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3. Fighting Hospital Infections with Engineering 4.0

Author

Mosca, Roberto, Mosca, Marco, Revetria, Roberto, Currò, Fabio, Briatore, Federico, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Valle, Maurizio, editor, Lehmhus, Dirk, editor, Gianoglio, Christian, editor, Ragusa, Edoardo, editor, Seminara, Lucia, editor, Bosse, Stefan, editor, Ibrahim, Ali, editor, and Thoben, Klaus-Dieter, editor

Published
2023
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4. Ansaldo Energia Progetto LHP (OR6.3) : Proper Management of PPE (Personal Protective Equipment) Financed by the Italian Ministry of Economic Development

Author

Mosca, Roberto, Mosca, Marco, Revetria, Roberto, Pagano, Saverio, Briatore, Federico, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Valle, Maurizio, editor, Lehmhus, Dirk, editor, Gianoglio, Christian, editor, Ragusa, Edoardo, editor, Seminara, Lucia, editor, Bosse, Stefan, editor, Ibrahim, Ali, editor, and Thoben, Klaus-Dieter, editor

Published
2023
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5. An Application of Engineering 4.0 to Hospitalized Patients

Author

Mosca, Roberto, Mosca, Marco, Revetria, Roberto, Currò, Fabio, Briatore, Federico, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Valle, Maurizio, editor, Lehmhus, Dirk, editor, Gianoglio, Christian, editor, Ragusa, Edoardo, editor, Seminara, Lucia, editor, Bosse, Stefan, editor, Ibrahim, Ali, editor, and Thoben, Klaus-Dieter, editor

Published
2023
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13. Applied Data Science for Leasing Score Prediction

Author

Cianci, Giuseppe, primary, Goglia, Roberto, additional, Guidotti, Riccardo, additional, Kapllaj, Matteo, additional, Mosca, Roberto, additional, Pugnana, Andrea, additional, Ricotti, Franco, additional, and Ruggieri, Salvatore, additional

Published
2023
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16. Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes

Author

Torrico, Barbara, Shaw, Alex D., Mosca, Roberto, Vivo-Luque, Norma, Hervas, Amaia, Fernandez-Castillo, Noelia, Aloy, Patrick, Bayes, Monica, Fullerton, Janice M., Cormand, Bru, and Toma, Claudio

Subjects
Phenotypes -- Analysis, Schizophrenia -- Genetic aspects -- Analysis, Genes -- Analysis, Autism -- Genetic aspects -- Analysis, Medical research -- Analysis, Genomics -- Analysis, Intellectual disabilities, Medical schools, Genomes, Mental disorders, Alleles, Health, Psychology and mental health
Abstract

Background: Previous research has implicated de novo and inherited truncating mutations in autism-spectrum disorder. We aim to investigate whether the load of inherited truncating mutations contributes similarly to high-functioning autism, and to characterize genes that harbour de novo variants in high-functioning autism. Methods: We performed whole-exome sequencing in 20 high- functioning autism families (average IQ = 100). Results: We observed no difference in the number of transmitted versus nontransmitted truncating alleles for high-functioning autism (117 v. 130, p = 0.78). Transmitted truncating and de novo variants in high- functioning autism were not enriched in gene ontology (GO) or Kyoto Encyclopedia of Genes and Genomes (KEGG) categories, or in autism-related gene sets. However, in a patient with high-functioning autism we identified a de novo variant in a canonical splice site of LRP1, a postsynaptic density gene that is a target for fragile X mental retardation protein (FRMP). This de novo variant leads to in-frame skipping of exon 29, removing 2 of 6 blades of the [beta]-propeller domain 4 of LRP1, with putative functional consequences. Large data sets implicate LRP1 across a number of psychiatric disorders: de novo variants are associated with autism-spectrum disorder (p = 0.039) and schizophrenia (p = 0.008) from combined sequencing projects; common variants using genome-wide association study data sets from the Psychiatric Genomics Consortium show gene-based association in schizophrenia (p = 6.6 x [E.sup.-07]) and in a meta-analysis across 7 psychiatric disorders (p = 2.3 x [E.sup.-03]); and the burden of ultra-rare pathogenic variants has been shown to be higher in autism- spectrum disorder (p = 1.2 x [E.sup.-05]), using whole-exome sequencing from 6135 patients with schizophrenia, 1778 patients with autism- spectrum disorder and 7875 controls. Limitations: We had a limited sample of patients with high-functioning autism, related to difficulty in recruiting probands with high cognitive performance and no family history of psychiatric disorders. Conclusion: Previous studies and ours suggest an effect of truncating mutations restricted to severe autism-spectrum disorder phenotypes that are associated with intellectual disability. We provide evidence for pleiotropic effects of common and rare variants in the LRP1 gene across psychiatric phenotypes., Introduction Autism-spectrum disorder (ASD) is characterized by impairments in social interactions and communication, and by repetitive behaviours. Appearing in approximately 1% of the general population, ASD is one of the [...]

