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4. Investigation of the tumor-macrophage crosstalk to identify palmitic acid as modulator of macrophage reprogramming in prostate cancer

Author

Lughezzani, G., primary, Marelli, G., additional, Buffi, N.M., additional, Casale, P., additional, Saita, A., additional, Hurle, R., additional, Fasulo, V., additional, Paciotti, M., additional, Finocchiaro, A., additional, Colombo, P., additional, Maria, G.M., additional, Carriero, R., additional, Iovino, M., additional, Kundefranco, P., additional, Morosi, C., additional, Di Mitri, D., additional, and Lazzeri, M., additional

Published
2024
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5. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Author

Stacchiotti, S., Miah, A.B., Frezza, A.M., Messiou, C., Morosi, C., Caraceni, A., Antonescu, C.R., Bajpai, J., Baldini, E., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Callegaro, D., De Alava, E., Deoras-Sutliff, M., Dufresne, A., Eriksson, M., Errani, C., Fedenko, A., Ferraresi, V., Ferrari, A., Fletcher, C.D.M., Garcia del Muro, X., Gelderblom, H., Gladdy, R.A., Gouin, F., Grignani, G., Gutkovich, J., Haas, R., Hindi, N., Hohenberger, P., Huang, P., Joensuu, H., Jones, R.L., Jungels, C., Kasper, B., Kawai, A., Le Cesne, A., Le Grange, F., Leithner, A., Leonard, H., Lopez Pousa, A., Martin Broto, J., Merimsky, O., Merriam, P., Miceli, R., Mir, O., Molinari, M., Montemurro, M., Oldani, G., Palmerini, E., Pantaleo, M.A., Patel, S., Piperno-Neumann, S., Raut, C.P., Ravi, V., Razak, A.R.A., Reichardt, P., Rubin, B.P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sapisochin, G., Sbaraglia, M., Scheipl, S., Schöffski, P., Strauss, D., Strauss, S.J., Sundby Hall, K., Tap, W.D., Trama, A., Tweddle, A., van der Graaf, W.T.A., Van De Sande, M.A.J., Van Houdt, W., van Oortmerssen, G., Wagner, A.J., Wartenberg, M., Wood, J., Zaffaroni, N., Zimmermann, C., Casali, P.G., Dei Tos, A.P., and Gronchi, A.

Published
2021
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7. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Blay, J.Y., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dufresne, A., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S.J., Hall, K Sundby, Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Gronchi, A., and Stacchiotti, S.

Published
2021
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8. Separation of variables in multi-Hamiltonian systems: an application to the Lagrange top

Author

Morosi, C. and Tondo, G.

Subjects
Nonlinear Sciences - Exactly Solvable and Integrable Systems
Abstract

Starting from the tri-Hamiltonian formulation of the Lagrange top in a six-dimensional phase space, we discuss the reduction of the vector field and of the Poisson tensors. We show explicitly that, after the reduction on each one of the symplectic leaves, the vector field of the Lagrange top is separable in the sense of Hamilton-Jacobi., Comment: report to XVI NEEDS (Cadiz 2002): 15 pages, no figures, LaTeX. To appear in Theor. Math. Phys

Published
2003

9. The quasi-bi-Hamiltonian formulation of the Lagrange top

Author

Morosi, C. and Tondo, G.

Subjects
Nonlinear Sciences - Exactly Solvable and Integrable Systems
Abstract

Starting from the tri-Hamiltonian formulation of the Lagrange top in a six-dimensional phase space, we discuss the possible reductions of the Poisson tensors, the vector field and its Hamiltonian functions on a four-dimensional space. We show that the vector field of the Lagrange top possesses, on the reduced phase space, a quasi-bi-Hamiltonian formulation, which provides a set of separation variables for the corresponding Hamilton-Jacobi equation., Comment: 12 pages, no figures, LaTeX, to appear in J. Phys. A: Math. Gen. (March 2002)

Published
2002
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10. On the constants in some inequalities for the Sobolev norms and pointwise product

Author

Morosi, C. and Pizzocchero, L.

