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2. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial

Author

Bistervels, Ingrid M, primary, Buchmüller, Andrea, additional, Wiegers, Hanke M G, additional, Ní Áinle, Fionnuala, additional, Tardy, Bernard, additional, Donnelly, Jennifer, additional, Verhamme, Peter, additional, Jacobsen, Anne F, additional, Hansen, Anette T, additional, Rodger, Marc A, additional, DeSancho, Maria T, additional, Shmakov, Roman G, additional, van Es, Nick, additional, Prins, Martin H, additional, Chauleur, Céline, additional, Middeldorp, Saskia, additional, van den Akker, Eline S, additional, Bekker, Mireille N, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Blanc, Julie, additional, Bleker, Suzanne M, additional, Bourtembourg-Matras, Aude, additional, Bretelle, Florence, additional, Byrne, Bridgette, additional, Couturaud, Francis, additional, Delorme, Pierre, additional, Eerenberg, Elise S, additional, Franssen, Maureen TM, additional, Fuglsang, Jens, additional, Ganzevoort, Wessel, additional, Goffinet, François, additional, de Haan-Jebbink, Jiska M, additional, Heidema, Wieteke, additional, Hertzberg, Monique A, additional, Hovens, Marcel MC, additional, Huisman, Menno V, additional, de Jong-Speksnijder, Leonie, additional, Kamphuisen, Pieter-Willem, additional, O'Keeffe, Denis J, additional, Lacut, Karine, additional, Langenveld, Josje, additional, Lunshof, M Simone, additional, Martens, Caroline P, additional, Merah, Adel, additional, Le Moigne, Emmanuelle, additional, Papatsonis, Dimitri NM, additional, Pernod, Gilles, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Pierre, Fabrice, additional, Plu Bureau, Geneviève, additional, Raia-Barjat, Tiphaine, additional, Rijnders, Robbert JP, additional, Rosario, Roger, additional, Ruivard, Marc, additional, Schmidt, Jeannot, additional, Sueters, Marieke, additional, Vanassche, Thomas, additional, Varlet, Marie-Noëlle, additional, Vivanti, Alexandre J, additional, van der Vlist, Matthieu Y, additional, van der Voet, Lucet F, additional, Vollebregt, Karlijn C, additional, de Vries, Johanna IP, additional, de Weerd, Sabina, additional, Westerweel, Peter E, additional, Wijnberger, Lia DE, additional, ten Wolde, Marije, additional, Ypma, Paula F, additional, Zuily-Lamy, Catherine, additional, Zwart, Joost J, additional, Benachi, Alexandra, additional, Beucher, Gaël, additional, Bezanahary, Holy, additional, de Boer, Karin, additional, de Boer, Marjon A., additional, Bousquet, Frantz, additional, Bremer, Henk A., additional, Bressollette, Luc, additional, Brossard, Aurélie, additional, Chau, Cécile, additional, Cleary, Brian, additional, Comte, Fabienne, additional, Corsini, Thomas, additional, Coustel, Anne, additional, Debaveye, Barbara, additional, Desbrière, Raoul, additional, Duvillard, Cécile, additional, Eckman, Astrid, additional, Eikenboom, Jeroen, additional, Elias, Antoine, additional, Faber, Laura M., additional, Ferrari, Emile, additional, Gallot, Denis, additional, Gauchotte, Emilie, additional, Gaugler, Ingrid, additional, Geerlings, Abby E., additional, O'Gorman, Audrey, additional, Grobost, Vincent, additional, de Groot, Pieter-Kees, additional, van der Ham, David P., additional, Hermsen, Brenda, additional, Kamphorst, Kim, additional, Karovitch, Alan, additional, Kleiverda, Gunilla, additional, Kloster, Aiste, additional, Koops, Annemarieke, additional, Krabbendam, Inneke, additional, Kruip, Marieke J.H.A., additional, Kuipers, Saskia, additional, van Laar, Judith, additional, Laneelle, Damien, additional, Lima, Suzanne, additional, MacMahon, Peter, additional, Mandelbrot, Laurent, additional, van Meir, Claudia A., additional, Menez, Caroline, additional, Morssink, Leonard P., additional, Moulin, Nathalie, additional, Mousty, Eve, additional, Muller, Matthieu, additional, Murphy, Lucy, additional, Peerlinck, Kathelijne, additional, O'Reilly, Alma, additional, de Reus, Maartje, additional, Le Roux, Magali Hilmi, additional, Ryan, Kevin, additional, Samren, Bettina, additional, Schippers, Daniela, additional, Schuitemaker, Nico, additional, Schweizer, Chloé, additional, van der Straaten, Hanneke, additional, Tromeur, Cécile, additional, Vanheule, Kristine, additional, Verhagen, Tamara, additional, Visser, Jantien, additional, Watts, Michael, additional, van Wijngaarden, Wim J., additional, Woiski, Mallory, additional, and Zelis, Maartje, additional

