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Your search keyword '"Morris, Lucy X."' showing total 8 results
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8 results on '"Morris, Lucy X."'

1. NINJ1 mediates plasma membrane rupture during lytic cell death

Author

Kayagaki, Nobuhiko, Kornfeld, Opher S., Lee, Bettina L., Stowe, Irma B., O’Rourke, Karen, Li, Qingling, Sandoval, Wendy, Yan, Donghong, Kang, Jing, Xu, Min, Zhang, Juan, Lee, Wyne P., McKenzie, Brent S., Ulas, Gözde, Payandeh, Jian, Roose-Girma, Merone, Modrusan, Zora, Reja, Rohit, Sagolla, Meredith, Webster, Joshua D., Cho, Vicky, Andrews, T. Daniel, Morris, Lucy X., Miosge, Lisa A., Goodnow, Christopher C., Bertram, Edward M., and Dixit, Vishva M.

Published
2021
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2. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Author

Kayagaki, Nobuhiko, Stowe, Irma B., Lee, Bettina L., O'Rourke, Karen, Anderson, Keith, Warming, Soren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui T., Liu, Peter S., Lill, Jennie R., Li, Hong, Wu, Jiansheng, Kummerfeld, Sarah, Zhang, Juan, Lee, Wyne P., Snipas, Scott J., Salvesen, Guy S., Morris, Lucy X., Fitzgerald, Linda, Zhang, Yafei, Bertram, Edward M., Goodnow, Christopher C., and Dixit, Vishva M.

Subjects
Inflammation -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock. How caspase-11 executes these downstream signalling events is largely unknown. Here we show that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukm-1β maturation. A forward genetic screen with ethyl-N-nitrosourea-mutagenized mice links Gsdmd to the intracellular lipopolysaccharide response. Macrophages from [Gsdmd.sup.-/-] mice generated by gene targeting also exhibit defective pyroptosis and interleukin-1β secretion induced by cytoplasmic lipopolysaccharide or Gram-negative bacteria. In addition, [Gsdmd.sup.-/-] mice are protected from a lethal dose of lipopolysaccharide. Mechanistically, caspase-11 cleaves gasdermin D, and the resulting amino-terminal fragment promotes both pyroptosis and NLRP3-dependent activation of caspase-1 in a cell-intrinsic manner. Our data identify gasdermin D as a critical target of caspase-11 and a key mediatorof the host response against Gram-negative bacteria., Cytoplasmic caspase-11 (also known as caspase-4) defines the non-canonical inflammasome that is activated by various Gram-negative bacterial infections and causes infected cells to die by pyroptosis (1-4). Caspase-11 also triggers [...]

Published
2015
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3. IRF2 transcriptionally induces GSDMD expression for pyroptosis

Author

Kayagaki, Nobuhiko, primary, Lee, Bettina L., additional, Stowe, Irma B., additional, Kornfeld, Opher S., additional, O'Rourke, Karen, additional, Mirrashidi, Kathleen M., additional, Haley, Benjamin, additional, Watanabe, Colin, additional, Roose-Girma, Merone, additional, Modrusan, Zora, additional, Kummerfeld, Sarah, additional, Reja, Rohit, additional, Zhang, Yafei, additional, Cho, Vicky, additional, Andrews, T. Daniel, additional, Morris, Lucy X., additional, Goodnow, Christopher C., additional, Bertram, Edward M., additional, and Dixit, Vishva M., additional

Published
2019
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4. Dynamics of thymus organogenesis and colonization in early human development

Author

Farley, Alison M., primary, Morris, Lucy X., additional, Vroegindeweij, Eric, additional, Depreter, Marianne L. G., additional, Vaidya, Harsh, additional, Stenhouse, Frances H., additional, Tomlinson, Simon R., additional, Anderson, Richard A., additional, Cupedo, Tom, additional, Cornelissen, Jan J., additional, and Blackburn, C. Clare, additional

Published
2013
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8. IRF2 transcriptionally induces GSDMDexpression for pyroptosis

Author

Kayagaki, Nobuhiko, Lee, Bettina L., Stowe, Irma B., Kornfeld, Opher S., O'Rourke, Karen, Mirrashidi, Kathleen M., Haley, Benjamin, Watanabe, Colin, Roose-Girma, Merone, Modrusan, Zora, Kummerfeld, Sarah, Reja, Rohit, Zhang, Yafei, Cho, Vicky, Andrews, T. Daniel, Morris, Lucy X., Goodnow, Christopher C., Bertram, Edward M., and Dixit, Vishva M.

Abstract

Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.

Published
2019
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