Subjects
Mathematics - Functional Analysis, Mathematical Physics
Abstract

We consider the Sobolev norms of the pointwise product of two functions, and estimate from above and below the constants appearing in two related inequalities., Comment: to appear in the Journal of Inequalities and Applications

Published
2000

11. On the constants for some Sobolev imbeddings

Author

Morosi, C. and Pizzocchero, L.

Subjects
Mathematics - Functional Analysis, Mathematical Physics
Abstract

We consider the imbedding inequality || f ||_{L^r(R^d)} <= S_{r,n,d} || f ||_{H^{n}(R^d)}; H^{n}(R^d) is the Sobolev space (or Bessel potential space) of L^2 type and (integer or fractional) order n. We write down upper bounds for the constants S_{r, n, d}, using an argument previously applied in the literature in particular cases. We prove that the upper bounds computed in this way are in fact the sharp constants if (r=2 or) n > d/2, r=infinity, and exhibit the maximising functions. Furthermore, using convenient trial functions, we derive lower bounds on S_{r,n,d} for n > d/2, 2 < r < infinity; in many cases these are close to the previous upper bounds, as illustrated by a number of examples, thus characterizing the sharp constants with little uncertainty., Comment: 12 pages, to appear in the Journal of Inequalities and Applications

Published
2000

12. On a class of dynamical systems both quasi-bi-Hamiltonian and bi-Hamiltonian

Author

Morosi, C. and Tondo, G.

Subjects
Nonlinear Sciences - Exactly Solvable and Integrable Systems
Abstract

It is shown that a class of dynamical systems (encompassing the one recently considered by F. Calogero [J. Math. Phys. 37 (1996) 1735]) is both quasi-bi-Hamiltonian and bi-Hamiltonian. The first formulation entails the separability of these systems; the second one is obtained trough a non canonical map whose form is directly suggested by the associated Nijenhuis tensor., Comment: 11 pages, AMS-LaTex 1.1

Published
1998
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13. Bi-Hamiltonian manifolds, quasi-bi-Hamiltonian systems and separation variables

Author

Tondo, G. and Morosi, C.

Subjects
Nonlinear Sciences - Exactly Solvable and Integrable Systems
Abstract

We discuss from a bi-Hamiltonian point of view the Hamilton-Jacobi separability of a few dynamical systems. They are shown to admit, in their natural phase space, a quasi-bi-Hamiltonian formulation of Pfaffian type. This property allows us to straightforwardly recover a set of separation variables for the corresponding Hamilton-Jacobi equation., Comment: 12 pages, no figures, LaTeX 2.09, to be published in Report on Mathematical Physics

Published
1998
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14. Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group

Author

Stacchiotti, S., Gronchi, A., Fossati, P., Akiyama, T., Alapetite, C., Baumann, M., Blay, J.Y., Bolle, S., Boriani, S., Bruzzi, P., Capanna, R., Caraceni, A., Casadei, R., Colia, V., Debus, J., Delaney, T., Desai, A., Dileo, P., Dijkstra, S., Doglietto, F., Flanagan, A., Froelich, S., Gardner, P.A., Gelderblom, H., Gokaslan, Z.L., Haas, R., Heery, C., Hindi, N., Hohenberger, P., Hornicek, F., Imai, R., Jeys, L., Jones, R.L., Kasper, B., Kawai, A., Krengli, M., Leithner, A., Logowska, I., Martin Broto, J., Mazzatenta, D., Morosi, C., Nicolai, P., Norum, O.J., Patel, S., Penel, N., Picci, P., Pilotti, S., Radaelli, S., Ricchini, F., Rutkowski, P., Scheipl, S., Sen, C., Tamborini, E., Thornton, K.A., Timmermann, B., Torri, V., Tunn, P.U., Uhl, M., Yamada, Y., Weber, D.C., Vanel, D., Varga, P.P., Vleggeert-Lankamp, C.L.A., Casali, P.G., and Sommer, J.

