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9. Cover

Author

Morrow, John H., Jr. and Rogers, Earl

Published
2015

10. Preface

Author

Morrow, John H., Jr. and Rogers, Earl

Published
2015

12. Introduction

Author

Morrow, John H., Jr. and Rogers, Earl

Published
2015

25. Back Cover

Author

Morrow, John H., Jr. and Rogers, Earl

Published
2015

27. Cover

Author

Morrow, John H.

Published
2009

29. Index

Author

Morrow, John H.

Published
2009

34. Notes

Author

Morrow, John H.

Published
2009

41. Preface

Author

Morrow, John H.

Published
2009

42. From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.

Author

Visser, Emira, Jaishankar, Priyadarshini, Sijbesma, Eline, Pennings, Marloes, Vandenboorn, Edmee, Guillory, Xavier, Neitz, R, Morrow, John, Dutta, Shubhankar, Renslo, Adam, Brunsveld, Luc, Arkin, Michelle, and Ottmann, Christian

Subjects
Drug Discovery, Fragment Linking, Fragment-Based Drug Discovery, Molecular Glues, Proteins, 14-3-3 Proteins, Estrogen Receptor alpha, Protein Binding, Drug Discovery
Abstract

Small-molecule stabilization of protein-protein interactions (PPIs) is a promising strategy in chemical biology and drug discovery. However, the systematic discovery of PPI stabilizers remains a largely unmet challenge. Herein we report a fragment-linking approach targeting the interface of 14-3-3 and a peptide derived from the estrogen receptor alpha (ERα) protein. Two classes of fragments-a covalent and a noncovalent fragment-were co-crystallized and subsequently linked, resulting in a noncovalent hybrid molecule in which the original fragment interactions were largely conserved. Supported by 20 crystal structures, this initial hybrid molecule was further optimized, resulting in selective, 25-fold stabilization of the 14-3-3/ERα interaction. The high-resolution structures of both the single fragments, their co-crystal structures and those of the linked fragments document a feasible strategy to develop orthosteric PPI stabilizers by linking to an initial tethered fragment.

Published
2023

45. Measuring a Robot Hand's Graspable Region using Power and Precision Grasps

Author

Morrow, John, Campbell, Joshua, Nishat, Nuha, Balasubramanian, Ravi, and Grimm, Cindy

Subjects
Computer Science - Robotics
Abstract

The variety of robotic hand designs and actuation schemes makes it difficult to measure a hand's graspable volume. For end-users, this lack of standardized measurements makes it challenging to determine a priori if a robot hand is the right size for grasping an object. We propose a practical hand measurement standard, based on precision and power grasps, that is applicable to a wide variety of robot hand designs. The resulting measurements can be used to both determine if an object will fit in the hand and characterize the size of an object with respect to the hand. Our measurement procedure uses a functional approach, based on grasping a hypothetical cylinder, that allows the measurer choose the exact hand orientation and finger configurations that are used for the measurements. This ensures that the measurements are functionally comparable while relying on the human to determine the finger configurations that best match the intended grasp. We demonstrate using our measurement standard with three commercial robot hand designs and objects from the YCB data set., Comment: Significantly changed second version of arXiv:2106.10402. Paper originally submitted to Robotics Automation Letters

Published
2022

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