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While matters of food waste and soil have become vital research arenas, compost remains the Cinderella of human geographical enquiry. In response, this paper brings compost to the centre of debates at the intersection of diverse economies and circular economy. In particular, the concept of community composting and the care involved in such practices is used to offset and problematise the technoscientific bias in circular economy discourses. Extending feminist perspectives on care in soil studies, this paper focuses on the careful circularities that are realised through community composting in New York City. This case study provides not only a material space for examining community composting but also a unique opportunity to consider the colliding worlds of worth that operate in and around urban sustainability transitions to zero waste. Drawing empirical insights from interviews, participant observation, and document analysis, this paper argues for a sensitisation of circular economy policy and research to matters of care and diverse economies as a means to better understand motivations, justifications, and outcomes of efforts to reorient food systems onto more sustainable pathways. We argue that privileging care in this way helps to shift focus away from dominant narratives of "scaling-up" towards sustainability to a more relational perspective that sees transformation in connecting, deepening, and even scaling-down. This means attending to the micro as well as macro transformations needed to enact the required sustainability transitions., (The information, practices and views in this article are those of the author(s) and do not necessarily reflect the opinion of the Royal Geographical Society (with IBG). © 2021 The Authors. Transactions of the Institute of British Geographers published by John Wiley & Sons Ltd on behalf of Royal Geographical Society (with The Institute of British Geographers).)

Activities utilising online tools are an increasingly visible part of our everyday lives, providing new subjects, objects and relationships - essentially new landscapes - for research, as well as new conceptual and methodological challenges for researchers. In parallel, calls for collaborative interdisciplinary, even transdisciplinary, research are increasing. Yet practical guidance and critical reflection on the challenges and opportunities of conducting collaborative research online, particularly in emergent areas, is limited. In response, this paper details what we term the 'creative construction' involved in a collaborative project building an exploratory database of more than 4000 food sharing activities in 100 cities that utilise internet and digital technologies in some way (ICT mediated for brevity) to pursue their goals. The research was undertaken by an international team of researchers, including geographers, which utilised a combination of reflexive coding and online collaboration to develop a system for exploring the practice and performance of ICT-mediated food sharing in cities. This paper will unpack the black box of using the internet as a source of data about emergent practices and provide critical reflection on that highly negotiated and essentially handcrafted process. While the substance of the paper focuses on the under-determined realm of food sharing, a site where it is claimed that ICT is transforming practices, the issues raised have resonance far beyond the specificities of this particular endeavour. While challenging, we argue that handcrafting systems for navigating emergent online data is vital, not least to render visible the complexities and contestations around definition, categorisation and translation.

The availability of glatiramer acetate (GA) for inducing immune tolerance is a significant advancement in the treatment of multiple sclerosis (MS). However, a sizable proportion of patients maintain active disease, regardless of treatment. Another approach to induce T-cell tolerance is therefore still an unmet medical need. We hypothesized that induction of mucosal tolerance toward a pro-inflammatory T-cell epitope derived from a heat shock protein (HSP) (RatP2) could translate into clinical benefit. We found that treatment of experimental autoimmune encephalomyelitis (EAE, a model of MS) with the peptide RatP2 determined a significant clinical improvement, which was comparable to the standard tolerization treatment (an MBP-derived peptide pool) and superior to GA. Histological analysis demonstrated a reduction of brain and spinal cord inflammatory lesions in treated animals. Moreover, with immunological analysis we identified biomarkers associated with clinical response. This work provides proof-of-concept to support the further testing of this approach as a possible complement to currently available therapies for MS., (Copyright © 2012 Elsevier Inc. All rights reserved.)