Published
2017
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15. Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour

Author

Stacchiotti, S., Saponara, M., Frapolli, R., Tortoreto, M., Cominetti, D., Provenzano, S., Negri, T., Dagrada, G.P., Gronchi, A., Colombo, C., Vincenzi, B., Badalamenti, G., Zuco, V., Renne, S.L., Collini, P., Morosi, C., Dei Tos, A.P., Bello, E., Pilotti, S., Casali, P.G., D'Incalci, M., and Zaffaroni, N.

Published
2017
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16. Quasi-BiHamiltonian Systems and Separability

Author

Morosi, C. and Tondo, G.

Subjects
Nonlinear Sciences - Exactly Solvable and Integrable Systems
Abstract

Two quasi--biHamiltonian systems with three and four degrees of freedom are presented. These systems are shown to be separable in terms of Nijenhuis coordinates. Moreover the most general Pfaffian quasi-biHamiltonian system with an arbitrary number of degrees of freedom is constructed (in terms of Nijenhuis coordinates) and its separability is proved., Comment: 10 pages, AMS-LaTeX 1.1, to appear in J. Phys. A: Math. Gen. (May 1997)

Published
1997
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17. Gastrointestinal stromal tumours

Author

Casali, P.G., Blay, J.Y., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Buonadonna, A., Alava, E. de, Tos, A.P. dei, Muro, X.G. del, Dufresne, A., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kasper, B., Kawai, A., Kopeckova, K., Krakorova, D.A., Cesne, A. le, Grange, F. le, Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schoffski, P., Sleijfer, S., Strauss, D., Strauss, S.J., Hall, K.S., Trama, A., Unk, M., Sande, M.A.J. van de, Graaf, W.T.A. van der, Houdt, W.J. van, Frebourg, T., Gronchi, A., Stacchiotti, S., ESMO Guidelines Comm, EURACAN, GENTURIS, Casali P.G., Blay J.Y., Abecassis N., Bajpai J., Bauer S., Biagini R., Bielack S., Bonvalot S., Boukovinas I., Bovee J.V.M.G., Boye K., Brodowicz T., Buonadonna A., De Alava E., Dei Tos A.P., Del Muro X.G., Dufresne A., Eriksson M., Fedenko A., Ferraresi V., Ferrari A., Frezza A.M., Gasperoni S., Gelderblom H., Gouin F., Grignani G., Haas R., Hassan A.B., Hindi N., Hohenberger P., Joensuu H., Jones R.L., Jungels C., Jutte P., Kasper B., Kawai A., Kopeckova K., Krakorova D.A., Le Cesne A., Le Grange F., Legius E., Leithner A., Lopez-Pousa A., Martin-Broto J., Merimsky O., Messiou C., Miah A.B., Mir O., Montemurro M., Morosi C., Palmerini E., Pantaleo M.A., Piana R., Piperno-Neumann S., Reichardt P., Rutkowski P., Safwat A.A., Sangalli C., Sbaraglia M., Scheipl S., Schoffski P., Sleijfer S., Strauss D., Strauss S.J., Hall K.S., Trama A., Unk M., van de Sande M.A.J., van der Graaf W.T.A., van Houdt W.J., Frebourg T., Gronchi A., Stacchiotti S., Medical Oncology, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Public Health Research (PHR), and Man, Biomaterials and Microbes (MBM)

Subjects
GIST, clinical practice guidelines, gastrointestinal stromal tumour, surgery, tyrosine kinase inhibitor, Oncology, Medizin, Hematology, clinical practice guideline
Abstract

Gastrointestinal stromal tumours (GISTs) are malignant mesenchymal tumours with a variable clinical behaviour, marked by differentiation towards the interstitial cells of Cajal.1 GISTs belong to the family of soft tissue sarcomas (STSs) but are treated separately due to their peculiar histogenesis, clinical behaviour and specific therapy. This European Society for Medical Oncology (ESMO)–European Reference Network for Rare Adult Solid Cancers (EURACAN)–European Reference Network for Genetic Tumour Risk Syndromes (GENTURIS) Clinical Practice Guideline (CPG) will cover GISTs while other STSs are covered in the ESMO–EURACAN–European Reference Network for Paediatric Oncology (ERN PaedCan)–GENTURIS STS CPG.

