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4. Cerebral enhancement in MOG antibody-associated disease.

Author

Elsbernd, Paul, Cacciaguerra, Laura, Krecke, Karl N., Chen, John J., Gritsch, David, Lopez-Chiriboga, A. Sebastian, Sechi, Elia, Redenbaugh, Vyanka, Morris, Padraig P., Carter, Jonathan L., Wingerchuk, Dean M., Tillema, Jan-Mendelt, Valencia-Sanchez, Cristina, Thakolwiboon, Smathorn, Pittock, Sean J., and Flanagan, Eoin P.

Published
2024
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5. Cerebral enhancement in MOG antibody-associated disease

Author

Elsbernd, Paul, primary, Cacciaguerra, Laura, additional, Krecke, Karl N, additional, Chen, John J, additional, Gritsch, David, additional, Lopez-Chiriboga, A Sebastian, additional, Sechi, Elia, additional, Redenbaugh, Vyanka, additional, Morris, Padraig P, additional, Carter, Jonathan L, additional, Wingerchuk, Dean M, additional, Tillema, Jan-Mendelt, additional, Valencia-Sanchez, Cristina, additional, Thakolwiboon, Smathorn, additional, Pittock, Sean J, additional, and Flanagan, Eoin P, additional

Published
2023
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7. Development of New or Enlarging MRI Lesions Outside of Clinical Attacks in MOG-Antibody-Associated Disease

Author

Syc-Mazurek, Stephanie, primary, Chen, John, additional, Morris, Padraig, additional, Sechi, Elia, additional, Mandrekar, Jayawant, additional, Tillema, Jan-Mendelt, additional, Lopez, Alfonso, additional, Lucchinetti, Claudia, additional, Zalewski, Nicholas, additional, Cacciaguerra, Laura, additional, Buciuc, Marina, additional, Krecke, Karl, additional, Messina, Steven, additional, Bhatti, M. Tariq, additional, Pittock, Sean, additional, and Flanagan, Eoin, additional

Published
2022
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9. Comparison of MRI Lesion Evolution in Different Central Nervous System Demyelinating Disorders

Author

Sechi, Elia, primary, Krecke, Karl N., additional, Messina, Steven A., additional, Buciuc, Marina, additional, Pittock, Sean J., additional, Chen, John J., additional, Weinshenker, Brian G., additional, Lopez-Chiriboga, A. Sebastian, additional, Lucchinetti, Claudia F., additional, Zalewski, Nicholas L., additional, Tillema, Jan Mendelt, additional, Kunchok, Amy, additional, Monaco, Salvatore, additional, Morris, Padraig P., additional, Fryer, James P., additional, Nguyen, Adam, additional, Greenwood, Tammy, additional, Syc-Mazurek, Stephanie B., additional, Keegan, B. Mark, additional, and Flanagan, Eoin P., additional

Published
2021
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11. Brainstem and cerebellar involvement in MOG-IgG-associated disorder versus aquaporin-4-IgG and MS

Author

Banks, Samantha A, primary, Morris, Padraig P, additional, Chen, John J, additional, Pittock, Sean J, additional, Sechi, Elia, additional, Kunchok, Amy, additional, Tillema, Jan-Mendelt, additional, Fryer, James P, additional, Weinshenker, Brian G, additional, Krecke, Karl N, additional, Lopez-Chiriboga, A Sebastian, additional, Nguyen, Adam, additional, Greenwood, Tammy M, additional, Lucchinetti, Claudia F, additional, Zalewski, Nicholas L, additional, Messina, Steven A, additional, and Flanagan, Eoin P, additional

Published
2020
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13. Myelin Oligodendrocyte Glycoprotein Autoantibody Myelitis; Clinical characteristics, MRI clues and discriminators from other demyelinating myelitis etiologies (S21.005)