Published
2019
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26. Buckling critical pressures in collapsible tubes relevant for biomedical flows

Author

Laudato, Marco, Mosca, Roberto, and Mihaescu, Mihai

Subjects
Fluid Mechanics and Acoustics, collapsible tubes, biomedical flows, Tube law, Strömningsmekanik och akustik, Buckling critical pressures
Abstract

The behaviour of collapsed or stenotic vessels in the human body can be studied by means of simplified geometries like a collapsible tube. The objective of this work is to determine the value of the buckling critical pressure of a collapsible tube by employing Landau’s theory of phase transition. The methodology is based on the implementation of an experimentally validated 3D numerical model of a collapsible tube. The buckling critical pressure is estimated for different values of geometric parameters of the system by treating the relation between the intramural pressure and the area of the central cross-section as the order parameter function of the system. The results show the dependence of the buckling critical pressures on the geometric parameters of a collapsible tube. General non-dimensional equations for the buckling critical pressures are derived. The advantage of this method is that it does not require any geometric assumption, but it is solely based on the observation that the buckling of a collapsible tube can be treated as a second-order phase transition. The investigated geometric and elastic parameters are sensible for biomedical application, with particular interest to the study of the bronchial tree under pathophysiological conditions like asthma. QC 20230612

Published
2023

31. A Simplified Human Cognitive Approach for Supporting Crowd Modeling in Tunnel Fires Emergency Simulation

Author

Briano, Enrico, Mosca, Roberto, Revetria, Roberto, Testa, Alessandro, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Mehrotra, Kishan G., editor, Mohan, Chilukuri K., editor, Oh, Jae C., editor, Varshney, Pramod K., editor, and Ali, Moonis, editor

Published
2011
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33. A GA Approach to the Definition of Regulatory Signals in Genomic Sequences

Author

Mauri, Giancarlo, Mosca, Roberto, Pavesi, Giulio, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Deb, Kalyanmoy, editor

Published
2004
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35. Influence of Pulse Characteristics On Turbocharger Radial Turbine

Author

Mosca, Roberto, Lim, Shyang Maw, and Mihaescu, Mihai

Subjects
Flow (Dynamics), Vehicle Engineering, Fluid Mechanics and Acoustics, Applied Mechanics, Teknisk mekanik, Pulsatile flow, Entropy, Turbines, Strömningsmekanik och akustik, Piston engines, Computational fluid dynamics, Farkostteknik, Turbochargers, Heat transfer, Engines, Exergy, Inflow
Abstract

Due to the reciprocating engine, a pulsating flow occurs in the turbine turbocharger, which experiences conditions far from the continuous flow scenario. In this work, the effects of the characteristics of the mass flow pulse, parameterized through amplitude, frequency and temporal gradient, are decoupled and studied via unsteady Computational Fluid Dynamics calculations under on-engine operating conditions. Firstly, the model is validated based on comparisons with experimental data in steady flow conditions. Then, the effect of each parameter on exergy budget is assessed by considering a +/-10% variation with respect to a baseline pulse. The other factors defining the operating conditions (e.g. mass flow, shaft speed and inflow exergy) are kept the same as the baseline. The adopted approach enables to completely isolate the effects of each parameter in contrast with previous literature studies. Based on the results observed, pulse amplitude is identified as the primary parameter affecting the hot-side system response in terms of turbine performance, heat transfer and entropy generation, while frequency and temporal gradient show a smaller influence compared to it. As the pulse amplitude increases, the turbine work is reported to improve up to 9.4%. Smaller variations are observed for the frequency and temporal gradient analysis. With a 10% increase of the pulse frequency the turbine work is registered to improve by 5.0%, while the same percentage reduction of the temporal gradient leads to an increase of turbine work equal to 3.6%. QC 20220919 CCGEx

