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613 results on '"Morrison, Katherine M"'

5. Definition and diagnostic criteria of clinical obesity

Author

Rubino, Francesco, Cummings, David E, Eckel, Robert H, Cohen, Ricardo V, Wilding, John P H, Brown, Wendy A, Stanford, Fatima Cody, Batterham, Rachel L, Farooqi, I Sadaf, Farpour-Lambert, Nathalie J, le Roux, Carel W, Sattar, Naveed, Baur, Louise A, Morrison, Katherine M, Misra, Anoop, Kadowaki, Takashi, Tham, Kwang Wei, Sumithran, Priya, Garvey, W Timothy, Kirwan, John P, Fernández-Real, José-Manuel, Corkey, Barbara E, Toplak, Hermann, Kokkinos, Alexander, Kushner, Robert F, Branca, Francesco, Valabhji, Jonathan, Blüher, Matthias, Bornstein, Stefan R, Grill, Harvey J, Ravussin, Eric, Gregg, Edward, Al Busaidi, Noor B, Alfaris, Nasreen F, Al Ozairi, Ebaa, Carlsson, Lena M S, Clément, Karine, Després, Jean-Pierre, Dixon, John B, Galea, Gauden, Kaplan, Lee M, Laferrère, Blandine, Laville, Martine, Lim, Soo, Luna Fuentes, Jesús R, Mooney, Vicki M, Nadglowski, Joseph, Jr, Urudinachi, Agbo, Olszanecka-Glinianowicz, Magdalena, Pan, An, Pattou, Francois, Schauer, Philip R, Tschöp, Matthias H, van der Merwe, Maria T, Vettor, Roberto, and Mingrone, Geltrude

Published
2025
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6. Prenatal PFAS exposures and cardiometabolic health in middle childhood in the MIREC cohort

Author

Fossa, Alan J., Hall, Amber M., Papandonatos, George D., Arbuckle, Tye E., Ashley-Martin, Jillian, Borghese, Michael M., Bruin, Jenny, Chen, Aimin, Fisher, Mandy, Krzeczkowski, John E., Lanphear, Bruce P., MacFarlane, Amanda J., Manz, Katherine E., Morrison, Katherine M., Oulhote, Youssef, Palaniyandi, Jana, Palmert, Mark R., Pennell, Kurt D., Vuong, Ann M., Walker, Douglas I., Weiler, Hope A., and Braun, Joseph M.

Published
2025
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13. Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis

Author

Azab, Sandi M, Shanmuganathan, Meera, de Souza, Russell J, Kroezen, Zachary, Desai, Dipika, Williams, Natalie C, Morrison, Katherine M, Atkinson, Stephanie A, Teo, Koon K, Azad, Meghan B, Simons, Elinor, Moraes, Theo J, Mandhane, Piush J, Turvey, Stuart E, Subbarao, Padmaja, Britz-McKibbin, Philip, and Anand, Sonia S

Published
2023
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20. Individual and family characteristics associated with health indicators at entry into multidisciplinary pediatric weight management: findings from the CANadian Pediatric Weight management Registry (CANPWR)

Author

McPhee, Patrick G., Zenlea, Ian, Hamilton, Jill K., Ho, Josephine, Ball, Geoff D. C., Mian, Rajibul, Buchholz, Annick, Laberge, Anne-Marie, Legault, Laurent, Tremblay, Mark S., Chanoine, Jean-Pierre, Thabane, Lehana, and Morrison, Katherine M.

Published
2022
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26. Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

Author

Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., and Morrison, Katherine M.

Published
2021
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27. Effectiveness of pharmacological interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline

Author

Wahi, Gita, St‐Pierre, Julie, Johnston, Bradley C., Fitzpatrick‐Lewis, Donna, Usman, Ali, Sherifali, Diana, Merdad, Roah, Esmaeilinezhad, Zahra, Birken, Catherine S., Hamilton, Jill, Henderson, Mélanie, Moore, Sarah A., Ball, Geoff D. C., Morrison, Katherine M., Buchholz, Annick, Cantwell, Jennifer, Cooper, Jenny, Erdstein, Julius, Hadjiyannakis, Stasia, and Hatanaka, Dawn

Subjects
METFORMIN, GLUCAGON-like peptide-1 agonists, MEDICAL information storage & retrieval systems, BODY mass index, PATIENT safety, RESEARCH funding, META-analysis, CARDIOVASCULAR diseases risk factors, HYPOGLYCEMIC agents, LDL cholesterol, SYSTEMATIC reviews, INSULIN resistance, MEDLINE, ANTIOBESITY agents, DRUG efficacy, MEDICAL databases, CHILDHOOD obesity, HEALTH outcome assessment, ANTHROPOMETRY, TRIGLYCERIDES, PHARMACODYNAMICS
Abstract

