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2. Expert consensus on the management of systemic sclerosis-associated interstitial lung disease.

Author

Rahaghi, Franck, Hsu, Vivien, Kaner, Robert, Mayes, Maureen, Rosas, Ivan, Saggar, Rajan, Steen, Virginia, Strek, Mary, Bernstein, Elana, Bhatt, Nitin, Castelino, Flavia, Chung, Lorinda, Domsic, Robyn, Flaherty, Kevin, Gupta, Nishant, Kahaleh, Bashar, Martinez, Fernando, Morrow, Lee, Moua, Teng, Patel, Nina, Shlobin, Oksana, Southern, Brian, Volkmann, Elizabeth, and Khanna, Dinesh

Subjects
Algorithms, Autoimmune diseases, Connective tissue diseases, Drug therapy, Pulmonary fibrosis, Humans, Consensus, Immunosuppressive Agents, Lung Diseases, Interstitial, Lung, Mycophenolic Acid, Scleroderma, Systemic
Abstract

BACKGROUND: Systemic sclerosis (SSc) is a rare, complex, connective tissue disorder. Interstitial lung disease (ILD) is common in SSc, occurring in 35-52% of patients and accounting for 20-40% of mortality. Evolution of therapeutic options has resulted in a lack of consensus on how to manage this condition. This Delphi study was initiated to develop consensus recommendations based on expert physician insights regarding screening, progression, treatment criteria, monitoring of response, and the role of recent therapeutic advances with antifibrotics and immunosuppressants in patients with SSc-ILD. METHODS: A modified Delphi process was completed by pulmonologists (n = 13) and rheumatologists (n = 12) with expertise in the management of patients with SSc-ILD. Panelists rated their agreement with each statement on a Likert scale from - 5 (complete disagreement) to + 5 (complete agreement). Consensus was predefined as a mean Likert scale score of ≤  - 2.5 or ≥  + 2.5 with a standard deviation not crossing zero. RESULTS: Panelists recommended that all patients with SSc be screened for ILD by chest auscultation, spirometry with diffusing capacity of the lungs for carbon monoxide, high-resolution computed tomography (HRCT), and/or autoantibody testing. Treatment decisions were influenced by baseline and changes in pulmonary function tests, extent of ILD on HRCT, duration and degree of dyspnea, presence of pulmonary hypertension, and potential contribution of reflux. Treatment success was defined as stabilization or improvement of signs or symptoms of ILD and functional status. Mycophenolate mofetil was identified as the initial treatment of choice. Experts considered nintedanib a therapeutic option in patients with progressive fibrotic ILD despite immunosuppressive therapy or patients contraindicated/unable to tolerate immunotherapy. Concomitant use of nintedanib with MMF/cyclophosphamide can be considered in patients with advanced disease at initial presentation, aggressive ILD, or significant disease progression. Although limited consensus was achieved on the use of tocilizumab, the experts considered it a therapeutic option for patients with early SSc and ILD with elevated acute-phase reactants. CONCLUSIONS: This modified Delphi study generated consensus recommendations for management of patients with SSc-ILD in a real-world setting. Findings from this study provide a management algorithm that will be helpful for treating patients with SSc-ILD and addresses a significant unmet need.

Published
2023

3. Use of Quantitative CT Imaging to Identify Bronchial Thermoplasty Responders

Author

Samant, Maanasi, Krings, James G., Lew, Daphne, Goss, Charles W., Koch, Tammy, McGregor, Mary Clare, Boomer, Jonathan, Hall, Chase S., Schechtman, Ken B., Sheshadri, Ajay, Peterson, Samuel, Erzurum, Serpil, DePew, Zachary, Morrow, Lee E., Hogarth, D. Kyle, Tejedor, Richard, Trevor, Jennifer, Wechsler, Michael E., Sam, Afshin, Shi, Xiaosong, Choi, Jiwoong, and Castro, Mario

Published
2024
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4. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