Published
2022

18. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

Author

Strauss, S.J., Frezza, A.M., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., Alava, E. de, Tos, A.P. dei, Muro, X.G. del, Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Gaspar, N., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Gronchi, A., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krakorova, D.A., Cesne, A. le, Grange, F. le, Legius, E., Leithner, A., Pousa, A.L., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schoffski, P., Sleijfer, S., Strauss, D., Hall, K.S., Trama, A., Unk, M., Sande, M.A.J. van de, Graaf, W.T.A. van der, Houdt, W.J. van, Frebourg, T., Ladenstein, R., Casali, P.G., Stacchiotti, S., ESMO Guidelines Comm, EURACAN, GENTURIS, ERN PaedCan, European Society for Medical Oncology, Strauss S.J., Frezza A.M., Abecassis N., Bajpai J., Bauer S., Biagini R., Bielack S., Blay J.Y., Bolle S., Bonvalot S., Boukovinas I., Bovee J.V.M.G., Boye K., Brennan B., Brodowicz T., Buonadonna A., de Alava E., Dei Tos A.P., Garcia del Muro X., Dufresne A., Eriksson M., Fagioli F., Fedenko A., Ferraresi V., Ferrari A., Gaspar N., Gasperoni S., Gelderblom H., Gouin F., Grignani G., Gronchi A., Haas R., Hassan A.B., Hecker-Nolting S., Hindi N., Hohenberger P., Joensuu H., Jones R.L., Jungels C., Jutte P., Kager L., Kasper B., Kawai A., Kopeckova K., Krakorova D.A., Le Cesne A., Le Grange F., Legius E., Leithner A., Lopez Pousa A., Martin-Broto J., Merimsky O., Messiou C., Miah A.B., Mir O., Montemurro M., Morland B., Morosi C., Palmerini E., Pantaleo M.A., Piana R., Piperno-Neumann S., Reichardt P., Rutkowski P., Safwat A.A., Sangalli C., Sbaraglia M., Scheipl S., Schoffski P., Sleijfer S., Strauss D., Sundby Hall K., Trama A., Unk M., van de Sande M.A.J., van der Graaf W.T.A., van Houdt W.J., Frebourg T., Ladenstein R., Casali P.G., Stacchiotti S., ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Public Health Research (PHR), and Man, Biomaterials and Microbes (MBM)

Subjects
medicine.medical_specialty, diagnosis, Medizin, bone sarcoma, Bone Neoplasm, Bone Sarcoma, Follow-Up Studie, 03 medical and health sciences, 0302 clinical medicine, follow-up, medicine, 030304 developmental biology, Osteosarcoma, 0303 health sciences, treatment, business.industry, Sarcoma, Hematology, Guideline, clinical practice guideline, management, 3. Good health, Clinical Practice, diagnosi, Oncology, Diagnosis treatment, 030220 oncology & carcinogenesis, Radiology, business, Human
Abstract

A. Kawai43, K. Kopeckova44, D. A. Krakorova45, A. Le Cesne46, F. Le Grange1, E. Legius47, A. Leithner48, A. Lopez Pousa49, J. Martin-Broto36, O. Merimsky50, C. Messiou51, A. B. Miah52, O. Mir53, M. Montemurro54, B. Morland55, C. Morosi56, E. Palmerini57, M. A. Pantaleo58, R. Piana59, S. Piperno-Neumann60, P. Reichardt61, P. Rutkowski62, A. A. Safwat63, C. Sangalli64, M. Sbaraglia19, S. Scheipl48, P. Schoffski65, S. Sleijfer66, D. Strauss67, K. Sundby Hall13, A. Trama68, M. Unk69, M. A. J. van de Sande70, W. T. A. van der Graaf66,71, W. J. van Houdt72, T. Frebourg73x, R. Ladenstein41z, P. G. Casali2,74z &

