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1. Intravitreal ranibizumab in a patient with choroidal neovascularization secondary to multiple evanescent white dot syndrome

Author: ROUVAS, A. A., LADAS, I. D., PAPAKOSTAS, T. D., MOSCHOS, M. M., and VERGADOS, I.
Published: 2007

2. Burden of injury along the development spectrum : Associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017

Author: Haagsma, J. A., James, S. L., Castle, C. D., Dingels, Z. V., Fox, J. T., Hamilton, E. B., Liu, Z., Lucchesi, L. R., Roberts, N. L. S., Sylte, D. O., Adebayo, O. M., Ahmadi, A., Ahmed, M. B., Aichour, M. T. E., Alahdab, F., Alghnam, S. A., Aljunid, S. M., Al-Raddadi, R. M., Alsharif, U., Altirkawi, K., Anjomshoa, M., Antonio, C. A. T., Appiah, S. C. Y., Aremu, O., Arora, A., Asayesh, H., Assadi, R., Awasthi, A., Ayala Quintanilla, B. P., Balalla, S., Banstola, A., Barker-Collo, S. L., BÃ€rnighausen, T. W., Bazargan-Hejazi, S., Bedi, N., Behzadifar, M., Benjet, C., Bennett, D. A., Bensenor, I. M., Bhaumik, S., Bhutta, Z. A., Bijani, A., Borges, G., Borschmann, R., Bose, D., Boufous, S., Brazinova, A., Campuzano Rincon, J. C., CÃ¡rdenas, R., Carrero, J. J., Carvalho, F., CastaÃ±eda-Orjuela, C. A., CatalÃ¡-LÃ³pez, F., Choi, J. -YJ., Christopher, D. J., Crowe, C. S., Dalal, Koustuv, Daryani, A., Davitoiu, D. V., Degenhardt, L., De Leo, D., De Neve, J. -W, Deribe, K., Dessie, G. A., Deveber, G. A., Dharmaratne, S. D., Doan, L. P., Dolan, K. A., Driscoll, T. R., Dubey, M., El-Khatib, Z., Ellingsen, C. L., El Sayed Zaki, M., Endries, A. Y., Eskandarieh, S., Faro, A., Fereshtehnejad, S. -M, Fernandes, E., Filip, I., Fischer, F., Franklin, R. C., Fukumoto, T., Gezae, K. E., Gill, T. K., Goulart, A. C., Grada, A., Guo, Y., Gupta, R., Haghparast Bidgoli, H., Haj-Mirzaian, A., Hamadeh, R. R., Hamidi, S., Haro, J. M., Hassankhani, H., Hassen, H. Y., Havmoeller, R., Hendrie, D., Henok, A., HÃjar, M., Hole, M. K., Homaie Rad, E., Hossain, N., Hostiuc, S., Hu, G., Igumbor, E. U., Ilesanmi, O. S., Irvani, S. S. N., Islam, S. M. S., Ivers, R. Q., Jacobsen, K. H., Jahanmehr, N., Jakovljevic, M., Jayatilleke, A. U., Jha, R. P., Jonas, J. B., Jorjoran Shushtari, Z., Jozwiak, J. J., JÃŒrisson, M., Kabir, A., Kalani, R., Kasaeian, A., Kelbore, A. G., Kengne, A. P., Khader, Y. S., Khafaie, M. A., Khalid, N., Khan, E. A., Khoja, A. T., Kiadaliri, A. A., Kim, Y. -E, Kim, D., Kisa, A., Koyanagi, A., Kuate Defo, B., Kucuk Bicer, B., Kumar, M., Lalloo, R., Lam, H., Lami, F. H., Lansingh, V. C., Leasher, J. L., Li, S., Linn, S., Lunevicius, R., MacHado, F. R., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Mahotra, N. B., Majdan, M., Majeed, A., Malekzadeh, R., Malik, M. A., Malta, D. C., Manda, A. -L, Mansournia, M. A., Massenburg, B. B., Maulik, P. K., Meheretu, H. A. A., Mehndiratta, M. M., Melese, A., Mendoza, W., Mengesha, M. M., Meretoja, T. J., Meretoja, A., Mestrovic, T., Miazgowski, T., Miller, T. R., Mini, G. K., Mirrakhimov, E. M., Moazen, B., Mohammad Gholi Mezerji, N., Mohammadibakhsh, R., Mohammed, S., Molokhia, M., Monasta, L., Mondello, S., Montero-Zamora, P. A., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi-Lakeh, M., Morawska, L., VelÃ¡squez, I. M., Morrison, S. D., Moschos, M. M., Mousavi, S. M., Murthy, S., Musa, K. I., Naik, G., Najafi, F., Nangia, V., Nascimento, B. R., Ndwandwe, D. E., Negoi, I., Nguyen, T. H., Nguyen, S. H., Nguyen, L. H., Nguyen, H. L. T., Ningrum, D. N. A., Nirayo, Y. L., Ofori-Asenso, R., Ogbo, F. A., Oh, I. -H, Oladimeji, O., Olagunju, A. T., Olagunju, T. O., Olivares, P. R., Orpana, H. M., Otstavnov, S. S., Mahesh, P. A., Pakhale, S., Park, E. -K, Patton, G. C., Pesudovs, K., Phillips, M. R., Polinder, S., Prakash, S., Radfar, A., Rafay, A., Rafiei, A., Rahimi, S., Rahimi-Movaghar, V., Rahman, M. A., Rai, R. K., Ramezanzadeh, K., Rawaf, S., Rawaf, D. L., Renzaho, A. M. N., Resnikoff, S., Rezaeian, S., Roever, L., Ronfani, L., Roshandel, G., Sabde, Y. D., Saddik, B., Salamati, P., Salimi, Y., Salz, I., Samy, A. M., Sanabria, J., Sanchez Riera, L., Santric Milicevic, M. M., Satpathy, M., Sawhney, M., Sawyer, S. M., Saxena, S., Saylan, M., Schneider, I. J. C., Schwebel, D. C., Seedat, S., Sepanlou, S. G., Shaikh, M. A., Shams-Beyranvand, M., Shamsizadeh, M., Sharif-Alhoseini, M., Sheikh, A., Shen, J., Shigematsu, M., Shiri, R., Shiue, I., Silva, J. P., Singh, J. A., Sinha, D. N., Soares Filho, A. M., Soriano, J. B., Soshnikov, S., Soyiri, I. N., Starodubov, V. I., Stein, D. J., Stokes, M. A., Sufiyan, M. B., Sunshine, J. E., Sykes, B. L., TabarÃ©s-Seisdedos, R., Tabb, K. M., Tehrani-Banihashemi, A., Tessema, G. A., Thakur, J. S., Tran, K. B., Tran, B. X., Tudor Car, L., Uthman, O. A., Uzochukwu, B. S. C., Valdez, P. R., Varavikova, E., Vasconcelos, A. M. N., Venketasubramanian, N., Violante, F. S., Vlassov, V., Waheed, Y., Wang, Y. -P, Wijeratne, T., Winkler, A. S., Yadav, P., Yano, Y., Yenesew, M. A., Yip, P., Yisma, E., Yonemoto, N., Younis, M. Z., Yu, C., Zafar, S., Zaidi, Z., Zaman, S. B., Zamani, M., Zhao, Y., Zodpey, S., Hay, S. I., Lopez, A. D., Mokdad, A. H., Vos, T., Haagsma, J. A., James, S. L., Castle, C. D., Dingels, Z. V., Fox, J. T., Hamilton, E. B., Liu, Z., Lucchesi, L. R., Roberts, N. L. S., Sylte, D. O., Adebayo, O. M., Ahmadi, A., Ahmed, M. B., Aichour, M. T. E., Alahdab, F., Alghnam, S. A., Aljunid, S. M., Al-Raddadi, R. M., Alsharif, U., Altirkawi, K., Anjomshoa, M., Antonio, C. A. T., Appiah, S. C. Y., Aremu, O., Arora, A., Asayesh, H., Assadi, R., Awasthi, A., Ayala Quintanilla, B. P., Balalla, S., Banstola, A., Barker-Collo, S. L., BÃ€rnighausen, T. W., Bazargan-Hejazi, S., Bedi, N., Behzadifar, M., Benjet, C., Bennett, D. A., Bensenor, I. M., Bhaumik, S., Bhutta, Z. A., Bijani, A., Borges, G., Borschmann, R., Bose, D., Boufous, S., Brazinova, A., Campuzano Rincon, J. C., CÃ¡rdenas, R., Carrero, J. J., Carvalho, F., CastaÃ±eda-Orjuela, C. A., CatalÃ¡-LÃ³pez, F., Choi, J. -YJ., Christopher, D. J., Crowe, C. S., Dalal, Koustuv, Daryani, A., Davitoiu, D. V., Degenhardt, L., De Leo, D., De Neve, J. -W, Deribe, K., Dessie, G. A., Deveber, G. A., Dharmaratne, S. D., Doan, L. P., Dolan, K. A., Driscoll, T. R., Dubey, M., El-Khatib, Z., Ellingsen, C. L., El Sayed Zaki, M., Endries, A. Y., Eskandarieh, S., Faro, A., Fereshtehnejad, S. -M, Fernandes, E., Filip, I., Fischer, F., Franklin, R. C., Fukumoto, T., Gezae, K. E., Gill, T. K., Goulart, A. C., Grada, A., Guo, Y., Gupta, R., Haghparast Bidgoli, H., Haj-Mirzaian, A., Hamadeh, R. R., Hamidi, S., Haro, J. M., Hassankhani, H., Hassen, H. Y., Havmoeller, R., Hendrie, D., Henok, A., HÃjar, M., Hole, M. K., Homaie Rad, E., Hossain, N., Hostiuc, S., Hu, G., Igumbor, E. U., Ilesanmi, O. S., Irvani, S. S. N., Islam, S. M. S., Ivers, R. Q., Jacobsen, K. H., Jahanmehr, N., Jakovljevic, M., Jayatilleke, A. U., Jha, R. P., Jonas, J. B., Jorjoran Shushtari, Z., Jozwiak, J. J., JÃŒrisson, M., Kabir, A., Kalani, R., Kasaeian, A., Kelbore, A. G., Kengne, A. P., Khader, Y. S., Khafaie, M. A., Khalid, N., Khan, E. A., Khoja, A. T., Kiadaliri, A. A., Kim, Y. -E, Kim, D., Kisa, A., Koyanagi, A., Kuate Defo, B., Kucuk Bicer, B., Kumar, M., Lalloo, R., Lam, H., Lami, F. H., Lansingh, V. C., Leasher, J. L., Li, S., Linn, S., Lunevicius, R., MacHado, F. R., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Mahotra, N. B., Majdan, M., Majeed, A., Malekzadeh, R., Malik, M. A., Malta, D. C., Manda, A. -L, Mansournia, M. A., Massenburg, B. B., Maulik, P. K., Meheretu, H. A. A., Mehndiratta, M. M., Melese, A., Mendoza, W., Mengesha, M. M., Meretoja, T. J., Meretoja, A., Mestrovic, T., Miazgowski, T., Miller, T. R., Mini, G. K., Mirrakhimov, E. M., Moazen, B., Mohammad Gholi Mezerji, N., Mohammadibakhsh, R., Mohammed, S., Molokhia, M., Monasta, L., Mondello, S., Montero-Zamora, P. A., Moodley, Y., Moosazadeh, M., Moradi, G., Moradi-Lakeh, M., Morawska, L., VelÃ¡squez, I. M., Morrison, S. D., Moschos, M. M., Mousavi, S. M., Murthy, S., Musa, K. I., Naik, G., Najafi, F., Nangia, V., Nascimento, B. R., Ndwandwe, D. E., Negoi, I., Nguyen, T. H., Nguyen, S. H., Nguyen, L. H., Nguyen, H. L. T., Ningrum, D. N. A., Nirayo, Y. L., Ofori-Asenso, R., Ogbo, F. A., Oh, I. -H, Oladimeji, O., Olagunju, A. T., Olagunju, T. O., Olivares, P. R., Orpana, H. M., Otstavnov, S. S., Mahesh, P. A., Pakhale, S., Park, E. -K, Patton, G. C., Pesudovs, K., Phillips, M. R., Polinder, S., Prakash, S., Radfar, A., Rafay, A., Rafiei, A., Rahimi, S., Rahimi-Movaghar, V., Rahman, M. A., Rai, R. K., Ramezanzadeh, K., Rawaf, S., Rawaf, D. L., Renzaho, A. M. N., Resnikoff, S., Rezaeian, S., Roever, L., Ronfani, L., Roshandel, G., Sabde, Y. D., Saddik, B., Salamati, P., Salimi, Y., Salz, I., Samy, A. M., Sanabria, J., Sanchez Riera, L., Santric Milicevic, M. M., Satpathy, M., Sawhney, M., Sawyer, S. M., Saxena, S., Saylan, M., Schneider, I. J. C., Schwebel, D. C., Seedat, S., Sepanlou, S. G., Shaikh, M. A., Shams-Beyranvand, M., Shamsizadeh, M., Sharif-Alhoseini, M., Sheikh, A., Shen, J., Shigematsu, M., Shiri, R., Shiue, I., Silva, J. P., Singh, J. A., Sinha, D. N., Soares Filho, A. M., Soriano, J. B., Soshnikov, S., Soyiri, I. N., Starodubov, V. I., Stein, D. J., Stokes, M. A., Sufiyan, M. B., Sunshine, J. E., Sykes, B. L., TabarÃ©s-Seisdedos, R., Tabb, K. M., Tehrani-Banihashemi, A., Tessema, G. A., Thakur, J. S., Tran, K. B., Tran, B. X., Tudor Car, L., Uthman, O. A., Uzochukwu, B. S. C., Valdez, P. R., Varavikova, E., Vasconcelos, A. M. N., Venketasubramanian, N., Violante, F. S., Vlassov, V., Waheed, Y., Wang, Y. -P, Wijeratne, T., Winkler, A. S., Yadav, P., Yano, Y., Yenesew, M. A., Yip, P., Yisma, E., Yonemoto, N., Younis, M. Z., Yu, C., Zafar, S., Zaidi, Z., Zaman, S. B., Zamani, M., Zhao, Y., Zodpey, S., Hay, S. I., Lopez, A. D., Mokdad, A. H., and Vos, T.
Abstract: Background: The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods: Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. Results: For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions: The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum. Â© 2020 Author(s).
Published: 2019
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3. Polypoidal choroidal vasculopathy associated with Doyne's familial choroiditis: treatment with thermal laser