Author

Wahid, Lana, Walter, Emmanuel B., Belur, Akhila G., Dreyer, Grace, Patterson, Jan E., Bowling, Jason E., Dixon, Danielle O., Hewlett, Angela, Odrobina, Robert, Pupaibool, Jakrapun, Mocherla, Satish, Lazarte, Suzana, Cayabyab, Meilani, Hussein, Rezhan H., Golamari, Reshma R., Krill, Kaleigh L., Rajme, Sandra, Riska, Paul F., Zingman, Barry S., Mertz, Gregory, Sosa, Nestor, Goepfert, Paul A., Berhe, Mezgebe, Dishner, Emma, Fayed, Mohamed, Hubel, Kinsley, Martinez-Orozco, José Arturo, Bautista Felix, Nora, Elmor, Sammy T., Bechnak, Amer Ryan, Saklawi, Youssef, Van Winkle, Jason W., Zea, Diego F., Laguio-Vila, Maryrose, Walsh, Edward E., Falsey, Ann R., Carvajal, Karen, Hyzy, Robert C., Hanna, Sinan, Olbrich, Norman, Traenkner, Jessica J., Kraft, Colleen S., Tebas, Pablo, Baron, Jillian T, Levine, Corri, Nock, Joy, Billings, Joanne, Kim, Hyun, Elie-Turenne, Marie-Carmelle, Whitaker, Jennifer A., Luetkemeyer, Anne F., Dwyer, Jay, Bainbridge, Emma, Gyun Choe, Pyoeng, Kyung Kang, Chang, Jilg, Nikolaus, Cantos, Valeria D, Bhamidipati, Divya R., Nithin Gopalsamy, Srinivasa, Chary, Aarthi, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Benson, Constance A., McConnell, Kimberly, Wang, Jennifer P., Wessolossky, Mireya, Perez, Katherine, Eubank, Taryn A, Berjohn, Catherine, Utz, Gregory C., Jackson, Patrick E.H., Bell, Taison D., Haughey, Heather M., Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Tapson, Victor F., Grein, Jonathan, Sutterwala, Fayyaz, Ince, Dilek, Winokur, Patricia L., Fung, Monica, Jang, Hannah, Wyles, David, Frank, Maria G., Sarcone, Ellen, Neumann, Henry, Viswanathan, Anand, Hochman, Sarah, Mulligan, Mark, Eckhardt, Benjamin, Carmody, Ellie, Ahuja, Neera, Nadeau, Kari, Svec, David, Macaraeg, Jeffrey C., Morrow, Lee, Quimby, Dave, Bessesen, Mary, Nicholson, Lindsay, Adams, Jill, Kumar, Princy, Lambert, Allison A., Arguinchona, Henry, Alicic, Radica Z., Saito, Sho, Ohmagari, Norio, Mikami, Ayako, Chien Lye, David, Hong Lee, Tau, Ying Chia, Po, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Candiotti, Keith A., Castro, Jose G., Antor, Maria A., Lee, Tida, Lalani, Tahaniyat, Novak, Richard M., Wendrow, Andrea, Borgetti, Scott A., George, Sarah L., Hoft, Daniel F., Brien, James D., Cohen, Stuart H., Thompson, George R., 3rd, Chakrabarty, Melony, Guirgis, Faheem, Davey, Richard T., Voell, Jocelyn, Strich, Jeffrey R., Lindholm, David A., Mende, Katrin, Wellington, Trevor R., Rapaka, Rekha R., Husson, Jennifer S., Levine, Andrea R., Yen Tan, Seow, Shafi, Humaira, Chien, Jaime M F, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Adams, David H., Osinusi, Anu, Cao, Huyen, Burgess, Timothy H., Rozman, Julia, Chung, Kevin K., Nieuwoudt, Christina, El-Khorazaty, Jill A., Hill, Heather, Pettibone, Stephanie, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Deye, Gregory A., Nomicos, Effie, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Wolfe, Cameron R, Tomashek, Kay M, Patterson, Thomas F, Gomez, Carlos A, Marconi, Vincent C, Jain, Mamta K, Yang, Otto O, Paules, Catharine I, Palacios, Guillermo M Ruiz, Grossberg, Robert, Harkins, Michelle S, Mularski, Richard A, Erdmann, Nathaniel, Sandkovsky, Uriel, Almasri, Eyad, Pineda, Justino Regalado, Dretler, Alexandra W, de Castilla, Diego Lopez, Branche, Angela R, Park, Pauline K, Mehta, Aneesh K, Short, William R, McLellan, Susan L F, Kline, Susan, Iovine, Nicole M, El Sahly, Hana M, Doernberg, Sarah B, Oh, Myoung-don, Huprikar, Nikhil, Hohmann, Elizabeth, Kelley, Colleen F, Holodniy, Mark, Kim, Eu Suk, Sweeney, Daniel A, Finberg, Robert W, Grimes, Kevin A, Maves, Ryan C, Ko, Emily R, Engemann, John J, Taylor, Barbara S, Ponce, Philip O, Larson, LuAnn, Melendez, Dante Paolo, Seibert, Allan M, Rouphael, Nadine G, Strebe, Joslyn, Clark, Jesse L, Julian, Kathleen G, de Leon, Alfredo Ponce, Cardoso, Anabela, de Bono, Stephanie, Atmar, Robert L, Ganesan, Anuradha, Ferreira, Jennifer L, Green, Michelle, Makowski, Mat, Bonnett, Tyler, Beresnev, Tatiana, Ghazaryan, Varduhi, Dempsey, Walla, Nayak, Seema U, Dodd, Lori E, Beigel, John H, and Kalil, Andre C