Summary: Objective: To summarize the literature on pharmacotherapy for managing paediatric obesity. Methods: A systematic review and meta‐analysis were conducted of randomized controlled trials (RCTs) with <18‐year‐olds of pharmacotherapeutic agents published up to November 2022. Estimates of effect for outcomes were presented relative to minimal important differences and GRADE certainty of evidence. We examined data on patient/proxy‐reported outcome measures (PROMs), cardiometabolic risk factors, anthropometry and adverse events (AEs). Results: Overall, 35 RCTs were included. Trials examined metformin (n = 26), glucagon‐like peptide‐1 receptor agonists (GLP1RAs) (n = 7) and a lipase inhibitor (orlistat; n = 2). Intervention duration varied (3−24 months). Metformin had little to no benefit on PROMs (e.g., health‐related quality of life [HRQoL]; 6 RCTs), moderate reductions in triglycerides, a moderate decline in insulin resistance, a small to moderate decline in BMI z‐score (BMIz) and a moderate increase in mild to moderate gastrointestinal AEs. Response to GLP1RAs was heterogeneous and results of subgroup analysis demonstrated variability of impact. Liraglutide (2 RCTs) resulted in a small reduction in HOMA‐IR and BMIz, but little to no benefit on other outcomes. Exenatide (4 RCTs) had a moderate reduction on blood pressure and a small decrease in BMIz with little to no benefit on other outcomes. Semaglutide (1 RCT) had a small benefit on HRQoL, a small reduction on SBP, a moderate reduction on total cholesterol and LDL‐cholesterol, a large reduction on triglyceride, and a very large decline in BMIz accompanied by a small increase in mild to moderate gastrointestinal AEs. Orlistat had a moderate reduction in DBP and little to no benefit in other outcomes measured, but had a very large increased risk of mild to moderate gastrointestinal AEs. Serious AEs were rare and for interventions with sufficent AE reporting, were considered not likely attributable to the interventions. Conclusion: Few studies examined the impact of pharmacotherapy on PROMs. There is evidence that metformin and GLP1RAs lead to important improvements in cardiometabolic and anthropometric outcomes while accompanied by mild to moderate AEs. Long‐term effectiveness and safety of GLP1RAs remain to be evaluated. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Effectiveness of surgical interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline.

Author

Oei, Krista, Johnston, Bradley C., Ball, Geoff D. C., Fitzpatrick‐Lewis, Donna, Usman, Ali, Sherifali, Diana, Esmaeilinezhad, Zahra, Merdad, Roah, Dettmer, Elizabeth, Erdstein, Julius, Langer, Jacob C., Birken, Catherine, Henderson, Mélanie, Moore, Sarah A., Morrison, Katherine M., Hamilton, Jill, Buchholz, Annick, Cantwell, Jennifer, Cooper, Jenny, and Hadjiyannakis, Stasia

Subjects
BARIATRIC surgery, MEDICAL protocols, MEDICAL information storage & retrieval systems, BODY mass index, RESEARCH funding, TREATMENT effectiveness, CARDIOVASCULAR diseases risk factors, META-analysis, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, MEDICAL databases, QUALITY of life, CHILDHOOD obesity, HEALTH outcome assessment, ANTHROPOMETRY, ADOLESCENCE, CHILDREN
Abstract

Summary: Objective: To summarize the literature on bariatric surgery for managing pediatric obesity, including intervention effects to improve patient‐reported outcome measures (PROMs), cardiometabolic risk factors, anthropometry, and assess adverse events (AEs). Methods: Eligible studies were published between January 2012 and January 2022 and included randomized controlled trials (RCTs) and observational (controlled and uncontrolled) studies before and after surgery with a mean age <18 years old. Outcomes and subgroups were selected a priori by stakeholders; estimates of effect for outcomes were presented relative to minimal important differences (MIDs) and GRADE certainty of evidence. We examined data on PROMs, cardiometabolic risk factors, anthropometry, and AEs. Subgroup analyses examined outcomes by follow‐up duration and surgical technique, when possible. Results: Overall, 63 publications (43 original studies) met our inclusion criteria (n = 6128 participants; 66% female). Studies reported six different surgical techniques that were evaluated using uncontrolled single arm observational (n = 49), controlled observational (n = 13), and RCT (n = 1) designs. Most studies included short‐term follow‐up (<18 months) only. PROMs were measured in 12 (28%) studies. Surgery led to large improvements in health‐related quality of life compared to baseline and control groups, and moderate to very large improvements in cardiometabolic risk factors compared to baseline. Large to very large improvements in BMIz were noted compared to baseline across all follow‐up periods. There was limited evidence of AEs with most reporting mild or non‐specific AEs; serious AEs were uncommon. Conclusion: Bariatric surgery demonstrated primarily moderate to very large improvements across diverse outcomes with limited evidence of AEs, albeit with low to moderate certainty of evidence. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Exploring the complexities of weight management care for children with spina bifida: a qualitative study with children and parents