Published
2022
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4. A homozygous variant in growth and differentiation factor 2 (GDF2) may cause lymphatic dysplasia with hydrothorax and nonimmune hydrops fetalis

Author

Aukema, Sietse M., primary, ten Brinke, Gerdien A., additional, Timens, Wim, additional, Vos, Yvonne J., additional, Accord, Ryan E., additional, Kraft, Karianne E., additional, Santing, Michiel J., additional, Morssink, Leonard P., additional, Streefland, Esther, additional, Diemen, Cleo C., additional, Vrijlandt, Elianne JLE, additional, Hulzebos, Christian V., additional, and Kerstjens‐Frederikse, Wilhelmina S., additional

Published
2020
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10. Risks versus benefits of medication use during pregnancy: what do women perceive?

Author

Mulder B, Bijlsma MJ, Schuiling-Veninga CC, Morssink LP, van Puijenbroek E, Aarnoudse JG, Hak E, and de Vries TW

Abstract

Background: Understanding perception of risks and benefits is essential for informed patient choices regarding medical care. The primary aim of this study was to evaluate the perception of risks and benefits of 9 drug classes during pregnancy and associations with women's characteristics., Methods: Questionnaires were distributed to pregnant women who attended a Dutch Obstetric Care facility (first- and second-line care). Mean perceived risk and benefit scores were computed for 9 different drug classes (paracetamol, antacids, antibiotics, antifungal medication, drugs against nausea and vomiting, histamine-2 receptor antagonists/proton pump inhibitors, antidepressants, nonsteroidal anti-inflammatory drugs, and sedatives/anxiolytics). For each participant, we computed weighted risk and benefit sum scores with principal component analysis. In addition, major concerns regarding medication use were evaluated., Results: The questionnaire was completed by 136 women (response rate 77%). Pregnant women were most concerned about having a child with a birth defect (35%), a miscarriage (35%), or their child developing an allergic disease (23%), respectively, as a result of drug use. The majority of studied drug classes were perceived relatively low in risk and high in benefit. Higher risk scores were reported if women were in their first trimesters of pregnancy ( p =0.007). Lower benefit scores were reported if women were single ( p =0.014), smoking ( p =0.028), nulliparous ( p =0.006), or did not have a family history of birth defects ( p =0.005)., Conclusion: Pregnant women's concerns regarding potential drug adverse effects were not only focused on congenital birth defects but also included a wider range of adverse outcomes. This study showed that most of the studied drug classes were perceived relatively low in risk and high in benefit., Competing Interests: Disclosure All authors declare that they had support from the Department of Pharmacy, University of Groningen, for the submitted work; had no financial relationships with any organization that might have an interest in the submitted work in the previous 3 years; had no other relationships or activities that could appear to have influenced the submitted work; and report no conflicts of interest in this work.

Published
2017
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