Author

Dubey, Divyanshu, primary, Pittock, Sean, additional, Krecke, Karl, additional, Morris, Padraig P., additional, Sechi, Elia, additional, Zalewski, Nicholas, additional, Weinshenker, Brian, additional, Shosha, Eslam, additional, Lucchinetti, Claudia, additional, Fryer, James, additional, Lopez Chiriboga, Alfonso S., additional, Chen, John, additional, Jitprapaikulsan, Jiraporn, additional, McKeon, Andrew, additional, Gadoth, Avi, additional, Keegan, Mark, additional, Tillema, Jan-Mendelt, additional, Naddaf, Elie, additional, Patterson, Marc, additional, Messacar, Kevin, additional, Tyler, Kenneth, additional, and Flanagan, Eoin, additional

Published
2019
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14. Brainstem and cerebellar involvement in MOG-IgG-associated disorder versus aquaporin-4-IgG and MS.

Author

Banks, Samantha A., Morris, Padraig P., Chen, John J., Pittock, Sean J., Sechi, Elia, Kunchok, Amy, Tillema, Jan-Mendelt, Fryer, James P., Weinshenker, Brian G., Krecke, Karl N., Lopez-Chiriboga, A. Sebastian, Nguyen, Adam, Greenwood, Tammy M., Lucchinetti, Claudia F., Zalewski, Nicholas L., Messina, Steven A., and Flanagan, Eoin P.

Subjects
NEUROMYELITIS optica, BRAIN stem, MYELIN oligodendrocyte glycoprotein
Abstract

Objective: To determine the frequency and characteristics of brainstem or cerebellar involvement in myelin-oligodendrocyte-glycoprotein-antibody-associated-disorder (MOGAD) versus aquaporin-4-IgG-seropositive-neuromyelitis optica spectrum disorder (AQP4-IgG-NMOSD) and multiple sclerosis (MS).Methods: In this observational study, we retrospectively identified 185 Mayo Clinic MOGAD patients with: (1) characteristic MOGAD phenotype, (2) MOG-IgG seropositivity by live cell-based assay and (3) MRI lesion(s) of brainstem, cerebellum or both. We compared the symptomatic attacks to AQP4-IgG-NMOSD (n=30) and MS (n=30).Results: Brainstem or cerebellar involvement occurred in 62/185 (34%) MOGAD patients of which 39/62 (63%) were symptomatic. Ataxia (45%) and diplopia (26%) were common manifestations. The median age in years (range) in MOGAD of 24 (2-65) was younger than MS at 36 (16-65; p=0.046) and AQP4-IgG-NMOSD at 45 (6-72; p=0.006). Isolated attacks involving the brainstem, cerebellum or both were less frequent in MOGAD (9/39 (23%)) than MS (22/30 (73%); p<0.001) but not significantly different from AQP4-IgG-NMOSD (14/30 (47%); p=0.07). Diffuse middle cerebellar peduncle MRI-lesions favoured MOGAD (17/37 (46%)) over MS (3/30 (10%); p=0.001) and AQP4-IgG-NMOSD (3/30 (10%); p=0.001). Diffuse medulla, pons or midbrain MRI lesions occasionally occurred in MOGAD and AQP4-IgG-NMOSD but never in MS. Cerebrospinal fluid (CSF) oligoclonal bands were rare in MOGAD (5/30 (17%)) and AQP4-IgG-NMOSD (2/22 (9%); p=0.68) but common in MS (18/22 (82%); p<0.001). Disability at nadir or recovery did not differ between the groups.Conclusion: Involvement of the brainstem, cerebellum or both is common in MOGAD but usually occurs as a component of a multifocal central nervous system attack rather than in isolation. We identified clinical, CSF and MRI attributes that can help discriminate MOGAD from AQP4-IgG-NMOSD and MS. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody

Author

Dubey, Divyanshu, primary, Pittock, Sean J., additional, Krecke, Karl N., additional, Morris, Padraig P., additional, Sechi, Elia, additional, Zalewski, Nicholas L., additional, Weinshenker, Brian G., additional, Shosha, Eslam, additional, Lucchinetti, Claudia F., additional, Fryer, James P., additional, Lopez-Chiriboga, A. Sebastian, additional, Chen, John C., additional, Jitprapaikulsan, Jiraporn, additional, McKeon, Andrew, additional, Gadoth, Avi, additional, Keegan, B. Mark, additional, Tillema, Jan-Mendelt, additional, Naddaf, Elie, additional, Patterson, Marc C., additional, Messacar, Kevin, additional, Tyler, Kenneth L., additional, and Flanagan, Eoin P., additional