Author: LADAS, I. D., KARAGIANNIS, D. A., GEORGALAS, I., ROUVAS, A. A., MOSCHOS, M. M., and APOSTOLOPOULOS, M.
Published: 2004

4. Targeting histone deacetylases in endometrial cancer: a paradigm-shifting therapeutic strategy?

Author: Garmpis, N. Damaskos, C. Garmpi, A. Spartalis, E. Kalampokas, E. Kalampokas, T. Margonis, G.-A. Schizas, D. Andreatos, N. Angelou, A. Lavaris, A. Athanasiou, A. Apostolou, K. G. Spartalis, M. Damaskou, Z. Daskalopoulou, A. Diamantis, E. Tsivelekas, K. Alavanos, A. Valsami, S. Moschos, M. M. Sampani, A. Nonni, A. Antoniou, E. A. Mantas, D. Tsourouflis, G. Markatos, K. Kontzoglou, K. Perrea, D. Nikiteas, N. Kostakis, A. Dimitroulis, D.
Abstract: OBJECTIVE: Endometrial cancer is increasingly prevalent in western societies and affects mainly postmenopausal women; notably incidence rates have been rising by 1.9% per year on average since 2005. Although the early-stage endometrial cancer can be effectively managed with surgery, more advanced stages of the disease require multimodality treatment with varying results. In recent years, endometrial cancer has been extensively studied at the molecular level in an attempt to develop effective therapies. Recently, a family of compounds that alter epigenetic expression, namely histone deacetylase inhibitors, have shown promise as possible therapeutic agents in endometrial cancer. The present review aims to discuss the therapeutic potential of these agents. MATERIALS AND METHODS: This literature review was performed using the MEDLINE database; the search terms histone, deacetylase, inhibitors, endometrial, targeted therapies for endometrial cancer were employed to identify relevant studies. We only reviewed English language publications and also considered studies that were not entirely focused on endometrial cancer. Ultimately, sixty-four articles published until January 2018 were incorporated into our review. RESULTS: Studies in cell cultures have demonstrated that histone deacetylase inhibitors exert their antineoplastic activity by promoting expression of p21WAF1 and p27KIP1, cyclin-dependent kinase inhibitors, that have important roles in cell cycle regulation; importantly, the transcription of specific genes (e.g., E-cadherin, PTEN) that are commonly silenced in endometrial cancer is also enhanced. In addition to these abstracts effects, novel compounds with histone deacetylase inhibitor activity (e.g., scriptaid, trichostatin, entinostat) have also demonstrated significant antineoplastic activity both in vitro and in vivo, by liming tumor growth, inducing apoptosis, inhibiting angiogenesis and potentiating the effects of chemotherapy. CONCLUSIONS: The applications of histone deacetylase inhibitors in endometrial cancer appear promising; nonetheless, additional trials are necessary to establish the therapeutic role, clinical utility, and safety of these promising compounds.
Published: 2018

5. Erratum: Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1736–1788)(S0140673618322037)(10.1016/S0140-6736(18)32203-7))