Published
2022
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7. Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial

Author

Beigel, John H, Aga, Evgenia, Elie-Turenne, Marie-Carmelle, Cho, Josalyn, Tebas, Pablo, Clark, Carol L, Metcalf, Jordan P, Ozment, Caroline, Raviprakash, Kanakatte, Beeler, Joy, Holley, H. Preston, Jr., Warner, Stephanie, Chorley, Carla, Lane, H. Clifford, Hughes, Michael D, Davey, Richard T, Barron, Michelle, Bastani, Aveh, Bauer, Philippe, Borkowsky, William, Cairns, Charles, Deville, Jaime, Elie, Marie-Carmelle, Fichtenbaum, Carl, Finberg, Robert, Jain, Mamta, Kaufman, David, Lin, Michael, Lin, John, Maves, Ryan, Morrow, Lee, Nguyen, Minh-Hong, Park, Pauline, Polk, Christopher, Randolph, Adrienne, Rao, Suchitra, Rubinson, Lewis, Schofield, Christina, Shoham, Shmuel, Stalets, Erika, Stapleton, Renee D, Holley, H Preston, Jr, Lane, H Clifford, and Davey, Richard T, Jr

Published
2019
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16. Additional file 1 of Expert consensus on the management of systemic sclerosis-associated interstitial lung disease

Author

Rahaghi, Franck F., Hsu, Vivien M., Kaner, Robert J., Mayes, Maureen D., Rosas, Ivan O., Saggar, Rajan, Steen, Virginia D., Strek, Mary E., Bernstein, Elana J., Bhatt, Nitin, Castelino, Flavia V., Chung, Lorinda, Domsic, Robyn T., Flaherty, Kevin R., Gupta, Nishant, Kahaleh, Bashar, Martinez, Fernando J., Morrow, Lee E., Moua, Teng, Patel, Nina, Shlobin, Oksana A., Southern, Brian D., Volkmann, Elizabeth R., and Khanna, Dinesh

Abstract

Additional file 1. Table S1. SSc-ILD Delphi Questionnaire 3 results. Table S2. SSc-ILD Delphi Supplemental Questionnaire 2 results

Published
2023
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19. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

