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3. Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

Author

Mittal, Karuna, Cooper, Garrett W., Lee, Benjamin P., Su, Yongdong, Skinner, Katie T., Shim, Jenny, Jonus, Hunter C., Kim, Won Jun, Doshi, Mihir, Almanza, Diego, Kynnap, Bryan D., Christie, Amanda L., Yang, Xiaoping, Cowley, Glenn S., Leeper, Brittaney A., Morton, Christopher L., Dwivedi, Bhakti, Lawrence, Taylor, Rupji, Manali, Keskula, Paula, Meyer, Stephanie, Clinton, Catherine M., Bhasin, Manoj, Crompton, Brian D., Tseng, Yuen-Yi, Boehm, Jesse S., Ligon, Keith L., Root, David E., Murphy, Andrew J., Weinstock, David M., Gokhale, Prafulla C., Spangle, Jennifer M., Rivera, Miguel N., Mullen, Elizabeth A., Stegmaier, Kimberly, Goldsmith, Kelly C., Hahn, William C., and Hong, Andrew L.

Published
2024
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6. Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q

Author

Murphy, Andrew J., Cheng, Changde, Williams, Justin, Shaw, Timothy I., Pinto, Emilia M., Dieseldorff-Jones, Karissa, Brzezinski, Jack, Renfro, Lindsay A., Tornwall, Brett, Huff, Vicki, Hong, Andrew L., Mullen, Elizabeth A., Crompton, Brian, Dome, Jeffrey S., Fernandez, Conrad V., Geller, James I., Ehrlich, Peter F., Mulder, Heather, Oak, Ninad, Maciezsek, Jamie, Jablonowski, Carolyn M., Fleming, Andrew M., Pichavaram, Prahalathan, Morton, Christopher L., Easton, John, Nichols, Kim E., Clay, Michael R., Santiago, Teresa, Zhang, Jinghui, Yang, Jun, Zambetti, Gerard P., Wang, Zhaoming, Davidoff, Andrew M., and Chen, Xiang

Published
2023
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7. Structural and biophysical analysis of human DNA repair protein CtIP

Author

Morton, Christopher Robert and Pellegrini, Luca

Subjects
DNA Repair, Homologous Recombination, CtIP
Abstract

The integrity of our genome is constantly threatened by endogenous and exogenous sources of DNA damage. The successful repair of DNA lesions is necessary for cellular survival and prevention of disease such as cancer. Therefore, complex molecular pathways have evolved to allow for accurate and timely DNA repair. It is now well-established that mammalian CtIP (CtBP-Interacting Protein) has an important function in DNA Double-Strand Break repair, by promoting the resection of DNA ends in preparation for homologous recombination (HR) and micro-homology mediated end joining (MMEJ). However, the biochemical basis of CtIP's critical role in DNA double-strand break repair remains poorly understood. The aim of this work is to improve our understanding of CtIP's function in maintaining genomic stability. In my thesis I describe the structural and biophysical characterisation of human CtIP and its two evolutionarily conserved N- and C-domains that are critical for CtIP function. Sufficient quantities of recombinant CtIP were expressed and purified for in vitro analysis. A combination of biophysical approaches, including analytical ultra-centrifugation, size-exclusion chromatography and cryo EM, were used to probe the oligomeric nature of CtIP. All techniques showed the presence of high molecular weight oligomeric CtIP species. The N-terminal region of CtIP has been previously shown to be essential for its role in DNA end resection, HR and MMEJ. Using X-ray crystallography in combination with small-angle X-ray scattering I demonstrate that an extended region of the CtIP N-terminus spanning amino acids 31 to 136 forms an elongated parallel helical dimer with coiled-coil segments flanking a central zinc-binding motif. In combination with previous crystallographic analysis of the N-terminal tetramerisation motif of CtIP, my new structural information allows modelling the overall architecture of the CtIP NTD. I have explored the ability of CtIP to bind DNA, via electrophoretic mobility shift assays and fluorescence polarisation, to determine the affinity and minimum binding site of its interaction with double-strand DNA. Using alanine scanning mutagenesis, I have investigated the zinc-binding ability of putative metal-coordination residues within the C-terminal domain. Furthermore, I provide evidence for the presence of a coiled-coil region N-terminally juxtaposed to the CtIP-CTD, which might mediate its dimerization. My findings advance our current knowledge of the biochemical and structural properties of human CtIP. They represent a useful contribution to our current efforts to improve our limited understanding of the molecular mechanisms presiding over the critical DNA-end resection step of HR.