Published
2022

41. International consensus recommendations for anesthetic and intensive care management of lung transplantation. An EACTAIC, SCA, ISHLT, ESOT, ESTS, and AST approved document

Author

Marczin, Nandor, primary, de Waal, Eric E.C., additional, Hopkins, Peter M.A., additional, Mulligan, Michael S., additional, Simon, Andre, additional, Shaw, Andrew D., additional, Van Raemdonck, Dirk, additional, Neyrinck, Arne, additional, Gries, Cynthia J., additional, Algotsson, Lars, additional, Szegedi, Laszlo, additional, von Dossow, Vera, additional, Burrell, Aidan, additional, Carmona, Paula, additional, Greenhalgh, Donna, additional, Höchter, Dominik, additional, Kachulis, Bessie, additional, King, Christopher S., additional, Licker, Marc J., additional, McIlroy, David R., additional, Nair, Priya, additional, Pasero, Daniela, additional, Pilcher, David, additional, Rex, Steffen, additional, Royston, David, additional, Slinger, Peter, additional, Valenza, Franco, additional, Walker, Chris, additional, Arcadipane, Antonio, additional, Bastien, Oliver, additional, Bekkers, Joseph A., additional, Bettex, Dominique, additional, Caliandro, Francesca, additional, Checco, Erika Dal, additional, Davis, Robert Duane, additional, Dellgren, Göran, additional, Espinoza, Andreas, additional, Felten, Marie Louise, additional, Feltracco, Paolo, additional, Fischler, Marc, additional, Fitzgerald, Linda J, additional, Forner, Ana Flo, additional, Fragata, Isabel, additional, Román, Ana González, additional, Harris, Paul, additional, Hommel, Matthias, additional, Lees, Nicholas J., additional, Guen, Morgan Le, additional, Leone, Marc, additional, Lepoivre, Thierry, additional, Marcucci, Carlo, additional, Martelli, Sabina, additional, Michel-Cherqui, Mireille, additional, Molitoris, Ulrich, additional, Montravers, Philippe, additional, Mosca, Roberto, additional, Parizkova, Barbora, additional, Prabhu, Mahesh, additional, Pugliese, Francesco, additional, Raman, Sanjeev M., additional, Ramos, Cristina, additional, Ranieri, Vito Marco, additional, Real, Maria I., additional, Ricksten, Sven-Erik, additional, Roman, Ana Gonzalez, additional, Rozec, Bertrand, additional, Sale, Shiva M., additional, Sanchez, Juan F., additional, Schwarzenberger, Johanna, additional, Turan, Sema, additional, Valchanov, Kamen, additional, Valentine, Vincent G., additional, von Homeyer, Peter, additional, Vuylsteke, Alain, additional, Weig, Thomas, additional, Zarragoikoetxea, Iratxe, additional, Zenz, Sebastian, additional, Falcoz, Pierre-Emmanuel, additional, Inci, Ilhan, additional, Roscoe, Andrew, additional, and Senturk, Mert, additional

Published
2021
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42. The binary protein-protein interaction landscape of Escherichia coli

Author

Rajagopala, Seesandra V, Sikorski, Patricia, Kumar, Ashwani, Mosca, Roberto, Vlasblom, James, Arnold, Roland, Franca-Koh, Jonathan, Pakala, Suman B, Phanse, Sadhna, Ceol, Arnaud, Häuser, Roman, Siszler, Gabriella, Wuchty, Stefan, Emili, Andrew, Babu, Mohan, Aloy, Patrick, Pieper, Rembert, and Uetz, Peter

Published
2014
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