Author: Roth G. A., Roth, G, Abate, D, Abate, K, Abay, S, Abbafati, C, Abbasi, N, Abbastabar, H, Abd-Allah, F, Abdela, J, Abdelalim, A, Abdollahpour, I, Abdulkader, R, Abebe, H, Abebe, M, Abebe, Z, Abejie, A, Abera, S, Abil, O, Abraha, H, Abrham, A, Abu-Raddad, L, Accrombessi, M, Acharya, D, Adamu, A, Adebayo, O, Adedoyin, R, Adekanmbi, V, Adetokunboh, O, Adhena, B, Adib, M, Admasie, A, Afshin, A, Agarwal, G, Agesa, K, Agrawal, A, Agrawal, S, Ahmadi, A, Ahmadi, M, Ahmed, M, Ahmed, S, Aichour, A, Aichour, I, Aichour, M, Akbari, M, Akinyemi, R, Akseer, N, Al-Aly, Z, Al-Eyadhy, A, Al-Raddadi, R, Alahdab, F, Alam, K, Alam, T, Alebel, A, Alene, K, Alijanzadeh, M, Alizadeh-Navaei, R, Aljunid, S, Alkerwi, A, Alla, F, Allebeck, P, Alonso, J, Altirkawi, K, Alvis-Guzman, N, Amare, A, Aminde, L, Amini, E, Ammar, W, Amoako, Y, Anber, N, Andrei, C, Androudi, S, Animut, M, Anjomshoa, M, Ansari, H, Ansha, M, Antonio, C, Anwari, P, Aremu, O, Arnlov, J, Arora, A, Arora, M, Artaman, A, Aryal, K, Asayesh, H, Asfaw, E, Ataro, Z, Atique, S, Atre, S, Ausloos, M, Avokpaho, E, Awasthi, A, Ayala Quintanilla, B, Ayele, Y, Ayer, R, Azzopardi, P, Babazadeh, A, Bacha, U, Badali, H, Badawi, A, Bali, A, Ballesteros, K, Banach, M, Banerjee, K, Bannick, M, Banoub, J, Barboza, M, Barker-Collo, S, Barnighausen, T, Barquera, S, Barrero, L, Bassat, Q, Basu, S, Baune, B, Baynes, H, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Behzadifar, M, Bejot, Y, Bekele, B, Belachew, A, Belay, E, Belay, Y, Bell, M, Bello, A, Bennett, D, Bensenor, I, Berman, A, Bernabe, E, Bernstein, R, Bertolacci, G, Beuran, M, Beyranvand, T, Bhalla, A, Bhattarai, S, Bhaumik, S, Bhutta, Z, Biadgo, B, Biehl, M, Bijani, A, Bikbov, B, Bilano, V, Bililign, N, Bin Sayeed, M, Bisanzio, D, Biswas, T, Blacker, B, Basara, B, Borschmann, R, Bosetti, C, Bozorgmehr, K, Brady, O, Brant, L, Brayne, C, Brazinova, A, Breitborde, N, Brenner, H, Briant, P, Britton, G, Brugha, T, Busse, R, Butt, Z, Callender, C, Campos-Nonato, I, Campuzano Rincon, J, Cano, J, Car, M, Cardenas, R, Carreras, G, Carrero, J, Carter, A, Carvalho, F, Castaneda-Orjuela, C, Castillo Rivas, J, Castle, C, Castro, C, Castro, F, Catala-Lopez, F, Cerin, E, Chaiah, Y, Chang, J, Charlson, F, Chaturvedi, P, Chiang, P, Chimed-Ochir, O, Chisumpa, V, Chitheer, A, Chowdhury, R, Christensen, H, Christopher, D, Chung, S, Cicuttini, F, Ciobanu, L, Cirillo, M, Cohen, A, Cooper, L, Cortesi, P, Cortinovis, M, Cousin, E, Cowie, B, Criqui, M, Cromwell, E, Crowe, C, Crump, J, Cunningham, M, Daba, A, Dadi, A, Dandona, L, Dandona, R, Dang, A, Dargan, P, Daryani, A, Das, S, Gupta, R, Neves, J, Dasa, T, Dash, A, Davis, A, Davis Weaver, N, Davitoiu, D, Davletov, K, De La Hoz, F, De Neve, J, Degefa, M, Degenhardt, L, Degfie, T, Deiparine, S, Demoz, G, Demtsu, B, Denova-Gutierrez, E, Deribe, K, Dervenis, N, Des Jarlais, D, Dessie, G, Dey, S, Dharmaratne, S, Dicker, D, Dinberu, M, Ding, E, Dirac, M, Djalalinia, S, Dokova, K, Doku, D, Donnelly, C, Dorsey, E, Doshi, P, Douwes-Schultz, D, Doyle, K, Driscoll, T, Dubey, M, Dubljanin, E, Duken, E, Duncan, B, Duraes, A, Ebrahimi, H, Ebrahimpour, S, Edessa, D, Edvardsson, D, Eggen, A, El Bcheraoui, C, El Sayed Zaki, M, El-Khatib, Z, Elkout, H, Ellingsen, C, Endres, M, Endries, A, Er, B, Erskine, H, Eshrati, B, Eskandarieh, S, Esmaeili, R, Esteghamati, A, Fakhar, M, Fakhim, H, Faramarzi, M, Fareed, M, Farhadi, F, Farinha, C, Faro, A, Farvid, M, Farzadfar, F, Farzaei, M, Feigin, V, Feigl, A, Fentahun, N, Fereshtehnejad, S, Fernandes, E, Fernandes, J, Ferrari, A, Feyissa, G, Filip, I, Finegold, S, Fischer, F, Fitzmaurice, C, Foigt, N, Foreman, K, Fornari, C, Frank, T, Fukumoto, T, Fuller, J, Fullman, N, Furst, T, Furtado, J, Futran, N, Gallus, S, Garcia-Basteiro, A, Garcia-Gordillo, M, Gardner, W, Gebre, A, Gebrehiwot, T, Gebremedhin, A, Gebremichael, B, Gebremichael, T, Gelano, T, Geleijnse, J, Genova-Maleras, R, Geramo, Y, Gething, P, Gezae, K, Ghadami, M, Ghadimi, R, Ghasemi Falavarjani, K, Ghasemi-Kasman, M, Ghimire, M, Gibney, K, Gill, P, Gill, T, Gillum, R, Ginawi, I, Giroud, M, Giussani, G, Goenka, S, Goldberg, E, Goli, S, Gomez-Dantes, H, Gona, P, Gopalani, S, Gorman, T, Goto, A, Goulart, A, Gnedovskaya, E, Grada, A, Grosso, G, Gugnani, H, Guimaraes, A, Guo, Y, Gupta, P, Gupta, T, Gutierrez, R, Gyawali, B, Haagsma, J, Hafezi-Nejad, N, Hagos, T, Hailegiyorgis, T, Hailu, G, Haj-Mirzaian, A, Hamadeh, R, Hamidi, S, Handal, A, Hankey, G, Harb, H, Harikrishnan, S, Haro, J, Hasan, M, Hassankhani, H, Hassen, H, Havmoeller, R, Hay, R, Hay, S, He, Y, Hedayatizadeh-Omran, A, Hegazy, M, Heibati, B, Heidari, M, Hendrie, D, Henok, A, Henry, N, Herteliu, C, Heydarpour, F, Heydarpour, P, Heydarpour, S, Hibstu, D, Hoek, H, Hole, M, Homaie Rad, E, Hoogar, P, Hosgood, H, Hosseini, S, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hotez, P, Hoy, D, Hsiao, T, Hu, G, Huang, J, Husseini, A, Hussen, M, Hutfless, S, Idrisov, B, Ilesanmi, O, Iqbal, U, Irvani, S, Irvine, C, Islam, N, Islam, S, Islami, F, Jacobsen, K, Jahangiry, L, 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Abstract: GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736–88—The bottom row in figure 7 was cut off. This correction has been made to the online version as of Nov 9, 2018, and has been made to the printed Article.
Published: 2018

6. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017

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A., Manda A. -L., Manguerra H., Mansournia M. A., Mantilla Herrera A. M., Mantovani L. G., Maravilla J. C., Marcenes W., Marks A., Martins-Melo F. R., Martopullo I., Marz W., Marzan M. B., Massano J., Massenburg B. B., Mathur M. R., Maulik P. K., Mazidi M., McAlinden C., McGrath J. J., McKee M., McMahon B. J., Mehata S., Mehrotra R., Mehta K. M., Mehta V., Mejia-Rodriguez F., Mekonen T., Melese A., Melku M., Memiah P. T. N., Memish Z. A., Mendoza W., Mengistu G., Mensah G. A., Mereta S. T., Meretoja A., Meretoja T. J., Mestrovic T., Miazgowski B., Miazgowski T., Millear A. I., Miller T. R., Mini G. K., Mirarefin M., Mirica A., Mirrakhimov E. M., Misganaw A. T., Mitchell P. B., Mitiku H., Moazen B., Mohajer B., Mohammad K. A., Mohammadi M., Mohammadifard N., Mohammadnia-Afrouzi M., Mohammed M. A., Mohammed S., Mohebi F., Mokdad A. H., Molokhia M., Monasta L., Montanez J. C., Moosazadeh M., Moradi G., Moradi M., Moradi-Lakeh M., Moradinazar M., Moraga P., Morawska L., Velasquez I. M., Morgado-Da-Costa J., Morrison S. D., Moschos M. M., Mousavi S. M., Mruts K. B., Muche A. A., Muchie K. F., Mueller U. O., Muhammed O. S., Mukhopadhyay S., Muller K., Mumford J. E., Murthy G. V. S., Musa K. I., Mustafa G., Nabhan A. F., Nagata C., Nagel G., Naghavi M., Naheed A., Nahvijou A., Naik G., Najafi F., Nam H. S., Nangia V., Nansseu J. R., Neamati N., Negoi I., Negoi R. I., Neupane S., Newton C. R. J., Ngunjiri J. W., Nguyen A. Q., Nguyen G., Nguyen H. T., Nguyen H. L. T., Nguyen L. H., Nguyen M., Nguyen N. B., Nguyen S. H., Nichols E., Ningrum D. N. A., Nixon M. R., Nomura S., Noroozi M., Norrving B., Noubiap J. J., Nouri H. R., Shiadeh M. N., Nowroozi M. R., Nsoesie E. O., Nyasulu P. S., Odell C. M., Ofori-Asenso R., Ogbo F. A., Oh I. -H., Oladimeji O., Olagunju A. T., Olagunju T. O., Olivares P. R., Olsen H. E., Olusanya B. O., Olusanya J. O., Ong K. L., Ong S. K., Oren E., Ortiz A., Ota E., Otstavnov S. S., Overland S., Owolabi M. O., Mahesh P. A., Pacella R., Pakhare A. P., Pakpour A. H., Pana A., Panda-Jonas S., Park E. -K., Park J., Parry C. D. H., Parsian H., Pasdar Y., Patel S., Patil S. T., Patle A., Patton G. C., Paturi V. R., Paudel D., Paulson K. R., Pearce N., Pereira A., Pereira D. M., Perico N., Pesudovs K., Petzold M., Pham H. Q., Phillips M. R., Pigott D. M., Pillay J. D., Piradov M. A., Pirsaheb M., Pishgar F., Plana-Ripoll O., Polinder S., Popova S., Postma M. J., Pourshams A., Poustchi H., Prabhakaran D., Prakash S., Prakash V., Prasad N., Purcell C. A., Qorbani M., Quistberg D. A., Radfar A., Rafay A., Rafiei A., Rahim F., Rahimi K., Rahimi Z., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Ur Rahman M. H., Rahman M. A., Rahman S. U., Rai R. K., Rajati F., Ranjan P., Rao P. C., Rasella D., Rawaf D. L., Rawaf S., Reddy K. S., Reiner R. C., Reitsma M. B., Remuzzi G., Renzaho A. M. N., Resnikoff S., Rezaei S., Rezai M. S., Ribeiro A. L. P., Roberts N. L. S., Robinson S. R., Roever L., Ronfani L., Roshandel G., Rostami A., Roth G. A., Rothenbacher D., Rubagotti E., Sachdev P. S., Sadat N., Sadeghi E., Saeedi Moghaddam S., Safari H., Safari Y., Safari-Faramani R., Safdarian M., Safi S., Safiri S., Sagar R., Sahebkar A., Sahraian M. A., Sajadi H. S., Salam N., Salama J. S., Salamati P., Saleem Z., Salimi Y., Salimzadeh H., Salomon J. A., Salvi S. S., Salz I., Samy A. M., Sanabria J., Sanchez-Nino M. D., Santomauro D. F., Santos I. S., Santos J. V., Santric Milicevic M. M., Sao Jose B. P., Sardana M., Sarker A. R., Sarmiento-Suarez R., Sarrafzadegan N., Sartorius B., Sarvi S., Sathian B., Satpathy M., Sawant A. R., Sawhney M., Saxena S., Schaeffner E., Schmidt M. I., Schneider I. J. C., Schutte A. E., Schwebel D. C., Schwendicke F., Scott J. G., Sekerija M., Sepanlou S. G., Servan-Mori E., Seyedmousavi S., Shabaninejad H., Shafieesabet A., Shahbazi M., Shaheen A. A., Shaikh M. A., Shams-Beyranvand M., Shamsi M., Sharafi H., Sharafi K., Sharif M., Sharif-Alhoseini M., Sharma J., Sharma R., She J., Sheikh A., Shi P., Shibuya K., Shiferaw M. S., Shigematsu M., Shiri R., Shirkoohi R., Shiue I., Shokoohinia Y., Shokraneh F., Shoman H., Shrime M. G., Si S., Siabani S., Sibai A. M., Siddiqi T. J., Sigfusdottir I. D., Sigurvinsdottir R., Silva D. A. S., Silva J. P., Silveira D. G. A., Singam N. S. V., Singh J. A., Singh N. P., Singh V., Sinha D. N., Skiadaresi E., Skirbekk V., Sliwa K., Smith D. L., Smith M., Filho A. M. S., Sobaih B. H., Sobhani S., Soofi M., Sorensen R. J. D., Soyiri I. N., Sposato L. A., Sreeramareddy C. T., Srinivasan V., Stanaway J. D., Starodubov V. I., Stein D. J., Steiner C., Steiner T. J., Stokes M. A., Stovner L. J., Subart M. L., Sudaryanto A., Sufiyan M. B., Sulo G., Sunguya B. F., Sur P. J., Sykes B. L., Sylaja P. N., Sylte D. O., Szoeke C. E. I., Tabares-Seisdedos R., Tabuchi T., Tadakamadla S. K., Tandon N., Tassew S. G., Tavakkoli M., Taveira N., Taylor H. R., Tehrani-Banihashemi A., Tekalign T. G., Tekelemedhin S. W., Tekle M. G., Temsah M. -H., Temsah O., Terkawi A. S., Tessema B., Teweldemedhin M., Thankappan K. R., Theis A., Thirunavukkarasu S., Thomas N., Tilahun B., To Q. G., Tonelli M., Topor-Madry R., Torre A. E., Tortajada-Girbes M., Touvier M., Tovani-Palone M. R., Towbin J. A., Tran B. X., Tran K. B., Troeger C. E., Tsadik A. G., Tsoi D., Tudor Car L., Tyrovolas S., Ukwaja K. N., Ullah I., Undurraga E. A., Updike R. L., Usman M. S., Uthman O. A., Vaduganathan M., Vaezi A., Valdez P. R., Varavikova E., Varughese S., Vasankari T. J., Venketasubramanian N., Villafaina S., Violante F. S., Vladimirov S. K., Vlassov V., Vollset S. E., Vos T., Vosoughi K., Vujcic I. S., Wagnew F. S., Waheed Y., Wang Y., Wang Y. -P., Weiderpass E., Weintraub R. G., Weiss D. J., Weldegebreal F., Weldegwergs K. G., Werdecker A., West T. E., Westerman R., Whiteford H. A., Widecka J., Wijeratne T., Williams H. C., Wilner L. B., Wilson S., Winkler A. S., Wiyeh A. B., Wiysonge C. S., Wolfe C. D. A., Woolf A. D., Wyper G. M. A., Xavier D., Xu G., Yadgir S., Yahyazadeh Jabbari S. H., Yamada T., Yan L. L., Yano Y., Yaseri M., Yasin Y. J., Yeshaneh A., Yimer E. M., Yip P., Yisma E., Yonemoto N., Yoon S. -J., Yotebieng M., Younis M. Z., Yousefifard M., Yu C., Zadnik V., Zaidi Z., Zaman S. B., Zamani M., Zandian H., Zar H. J., Zenebe Z. M., Zipkin B., Zhou M., Zodpey S., Zucker I., Zuhlke L. J., and Murray C. J. L.
Abstract: Background: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted lifeyears (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severityof ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-speci?c mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased
Published: 2018

7. Comparison of endothelial cell loss and complications following DMEK with the use of three different graft injectors

Author: Droutsas, K, primary, Lazaridis, A, additional, Kymionis, G D, additional, Chatzistefanou, K, additional, Moschos, M M, additional, Koutsandrea, C, additional, and Sekundo, W, additional
Published: 2017
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8. Endothelial keratoplasty: is Descemet membrane endothelial keratoplasty the Holy Grail of lamellar surgery? No

Author: Tsatsos, M, primary, Liarakos, V S, additional, MacGregor, C, additional, Athanasiadis, I, additional, Detorakis, E T, additional, Moschos, M M, additional, Hossain, P, additional, and Anderson, D F, additional
Published: 2017
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9. Association of serum inflammatory markers and diabetic retinopathy: a review of literature.