Published
2021

20. Supplementary Figure 1 from Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

Author

Stacchiotti, S., primary, Tortoreto, M., primary, Bozzi, F., primary, Tamborini, E., primary, Morosi, C., primary, Messina, A., primary, Libertini, M., primary, Palassini, E., primary, Cominetti, D., primary, Negri, T., primary, Gronchi, A., primary, Pilotti, S., primary, Zaffaroni, N., primary, and Casali, P.G., primary

Published
2023
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21. Supplementary Figure 3 from Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

Author

Stacchiotti, S., primary, Tortoreto, M., primary, Bozzi, F., primary, Tamborini, E., primary, Morosi, C., primary, Messina, A., primary, Libertini, M., primary, Palassini, E., primary, Cominetti, D., primary, Negri, T., primary, Gronchi, A., primary, Pilotti, S., primary, Zaffaroni, N., primary, and Casali, P.G., primary

Published
2023
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22. Supplementary Figure 2 from Dacarbazine in Solitary Fibrous Tumor: A Case Series Analysis and Preclinical Evidence vis-à-vis Temozolomide and Antiangiogenics

Author

Stacchiotti, S., primary, Tortoreto, M., primary, Bozzi, F., primary, Tamborini, E., primary, Morosi, C., primary, Messina, A., primary, Libertini, M., primary, Palassini, E., primary, Cominetti, D., primary, Negri, T., primary, Gronchi, A., primary, Pilotti, S., primary, Zaffaroni, N., primary, and Casali, P.G., primary

Published
2023
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23. Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee.

Author

Ewijk, R. van, Chatziantoniou, C., Adams, M., Bertolini, P., Bisogno, G., Bouhamama, A., Caro-Dominguez, P., Charon, V., Coma, A., Dandis, R., Devalck, C., Donno, G. De, Ferrari, Andrea, Fiocco, M., Gallego, S., Giraudo, C., Glosli, H., Horst, S.A.J. Ter, Jenney, M., Klein, W.M., Leemans, A., Leseur, J., Mandeville, H.C., McHugh, K., Merks, J.H.M., Minard-Colin, V., Moalla, S., Morosi, C., Orbach, D., Ording Muller, L.S., Pace, E., Paolo, P.L. Di, Perruccio, K., Quaglietta, L., Renard, M., Rijn, R.R. van, Ruggiero, A., Sirvent, S.I., Luca, A. De, Schoot, R.A., Ewijk, R. van, Chatziantoniou, C., Adams, M., Bertolini, P., Bisogno, G., Bouhamama, A., Caro-Dominguez, P., Charon, V., Coma, A., Dandis, R., Devalck, C., Donno, G. De, Ferrari, Andrea, Fiocco, M., Gallego, S., Giraudo, C., Glosli, H., Horst, S.A.J. Ter, Jenney, M., Klein, W.M., Leemans, A., Leseur, J., Mandeville, H.C., McHugh, K., Merks, J.H.M., Minard-Colin, V., Moalla, S., Morosi, C., Orbach, D., Ording Muller, L.S., Pace, E., Paolo, P.L. Di, Perruccio, K., Quaglietta, L., Renard, M., Rijn, R.R. van, Ruggiero, A., Sirvent, S.I., Luca, A. De, and Schoot, R.A.