Author

Wolfe, Cameron R, primary, Tomashek, Kay M, additional, Patterson, Thomas F, additional, Gomez, Carlos A, additional, Marconi, Vincent C, additional, Jain, Mamta K, additional, Yang, Otto O, additional, Paules, Catharine I, additional, Palacios, Guillermo M Ruiz, additional, Grossberg, Robert, additional, Harkins, Michelle S, additional, Mularski, Richard A, additional, Erdmann, Nathaniel, additional, Sandkovsky, Uriel, additional, Almasri, Eyad, additional, Pineda, Justino Regalado, additional, Dretler, Alexandra W, additional, de Castilla, Diego Lopez, additional, Branche, Angela R, additional, Park, Pauline K, additional, Mehta, Aneesh K, additional, Short, William R, additional, McLellan, Susan L F, additional, Kline, Susan, additional, Iovine, Nicole M, additional, El Sahly, Hana M, additional, Doernberg, Sarah B, additional, Oh, Myoung-don, additional, Huprikar, Nikhil, additional, Hohmann, Elizabeth, additional, Kelley, Colleen F, additional, Holodniy, Mark, additional, Kim, Eu Suk, additional, Sweeney, Daniel A, additional, Finberg, Robert W, additional, Grimes, Kevin A, additional, Maves, Ryan C, additional, Ko, Emily R, additional, Engemann, John J, additional, Taylor, Barbara S, additional, Ponce, Philip O, additional, Larson, LuAnn, additional, Melendez, Dante Paolo, additional, Seibert, Allan M, additional, Rouphael, Nadine G, additional, Strebe, Joslyn, additional, Clark, Jesse L, additional, Julian, Kathleen G, additional, de Leon, Alfredo Ponce, additional, Cardoso, Anabela, additional, de Bono, Stephanie, additional, Atmar, Robert L, additional, Ganesan, Anuradha, additional, Ferreira, Jennifer L, additional, Green, Michelle, additional, Makowski, Mat, additional, Bonnett, Tyler, additional, Beresnev, Tatiana, additional, Ghazaryan, Varduhi, additional, Dempsey, Walla, additional, Nayak, Seema U, additional, Dodd, Lori E, additional, Beigel, John H, additional, Kalil, Andre C, additional, Wahid, Lana, additional, Walter, Emmanuel B., additional, Belur, Akhila G., additional, Dreyer, Grace, additional, Patterson, Jan E., additional, Bowling, Jason E., additional, Dixon, Danielle O., additional, Hewlett, Angela, additional, Odrobina, Robert, additional, Pupaibool, Jakrapun, additional, Mocherla, Satish, additional, Lazarte, Suzana, additional, Cayabyab, Meilani, additional, Hussein, Rezhan H., additional, Golamari, Reshma R., additional, Krill, Kaleigh L., additional, Rajme, Sandra, additional, Riska, Paul F., additional, Zingman, Barry S., additional, Mertz, Gregory, additional, Sosa, Nestor, additional, Goepfert, Paul A., additional, Berhe, Mezgebe, additional, Dishner, Emma, additional, Fayed, Mohamed, additional, Hubel, Kinsley, additional, Martinez-Orozco, José Arturo, additional, Bautista Felix, Nora, additional, Elmor, Sammy T., additional, Bechnak, Amer Ryan, additional, Saklawi, Youssef, additional, Van Winkle, Jason W., additional, Zea, Diego F., additional, Laguio-Vila, Maryrose, additional, Walsh, Edward E., additional, Falsey, Ann R., additional, Carvajal, Karen, additional, Hyzy, Robert C., additional, Hanna, Sinan, additional, Olbrich, Norman, additional, Traenkner, Jessica J., additional, Kraft, Colleen S., additional, Tebas, Pablo, additional, Baron, Jillian T, additional, Levine, Corri, additional, Nock, Joy, additional, Billings, Joanne, additional, Kim, Hyun, additional, Elie-Turenne, Marie-Carmelle, additional, Whitaker, Jennifer A., additional, Luetkemeyer, Anne F., additional, Dwyer, Jay, additional, Bainbridge, Emma, additional, Gyun Choe, Pyoeng, additional, Kyung Kang, Chang, additional, Jilg, Nikolaus, additional, Cantos, Valeria D, additional, Bhamidipati, Divya R., additional, Nithin Gopalsamy, Srinivasa, additional, Chary, Aarthi, additional, Jung, Jongtak, additional, Song, Kyoung-Ho, additional, Kim, Hong Bin, additional, Benson, Constance A., additional, McConnell, Kimberly, additional, Wang, Jennifer P., additional, Wessolossky, Mireya, additional, Perez, Katherine, additional, Eubank, Taryn A, additional, Berjohn, Catherine, additional, Utz, Gregory C., additional, Jackson, Patrick E.H., additional, Bell, Taison D., additional, Haughey, Heather M., additional, Moanna, Abeer, additional, Cribbs, Sushma, additional, Harrison, Telisha, additional, Colombo, Christopher J., additional, Schofield, Christina, additional, Colombo, Rhonda E., additional, Tapson, Victor F., additional, Grein, Jonathan, additional, Sutterwala, Fayyaz, additional, Ince, Dilek, additional, Winokur, Patricia L., additional, Fung, Monica, additional, Jang, Hannah, additional, Wyles, David, additional, Frank, Maria G., additional, Sarcone, Ellen, additional, Neumann, Henry, additional, Viswanathan, Anand, additional, Hochman, Sarah, additional, Mulligan, Mark, additional, Eckhardt, Benjamin, additional, Carmody, Ellie, additional, Ahuja, Neera, additional, Nadeau, Kari, additional, Svec, David, additional, Macaraeg, Jeffrey C., additional, Morrow, Lee, additional, Quimby, Dave, additional, Bessesen, Mary, additional, Nicholson, Lindsay, additional, Adams, Jill, additional, Kumar, Princy, additional, Lambert, Allison A., additional, Arguinchona, Henry, additional, Alicic, Radica Z., additional, Saito, Sho, additional, Ohmagari, Norio, additional, Mikami, Ayako, additional, Chien Lye, David, additional, Hong Lee, Tau, additional, Ying Chia, Po, additional, Hsieh, Lanny, additional, Amin, Alpesh N., additional, Watanabe, Miki, additional, Candiotti, Keith A., additional, Castro, Jose G., additional, Antor, Maria A., additional, Lee, Tida, additional, Lalani, Tahaniyat, additional, Novak, Richard M., additional, Wendrow, Andrea, additional, Borgetti, Scott A., additional, George, Sarah L., additional, Hoft, Daniel F., additional, Brien, James D., additional, Cohen, Stuart H., additional, Thompson, George R., additional, Chakrabarty, Melony, additional, Guirgis, Faheem, additional, Davey, Richard T., additional, Voell, Jocelyn, additional, Strich, Jeffrey R., additional, Lindholm, David A., additional, Mende, Katrin, additional, Wellington, Trevor R., additional, Rapaka, Rekha R., additional, Husson, Jennifer S., additional, Levine, Andrea R., additional, Yen Tan, Seow, additional, Shafi, Humaira, additional, Chien, Jaime M F, additional, Hostler, David C., additional, Hostler, Jordanna M., additional, Shahan, Brian T., additional, Adams, David H., additional, Osinusi, Anu, additional, Cao, Huyen, additional, Burgess, Timothy H., additional, Rozman, Julia, additional, Chung, Kevin K., additional, Nieuwoudt, Christina, additional, El-Khorazaty, Jill A., additional, Hill, Heather, additional, Pettibone, Stephanie, additional, Gettinger, Nikki, additional, Engel, Theresa, additional, Lewis, Teri, additional, Wang, Jing, additional, Deye, Gregory A., additional, Nomicos, Effie, additional, Pikaart-Tautges, Rhonda, additional, Elsafy, Mohamed, additional, Jurao, Robert, additional, Koo, Hyung, additional, Proschan, Michael, additional, Yokum, Tammy, additional, Arega, Janice, additional, and Florese, Ruth, additional

