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This paper presents the outcomes of a project carried out with Cesano Boscone (Milan, Italy) students (6th-7th grade), consistent with the National Operational Programme, For School - Competences and Learning Environments, 2014-2020 (MIUR), on citizenship education in an intercultural and interdisciplinary perspective, with a focus on an aware use of social networks. The project was evaluated using the “fourth generation” approach, activating a reflexive comparison between participants. The perception of the project’s educational impact shows a coherent relationship between the objectives that guided the design work and the learning outcomes that emerge from the analysis of the classroom activities. The results of the content analysis of the conversations with children highlighted the effectiveness of the educational alliance between teachers and educators and the assumption of a reflective attitude towards their own practices. The first identified learning outcome is a responsibility towards a common heritage, a second outcome is a greater awareness of the potential and risks of the digital environment, a third point underlined by the students is the ability to interact in a group, understanding different points of view, valuing one's own and others' skills, contributing to common learning and implementing collective activities.

The scarcity of drinking water is an increasingly pressing issue in many regions of the world, even in areas up till now considered developed. Climate change deprives many populations of the amount of water necessary for human consumption and traditional crops. Therefore, finding new water sources and making their usage more efficient and able to adapt to new environmental conditions without worsening the situation with further pollution is becoming mandatory. In the case study considered here, set on the Italian island of Vulcano in the Central Mediterranean, we propose the economic analysis and financial sustainability of plants for the desalination and recycled wastewater, powered by a DC-DC photovoltaic tracker system with silicon crystal panels sustained by a daily pack of lithium batteries. We present an estimation of the necessary budget, and propose a mix of traditional and innovative financial instruments to construct and analyse the economic trends of the installations over 30 years, considering the specific area price levels, salaries and interest rates. Finally, through the net present value index, we evaluate the financial sustainability of the entire operation, namely, identifying the circumstances when funding and building these plants in areas as remote as the one considered here is cost-effective.

Developing citizenship skills through cultural heritage and social networks The project, consistent with the orientation of the National Operational Programme, For School - Competences and Learning Environments (2014-2020) of the Ministry of Education, Universities and Research - aimed at form competent and responsible citizens in a modern, connected and interdependent society - is intended to: - developing a feeling of belonging to a broad, democratic and inclusive community, starting from an interdependence of political, economic, environmental, social and cultural dimensions, between local and global levels (Balibar, 2012); - in-depth exploration of citizenship education in an intercultural perspective, with a specific focus on heritage education (Bortolotti, Calidoni, Mascheroni, & Mattozzi 2008) in connection with a more aware use of digital tools and social networks. The project involved 5th-6th grade classes of the IC Alessandrini and IC Da Vinci in Cesano Boscone (Milan) to work on continuity between the different school levels; it has been monitored and evaluated using the participatory and “fourth generation” evaluation approach (Guba & Lincoln, 1989), aimed at enhancing the subjectivity of the participants, activating a reflexive comparison between them and providing useful evidence for the redesigning of similar actions. In this context we will focus on students’ activities analysis, carried out according to the qualitative method of content analysis (Krippendorff, 2004) with a coding system inspired by the constructivist approach of Grounded Theory (Charmaz, 2006). In a first phase, labels adhered to the text, following an analytical process of “naming” the data (Tarozzi, 2008, p. 84) and then grouped into categories representing the different identified units of meaning. A key aspect of the process has been intersubjectivity between the researchers who, coding the texts first separately then comparing each other, have been gradually redefining

Nel capitolo presentiamo il nido d’infanzia e le altre tipologie di servizi per la fascia di età zero tre anni, a partire da un breve excursus della loro storia ed evoluzione pedagogica e culturale, fino alla loro attualità come componenti del sistema integrato di educazione zero sei. I cambiamenti normativi e culturali in corso sono trattati mettendo in luce le questioni che con il processo di integrazione sono aperte, come la formazione di base e in servizio degli educatori e la qualità delle offerte educative. Nella seconda parte del capitolo, trattiamo l’argomento dei servizi educativi rivolti ai soggetti in età pre-adolescenziale, adolescenziale e giovanile.

BACKGROUND AND OBJECTIVES: Renin-angiotensin system (RAS) inhibitors reduce cardiovascular morbidity and mortality in patients with CKD. We evaluated the cardioprotective effects of the angiotensin-converting enzyme inhibitor ramipril in patients on maintenance hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this phase 3, prospective, randomized, open-label, blinded end point, parallel, multicenter trial, we recruited patients on maintenance hemodialysis with hypertension and/or left ventricular hypertrophy from 28 Italian centers. Between July 2009 and February 2014, 140 participants were randomized to ramipril (1.25-10 mg/d) and 129 participants were allocated to non-RAS inhibition therapy, both titrated up to the maximally tolerated dose to achieve predefined target BP values. The primary efficacy end point was a composite of cardiovascular death, myocardial infarction, or stroke. Secondary end points included the single components of the primary end point, new-onset or recurrence of atrial fibrillation, hospitalizations for symptomatic fluid overload, thrombosis or stenosis of the arteriovenous fistula, and changes in cardiac mass index. All outcomes were evaluated up to 42 months after randomization. RESULTS: At comparable BP control, 23 participants on ramipril (16%) and 24 on non-RAS inhibitor therapy (19%) reached the primary composite end point (hazard ratio, 0.93; 95% confidence interval, 0.52 to 1.64; P=0.80). Ramipril reduced cardiac mass index at 1 year of follow-up (between-group difference in change from baseline: -16.3 g/m2; 95% confidence interval, -29.4 to -3.1), but did not significantly affect the other secondary outcomes. Hypotensive episodes were more frequent in participants allocated to ramipril than controls (41% versus 12%). Twenty participants on ramipril and nine controls developed cancer, including six gastrointestinal malignancies on ramipril (four were fatal), compared with none in controls. CONCLUSIONS: Ramipril di