Abstract

Contains fulltext : 300161.pdf (Publisher’s version ) (Open Access), OBJECTIVE: To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive imaging marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma. MATERIAL AND METHODS: We performed a multicenter retrospective study including pediatric, adolescent and young adult patients with rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was performed according to institutional protocols. We performed two-dimensional single-slice tumor delineation. Areas of necrosis or hemorrhage were delineated to be excluded in the primary analysis. Mean, median and 5th and 95th apparent diffusion coefficient (ADC) were extracted. RESULTS: Of 134 included patients, 82 had measurable tumor at diagnosis and response and DW-MRI scans of adequate quality and were included in the analysis. Technical heterogeneity in scan acquisition protocols and scanners was observed. Mean ADC at diagnosis was 1.1 (95% confidence interval [CI]: 1.1-1.2) (all ADC expressed in * 10(-3) mm(2)/s), versus 1.6 (1.5-1.6) at response assessment. The 5th percentile ADC was 0.8 (0.7-0.9) at diagnosis and 1.1 (1.0-1.2) at response. Absolute change in mean ADC after neoadjuvant chemotherapy was 0.4 (0.3-0.5). Exploratory analyses for association between ADC and clinical parameters showed a significant difference in mean ADC at diagnosis for alveolar versus embryonal histology. Landmark analysis at nine weeks after the date of diagnosis showed no significant association (hazard ratio 1.3 [0.6-3.2]) between the mean ADC change and event-free survival. CONCLUSION: A significant change in the 5th percentile and the mean ADC after chemotherapy was observed. Strong heterogeneity was identified in DW-MRI acquisition protocols between centers and in individual patients., 01 november 2023

Published
2023

26. Soft tissue and visceral sarcomas

Author

Gronchi, A., Miah, A.B., DeiTos, A.P., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., DeAlava, E., Muro, X.G. del, Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krakorova, D.A., Cesne, A. le, LeGrange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schoffski, P., Sleijfer, S., Strauss, D., Strauss, S., SundbyHall, K., Trama, A., Unk, M., VandeSande, M.A.J., VanderGraaf, W.T.A., Houdt, W.J. van, Frebourg, T., Casali, P.G., Stacchiotti, S., ESMO Guidelines Comm, EURACAN, GENTURIS, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Public Health Research (PHR), Man, Biomaterials and Microbes (MBM), Gronchi A., Miah A.B., Dei Tos A.P., Abecassis N., Bajpai J., Bauer S., Biagini R., Bielack S., Blay J.Y., Bolle S., Bonvalot S., Boukovinas I., Bovee J.V.M.G., Boye K., Brennan B., Brodowicz T., Buonadonna A., De Alava E., Del Muro X.G., Dufresne A., Eriksson M., Fagioli F., Fedenko A., Ferraresi V., Ferrari A., Frezza A.M., Gasperoni S., Gelderblom H., Gouin F., Grignani G., Haas R., Hassan A.B., Hecker-Nolting S., Hindi N., Hohenberger P., Joensuu H., Jones R.L., Jungels C., Jutte P., Kager L., Kasper B., Kawai A., Kopeckova K., Krakorova D.A., Le Cesne A., Le Grange F., Legius E., Leithner A., Lopez-Pousa A., Martin-Broto J., Merimsky O., Messiou C., Mir O., Montemurro M., Morland B., Morosi C., Palmerini E., Pantaleo M.A., Piana R., Piperno-Neumann S., Reichardt P., Rutkowski P., Safwat A.A., Sangalli C., Sbaraglia M., Scheipl S., Schoffski P., Sleijfer S., Strauss D., Strauss S., Sundby Hall K., Trama A., Unk M., van de Sande M.A.J., van der Graaf W.T.A., van Houdt W.J., Frebourg T., Casali P.G., and Stacchiotti S.

Subjects
sarcoma, uterine sarcoma, treatment, diagnosis, desmoid, Medizin, Sarcoma, Soft Tissue Neoplasms, Hematology, Clinical Practice Guideline, Soft tissue sarcomas, retroperitoneal sarcoma, Retroperitoneal Sarcoma, soft tissue sarcomas, Follow-Up Studie, Desmoid, Uterine Sarcoma, follow-up, management, Oncology, soft tissue sarcoma, Human
Abstract

ispartof: ANNALS OF ONCOLOGY vol:32 issue:11 pages:1348-1365 ispartof: location:England status: published