Published
2022
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21. A Retrospective Analysis of the Effects of Time on Compliance and Driving Pressures in ARDS

Author

Jagan, Nikhil, primary, Morrow, Lee E, additional, Walters, Ryan W, additional, Plambeck, Robert W, additional, Ng, Ian, additional, Chovatiya, Jasmin J, additional, Macaraeg, Jeffrey C, additional, Kalian, Karson F, additional, Wittenberg, Zachariah L, additional, Pruett, William M, additional, Knedler, Jonathan, additional, Klein, Lauren P, additional, Kasinath, Pooja, additional, Dyer, Emily D, additional, Bergh, Adam A, additional, and Malesker, Mark A, additional

Published
2022
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24. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies

Author

Melsen, Wilhelmina G, Rovers, Maroeska M, Groenwold, Rolf HH, Bergmans, Dennis CJJ, Camus, Christophe, Bauer, Torsten T, Hanisch, Ernst W, Klarin, Bengt, Koeman, Mirelle, Krueger, Wolfgang A, Lacherade, Jean-Claude, Lorente, Leonardo, Memish, Ziad A, Morrow, Lee E, Nardi, Giuseppe, van Nieuwenhoven, Christianne A, O'Keefe, Grant E, Nakos, George, Scannapieco, Frank A, Seguin, Philippe, Staudinger, Thomas, Topeli, Arzu, Ferrer, Miquel, and Bonten, Marc JM

Published
2013
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29. Contributors