Published
2019
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16. Gliosarcoma with Primary Skull Base Invasion

Author

Nguyen, Quoc-Bao D., Perry, Avital, Graffeo, Christopher S., Nesvick, Cody L., Raghunathan, Aditya, Jentoft, Mark E., O’Neill, Brian P., Morris, Padraig P., Morris, Jonathan M., and Van Gompel, Jamie J.

Subjects
Article Subject
Abstract

Gliosarcoma is an uncommon variant of glioblastoma, which commonly demonstrates dural attachment. However, skull base invasion is rarely seen with this entity. Herein, we report a 44-year-old female patient diagnosed with primary intracranial gliosarcoma extensively invading the skull base and muscles of mastication. She presented to our institution with a three-month history of difficult right jaw opening and retro-orbital pressure and one week of severe right-sided postauricular headache. Head CT demonstrated a 6 cm mass with marked bony erosion. Brain MRI at a one-week interval more clearly characterized tumor extension through the right orbit and muscles of mastication, with overall growth to 7 cm and worsening midline shift. The patient underwent a right frontotemporal craniotomy for gross total resection. Pathology confirmed the diagnosis of gliosarcoma, IDH-wildtype (WHO grade IV). Her postoperative course was uneventful and she was discharged at preoperative neurologic baseline. To our knowledge, this is the third reported case of a primary intracranial gliosarcoma with direct invasion of skull base, brain parenchyma, and extracranial compartment. However, this is the first report case of primary GS invading the surrounding musculature and orbit. This case report highlights the rapid aggressiveness of gliosarcomas and further a prior undescribed radiographic and anatomic finding of skull base invasion with this entity.

Published
2016
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18. Ring-enhancing spinal cord lesions in neuromyelitis optica spectrum disorders

Author

Zalewski, Nicholas L, primary, Morris, Padraig P, additional, Weinshenker, Brian G, additional, Lucchinetti, Claudia F, additional, Guo, Yong, additional, Pittock, Sean J, additional, Krecke, Karl N, additional, Kaufmann, Timothy J, additional, Wingerchuk, Dean M, additional, Kumar, Neeraj, additional, and Flanagan, Eoin P, additional

Published
2016
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22. Gliosarcoma with Primary Skull Base Invasion

Author

D. Nguyen, Quoc-Bao, Perry, Avital, S. Graffeo, Christopher, L. Nesvick, Cody, Raghunathan, Aditya, E. Jentoft, Mark, P. O’Neill, Brian, P. Morris, Padraig, M. Morris, Jonathan, and J. Van Gompel, Jamie

Abstract

Gliosarcoma is an uncommon variant of glioblastoma, which commonly demonstrates dural attachment. However, skull base invasion is rarely seen with this entity. Herein, we report a 44-year-old female patient diagnosed with primary intracranial gliosarcoma extensively invading the skull base and muscles of mastication. She presented to our institution with a three-month history of difficult right jaw opening and retro-orbital pressure and one week of severe right-sided postauricular headache. Head CT demonstrated a 6 cm mass with marked bony erosion. Brain MRI at a one-week interval more clearly characterized tumor extension through the right orbit and muscles of mastication, with overall growth to 7 cm and worsening midline shift. The patient underwent a right frontotemporal craniotomy for gross total resection. Pathology confirmed the diagnosis of gliosarcoma, IDH-wildtype (WHO grade IV). Her postoperative course was uneventful and she was discharged at preoperative neurologic baseline. To our knowledge, this is the third reported case of a primary intracranial gliosarcoma with direct invasion of skull base, brain parenchyma, and extracranial compartment. However, this is the first report case of primary GS invading the surrounding musculature and orbit. This case report highlights the rapid aggressiveness of gliosarcomas and further a prior undescribed radiographic and anatomic finding of skull base invasion with this entity.

Published
2016
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