Published
2019
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8. Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

Author

Rokita, Jo Lynne, Rathi, Komal S, Cardenas, Maria F, Upton, Kristen A, Jayaseelan, Joy, Cross, Katherine L, Pfeil, Jacob, Egolf, Laura E, Way, Gregory P, Farrel, Alvin, Kendsersky, Nathan M, Patel, Khushbu, Gaonkar, Krutika S, Modi, Apexa, Berko, Esther R, Lopez, Gonzalo, Vaksman, Zalman, Mayoh, Chelsea, Nance, Jonas, McCoy, Kristyn, Haber, Michelle, Evans, Kathryn, McCalmont, Hannah, Bendak, Katerina, Böhm, Julia W, Marshall, Glenn M, Tyrrell, Vanessa, Kalletla, Karthik, Braun, Frank K, Qi, Lin, Du, Yunchen, Zhang, Huiyuan, Lindsay, Holly B, Zhao, Sibo, Shu, Jack, Baxter, Patricia, Morton, Christopher, Kurmashev, Dias, Zheng, Siyuan, Chen, Yidong, Bowen, Jay, Bryan, Anthony C, Leraas, Kristen M, Coppens, Sara E, Doddapaneni, HarshaVardhan, Momin, Zeineen, Zhang, Wendong, Sacks, Gregory I, Hart, Lori S, Krytska, Kateryna, Mosse, Yael P, Gatto, Gregory J, Sanchez, Yolanda, Greene, Casey S, Diskin, Sharon J, Vaske, Olena Morozova, Haussler, David, Gastier-Foster, Julie M, Kolb, E Anders, Gorlick, Richard, Li, Xiao-Nan, Reynolds, C Patrick, Kurmasheva, Raushan T, Houghton, Peter J, Smith, Malcolm A, Lock, Richard B, Raman, Pichai, Wheeler, David A, and Maris, John M

Subjects
Biological Sciences, Pediatric, Rare Diseases, Genetics, Human Genome, Pediatric Cancer, Pediatric Research Initiative, Clinical Research, Orphan Drug, Biotechnology, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Animals, Cell Line, Tumor, Central Nervous System Neoplasms, Child, Clinical Trials as Topic, Disease Models, Animal, Genomics, Humans, Mice, Mutation, Neuroblastoma, Neurofibromin 1, Osteosarcoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Tumor Suppressor Protein p53, Exome Sequencing, Wilms Tumor, Xenograft Model Antitumor Assays, classifier, copy number profiling, patient-derived xenograft, pediatric cancer, preclinical testing, relapse, transcriptome sequencing, whole-exome sequencing, Pediatric cancer, whole exome sequencing, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer.

Published
2019

9. Study protocol: MyoFit46—the cardiac sub-study of the MRC National Survey of Health and Development

Author

Webber, Matthew, Falconer, Debbie, AlFarih, Mashael, Joy, George, Chan, Fiona, Davie, Clare, Hamill Howes, Lee, Wong, Andrew, Rapala, Alicja, Bhuva, Anish, Davies, Rhodri H., Morton, Christopher, Aguado-Sierra, Jazmin, Vazquez, Mariano, Tao, Xuyuan, Krausz, Gunther, Tanackovic, Slobodan, Guger, Christoph, Xue, Hui, Kellman, Peter, Pierce, Iain, Schott, Jonathan, Hardy, Rebecca, Chaturvedi, Nishi, Rudy, Yoram, Moon, James C., Lambiase, Pier D., Orini, Michele, Hughes, Alun D., and Captur, Gabriella

Published
2022
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10. Data from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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11. Supplementary Data File 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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12. Supplementary Figure 15 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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13. Supplementary Table 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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14. Supplementary Data File 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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15. Supplementary Methods from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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16. Supplementary Figure 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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17. Supplementary Table 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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18. Supplementary Figure 9 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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19. Supplementary Data File 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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20. Supplementary Figure 6 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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21. Supplementary Figure 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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22. Supplementary Figure 4 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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23. Supplementary Figure 8 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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24. Supplementary Figure 5 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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25. Supplementary Figure 7 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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26. Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer

Author

Brimble, Mark A., primary, Morton, Christopher L., additional, Winston, Stephen M., additional, Reeves, Isaiah L., additional, Spence, Yunyu, additional, Cheng, Pei-Hsin, additional, Zhou, Junfang, additional, Nathwani, Amit C., additional, Thomas, Paul G., additional, Souquette, Aisha, additional, and Davidoff, Andrew M., additional

Published
2024
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27. RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

Author

Singh, Shivendra, primary, Fang, Jie, additional, Jin, Hongjian, additional, Van de Velde, Lee-Ann, additional, Wu, Qiong, additional, Cortes, Andrew, additional, Morton, Christopher L., additional, Woolard, Mary A., additional, Quarni, Waise, additional, Steele, Jacob A., additional, Connelly, Jon P., additional, He, Liusheng, additional, Thorne, Rebecca, additional, Turner, Gregory, additional, Confer, Thomas, additional, Johnson, Melissa, additional, Caufield, William V., additional, Freeman, Burgess B., additional, Lockey, Timothy, additional, Pruett-Miller, Shondra M., additional, Wang, Ruoning, additional, Davidoff, Andrew M., additional, Thomas, Paul G., additional, and Yang, Jun, additional

Published
2024
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32. Lemierre syndrome with pulmonary empyema caused by Prevotella intermedia.