Author: GOULIOPOULOS, N. S., KALOGEROPOULOS, C., LAVARIS, A., ROUVAS, A., ASPROUDIS, I., GARMPI, A., DAMASKOS, C., GARMPIS, N., KOSTAKIS, A., and MOSCHOS, M. M.
Abstract: OBJECTIVE: Diabetic retinopathy is the leading cause of irreversible blindness in the western world, among the working-age people. Its exact pathogenesis, however, remains obscure. Systemic inflammation is regarded to play a significant role in diabetes by contributing, among others, to the development of diabetic retinopathy. This review focuses on the possible involvement of the systemic inflammatory markers in the pathogenesis of diabetic retinopathy. MATERIALS AND METHODS: We performed a systematic search of the literature of published papers until August 2017 using the PubMed search engine. RESULTS: We demonstrated that many systemic inflammatory markers contribute to the pathogenesis and progression of retinopathy, while we highlighted in several occasions their usefulness as a key tool in the monitoring of the disease progression and the treatment efficacy. CONCLUSIONS: To the best of our knowledge this is the first review in the literature that elaborates the possible association of serum inflammatory markers and diabetic retinopathy, a disease that may cause irreversible loss of vision. [ABSTRACT FROM AUTHOR]
Published: 2018

10. The effect of fish consumption on macula structure and function of healthy individuals: an OCT and mfERG study.

Author: MOSCHOS, M. M., NITODA, E., LAVARIS, A., CHATZIRALLI, I. P., ASPROUDIS, I., ANDROUDI, S., DAMASKOS, C., GARMPIS, N., and KALOGEROPOULOS, C.
Abstract: OBJECTIVE: The study was designed to investigate the potential effect of fish consumption on macular structure and function of healthy individuals. PATIENTS AND METHODS: The participants were Greek, who used to consume less than one portion of fish per week since their childhood. All participants underwent body mass index (BMI) measurements and ophthalmological examination. At their first examination, they were asked to consume at least 2 portions of fish per week over a period of 8 weeks, after which all the measurements were repeated. RESULTS: Eighteen healthy individuals (36 eyes) participated in this study. The central macular thickness was reduced, while the amplitudes in the foveal and parafoveal area were increased after the fish consumption. However, all measurements remained within the normal range at both visits. CONCLUSIONS: Regular fish consumption could enhance the structural and functional status of the macula. [ABSTRACT FROM AUTHOR]
Published: 2018

11. Intravitreal ranibizumab in a patient with choroidal neovascularization secondary to multiple evanescent white dot syndrome

Author: Rouvas, A. A. Ladas, I. D. Papakostas, T. D. Moschos, M. M. and Vergados, I.
Subjects: genetic structures, sense organs, eye diseases
Abstract: PURPOSE. To report the effect of a single intravitreal injection of ranibizumab in a patient with choroidal neovascularization (CNV) secondary to multiple evanescent white dot syndrome (MEWDS). METHODS. A 65-year-old woman with visual acuity (VA) 20/40, mild vitreous inflammation, optic disc edema, and white deep retinal round lesions in the right eye underwent fluorescein angiography, indocyanine green angiography, and optical coherence tomography. The diagnosis of MEWDS with peripapillary CNV was made and a single injection of ranibizumab (0.5 mg) was administered. RESULTS. At the 6-month follow-up visit, the VA in the right eye was 20/20, the CNV completely regressed, and the MEWDS findings disappeared. CONCLUSIONS. Intravitreal ranibizumab appears to be a safe and effective treatment option in cases of CNV secondary to MEWDS, resulting in fast resolution of the macular edema and regression of the CNV. On the other hand, it is unclear whether the administration of ranibizumab contributed to a prompt regression of MEWDS.
Published: 2007

12. Dark Adaptation in Patients with Primary Open-Angle Glaucoma, Pseudoexfoliation Glaucoma and Childhood Glaucoma.

Author: Panos, G. D., Moschos, M. M., Kozeis, N., Deshmukh, R. R., Mansouri, K., Shaarawy, T., and Gatzioufas, Z.
Published: 2017
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13. Homosexuality according to ancient Greek physicians.

Author: Laios, K., Moschos, M. M., Koukaki, E., Kontaxaki, M.-I., and Androutsos, G.
Published: 2017
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14. Clinical Significance of Optic Disc Progression by Topographic Change Analysis Maps in Glaucoma: An 8-Year Follow-Up Study

Author: Kourkoutas, D., primary, Buys, Y. M., additional, Flanagan, J. G., additional, Karamaounas, N., additional, Georgopoulos, G., additional, Iliakis, E., additional, Moschos, M. M., additional, and Trope, G. E., additional
Published: 2014
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15. Comparison of endothelial cell loss and complications following DMEK with the use of three different graft injectors

Author: Droutsas, K, Lazaridis, A, Kymionis, G D, Chatzistefanou, K, Moschos, M M, Koutsandrea, C, and Sekundo, W
Abstract: PurposeTo compare endothelial cell loss and complications following Descemet membrane endothelial keratoplasty (DMEK) with use of three commercially available injectors.MethodsFrom 179 consecutive DMEK procedures, 66 cases with uncomplicated graft preparation and completed 12-month follow-up were included in this retrospective study. According to the injector used, 3 groups were formed: group 1 (D.O.R.C. injector, n=16), group 2 (Geuder injector, n=24), and group 3 (Pasteur laboratory pipette, n= 26). Endothelial cell density (ECD) and endothelial cell loss were evaluated preoperatively and at 3, 6 and 12 months postoperatively; surgery-related complications were recorded.ResultsDonor ECD was 2416±179 cells/mm2(group 1), 2417±164 cells/mm2(group 2), and 2478±234 cells/mm2(group 3). At 12 months postoperatively ECD was 1473±403 cells/mm2(group 1), 1379±317 cells/mm2(group 2), and 1316±456 cells/mm2(group 3) (P=0.533, ANOVA). Endothelial cell loss 12 months postoperatively was 39±15% (group 1), 43±13% (group 2), and 47±17% (group 3) (P=0.386, ANOVA). A single case of iris bleeding and reflux of the graft out of the anterior chamber (both in group 3) was noted. Partial graft detachment occurred in group 1 (n=1), group 2 (n=5), and group 3 (n=7) and rebubbling was performed in 6% (group 1), 17% (group 2), and 27% (group 3).ConclusionsTo our knowledge, this is the first clinical study assessing the safety of three different DMEK injectors. Group 1 (D.O.R.C injector) showed the least and group 3 (Pasteur laboratory pipette) the highest endothelial cell loss without reaching statistical significance at 12 months after surgery. Therefore, the graft injector may be chosen according to surgeon’s preference.
Published: 2018
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16. Impaired arterial wall properties in patients with diabetic retinopathy: the role of inflammation

Author: Gouliopoulos, N., primary, Siasos, G., additional, Moschos, M. M., additional, Tousoulis, D., additional, Oikonomou, E., additional, Athanasiou, D., additional, Kollia, C., additional, Siasou, G., additional, Tourikis, P., additional, and Stefanadis, C., additional
Published: 2013
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17. Intravitreal ranibizumab for choroidal neovascularization secondary to angiod streaks. Comparison of the 12 and 24-month results of treatment in treatment-naïve eyes.

Author: LADAS, D. S., KOUTSANDREA, C., KOTSOLIS, A. I., GEORGALAS, I., MOSCHOS, M. M., and LADAS, I. D.
Abstract: OBJECTIVE: Our aim study was to compare 12 and 24-month results of intravitreal ranibizumab therapy in the management of choroidal neovascularization (CNV) secondary to angioid streaks (ST). This could be of clinical importance helping us planning optimal dosing strategies. PATIENTS AND METHODS: Over a 7-year period, a consecutive series of treatment-naïve eyes with macular CNV due to AS were treated with intravitreal ranibizumab (0.5 mg). The main outcome measure was changed in best-corrected visual acuity (BCVA) at 12 and 24 months as compared to baseline. RESULTS: Twenty eyes completed 24-month therapy and regular follow-up visits. BCVA improved at 12 (0.42 ± 0.26 logMAR) and 24 months (0.44 ± 0.22 logMAR) as compared to baseline (0.75 ± 0.26 logMAR) (p < 0.001), but did not change between the 12 and 24-month follow-up (p = 0.48). BCVA improved in 15 (75%) and 16 (80%) of the eyes, but in 5 (25%) and 4 eyes (20%) remained unchanged (p = 0.71) at 12 and 24 months, respectively. CONCLUSIONS: These results suggest that during the first year of intravitreal ranibizumab therapy for patients with macular CNV due to AS, BCVA improved in most of the eyes, and was maintained during the second year. [ABSTRACT FROM AUTHOR]
Published: 2016

18. Dreams in ancient Greek Medicine.

Author: Laios, K., Moschos, M. M., Koukaki, E., Vasilopoulos, E., Karamanou, M., Kontaxaki, M.-l., and Androutsos, G.
Published: 2016
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19. Anatomical and functional impairment of the retina and optic nerve in patients with anorexia nervosa without vision loss

Author: Moschos, M. M., primary, Gonidakis, F., additional, Varsou, E., additional, Markopoulos, I., additional, Rouvas, A., additional, Ladas, I., additional, and Papadimitriou, G. N., additional
Published: 2010
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20. Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population

Author: Ladas, I D, primary, Rouvas, A A, additional, Moschos, M M, additional, Synodinos, E E, additional, Karagiannis, D A, additional, and Koutsandrea, C N, additional
Published: 2004
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21. Multifocal visual evoked potentials in amblyopia due to anisometropia.

