Search

Your search keyword '"Moser, Karen"' showing total 1,198 results
Start Over Author "Moser, Karen"
1,198 results on '"Moser, Karen"'

3. Interlaboratory Performance in Measurement of Dabigatran and Rivaroxaban: Results of the College of American Pathologists External Quality Assessment Program

Author

Volod, Oksana, Rollins-Raval, Marian, Iv, Andrew J. Goodwin, Higgins, Russell A., Long, Thomas, Chandler, Wayne L., Harris, Neil S., Pham, Huy P., Isom, James Alexander, Moser, Karen, Olson, John D., Smock, Kristi J., VanSandt, Amanda, Wool, Geoffrey, and Chen, Dong

Subjects
Rivaroxaban -- Testing, Pharmacokinetics -- Research, Pharmacology, Experimental, Chemistry, Analytic -- Quantitative, Biochemical assays -- Usage, Medical laboratories -- Standards -- Quality management, Dabigatran etexilate -- Testing, Health, College of American Pathologists -- Standards
Abstract

* Context.--Assessing direct oral anticoagulant (DOAC) drug levels by reliable laboratory assays is necessary in a number of clinical scenarios. Objective.--To evaluate the performance of DOACspecific assays for various concentrations [...]

Published
2022
Full Text
View/download PDF

4. Establishing reference intervals for von Willebrand factor multimers

Author

Pikta Marika, Vasse Marc, Smock Kristi J., Moser Karen A., van Dievoet Marie-Astrid, Lejniece Sandra, Szanto Timea, Bautista Hector, Nouadje George, and Banys Valdas

Subjects
von willebrand factor, von willebrand factor multimers, quantitative analysis, reference intervals, Biochemistry, QD415-436
Abstract

Background: von Willebrand factor (VWF) multimers (VWF:MM) methodologies are technically difficult, laborious, time consuming, non-standardized and results vary between laboratories. A new semi automated VWF:MM assay is available for routine use (Sebia). Due to lack of reference values for VWF:MM fractions, results interpretation can be challenging in some cases. The aim of this study was to determine reference intervals for low molecular weight (LMWM), intermediate molecular weight (IMWM) and high molecular weight (HMWM) multimers. Methods: By the international cooperation initiated between 4 countries (Estonia, Latvia, France, and USA) 131 samples of relatively healthy individuals were analyzed for VWF:MM (in total 51 males and 80 non-pregnant females aged 17-69 years). Reference intervals were calculated according to CLSI C28-A3 standard. Results: The proposed reference intervals for VWF:MM were calculated for LMWM 10.4-22.5%, IMWM 22.6-37.6%, HMWM 45.6-66.6%. Age related differences were seen in IMWM and HMWM (p

Published
2022
Full Text
View/download PDF

5. Essential laboratory tests for medical education

Author

Deyrup, Andrea, Knollmann-Ritschel, Barbara, D'Ambrosio, Danielle, Muir, Jeannie, Scordino, Teresa, Kraswoski, Matthew, Cao, Liyun, Shah, Kinjal, Zepf, Jennifer, Grindstaff, Samuel, Inman, Ashley, Moser, Karen, Olson, Kristin, Parker, Lynette, Shmookler, Aaron, Ou, Joyce, Putnam, Angelica, Watts, Luisa, Betts, Elham Vali, Lovitch, Scott, Stashek, Kristen, Flanagan, Melina, Singh, Nirupama, Suarez, Eric, Dudrey, Ellen, Furlong, Mary, Margeta, Marta, Wilberger, Adam, Chan, Joanna, Lin, Amy, and Deyrup, Andrea T.

Published
2022
Full Text
View/download PDF

7. Clinical, immunophenotypic and genomic findings of NK lymphoblastic leukemia: a study from the Bone Marrow Pathology Group

Author

Weinberg, Olga K., Chisholm, Karen M., Ok, Chi Young, Fedoriw, Yuri, Grzywacz, Bartosz, Kurzer, Jason H., Mason, Emily F., Moser, Karen A., Bhattacharya, Siddharth, Xu, Mina, Babu, Daniel, Foucar, Kathryn, Tam, Wayne, Bagg, Adam, Orazi, Attilio, George, Tracy I., Wang, Wei, Wang, Sa A., Arber, Daniel A., and Hasserjian, Robert P.