Author

Simsek, Bahadir, Zhang, Renee, Morton, Christopher, and Villanueva, Merceditas S.

Abstract

Lemierre syndrome is a rare disease that is most often caused by Fusobacterium necrophorum. We present a case caused by Prevotella intermedia in a young, healthy man, complicated by multiple cavitary lung lesions, loculated pleural effusions requiring chest tube placement and trapezius abscess. Our case highlights (a) P. intermedia as a rare cause of Lemierre syndrome and (b) clinical response to appropriate antimicrobial therapy may be protracted. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Oncogenic cells of renal embryonic lineage sensitive to the small molecule inhibitor QC6352 display depletion of KDM4 levels and disruption of ribosome biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., additional, Fang, Jie, additional, Fleming, Andrew M., additional, Gil, Hyea Jin, additional, Boghossian, Andrew S., additional, Rees, Matthew G., additional, Ronan, Melissa M., additional, Roth, Jennifer A., additional, Morton, Christopher L., additional, Zambetti, Gerard P., additional, Davidoff, Andrew M., additional, Yang, Jun, additional, and Murphy, Andrew J., additional

Published
2023
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46. Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

Author

Murphy, Andrew J., Chen, Xiang, Pinto, Emilia M., Williams, Justin S., Clay, Michael R., Pounds, Stanley B., Cao, Xueyuan, Shi, Lei, Lin, Tong, Neale, Geoffrey, Morton, Christopher L., Woolard, Mary A., Mulder, Heather L., Gil, Hyea Jin, Rehg, Jerold E., Billups, Catherine A., Harlow, Matthew L., Dome, Jeffrey S., Houghton, Peter J., Easton, John, Zhang, Jinghui, George, Rani E., Zambetti, Gerard P., and Davidoff, Andrew M.

Published
2019
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48. Dwelling and building in Ngamiland, Northern Botswana

Author

Morton, Christopher A.

Subjects
392, Dwellings, Land settlement patterns, Social life and customs, Botswana, Ngamiland (Botswana)
Abstract

This thesis is an investigation of the ways in which activities of house-building are woven into the histories and biographies of the people of Ngamiland in nothern Botswana. Criticising those approaches in anthropology that have tended to see forms of buildings as the symbolic expressions of (or metaphors for) aspects of social order, the thesis argues that building practices are themselves embedded in the current of social activity - that is, of dwelling - which, over time, is generative of both persons and places. Just as every inhabitant enfolds within his or her person a set of relations with others, which are played out in the manifold tasks of everyday dwelling (including building), so every place (including the buildings found there) embodies a set of relations with other places. The first set of relations, essentially social, are captured by the notion of the taskscape, the second set, essentially material, by the notion of landscape. The thesis seeks to demonstrate the dynamic interplay between taskscape and landscape, or between social and material relations over time. The thesis argues for several important ways in which this dynamic relationship can be considered anthropologically. The first is the notion of the 'otherplaceness' of dwelling, in which the inherent interconnectedness of the landscape is highlighted, describing the ways in which both personal biographies and the material biographies of places are mutually creative over time. This is extended to investigate the relationship between social and material permanence in the landscape through an analysis of the ways in which building with concrete has affected everyday dwelling. Another key notion is that dwelling involves a wide range of social practices that can be understood as containing both forces of a centrifugal (movement away from a centre) and centripetal (movement toward a centre) nature, being an important aspect of how social practice and homestead form are interrelated over time. This is also extended in the final chapter through an exploration of the ways in which the materiality of the homestead is interwoven with memory, biography and personal history.

Published
2002

49. Abstract 1197: B7-H3-CAR T cells for the treatment of pediatric adrenocortical carcinoma

Author

Epperly, Rebecca, primary, Pinto, Emilia M., additional, Santiago, Teresa, additional, Sheppard, Heather, additional, Clay, Michael R., additional, Morton, Christopher, additional, Nguyen, Phuong, additional, Zhou, Yinmei, additional, Woolard, Mary, additional, O'Reilly, Carla, additional, Justice, Julie, additional, Akers, Walter, additional, Johnson, Melissa, additional, Karlstrom, Asa, additional, Cheng, Cheng, additional, Zambetti, Gerard, additional, Davidoff, Andrew, additional, Ribeiro, Raul, additional, and DeRenzo, Christopher, additional

Published
2023
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50. Supplementary Tables, 1-5, Figure 1 from Stage 2 Combination Testing of Rapamycin with Cytotoxic Agents by the Pediatric Preclinical Testing Program

Author

Houghton, Peter J., primary, Morton, Christopher L., primary, Gorlick, Richard, primary, Lock, Richard B., primary, Carol, Hernan, primary, Reynolds, C. Patrick, primary, Kang, Min H., primary, Maris, John M., primary, Keir, Stephen T., primary, Kolb, E. Anders, primary, Wu, Jianrong, primary, Wozniak, Amy W., primary, Billups, Catherine A., primary, Rubinstein, Larry, primary, and Smith, Malcolm A., primary

Published
2023
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