Author: Moschos, M. M., Margetis, I., Tsapakis, S., Panagakis, G., Chatzistephanou, I. K., and Iliakis, E.
Published: 2010

22. Expression of the insulin-like growth factor 1 (IGF-1) and type I IGF receptor mRNAs in human HLE-B3 lens epithelial cells

Author: Moschos, M. M., Armakolas, A., Philippou, A., Pissimissis, N., Panteleakou, Z., Adrianos Nezos, Kaparelou, M., and Koutsilieris, M.

23. Polypoidal choroidal vasculopathy associated with Doyne's familial choroiditis: Treatment with thermal laser

Author: Ladas, I. D., Karagiannis, D. A., Ilias Georgalas, Rouvas, A. A., Moschos, M. M., and Apostolopoulos, M.
Subjects: 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, genetic structures, 030221 ophthalmology & optometry, sense organs, General Medicine, eye diseases, 030217 neurology & neurosurgery
Abstract: Purpose To report the unusual occurrence of polypoidal choroidal vasculopathy (PCV) in a patient with Doyne's familial honeycomb choroiditis (DFHC) and its course after laser treatment. DESIGN Interventional case report. METHODS Indocyanine green (ICG) angiography guided laser was performed on active polypoidal lesions. Results A 45-year-old man with a 15-year history of bilateral DFCH and a scarred macular choroidal neovascularization in the right eye (RE) was referred to us with exudative maculopathy in the left eye (LE). His best-corrected visual acuity (BCVA) was 20/800 in the RE and 20/40 in the LE. ICG angiography revealed a picture that was characteristic for PCV in both eyes. ICG guided argon green laser was performed on the active parapapillary and perifoveal polypoidal lesions of the LE. Eight months after the laser photocoagulation treatment, the macular exudative lesions had subsided and the BCVA improved to 20/20. The favorable anatomic and functional results have remained stable over 3 years. CONCLUSIONS This is, to our knowledge, the first case of a PCV that occurred secondary to DFHC.

24. Targeting histone deacetylases in endometrial cancer: A paradigm-shifting therapeutic strategy?

Author: Garmpis, N., Damaskos, C., Garmpi, A., Spartalis, E., Kalampokas, E., Kalampokas, T., Margonis, G. -A, Schizas, D., Andreatos, N., Angelou, A., Lavaris, A., Athanasiou, A., Apostolou, K. G., Spartalis, M., Damaskou, Z., Daskalopoulou, A., Diamantis, E., Tsivelekas, K., Alavanos, A., Serena Valsami, Moschos, M. M., Sampani, A., Nonni, A., Antoniou, E. A., Mantas, D., Tsourouflis, G., Markatos, K., Kontzoglou, K., Perrea, D., Nikiteas, N., Kostakis, A., and Dimitroulis, D.
Subjects: Histone Deacetylase Inhibitors, Endometrium, Quinolines, Humans, Antineoplastic Agents, Female, Hydroxamic Acids, Hydroxylamines, Histone Deacetylases, Endometrial Neoplasms
Abstract: Endometrial cancer is increasingly prevalent in western societies and affects mainly postmenopausal women; notably incidence rates have been rising by 1.9% per year on average since 2005. Although the early-stage endometrial cancer can be effectively managed with surgery, more advanced stages of the disease require multimodality treatment with varying results. In recent years, endometrial cancer has been extensively studied at the molecular level in an attempt to develop effective therapies. Recently, a family of compounds that alter epigenetic expression, namely histone deacetylase inhibitors, have shown promise as possible therapeutic agents in endometrial cancer. The present review aims to discuss the therapeutic potential of these agents.This literature review was performed using the MEDLINE database; the search terms histone, deacetylase, inhibitors, endometrial, targeted therapies for endometrial cancer were employed to identify relevant studies. We only reviewed English language publications and also considered studies that were not entirely focused on endometrial cancer. Ultimately, sixty-four articles published until January 2018 were incorporated into our review.Studies in cell cultures have demonstrated that histone deacetylase inhibitors exert their antineoplastic activity by promoting expression of p21WAF1 and p27KIP1, cyclin-dependent kinase inhibitors, that have important roles in cell cycle regulation; importantly, the transcription of specific genes (e.g., E-cadherin, PTEN) that are commonly silenced in endometrial cancer is also enhanced. In addition to these abstracts effects, novel compounds with histone deacetylase inhibitor activity (e.g., scriptaid, trichostatin, entinostat) have also demonstrated significant antineoplastic activity both in vitro and in vivo, by liming tumor growth, inducing apoptosis, inhibiting angiogenesis and potentiating the effects of chemotherapy.The applications of histone deacetylase inhibitors in endometrial cancer appear promising; nonetheless, additional trials are necessary to establish the therapeutic role, clinical utility, and safety of these promising compounds.

25. Evaluation of macular function and morphology following accelerated collagen cross-linking in progressive keratoconus.

Author: Dettoraki M, Droutsas K, Lazaridis A, and Moschos MM
Subjects: Collagen radiation effects, Corneal Topography, Cross-Linking Reagents therapeutic use, Humans, Refraction, Ocular, Ultraviolet Rays, Keratoconus diagnosis, Keratoconus drug therapy
Abstract: Purpose: To assess any changes in macular function and morphology in patients with progressive keratoconus undergoing accelerated corneal cross-linking (CXL)., Methods: This prospective case series included 9 eyes of 8 patients with progressive keratoconus undergoing CXL using a high intensity accelerated protocol (9 mW/cm 2 for 14 min) with a total surface dose of 7.5 J/cm 2 . Visual acuity assessment, slit lamp biomicroscopy, dilated fundoscopy, corneal tomography, multifocal electroretinography (mfERG) and spectral domain optical coherence tomography scan were performed at baseline, 2 weeks and 6 weeks postoperatively., Results: Uncorrected and corrected distance visual acuity did not change significantly at 2 weeks and 6 weeks following accelerated CXL compared to baseline. Retinal response density (RRD) of mfERG significantly decreased at 2 weeks postoperatively compared to baseline (p = 0.008) but did not differ from the baseline value at 6 weeks postoperatively in the fovea (ring 1) (p = 0.95). Similarly, P1 latency significantly decreased at 2 weeks (p = 0.04) but did not change at 6 weeks (p = 1.00) postoperatively compared to baseline in the fovea. No changes in RRD or P1 latency were observed in the retinal rings surrounding the fovea (rings 2 to 5). Central foveal thickness did not change at 2 weeks and 6 weeks postoperatively compared to baseline (p = 0.53 and p = 0.93, respectively)., Conclusions: A short-term reversible decrease in macular electrical activity without any structural changes seems to occur after accelerated CXL in patients with progressive keratoconus. The return of macular response to the preoperative values shows the safety of the CXL protocol.
Published: 2022
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26. Targeting histone deacetylases in endometrial cancer: a paradigm-shifting therapeutic strategy?