Published
2021
Full Text
View/download PDF

9. Protein C Deficiency

Author

Dinarvand, Peyman and Moser, Karen A.

Subjects
Thromboembolism -- Genetic aspects -- Risk factors, Anticoagulants, Protein C, Factor VII, Genes, Argatroban, Rivaroxaban, Hypercoagulation, Purpura, Apixaban, Newborn infants, Edoxaban, Health
Abstract

* Protein C (PC) deficiency is a heritable or acquired risk factor for thrombophilia, with presentations varying from asymptomatic to venous thromboembolism to neonatal purpura fulminans, a life-threatening disorder. Hereditary PC deficiency is caused by mutation in the PC (PROC) gene located on chromosome 2q14.3. Heterozygous and acquired PC deficiencies are more common than homozygous deficiency. The recommended initial laboratory test measures PC activity using either clot-based or chromogenic methods. There are numerous potential interferences in PC activity testing that may result in either false-positive (falsely low activity) or false-negative (falsely normal or elevated activity) results. In the present review, we discuss common clinical presentations; laboratory testing, with a focus on potential assay interferences; treatment options; and prognosis in patients with PC deficiency. (Arch Pathol Lab Med. 2019;143:1281-1285; doi: 10.5858/arpa.2017-0403-RS), Protein C (PC) is a vitamin K-dependent zymogen that has essential roles in the regulation of thrombosis and hemostasis in humans. The protein was purified and characterized by Stenflo (1) [...]

Published
2019
Full Text
View/download PDF

10. External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program

Author

Chandler, Wayne L., Brown, Alan F., Chen, Dong, Moser, Karen, Olson, John D., Pham, Huy Phu, Smock, Kristi J., Volod, Oksana, and Higgins, Russell A.

Subjects
Blood platelets -- Research, Pathologists -- Practice, Bioassay -- Usage, Collagen, Unsaturated fatty acids, EDTA, Tirofiban, Arachidonic acid, Fatty acids, ATPases, Health
Abstract

Context.--The College of American Pathologists (CAP) developed proficiency testing for platelet function assays by using blood collected by the participant added to challenge tubes containing either saline (normal) or tirofiban (abnormal). Objective.--To analyze platelet function proficiency testing for Platelet Function Analyzer PFA-100, platelet aggregation, PlateletWorks, and PlateletMapping. Design.--Proficiency testing data from 2012-2016 were analyzed. Results.--For PFA-100, a total of 1200 laboratories participated; the coefficient variation (CV) of cartridge closure times was 22% (saline); 44,952 of 45,616 survey responses (99%) provided an interpretation, and 42,934 of 44,952 (96%) were correct. For optical platelet aggregation, 190 laboratories participated; the CV was 17% (saline), 7444 of 7813 survey responses (95%) provided an interpretation, and 7015 of 7444 (94%) were correct. For PlateletWorks, 60 laboratories participated; the CV was 3% to 11% (saline); 2412 of 2454 survey responses (98%) provided an interpretation, and 1207 of 1276 (95%) were correct for adenosine diphosphate (ADP) and 936 of 1136 (82%) for collagen. For PlateletMapping, 200 laboratories participated. For ADP, 1128 of 2697 survey responses (42%) provided an interpretation, but only 927 of 1128 (82%) were correct. For arachidonic acid, 1139 of 2604 survey responses (44%) provided an interpretation and 964 of 1139 (85%) were correct. Conclusions.--CAP is the first to provide proficiency testing for platelet aggregation, PlateletWorks, and PlateletMapping. Platelet aggregation, PFA-100, and PlateletWorks using ADP as an agonist performed well with more than 90% of laboratories providing an interpretation and a similar number providing correct results. PlateletWorks using collagen and PlateletMapping showed worse interpretive accuracy than the other methods. (Arch Pathol Lab Med. 2019;143:472-482; doi: 10.5858/arpa.2017-0556-CP), Platelets perform multiple functions related to hemostasis and can be activated by multiple pathways; thus, no single platelet function test can assess all aspects of platelet function or diagnose all [...]