Background: Microbial lipids have been emerging as a sustainable alternative to vegetable oils and animal fat to produce biodiesel and industrial relevant chemicals. The use of wastes for microbial processes can represent a way for upgrading low value feedstock to high value products, addressing one of the main goals of circular economy, the reduction of wastes by recycling. Two oleaginous yeasts, Rhodosporidiobolus azoricus and Cutaneotrichosporon oleaginosum, were used in this study to demonstrate the feasibility of the proposed approach. Results: In this study wastes from industrial food processing, as pumpkin peels and syrup from candied fruits manufacture, were used for yeast cultivation and for lipids production. Evaluation of growth and sugar consumption revealed marked differences between the yeasts in capacity to utilize the main sugars present in the feedstock. In particular, we observed an unexpected limitation in glucose metabolism on mineral defined media by R. azoricus. Both species showed ability to grow and accumulate lipids on media exclusively composed by undiluted pumpkin peel hydrolysate, and R. azoricus was the best performing. By a two-stage process carried out in bioreactor, this species reached a biomass concentration of 45 g/L (dry weight) containing 55% of lipids, corresponding to a lipid concentration of 24 g/L, with a productivity of 0.26 g/L/h and yield of 0.24 g lipids per g of utilized sugar. Conclusions: Wastes from industrial food processing were sufficient to completely support yeast growth and to induce lipid accumulation. This study provides strong evidence that the concept of valorisation through the production of lipids from the metabolism of nutrients present in agro-industrial wastes by oleaginous yeasts is promising for implementation of biotechnological processes in a circular economy contest.

Aim: The Italian Society of Occupational Medicine (SIML), the Italian Diabetes Society (SID) and the Association of Diabetologists (AMD) joined a working group that produced a consensus paper aimed to assess the available evidence regarding the interplay between specific working conditions, including shift- and night-time work, working activities at high risk of accidents and work at heights, working tasks requiring high-energy expenditure, working activities at extreme temperatures and diabetes. Data synthesis: Diabetes is a group of metabolic disorders caused by defects in insulin secretion and/or action affecting millions of people worldwide, many of whom are or wish to be active members of the workforce. Although diabetes, generally, does not prevent a person from properly performing his/her working tasks, disease complications can significantly compromise a person's ability to work. Therefore, it appears evident the need to understand the relationship between occupational risk factors and diabetes. The working group included in the document some practical recommendations useful to ensure diabetic workers the possibility to safely and effectively undertake their jobs and to adequately manage and treat their disease, also in the workplace. In this perspective concerted action of all the workplace preventive figures, occupational physicians and diabetologists should be strongly encouraged. Conclusions: Further studies are necessary to define workplace-based interventions, which should be minimally invasive towards the work organization, allowing diabetic workers to fully realize their work skills while improving their wellbeing at work.

Il tema della giustizia e dell'ingiustizia continua ad affascinare pensatori e scienziati della nostra epoca, a dimostrazione del fatto che si tratta di una questione cruciale e di estrema importanza nell'esistenza di ciascuno di noi: sentirsi trattati in modo giusto o ingiusto non solo influisce sulla nostra percezione della qualità della vita quotidiana, ma è esperienza comune e frequente, di cui noi tutti spesso dibattiamo. Dopo una breve disamina delle più note teorie filosofiche e psicologiche che negli ultimi anni hanno trattato la complessità insita nei termini in questione, il testo affronta il tema della giustizia e dell'ingiustizia all'interno del contesto scolastico, inteso come luogo dove è possibile "fare esperienza" di tali valori, occupandosi in particolare del peso che essi assumono nella relazione educativa e didattica tra insegnanti e e allievi e di come i vissuti di giustizia e di ingiustizia degli studenti incidano in modo significativo sull'apprendimento, sulla motivazione allo studio e più in generale sul loro percorso scolastico, determinandone il successo o meno. Nel testo sono, inoltre, riportati molti esempi tratti dall'esperienza scolastica di tutti i giorni e frutto di racconti di insegnanti e allievi intervistati nell'ambito di ricerche che si sono occupate di questo argomento.

Il testo affronta il tema della giustizia e ingiustizia a scuola nel contesto scolastico quale luogo in cui fare esperienza di tali valori. In particolare, dopo una breve disamina delle più note teorie filosofiche e psicologiche che negli anni hanno trattato la complessità del tema, si occupa delle ricadute sulla relazione educativa e didattica tra alunni e insegnanti e di come tali vissuti, di giustizia e di ingiustizia, incidano sulla disponibilità e sull'atteggiamento ad apprendere, sulla motivazione allo studio e in generale sul successo scolastico.