Author

Abdolghaffari, Amir Hossein, primary, Abdollahi, Mohammad, additional, Ahanchian, Hamid, additional, Ahmad, Farah N., additional, Akbarzadeh, Fariborz, additional, Alighieri, Giovanni, additional, Amini, Amir, additional, Anadón, Arturo, additional, Anania, Caterina, additional, Annibale, Bruno, additional, Arena, Mattia Pia, additional, Arena, Angela, additional, Arés, Irma, additional, Argyri, Anthoula A., additional, Aslim, Belma, additional, Aydaş, Selcen Babaoğlu, additional, Azimi, Amirreza, additional, Ballesteros, Antonio O., additional, Barbosa, Joana, additional, Bastani, Parvin, additional, Bedani, Raquel, additional, Betta, Pasqua, additional, Biglu, Mohammad-Hossein, additional, Borges, Sandra, additional, Bucci, C., additional, Buriti, Flávia C.A., additional, Camacho-Ruiz, R.M., additional, Capozzi, Vittorio, additional, Catenazzi, Piero, additional, Celani, Camilla, additional, Chaluvadi, Saikiran, additional, Champagne, Claude P., additional, Chiesa, Claudio, additional, Clark, Eva H., additional, Collier, Robert J., additional, Colombo, Jacopo, additional, de Moreno de LeBlanc, Alejandra, additional, de Morais, Elisa Carvalho, additional, Dekker, M., additional, Di Venere, D., additional, Drago, Lorenzo, additional, Farnworth, Edward R., additional, Feleszko, Wojciech, additional, Fernandez-Arrojo, Lucia, additional, Fernández-López, J., additional, Finamore, Alberto, additional, Fiocco, Daniela, additional, Gatesoupe, F.J., additional, Ghasemi-Niri, Farnaz, additional, Giacchi, Valentina, additional, Golkhalkhali, Babak, additional, Gomez-Zavaglia, A., additional, Gooshe, Maziar, additional, Gundogdu, Zuhal, additional, Hanning, Irene, additional, Hashemi, Seyed Mohammad Bagher, additional, Hemalatha, Rajkumar, additional, Homayouni, Aziz, additional, Hotchkiss, Arland T., additional, Iovino, P., additional, Saad, Susana Marta Isay, additional, Jafarabadi, Mohammad Asghari, additional, Jafari, Seyed Ali, additional, Jamaluddin, Rosita, additional, Jeong, Ji-Kang, additional, Jirillo, Felicita, additional, Jirillo, Emilio, additional, Jones, Rheinallt M., additional, Kaur, Baljinder, additional, Kaur, Gaganjot, additional, Keshtiban, Ata K., additional, Khalili, Mohammad, additional, Khalili, Leyla, additional, Khalili, Leila, additional, Kirmiz, Nina, additional, Kumar, Manoj, additional, Lahner, Edith, additional, Lavermicocca, P., additional, LeBlanc, Jean Guy, additional, Likotrafiti, Eleni, additional, Lim, Ying-Jye, additional, Lingbeck, Jody, additional, López, Paloma, additional, Mohedano, Mª Luz, additional, Magrone, Thea, additional, Mahdavi, Reza, additional, Maleki, Davood, additional, Mallah, Fatemeh, additional, Marathe, Shreesh J., additional, Marotta, Francesco, additional, Martínez, María Aránzazu, additional, Martinez-Augustin, O., additional, Martínez-Larrañaga, María Rosa, additional, Mehrabany, Elnaz Vaghef, additional, Mills, David A., additional, Stover, Mitchel Graham, additional, Mobili, P., additional, Mohammad, Diya, additional, Mohammad-Alizadeh-Charandabi, Sakineh, additional, Redzwan, S. Mohd, additional, Monedero, Vicente, additional, Moreno Villares, Jose M., additional, Moreno-Vilet, L., additional, Morrow, Lee E., additional, Motoori, Masaaki, additional, Murthy, Jayasimha N., additional, Nácher-Vázquez, Montserrat, additional, Nagpal, Ravinder, additional, Nielsen, Dennis Sandris, additional, Nikniaz, Hossein, additional, Nikniaz, Leila, additional, Nikniaz, Zeinab, additional, Notararigo, Sara, additional, Nunes, Vânia dos Santos, additional, Orel, Rok, additional, Osman, Ali, additional, Ouwehand, Arthur C., additional, Pacifico, Lucia, additional, Panagou, Efstathios Z., additional, Park, Kun-Young, additional, Payahoo, Laleh, additional, Peluso, Ilaria, additional, Pérez-Alvarez, J.A., additional, Pérez-Ramos, Adrian, additional, Plou, Francisco J., additional, Poorbaghi, Seyedeh Leila, additional, Portales-Pérez, D.P., additional, Quigley, Eamonn M.M., additional, Ranjbar, Fatemeh, additional, Reberšak, Lea Vodušek, additional, Rhoades, Jonathan, additional, Ricke, Steven C., additional, Rodriguez-Colinas, Barbara, additional, Rodríguez-Díaz, Jesús, additional, Romano, N., additional, Russo, Pasquale, additional, Russo, F., additional, Ruszczyński, Marek, additional, Saad, Susana M.I., additional, de Medina, F. Sánchez, additional, Santonicola, A., additional, Sayas-Barberá, M.E., additional, Sciacca, Pietro, additional, Scorrano, Antonio, additional, Sendra, E., additional, Sepehrimanesh, Masood, additional, Serafini, Mauro, additional, Shek, Lynette Pei-Chi, additional, Shokrvash, Behjat, additional, Sisto, A., additional, Sivieri, Katia, additional, Skalkam, Maria Lena, additional, Soh, Shu-E, additional, Spano, Giuseppe, additional, Sugimura, Keijiro, additional, Tanaka, Koji, additional, Tassou, Chrysoula C., additional, Teixeira, Paula, additional, Tennilä, Julia, additional, Toscano, Marco, additional, Tripathi, Alok S., additional, Tymczyszyn, E., additional, Valerio, F., additional, van Zanten, Gabriella, additional, Villas Boas, Paulo José Fortes, additional, Wachholz, Patrick Alexander, additional, Watson, Ronald Ross, additional, Wiese, Maria, additional, Yadav, Hariom, additional, Yam, Kit L., additional, Yano, Masahiko, additional, Zeng, Hongliang, additional, Zhang, Yi, additional, Zheng, Baodong, additional, Ziyadi, Somayeh, additional, and Zuppa, Antonio Alberto, additional

Published
2016
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32. A Retrospective Analysis of the Effects of Time on Compliance and Driving Pressures in ARDS.