Author

Revalidatie Medisch Kinderen, Brain, Child Health, Giles, Madison L., Ball, Geoff D.C., Bonder, Revi, Buchholz, Annick, Gorter, Jan Willem, Morrison, Katherine M., Perez, Arnaldo, Walker, Meaghan, McPherson, Amy C., Revalidatie Medisch Kinderen, Brain, Child Health, Giles, Madison L., Ball, Geoff D.C., Bonder, Revi, Buchholz, Annick, Gorter, Jan Willem, Morrison, Katherine M., Perez, Arnaldo, Walker, Meaghan, and McPherson, Amy C.

Published
2024

34. Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

Author

Deng, Wei Q., primary, Cawte, Nathan, additional, Campbell, Natalie, additional, Azab, Sandi M., additional, de Souza, Russell J, additional, Lamri, Amel, additional, Morrison, Katherine M., additional, Atkinson, Stephanie A., additional, Subbarao, Padmaja, additional, Turvey, Stuart E., additional, Moraes, Theo J., additional, Teo, Koon K., additional, Mandhane, Piush, additional, Azad, Meghan B., additional, Simons, Elinor, additional, Pare, Guillaume, additional, and Anand, Sonia S., additional

Published
2024
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35. The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Author

Wang, Bo, Tsakiridis, Evangelia E., Zhang, Shuman, Llanos, Andrea, Desjardins, Eric M., Yabut, Julian M., Green, Alexander E., Day, Emily A., Smith, Brennan K., Lally, James S. V., Wu, Jianhan, Raphenya, Amogelang R., Srinivasan, Krishna A., McArthur, Andrew G., Kajimura, Shingo, Patel, Jagdish Suresh, Wade, Michael G., Morrison, Katherine M., Holloway, Alison C., and Steinberg, Gregory R.

Published
2021
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38. Exploring the complexities of weight management care for children with spina bifida: a qualitative study with children and parents.

Author

Giles, Madison L., Ball, Geoff D. C., Bonder, Revi, Buchholz, Annick, Gorter, Jan Willem, Morrison, Katherine M., Perez, Arnaldo, Walker, Meaghan, and McPherson, Amy C.

Subjects
HEALTH & psychology, SPINA bifida, RESEARCH funding, ACADEMIC medical centers, QUALITATIVE research, AUTONOMY (Psychology), REGULATION of body weight, BODY weight, HUMAN beings, INTERVIEWING, QUESTIONNAIRES, DESCRIPTIVE statistics, THEMATIC analysis, RESEARCH methodology, MEDICAL needs assessment, DATA analysis software, SOCIAL stigma
Abstract

1) To explore how children with spina bifida (SB) and their parents understand bodyweight, health and weight management; and 2) To identify what services and supports children with SB and their families feel are most appropriate to help them manage their health and weight. The study used interpretive description within a qualitative design. Participants were children with SB (aged 10-18) attending two Canadian SB clinics and their parents. Data were collected through individual interviews and analyzed using inductive thematic analysis. Five children and five parents participated in the study. Children and parents had a weight-centric approach to health, which was related to the child's mobility. Weight was considered to be under individual control and mostly through diet. Trusting relationships between healthcare providers, children and families were important to discuss weight in a non-judgemental manner. Children should be involved in setting meaningful and achievable weight management goals. Greater knowledge of how children with SB and their families understand weight and health offers opportunities for non-judgemental discussions about their needs and wishes. Helping families to place more value on health over weight may reduce feelings of stigma, while allowing children to develop some autonomy over health-related decisions. Children with spina bifida and their parents do not recognise the complexity of factors contributing to weight regulation. Weight regulation was often seen as the child's responsibility, which could lead to feelings of guilt and shame through internalised weight stigma Healthcare professionals working with children with spina bifida should explore their perceptions, beliefs, and behaviours related to weight, health and mobility to ensure they are not causing themselves physical and/or psychological harm [ABSTRACT FROM AUTHOR]