Published
2019
Full Text
View/download PDF

12. Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Author

Kanack, Adam J., primary, Bayas, Antonios, additional, George, Gemlyn, additional, Abou-Ismail, Mouhamed Yazan, additional, Singh, Bandana, additional, Kohlhagen, Mindy C., additional, Splinter, Noah P., additional, Christ, Monika, additional, Naumann, Markus, additional, Moser, Karen A., additional, Smock, Kristi J., additional, Grazioli, Alison, additional, Wen, Renren, additional, Wang, Demin, additional, Murray, David L., additional, and Padmanabhan, Anand, additional

Published
2022
Full Text
View/download PDF

14. Persistence of Ad26.COV2.S‐associated vaccine‐induced immune thrombotic thrombocytopenia (VITT) and specific detection of VITT antibodies

Author

Kanack, Adam J., primary, Singh, Bandana, additional, George, Gemlyn, additional, Gundabolu, Krishna, additional, Koepsell, Scott A., additional, Abou‐Ismail, Mouhamed Yazan, additional, Moser, Karen A., additional, Smock, Kristi J., additional, Green, David, additional, Major, Ajay, additional, Chan, Clarence W., additional, Wool, Geoffrey D., additional, Reding, Mark, additional, Ashrani, Aneel A., additional, Bayas, Antonios, additional, Grill, Diane E., additional, and Padmanabhan, Anand, additional

Published
2022
Full Text
View/download PDF

18. Efficacy of Avapritinib in Patients with Advanced Systemic Mastocytosis: Hematologic and Bone Marrow Responses from the Phase 2 Open-Label, Single-Arm, Pathfinder Study

Author

George, Tracy I., primary, Karner, Kristin H., additional, Moser, Karen A., additional, Rets, Anton, additional, Fredericks, Michelle, additional, Reiter, Andreas, additional, Radia, Deepti H., additional, Deininger, Michael W., additional, Lin, Hui-Min, additional, Sen, Jayita, additional, Gotlib, Jason, additional, Dimitrijević, Saša, additional, and DeAngelo, Daniel J., additional

Published
2021
Full Text
View/download PDF

19. Monoclonal and Oligoclonal Anti-PF4 Antibodies Mediate VITT

Author

Singh, Bandana, primary, Kanack, Adam, additional, Bayas, Antonios, additional, George, Gemlyn, additional, Abou-Ismail, Mouhamed Yazan Abou, additional, Kohlhagen, Mindy, additional, Christ, Monika, additional, Naumann, Markus, additional, Moser, Karen A, additional, Smock, Kristi J, additional, Grazioli, Alison, additional, Murray, David L, additional, and Padmanabhan, Anand, additional

Published
2021
Full Text
View/download PDF

21. The Interlaboratory Performance in Measurement of Dabigatran and Rivaroxaban: Results of the College of American Pathologists External Quality Assessment Program

Author

Volod, Oksana, primary, Rollins-Raval, Marian, additional, Goodwin, Andrew J., additional, Higgins, Russell A., additional, Long, Thomas, additional, Chandler, Wayne L., additional, Harris, Neil S., additional, Pham, Huy P., additional, Isom, James Alexander, additional, Moser, Karen, additional, Olson, John D., additional, Smock, Kristi J., additional, VanSandt, Amanda, additional, Wool, Geoffrey, additional, and Chen, Dong, additional

Published
2021
Full Text
View/download PDF

25. Letter to the Editor on “The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria”

Author

Moser, Karen A., primary, Pearson, Lauren N., additional, Pelt, Christopher E., additional, Olson, John D., additional, Goodwin, Andrew J., additional, Isom, James A., additional, Harris, Neil S., additional, Pham, Huy P., additional, Smock, Kristi J., additional, Unold, David, additional, VanSandt, Amanda M., additional, Volod, Oksana, additional, and Chen, Dong, additional

Published
2020
Full Text
View/download PDF

26. Exit taxes in the context of double tax treaties: is the individual emigrating from South Africa protected against double taxation?