Author

Jagan, Nikhil, Morrow, Lee E., Walters, Ryan W., Plambeck, Robert W., Ng, Ian, Chovatiya, Jasmin J., Macaraeg, Jeffrey C., Kalian, Karson F., Wittenberg, Zachariah L., Pruett, William M., Knedler, Jonathan, Klein, Lauren P., Kasinath, Pooja, Dyer, Emily D., Bergh, Adam A., and Malesker, Mark A.

Subjects
ADULT respiratory distress syndrome treatment, HOSPITALS, RURAL hospitals, LENGTH of stay in hospitals, COVID-19, NASAL cannula, ACADEMIC medical centers, CONFIDENCE intervals, TIME, AIRWAY (Anatomy), MECHANICAL ventilators, POSITIVE end-expiratory pressure, LOG-rank test, OPERATIVE surgery, TREATMENT duration, RESPIRATORY measurements, LUNG physiology, RETROSPECTIVE studies, SUBURBS, COMMUNITY health services, PATIENTS, MANN Whitney U Test, TREATMENT effectiveness, ARTIFICIAL respiration, COMPARATIVE studies, T-test (Statistics), ADULT respiratory distress syndrome, HOSPITAL mortality, RESPIRATORY therapy, DESCRIPTIVE statistics, QUESTIONNAIRES, KAPLAN-Meier estimator, COMBINED modality therapy, DATA analysis software, LONGITUDINAL method, PROPORTIONAL hazards models, EVALUATION
Abstract

BACKGROUND: The evolution of compliance and driving pressure in ARDS and the effects of time spent on noninvasive respiratory support prior to intubation have not been well studied. We conducted this study to assess the effect of the duration of noninvasive respiratory support prior to intubation (ie, noninvasive ventilation [NIV], high-flow nasal cannula [HFNC], or a combination of NIV and HFNC) on static compliance and driving pressure and retrospectively describe its trajectory over time for COVID-19 and non--COVID-19 ARDS while on mechanical ventilation. METHODS: This is a retrospective analysis of prospectively collected data from one university-affiliated academic medical center, one rural magnet hospital, and 3 suburban community facilities. A total of 589 subjects were included: 55 COVID-19 positive, 137 culture positive, and 397 culture-negative subjects. Static compliance and driving pressure were calculated at each 8-h subject-ventilator assessment. RESULTS: Days of pre-intubation noninvasive respiratory support were associated with worse compliance and driving pressure but did not moderate any trajectory. COVID-19--positive subjects showed non-statistically significant worsening compliance by 0.08 units per subject-ventilator assessment (P 5 .24), whereas COVID-19--negative subjects who were either culture positive or negative showed statistically significant improvement (0.12 and 0.18, respectively; both P < .05); a statistically similar but inverse pattern was observed for driving pressure. CONCLUSIONS: In contrast to non--COVID-19 ARDS, COVID-19 ARDS was associated with a more ominous trajectory with no improvement in static compliance or driving pressures. Though there was no association between days of pre-intubation noninvasive respiratory support and mortality, its use was associated with worse overall compliance and driving pressure. [ABSTRACT FROM AUTHOR]

Published
2023
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33. A Retrospective Analysis of the Effects of TIME on Compliance and Driving Pressures in Acute Respiratory Distress Syndrome: The TIMED Study

Author

Jagan, Nikhil, primary, Morrow, Lee, additional, Walters, Ryan, additional, Plambeck, Robert, additional, Ng, Ian, additional, Chovatiya, Jasmin, additional, Macaraeg, Jeffrey, additional, Kalian, Karson, additional, Wittenberg, Zachariah, additional, Pruett, William, additional, Knedler, Jonathan, additional, Klein, Lauren, additional, Kasinath, Pooja, additional, Dyer, Emily, additional, Bergh, Adam, additional, and Malesker, Mark, additional

Published
2021
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35. POINT-OF-CARE ULTRASOUND: TO CLEAN OR NOT TO CLEAN

Author

Lambrecht, Jason, primary, Narechania, Shraddha, additional, Morrow, Lee, additional, Sheridan, Nicholas, additional, Graumann, Evan, additional, Millner, Paul, additional, DeVrieze, Brad, additional, Cavalieri, Stephen, additional, and Walters, Ryan, additional

Published
2021
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41. Additional file 2 of Sympathetic stimulation increases serum lactate concentrations in patients admitted with sepsis: implications for resuscitation strategies

Author

Jagan, Nikhil, Morrow, Lee E., Walters, Ryan W., Plambeck, Robert W., Tej M. Patel, Moore, Douglas R., and Malesker, Mark A.