Published
2024
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40. Pathways to eating in children and adolescents with obesity

Author

Clairman, Hayyah, Dettmer, Elizabeth, Buchholz, Annick, Cordeiro, Kristina, Ibrahim, Quazi, Maximova, Katerina, Toulany, Alene, Taylor, Valerie H., Katzman, Debra K., Morrison, Katherine M., Hamilton, Jill, Ball, Geoff, Chanoine, Jean-Pierre, Ho, Josephine, Legault, Laurent, Mackie, Pam, Thabane, Lehana, and Zenlea, Ian

Published
2019
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42. Cohort profile update: The Canadian Maternal–Infant Research on Environmental Chemicals Child Development study (MIREC‐CD PLUS)

Author

Fisher, Mandy, primary, Muckle, Gina, additional, Lanphear, Bruce, additional, Arbuckle, Tye E., additional, Braun, Joseph M., additional, Zidek, Angelika, additional, Vélez, Maria P., additional, Lupien, Nicole, additional, Bastien, Stephanie, additional, Ashley‐Martin, Jillian, additional, Oulhote, Youssef, additional, Borghese, Michael M., additional, Walker, Mark, additional, Asztalos, Elizabeth, additional, Bouchard, Maryse F., additional, Booij, Linda, additional, Palmert, Mark R., additional, Morrison, Katherine M., additional, Cummings, Elizabeth A., additional, Khatchadourian, Karine, additional, Panagiotopoulos, Constadina, additional, Glendon, Gord, additional, Shutt, Robin, additional, Abdul‐Fatah, Ammanie, additional, Seal, Kelsey, additional, and Fraser, William D., additional

Published
2023
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47. The association of red and processed meat with gestational diabetes mellitus: Results from 2 Canadian birth cohort studies.

Author

Stennett, Rosain N., Gerstein, Hertzel C., Bangdiwala, Shrikant I., Rafiq, Talha, Teo, Koon K., Morrison, Katherine M., Atkinson, Stephanie A., Anand, Sonia S., and de Souza, Russell J.

Subjects
GESTATIONAL diabetes, COHORT analysis, MEAT, ODDS ratio, SOUTH Asians, PREGNANT women
Abstract

Objective: Red and processed meat is considered risk factors of gestational diabetes mellitus (GDM), but the evidence is inconclusive. We aimed to examine the association between red and processed meat intake and odds of GDM among South Asian and White European women living in Canada. Methods: This is a cross-sectional analysis of pregnant women from two birth cohorts: SouTh Asian biRth cohorT (START; n = 976) and Family Atherosclerosis Monitoring In earLY life (FAMILY; n = 581). Dietary intake was assessed using a validated 169-item semi-quantitative food-frequency questionnaire (FFQ). Multivariate logistic regression models were used to examine the associations between gestational diabetes and: 1) total red and processed meat; 2) unprocessed red meat; 3) processed meat and GDM after adjustment for potential confounders. Results: There were 241 GDM cases in START and 91 in FAMILY. The median total red and processed meat intake were 1.5 g/d (START) and 52.8 g/d (FAMILY). In START, the multivariable-adjusted odds ratio (OR) showed neither lower nor higher intakes of unprocessed red meat (p-trend = 0.68), processed meat (p-trend = 0.90), or total red and processed meat (p-trend = 0.44), were associated with increased odds of GDM, when compared with medium intake. Similar results were observed in FAMILY except for processed meat intake [OR = 0.94 (95% CI 0.47–1.91), for medium versus low and OR = 1.51 (95% CI 0.77–2.29) for medium versus high; p-trend = 0.18] after adjusting for additional dietary factors such as the diet quality score, total fiber, saturated fat and glycemic load. Conclusion: Medium compared with low or high red and processed meat intake is not associated with GDM in White Europeans and South Asians living in Canada. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

Author

Deng, Wei Q., primary, Cawte, Nathan, additional, Campbell, Natalie, additional, Azab, Sandi M., additional, de Souza, Russell J, additional, Lamri, Amel, additional, Morrison, Katherine M., additional, Atkinson, Stephanie A., additional, Subbarao, Padmaja, additional, Turvey, Stuart E., additional, Moraes, Theo J., additional, Teo, Koon K., additional, Mandhane, Piush, additional, Azad, Meghan B., additional, Simons, Elinor, additional, Pare, Guillaume, additional, and Anand, Sonia S., additional

Published
2023
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