Author

Moser, Karen and Roeleveld, Jennifer

Subjects
International Tax
Abstract

For some countries, such as South Africa, a change of residence to another jurisdiction is a taxable event and may give rise to taxation of capital gains, based on a deemed disposal, even though there has not been an actual realisation of the capital gain. Such taxation is referred to as ‘exit or departure tax’ or ‘exit charge’. Double taxation of capital gains may arise when the former State of residence applies such an exit tax at the time when the taxpayer ceases to be a tax resident of that State, and when the new State of residence, thereafter, taxes the capital gain at the time of the actual disposal of the asset and realisation of the capital gain. A South African resident individual who emigrates, is therefore exposed to the risk of such double taxation. Double tax treaties following the OECD Model Convention aim at avoiding double taxation and provide distributive rules regarding capital gains in Article 13. This study examines if double tax treaties protect the individual emigrating from South Africa against the application of South Africa’s exit tax. Typical assets considered in the study are shares in a company, held as an investment. The analysis begins with an overview of the applicable rules of the South African Income Tax Act in respect of the capital gains tax levied when a South African resident individual emigrates and ceases to be a resident of South Africa. It then distinguishes between exit taxes in the strict sense (taxation of the accrued value at the time of emigration) and trailing taxes (extended tax jurisdiction, taxing the capital gains at the time of realisation after the emigration). The analysis then concentrates on four subquestions, i.e. (i) whether Art. 13(5) of the OECD Model Convention (2017) applies to exit taxes, (ii) whether Art. 13(5) of the OECD Model precludes the application of an exit tax, (iii) to what extent double tax treaties are able to mitigate the risk of double taxation in the case of exit taxes, and (iv) whether the tax treaty network of South Africa provides any protection against double taxation caused by the application of the South African exit tax. It was concluded that it is generally accepted, with the exception of a minority of authors, that the distributive rule of Art. 13(5) OECD Model includes capital gains arising from a deemed alienation and that that article does not preclude the former State of residence from applying its exit tax at the time when the person is still a resident of that State. However, Art. 13(5) OECD Model does preclude the application of trailing taxes after the person ceases to be a resident. In order to allow the application of trailing taxes, double tax treaties need to explicitly provide for this in a specific clause in the capital gains-article of the tax treaty. The exclusive allocation of taxing rights in art. 13(5) OECD Model in favour of the State of residence does not mitigate the risk of double taxation in the case of exit taxes in the strict sense. In order to avoid double taxation of that portion of the capital gain that already has been subjected to an exit tax in the strict sense, double tax treaties need to include a specific clause in the capital gains-article of the tax treaty, which obliges the new State of residence, when taxing the capital gain at the moment of realisation, to take into account the value that was subjected to the exit tax (step-up in the base cost). South Africa concluded only two treaties which provide for such a step-up in the base cost, one of which has not yet entered into force. This leaves the individual South African resident who emigrates, largely unprotected against double taxation of capital gains at a tax treaty level. It is recommended that South Africa include such specific clauses that provide for a step-up in the base cost in more tax treaties, especially in tax treaties with countries that do not already grant a step-up in terms of their domestic tax laws.

Published
2019

33. Defining the Optimal VAD Coordinator to Patient Ratio

Author

Edwards, Lori, primary, Phillips, Sheila, additional, Binetti, Maria, additional, Moser, Karen, additional, Carter, Christine, additional, May, Christopher, additional, Desai, Shashank, additional, Singh, Ramesh, additional, and Shah, Palak, additional

Published
2017
Full Text
View/download PDF

34. Issues Surrounding Age-Adjusted D-Dimer Cutoffs That Practicing Physicians Need to Know When Evaluating Patients With Suspected Pulmonary Embolism

Author

Goodwin, Andrew J., primary, Higgins, Russell A., additional, Moser, Karen A., additional, Smock, Kristi J., additional, Chandler, Wayne L., additional, Kottke-Marchant, Kandice, additional, Hartman, Sarah K., additional, Volod, Oksana, additional, Brown, Alan F., additional, Johari, Vandita P., additional, Burr, Sharon, additional, Polyakov, Nataliya, additional, and Chen, Dong, additional