Author: Garmpis N, Damaskos C, Garmpi A, Spartalis E, Kalampokas E, Kalampokas T, Margonis GA, Schizas D, Andreatos N, Angelou A, Lavaris A, Athanasiou A, Apostolou KG, Spartalis M, Damaskou Z, Daskalopoulou A, Diamantis E, Tsivelekas K, Alavanos A, Valsami S, Moschos MM, Sampani A, Nonni A, Antoniou EA, Mantas D, Tsourouflis G, Markatos K, Kontzoglou K, Perrea D, Nikiteas N, Kostakis A, and Dimitroulis D
Subjects: Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Endometrium drug effects, Endometrium metabolism, Female, Histone Deacetylase Inhibitors pharmacology, Histone Deacetylase Inhibitors therapeutic use, Histone Deacetylases genetics, Humans, Hydroxamic Acids metabolism, Hydroxamic Acids pharmacology, Hydroxamic Acids therapeutic use, Hydroxylamines metabolism, Hydroxylamines pharmacology, Hydroxylamines therapeutic use, Quinolines metabolism, Quinolines pharmacology, Quinolines therapeutic use, Antineoplastic Agents metabolism, Endometrial Neoplasms drug therapy, Endometrial Neoplasms metabolism, Histone Deacetylase Inhibitors metabolism, Histone Deacetylases metabolism
Abstract: Objective: Endometrial cancer is increasingly prevalent in western societies and affects mainly postmenopausal women; notably incidence rates have been rising by 1.9% per year on average since 2005. Although the early-stage endometrial cancer can be effectively managed with surgery, more advanced stages of the disease require multimodality treatment with varying results. In recent years, endometrial cancer has been extensively studied at the molecular level in an attempt to develop effective therapies. Recently, a family of compounds that alter epigenetic expression, namely histone deacetylase inhibitors, have shown promise as possible therapeutic agents in endometrial cancer. The present review aims to discuss the therapeutic potential of these agents., Materials and Methods: This literature review was performed using the MEDLINE database; the search terms histone, deacetylase, inhibitors, endometrial, targeted therapies for endometrial cancer were employed to identify relevant studies. We only reviewed English language publications and also considered studies that were not entirely focused on endometrial cancer. Ultimately, sixty-four articles published until January 2018 were incorporated into our review., Results: Studies in cell cultures have demonstrated that histone deacetylase inhibitors exert their antineoplastic activity by promoting expression of p21WAF1 and p27KIP1, cyclin-dependent kinase inhibitors, that have important roles in cell cycle regulation; importantly, the transcription of specific genes (e.g., E-cadherin, PTEN) that are commonly silenced in endometrial cancer is also enhanced. In addition to these abstracts effects, novel compounds with histone deacetylase inhibitor activity (e.g., scriptaid, trichostatin, entinostat) have also demonstrated significant antineoplastic activity both in vitro and in vivo, by liming tumor growth, inducing apoptosis, inhibiting angiogenesis and potentiating the effects of chemotherapy., Conclusions: The applications of histone deacetylase inhibitors in endometrial cancer appear promising; nonetheless, additional trials are necessary to establish the therapeutic role, clinical utility, and safety of these promising compounds.
Published: 2018
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27. Visual problems in young adults due to computer use.

Author: Moschos MM, Chatziralli IP, Siasou G, and Papazisis L
Subjects: Adult, Comorbidity, Female, Humans, Male, Risk Assessment, Risk Factors, Surveys and Questionnaires, Workload, Activities of Daily Living, Computers statistics & numerical data, Dry Eye Syndromes epidemiology, Vision Disorders epidemiology
Abstract: Background: Computer use can cause visual problems. The purpose of our study was to evaluate visual problems due to computer use in young adults., Patients and Methods: Participants in our study were 87 adults, 48 male and 39 female, mean aged 31.3 years old (SD 7.6). All the participants completed a questionnaire regarding visual problems detected after computer use., Results: The mean daily use of computers was 3.2 hours (SD 2.7). 65.5 % of the participants complained for dry eye, mainly after more than 2.5 hours of computer use. 32 persons (36.8 %) had a foreign body sensation in their eyes, while 15 participants (17.2 %) complained for blurred vision which caused difficulties in driving, after 3.25 hours of continuous computer use. 10.3 % of the participants sought medical advice for their problem. There was a statistically significant correlation between the frequency of visual problems and the duration of computer use (p = 0.021). 79.3 % of the participants use artificial tears during or after long use of computers, so as not to feel any ocular discomfort., Conclusions: The main symptom after computer use in young adults was dry eye. All visual problems associated with the duration of computer use. Artificial tears play an important role in the treatment of ocular discomfort after computer use., (© Georg Thieme Verlag KG Stuttgart · New York.)
Published: 2012
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28. Intravitreal Triamcinolone Acetonide for Macular Edema in HLA-B27 Negative Ankylosing Spondylitis.

Author: Moschos MM, Gatzioufas Z, and Margetis I
Abstract: We report a case of a human leukocyte antigen B27 (HLA-B27)-negative patient with cystoid macular edema (CME) and ankylosing spondylitis (AS) after treatment with triamcinolone acetonide. The patient complained of deterioration of visual acuity of the right eye during the last 10 days. At presentation visual acuity of the right eye was 0.2, and the ophthalmic examination did not reveal any sign of active uveitis. Fluorescein angiography (FA) and ocular coherent tomography (OCT) showed CME. The left eye was normal with a visual acuity of 0.9. Eight weeks after intravitreal injection of triamcinolone acetonide, visual acuity improved to 0.8 and OCT revealed regression of macular edema. Six months later no recurrence was observed. Our case report indicates for the first time that CME may occur in AS independently of the presence of HLA-B27 and intraocular inflammation. Intravitreal use of triamcinolone acetonide can reduce macular edema and restore visual acuity.
Published: 2010
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29. Assessment of macular function by multifocal electroretinogram in age-related macular degeneration before and after photodynamic therapy.

Author: Moschos MM, Panayotidis D, Theodossiadis G, and Moschos M
Subjects: Adult, Aged, Aged, 80 and over, Electroretinography methods, Female, Humans, Male, Middle Aged, Time Factors, Macular Degeneration drug therapy, Macular Degeneration physiopathology, Photochemotherapy
Abstract: Purpose: To evaluate macular function, before and after photodynamic therapy (PDT) using multifocal electroretinogram (MF-ERG), in eyes suffering from classic subfoveal choroidal neovascularization (CNV) resulting from age-related macular degeneration (ARMD)., Methods: Twenty eyes of 20 patients (10 male, 10 female) with classic subfoveal CNV resulting from ARMD were studied. All received PDT with verteporfin. Fluorescein angiography and mF-ERG were performed in each patient 1 day before and 1 week, 3 months and 6 months after photodynamic therapy., Results: Before treatment, visual acuity (VA) and electrical retinal response densities (RRD) in the foveal and parafoveal areas were low in all patients. The mean VA (ETDRS chart) before PDT was 24.35 (SD, 15). The mean RRD before PDT in area 1 was 4.39 nV/deg(2) (SD, 2.59) and in area 2 it was 2.11 (SD, 1.86). Six months after treatment, the mean VA was stable in 70% of the patients. However, the mean RRD after PDT was 2.24 nV/deg(2) in area 1 (SD, 2.59) and 1.07 nV/deg(2) in area 2 (SD, 1.59)., Conclusion: Multifocal ERG objectively evaluates the macular function in eyes with CNV attributable to ARMD. In this study, the stability of VA coincided with a clear impairment of electrical activity of the foveal and parafoveal areas. This finding suggests that MF-ERG should be adopted to assess the efficacy of PDT objectively in the treatment of ARMD.
Published: 2004
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30. Arachnoid cyst of the optic nerve: a case report.

Author: Moschos MM, Lymberopoulos C, and Moschos M
Subjects: Adolescent, Evoked Potentials, Visual physiology, Female, Follow-Up Studies, Humans, Optic Nerve pathology, Treatment Refusal, Vision, Low diagnosis, Vision, Low etiology, Visual Acuity physiology, Arachnoid Cysts diagnosis, Magnetic Resonance Imaging, Optic Atrophy diagnosis, Optic Nerve Diseases diagnosis
Abstract: Background: To report a case of an arachnoid cyst of the optic nerve with homonymous optic atrophy., History and Signs: A 17-year-old female patient presented with severe visual loss, limited to light perception, of the left eye. She underwent complete ophthalmologic examination, color fundus photography and electrophysiological study. Magnetic resonance imaging (MRI) revealed the presence of a fusiform structure involving the left optic nerve from the orbital apex to the posterior surface of the globe. The clinical and radiographic features are consistent with an arachnoid cyst of the optic nerve., Therapy and Outcome: The patient refused to be treated. Two years later, the VA remained unchanged., Conclusions: The arachnoid cyst of the optic nerve is a rare entity. Its differential diagnosis from the primary optic nerve glioma is difficult and important to be made in order to be treated properly.
Published: 2004
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31. Retinal vasculitis and cystoid macular edema after body tattooing: a case report.

