benali, Laurent Pierot, Matthias Gawlitza, Joanna Schaafsma, Vitor Mendes Pereira, Jan Gralla and Urs Fischer in Therapeutic Advances in Neurological Disorders

Published
2019
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47. Effect of the phenotype of the M1-middle cerebral artery occlusion on the recanalization rates in the ASTER trial

Author

Consoli, Arturo, primary, Zhu, François, additional, Bourcier, Romain, additional, Dargazanli, Cyril, additional, Marnat, Gaultier, additional, Duhamel, Alain, additional, Blanc, Raphaël, additional, Saleme, Suzana, additional, Costalat, V, additional, Desal, Hubert, additional, Bracard, Serge, additional, Labreuche, Julien, additional, Kyheng, Maeva, additional, Puccinelli, Francesco, additional, Mosimann, Pascal J, additional, Gory, Benjamin, additional, Piotin, Michel, additional, and Lapergue, Bertrand, additional

Published
2019
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48. Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation

Author

Meinel, Thomas Raphael, primary, Kaesmacher, Johannes, additional, Chaloulos-Iakovidis, Panagiotis, additional, Panos, Leonidas, additional, Mordasini, Pasquale, additional, Mosimann, Pascal J, additional, Michel, Patrik, additional, Hajdu, Steven, additional, Ribo, Marc, additional, Requena, Manuel, additional, Maegerlein, Christian, additional, Friedrich, Benjamin, additional, Costalat, Vincent, additional, Benali, Amel, additional, Pierot, Laurent, additional, Gawlitza, Matthias, additional, Schaafsma, Joanna, additional, Pereira, Vitor M, additional, Gralla, Jan, additional, and Fischer, Urs, additional

Published
2019
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49. Endovascular treatment of tandem occlusions in vertebrobasilar stroke: technical aspects and outcome compared with isolated basilar artery occlusion

Author

Piechowiak, Eike I, primary, Kaesmacher, Johannes, additional, Zibold, Felix, additional, Dobrocky, Tomas, additional, Mosimann, Pascal J, additional, Jung, Simon, additional, Fischer, Urs, additional, Arnold, Marcel, additional, Bellwald, Sebastian, additional, Heldner, Mirjam R, additional, Gralla, Jan, additional, and Mordasini, Pasquale, additional

Published
2019
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50. Assessing Spinal Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension With a Scoring System Based on Brain Magnetic Resonance Imaging Findings

Author

Dobrocky, Tomas, primary, Grunder, Lorenz, additional, Breiding, Philipe S., additional, Branca, Mattia, additional, Limacher, Andreas, additional, Mosimann, Pascal J., additional, Mordasini, Pasquale, additional, Zibold, Felix, additional, Haeni, Levin, additional, Jesse, Christopher M., additional, Fung, Christian, additional, Raabe, Andreas, additional, Ulrich, Christian T., additional, Gralla, Jan, additional, Beck, Jürgen, additional, and Piechowiak, Eike I., additional

Published
2019
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