Published
2016
Full Text
View/download PDF

35. Compilers alleviate spreadsheet woes

Author

Abbattista, Susan, Brown, Bruce, Moser, Karen D., and Winship, Sally

Subjects
Spreadsheet add-on, Computer programming, Software quality, Compiler/decompiler, Spreadsheet software, Sheng Labs Inc. -- Product information, Baler Software Corp. -- Product information, Resource Analysis International Inc. -- Product information, SoftLogic Solutions Inc. -- Product information, Compile 1toC 2.2 (Compiler), Lotus 1-2-3 (Spreadsheet software) -- Product information -- Evaluation -- Product/service Evaluations, atliberty 2.01 (Add-in/on software), BalerXE (Compiler), King Jaguar 2.2 (Spreadsheet compiler), Software -- Product information -- Evaluation -- Product/service Evaluations, Computer programming -- Product information, Coroutines -- Evaluation -- Product information, Spreadsheets -- Product information -- Evaluation -- Product/service Evaluations, Compilers -- Evaluation -- Product information -- Product/service Evaluations, Compiling (Electronic computers) -- Evaluation -- Product information, Evaluation -- Product information
Abstract

Many organizations have to distribute spreadsheet-based applications in which the original structure, formulas and key data are maintained. With traditional spreadsheets, distributing worksheets is fraught with problems. Cells and ranges […]

Published
1990

36. Merrill & Bryan Enterprises Inc. Turbo EMS 5.0

Author

Coffee, Peter and Moser, Karen

Subjects
Company business management, Software quality, Storage capacity, Desktop utility, RAM, Merrill and Bryan Enterprises Inc. -- Product information -- Management, Turbo EMS 5.0 (Operating system enhancement), Software -- Evaluation -- Product information -- Product/service Evaluations, Memory refresh (Computers) -- Product information, Memory compaction -- Product information, Memory management -- Product information, Memory mapping -- Product information, Random access memory -- Management -- Evaluation -- Product information -- Product/service Evaluations, Memory protection -- Product information, Evaluation -- Product information, Memory partitioning -- Product information
Abstract

Merrill & Bryan Enterprises Inc. TURBO EMS 5.0 Turbo EMS is similar in function to Above Disc, but during testing Turbo EMS used 7K bytes less conventional RAM than its […]

Published
1990

39. Version-control system upgrade supports Windows

Author

Moser, Karen D.

Subjects
Application installation/distribution software, Application development software, Solution Systems Inc. -- Product introduction, Sourcerer's Apprentice for Windows (Program development software) -- Product introduction, Computer software industry -- Product introduction, Program development software -- Product introduction
Abstract

By Karen D. Moser Solution Systems will deliver at Comdex/Fall this week an upgrade to its version-control system that will support Windows as well as a Unix-like make utility. In […]

Published
1991

42. ODBMS shares objects on multiple platforms

Author

Moser, Karen D.

Subjects
DBMS, DBMS utility, Versant Object Technology Corp. -- Product introduction, Versant 3.0 (DBMS) -- Product introduction, Computer software industry -- Product introduction, Database management systems -- Product introduction
Abstract

Versant Object Technology Corp. this week will release a new version of its object database management system that supports cross-platform object sharing, and full or incremental on-line backup. Versant ODBMS […]

Published
1994

43. Borland releases beta version of Database Engine

Author

Moser, Karen D.

Subjects
DBMS, Application installation/distribution software, DBMS utility, Beta testing, Software quality, Time to market, CD-ROM catalog, Application development software, Database, CD-ROM database, Borland Software Corp. -- Product development, Borland Database Engine (DBMS) -- Product development, Computer software industry -- Product development, Software -- Product development, Database management systems -- Product development, Beta testing, Product development, Databases -- Product development, Program development software -- Product development, Interoperability
Abstract

Borland International Inc. last week provided users with beta copies of its Borland Database Engine, which includes Independent Database API technology. The IDAPI technology provides database connectivity for both Windows […]

Published
1994

44. Plug and play is years away; benefits of objects won't be available to all immediately

Author

Vizard, Michael and Moser, Karen D.

Subjects
Object-oriented programming, Reusable code, Software quality, Distributed object technology, Market trend/market analysis, OLE, Microsoft Corp. -- Product information -- Forecasts and trends, Software -- Product information, Computer software industry -- Forecasts and trends -- Product information, Object-oriented programming -- Forecasts and trends -- Product information
Abstract

As OLE 2.0 software packages get set to go mainstream, Microsoft Corp. is painting a rosy future for developers, based on plug-and-play software components using object technology that alters how […]

Published
1994

45. Island Software launches Windows document manager

Author

Moser, Karen D.