Abstract

Additional file 2:Table S1. Serum lactate level: Final model results using continuous mean arterial pressure and heart rate using the entire cohort (used to create manuscript Fig. 2).

Published
2021
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43. Sepsis, the Administration of IV Fluids, and Respiratory Failure

Author

Jagan, Nikhil, primary, Morrow, Lee E., additional, Walters, Ryan W., additional, Plambeck, Robert W., additional, Patel, Tej M., additional, Kalian, Karson F., additional, Macaraeg, Jeffrey C., additional, Dyer, Emily D., additional, Bergh, Adam A., additional, Fried, Aaron J., additional, Moore, Douglas R., additional, and Malesker, Mark A., additional

Published
2021
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44. Supplememt_material - Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study

Author

Smischney, Nathan J., Khanna, Ashish K., Brauer, Ernesto, Morrow, Lee E., Uchenna R. Ofoma, Kaufman, David A., Sen, Ayan, Chakradhar Venkata, Morris, Peter, and Bansal, Vikas

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, education, 111702 Aged Health Care, FOS: Health sciences, 110305 Emergency Medicine, humanities
Abstract

Supplememt_material for Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study by Nathan J. Smischney, Ashish K. Khanna, Ernesto Brauer, Lee E. Morrow, Uchenna R. Ofoma, David A. Kaufman, Ayan Sen, Chakradhar Venkata, Peter Morris, Vikas Bansal and On behalf of SCCM Discovery (Critical Care Research Network of Critical Care Medicine) HEMAIR Investigators in Journal of Intensive Care Medicine

Published
2020
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46. Contributors

Author

Agosti, Jan, primary, Alter, Miriam J., additional, Anaya, Daniel A., additional, Ansdell, Vernon, additional, Babineaux, Michael James, additional, Bartlett, John G., additional, Bash, Margaret C., additional, Beach, Michael J., additional, Becker, Natasha S., additional, Blue, Sky R., additional, Blumberg, Dean A., additional, Bower, John R., additional, Bryant, Amy E., additional, Campbell, Grant L., additional, Chow, Anthony W., additional, Coffman, Thomas J., additional, Cohen, Stephanie E., additional, Congeni, Blaise L., additional, Coyle, Christina M., additional, Dhanireddy, Shireesha, additional, Drekonja, Dimitri M., additional, Dunne, Eileen F., additional, Engelman, Joseph, additional, Fischer, Marc, additional, Froom, Paul, additional, Garcia, Hector H., additional, Geisler, William M., additional, Gershman, Mark D., additional, Haditsch, Martin, additional, Hull, Christopher M., additional, Huppert, Jill S., additional, Isturiz, Raul E., additional, Johnson, James R., additional, Johnson, Katherine J., additional, Kauffman, Carol A., additional, Kesson, Alison Margaret, additional, Klausner, Jeffrey D., additional, Kollef, Marin H., additional, Kriesel, John D., additional, Kunz, Anjali N., additional, Kurrus, Thomas A., additional, Machado, Fabiana Simão, additional, MacPherson, Douglas William, additional, Marano, Nina, additional, Marcy, S. Michael, additional, Meade, Bruce D., additional, Meade, Kristin E., additional, Morris, Arden M., additional, Morrow, Lee E., additional, Moser, Benjamin D., additional, Moss, Nicholas J., additional, Newman, Lori Marie, additional, Nguyen, Thao U., additional, Park, James O., additional, Partridge, Susan, additional, Pottinger, Paul S., additional, Pratt, R. Douglas, additional, Raugi, Gregory, additional, Robertson, Kis, additional, Sanford, Christopher, additional, Sawyer, Robert G., additional, Schneider, Eileen, additional, Sejvar, James J., additional, Sethi, Sanjay, additional, Shadomy, Sean V., additional, Shimoni, Zvi, additional, Smith, Theresa L., additional, Spitters, Christopher Edward, additional, Spitzer, Austin L., additional, Staples, J. Erin, additional, Steele, Russell W., additional, Tan, Michael J., additional, Tanowitz, Herbert B., additional, Täuber, Martin G., additional, Toney, John F., additional, Tsai, Theodore F., additional, Tulloch, Luis G., additional, Vasser, Heather M., additional, Visvesvara, Govinda S., additional, Wald, Anna, additional, Watson, Christopher M., additional, Wolf, Patrick S., additional, Wolfe, Martin S., additional, Woodward, Joseph F., additional, Workowski, Kimberly, additional, Wyatt, Casi M., additional, Yeh, Sylvia H., additional, and Yoder, Jonathan S., additional

Published
2012
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