Author: Moschos MM and Guex-Crosier Y
Subjects: Adult, Drug Therapy, Combination, Fluorescein Angiography, Follow-Up Studies, Humans, Immunosuppressive Agents administration & dosage, Macula Lutea drug effects, Macula Lutea pathology, Macular Edema diagnosis, Macular Edema drug therapy, Male, Ophthalmoscopy, Recurrence, Retina drug effects, Retina pathology, Retinal Vasculitis diagnosis, Retinal Vasculitis drug therapy, Tomography, Optical Coherence, Vision, Low diagnosis, Vision, Low drug therapy, Vision, Low etiology, Visual Acuity drug effects, Macular Edema etiology, Retinal Vasculitis etiology, Tattooing adverse effects
Abstract: Background: To report a case of retinal vasculitis occurring after the placement of permanent tattoos., History and Signs: A 21-year-old male was referred to our department with impairment of visual acuity. Permanent tattoos covered the head, body, arms and legs. The patient was examined with ophthalmoscopy, fluorescein angiography, indocyanine green angiography and optical coherence tomography. Systemic medical and laboratory work-up were performed in order to exclude an infectious agent or an inflammatory disease. He had no history of intravenous drug abuse., Therapy and Outcome: Our patient presented severe posterior uveitis associated with retinal vasculitis and cystoid macular edema. Laboratory tests ruled out all diseases causing vasculitis. HIV and B, C hepatitis tests were negative. Cystoid macular edema and vasculitis were resolved after immunosuppressive therapy., Conclusions: This is the first description of a retinal vasculitis associated with cystoid macular edema in a completely healthy individual after the placement of permanent tattoos. A phagocytosis of tattoo pigments leading to their lysis is described in the literature as a mechanism causing vasculitis.
Published: 2004
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32. Phacoemulsification with intraocular lens implantation in patients with uveitis.

Author: Moschos MM, Bui MA, and Guex-Crosier Y
Subjects: Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Uveitis diagnosis, Visual Acuity, Lenses, Intraocular, Phacoemulsification, Postoperative Complications diagnosis, Uveitis surgery
Abstract: Background: Cataract remains a challenge for ophthalmologists in uveitic eyes. The aim of this study is to report the clinical course of phacoemulsification with intraocular lens implantation in eyes suffering from uveitis., Patients and Methods: Patients presenting a uveitis were prospectively followed from June 2001 to June 2003. Ocular surgery was performed according to a standard protocol, autoimmune follow-up visits were focused on the early detection of complications of uveitis: increased ocular inflammation, synechiae, retraction of the rhexis, opacification of the posterior capsule or onset of cystoid macular edema., Results: Thirty-two eyes of 24 patients suffering from uveitis were operated with cataract surgery between June 2001 and June 2003. The mean age at surgery was 56 years (range 24 - 86 years). Mean preoperative visual acuity in uveitis patients presenting cataract was 0.3 +/- 0.3, and final visual acuity was 0.8 +/- 0.3. Three patients presented minor postoperative complications. One patient had a cystoid macular edema that appeared 5 months after surgery and one patient had a relapse of herpetic dendritic keratopathy despite topical antiviral therapy combined with steroid drops. The latter presented a slight increase of intraocular pressure (24 mm Hg)., Conclusions: In patients with uveitis requiring cataract surgery, intraocular lens implantation is safe. Visual prognosis is better when pre- and postoperative inflammation is minimized. Macular scars or other retinal lesions are poor prognostic indicators.
Published: 2004
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33. Lacquer crack formation after photodynamic therapy.

Author: Ladas ID, Moschos MM, Rouvas AA, Karagiannis DA, and Kokolakis SN
Subjects: Adult, Angiography, Choroidal Neovascularization diagnosis, Coloring Agents, Female, Fluorescein Angiography, Fovea Centralis, Fundus Oculi, Humans, Indocyanine Green, Retinal Perforations diagnosis, Verteporfin, Choroidal Neovascularization drug therapy, Photochemotherapy adverse effects, Photosensitizing Agents adverse effects, Porphyrins adverse effects, Retinal Perforations chemically induced
Abstract: Purpose: To report the occurrence of a lacquer crack after photodynamic therapy (PDT) of choroidal neovascularization (CNV) in a patient with pathologic myopia., Methods: PDT was performed with verteporfin, which was activated by a diode laser light at 690 nm., Results: The left eye of a 42-year-old woman was treated with PDT because of juxtafoveal CNV caused by pathologic myopia. No lacquer crack was present in the macula on either fluorescein or indocyanine green angiography before treatment. The CNV subsided after treatment. However, a large lacquer crack underlying a subretinal hemorrhage was formatted in the macula of the treated eye soon after PDT., Conclusions: Although the chorioretinal damage produced by PDT is minimal, it is enough to create, directly or indirectly, the basis for the formation of a lacquer crack in an eye with pathologic myopia.
Published: 2003
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34. A preliminary assessment of macular function by MF-ERG in myopic eyes with CNV with complete response to photodynamic therapy.

Author: Moschos MN, Panayotidis D, Moschos MM, Bouros C, Theodossiadis PG, and Theodossiadis GP
Subjects: Adult, Choroidal Neovascularization etiology, Coloring Agents, Electroretinography, Female, Fluorescein Angiography, Follow-Up Studies, Humans, Indocyanine Green, Male, Middle Aged, Prognosis, Verteporfin, Visual Acuity, Choroidal Neovascularization drug therapy, Myopia complications, Photochemotherapy, Photosensitizing Agents therapeutic use, Porphyrins therapeutic use, Retina physiology
Abstract: Purpose: To evaluate by multifocal electroretinogram (MF-ERG) macular function before and after photodynamic therapy (PDT) in myopic eyes with choroidal neovascularization (CNV)., Patients and Methods: Ten eyes with classic subfoveal CNV due to pathologic myopia were studied with MF-ERG before and after PDT in order to evaluate the results of PDT with verteporfin. The post-treatment follow-up was 6 months. Visual acuity testing, ophthalmic examinations, fluorescein and indocyanine green angiograms, and MF-ERG recordings were used to evaluate the results of PDT with verteporfin. The post-treatment period was 6 months., Results: Before treatment, the electrical response densities in the foveal and perifoveal areas were apparently decreased in all patients. Six months after treatment, the mean retinal response densities in the same areas were found to be higher than before treatment., Conclusions: MF-ERG evaluates objectively the macular function in myopic eyes with CNV. After successful PDT, the electrical activity of the foveal and parafoveal areas is higher than before treatment. This finding postulates the efficacy of PDT in the treatment of CNV.
Published: 2003
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34 results on '"Moschos, M. M."'

1. Intravitreal ranibizumab in a patient with choroidal neovascularization secondary to multiple evanescent white dot syndrome

2. Burden of injury along the development spectrum : Associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017

3. Polypoidal choroidal vasculopathy associated with Doyne's familial choroiditis: treatment with thermal laser

4. Targeting histone deacetylases in endometrial cancer: a paradigm-shifting therapeutic strategy?

6. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017

7. Comparison of endothelial cell loss and complications following DMEK with the use of three different graft injectors

8. Endothelial keratoplasty: is Descemet membrane endothelial keratoplasty the Holy Grail of lamellar surgery? No

9. Association of serum inflammatory markers and diabetic retinopathy: a review of literature.

10. The effect of fish consumption on macula structure and function of healthy individuals: an OCT and mfERG study.

11. Intravitreal ranibizumab in a patient with choroidal neovascularization secondary to multiple evanescent white dot syndrome

12. Dark Adaptation in Patients with Primary Open-Angle Glaucoma, Pseudoexfoliation Glaucoma and Childhood Glaucoma.

13. Homosexuality according to ancient Greek physicians.

14. Clinical Significance of Optic Disc Progression by Topographic Change Analysis Maps in Glaucoma: An 8-Year Follow-Up Study

15. Comparison of endothelial cell loss and complications following DMEK with the use of three different graft injectors

16. Impaired arterial wall properties in patients with diabetic retinopathy: the role of inflammation

17. Intravitreal ranibizumab for choroidal neovascularization secondary to angiod streaks. Comparison of the 12 and 24-month results of treatment in treatment-naïve eyes.

18. Dreams in ancient Greek Medicine.

19. Anatomical and functional impairment of the retina and optic nerve in patients with anorexia nervosa without vision loss

20. Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population

21. Multifocal visual evoked potentials in amblyopia due to anisometropia.

22. Expression of the insulin-like growth factor 1 (IGF-1) and type I IGF receptor mRNAs in human HLE-B3 lens epithelial cells

23. Polypoidal choroidal vasculopathy associated with Doyne's familial choroiditis: Treatment with thermal laser

24. Targeting histone deacetylases in endometrial cancer: A paradigm-shifting therapeutic strategy?

25. Evaluation of macular function and morphology following accelerated collagen cross-linking in progressive keratoconus.

26. Targeting histone deacetylases in endometrial cancer: a paradigm-shifting therapeutic strategy?

27. Visual problems in young adults due to computer use.

28. Intravitreal Triamcinolone Acetonide for Macular Edema in HLA-B27 Negative Ankylosing Spondylitis.

29. Assessment of macular function by multifocal electroretinogram in age-related macular degeneration before and after photodynamic therapy.

30. Arachnoid cyst of the optic nerve: a case report.

31. Retinal vasculitis and cystoid macular edema after body tattooing: a case report.

32. Phacoemulsification with intraocular lens implantation in patients with uveitis.

33. Lacquer crack formation after photodynamic therapy.

34. A preliminary assessment of macular function by MF-ERG in myopic eyes with CNV with complete response to photodynamic therapy.

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34 results on '"Moschos, M. M."'

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