Subjects
Document processing system, Document editing software, Word processing software, Island Software Inc. -- Product introduction, Island InText for Windows (File format conversion software) -- Product introduction, Computer software industry -- Product introduction, Word processing software -- Product introduction, Document management systems -- Product introduction
Abstract

As part of an overall strategy to move into the Windows arena, longtime Unix software provider Island Software will integrate InText Systems Inc.'s text-manipulation and -retrieval tools with Island Software's […]

Published
1994

46. Evolution to DB2 client/server proceeds with new platforms, tools

Author

Moser, Karen D. and Leach, Norvin

Subjects
DBMS, DBMS utility, Time to market, Client/server architecture, International Business Machines Corp. -- Product development, DB2 (DBMS) -- Product development, Computer software industry -- Product development, Client/server architecture -- Product development, Database management systems -- Product development, Product development
Abstract

IBM, evolving DB2 into a strategic client/server environment, is assembling a parcel of development tools and platforms around the venerable database. The firm's Software Solutions Division plans to add over […]

Published
1994

47. Oracle's Ellison ponders the future

Author

Dodge, John and Moser, Karen D.

Subjects
DBMS, Database industry, Relational database, DBMS utility, Oracle Corp. -- Officials and employees, Oracle Media Server (DBMS) -- Design and construction, Oracle8 (DBMS) -- Design and construction, Oracle7 7.1 (DBMS) -- Design and construction, Oracle Documents (Text processing software) -- Design and construction, Database management systems, Database industry -- Officials and employees, Chief executive officers -- Interviews, Relational databases -- Design and construction
Abstract

Oracle Corp. CEO Lawrence Ellison's view of the future extends well beyond his company's RDBMS roots. In February, the company unveiled its plans to deliver the Oracle Media Server -- […]

Published
1994

48. Raima targets corporate IS with faster database engine

Author

Moser, Karen D.

Subjects
Application installation/distribution software, Database design, DBMS, DBMS utility, Application development software, Centura Software Corp. -- Product introduction, Velocis (DBMS) -- Product introduction, Computer software industry -- Product introduction, Database management systems -- Product introduction, Database design, Program development software -- Product introduction
Abstract

Raima Corp. last week announced a speedier database engine aimed at luring corporate developers and OEMs into its fold. The new engine, called Velocis, is a stand-alone embedded database engine […]

Published
1994

49. Lotus improving performance in Approach 3.0

Author

Moser, Karen D.

Subjects
DBMS, DBMS utility, Beta testing, Time to market, Performance improvement, Lotus Development Corp. -- Product development, Lotus Approach for Windows 3.0 (DBMS) -- Product development, Computer software industry -- Product development, Database management systems -- Product development, Beta testing, Product development
Abstract

Lotus Development Corp.'s Approach 3.0 will feature performance enhancements and a slew of new features aimed at making complex database operations easier. The upgrade, currently in beta, also sports tighter […]

Published
1994

50. Tandem positions hardware/software packages at DSS

Author

Moser, Karen D.

Subjects
DBMS, Application installation/distribution software, Minicomputer, DBMS utility, Microcomputer industry, Application development software, Computer industry, Product enhancement, Evolutionary Technologies International Inc. -- Product introduction -- Product enhancement, Tandem Computers Inc. -- Product introduction -- Product enhancement, Prism Solutions Inc. -- Product introduction -- Product enhancement, Warehouse Manager (DBMS) -- Product enhancement -- Product introduction, NonStop SQL (DBMS) -- Usage -- Product enhancement -- Product introduction, Tandem Computers NonStop Himalaya K100 (MIPS-based system) -- Product introduction -- Product enhancement, Database management systems -- Product introduction -- Product enhancement -- Usage, Program development software -- Usage -- Product enhancement -- Product introduction, Minicomputers -- Product introduction -- Usage -- Product enhancement, Computer industry -- Product introduction -- Product enhancement
Abstract

Tandem Computers Inc. has joined forces with several decision-support vendors to provide a hardware and software system that includes an optimized SQL database tuned for data analysis. In conjunction with […]

Published
1994

Catalog

Books, media, physical & digital resources
See catalog results