Published
2021

27. Reduced-dose craniospinal irradiation is feasible for standard-risk adult medulloblastoma patients

Author

Massimino, M, Sunyach, M, Barretta, F, Gandola, L, Garegnani, A, Pecori, E, Spreafico, F, Bonneville-Levard, A, Meyronet, D, Mottolese, C, Boschetti, L, Biassoni, V, Schiavello, E, Giussani, C, Carrabba, G, Diletto, B, Pallotti, F, Stefini, R, Ferrari, A, Terenziani, M, Casanova, M, Luksch, R, Meazza, C, Podda, M, Chiaravalli, S, Puma, N, Bergamaschi, L, Morosi, C, Calareso, G, Giangaspero, F, Antonelli, M, Buttarelli, F, Frappaz, D, Massimino M., Sunyach M. P., Barretta F., Gandola L., Garegnani A., Pecori E., Spreafico F., Bonneville-Levard A., Meyronet D., Mottolese C., Boschetti L., Biassoni V., Schiavello E., Giussani C., Carrabba G., Diletto B., Pallotti F., Stefini R., Ferrari A., Terenziani M., Casanova M., Luksch R., Meazza C., Podda M., Chiaravalli S., Puma N., Bergamaschi L., Morosi C., Calareso G., Giangaspero F., Antonelli M., Buttarelli F. R., Frappaz D., Massimino, M, Sunyach, M, Barretta, F, Gandola, L, Garegnani, A, Pecori, E, Spreafico, F, Bonneville-Levard, A, Meyronet, D, Mottolese, C, Boschetti, L, Biassoni, V, Schiavello, E, Giussani, C, Carrabba, G, Diletto, B, Pallotti, F, Stefini, R, Ferrari, A, Terenziani, M, Casanova, M, Luksch, R, Meazza, C, Podda, M, Chiaravalli, S, Puma, N, Bergamaschi, L, Morosi, C, Calareso, G, Giangaspero, F, Antonelli, M, Buttarelli, F, Frappaz, D, Massimino M., Sunyach M. P., Barretta F., Gandola L., Garegnani A., Pecori E., Spreafico F., Bonneville-Levard A., Meyronet D., Mottolese C., Boschetti L., Biassoni V., Schiavello E., Giussani C., Carrabba G., Diletto B., Pallotti F., Stefini R., Ferrari A., Terenziani M., Casanova M., Luksch R., Meazza C., Podda M., Chiaravalli S., Puma N., Bergamaschi L., Morosi C., Calareso G., Giangaspero F., Antonelli M., Buttarelli F. R., and Frappaz D.

Abstract

Introduction: Medulloblastoma is the most common malignant brain tumor in children, but accounts for only 1% of brain cancers in adults. For standard-risk pediatric medulloblastoma, current therapy includes craniospinal irradiation (CSI) at reduced doses (23.4 Gy) associated with chemotherapy. Whereas most same-stage adult patients are still given CSI at 36 Gy, with or without chemotherapy, we report here on our use of reduced-dose CSI associated with chemotherapy for older patients. Methods: We gathered non-metastatic patients over 18 years old (median age 28 years, range 18–48) with minimal or no residual disease after surgery, no negative histological subtypes, treated between 1996–2018 at the Centre Léon Bérard (Lyon) and the INT (Milano). A series of 54 children with similar tumors treated in Milano was used for comparison. Results: Forty-four adults were considered (median follow-up 101 months): 36 had 23.4 Gy of CSI, and 8 had 30.6 Gy, plus a boost to the posterior fossa/tumor bed; 43 had chemotherapy as all 54 children, who had a median 83-month follow-up. The PFS and OS were 82.2 ± 6.1% and 89 ± 5.2% at 5 years, and 78.5 ± 6.9% and 75.2 ± 7.8% at ten, not significantly different from those of the children. CSI doses higher than 23.4 Gy did not influence PFS. Female adult patients tended to have a better outcome than males. Conclusion: The results obtained in our combined series are comparable with, or even better than those obtained after high CSI doses, underscoring the need to reconsider this treatment in adults.

Published
2020

29. Radioembolization of hepatocarcinoma with 90Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology

Author

Chiesa, C., Mira, M., Maccauro, M., Spreafico, C., Romito, R., Morosi, C., Camerini, T., Carrara, M., Pellizzari, S., Negri, A., Aliberti, G., Sposito, C., Bhoori, S., Facciorusso, A., Civelli, E., Lanocita, R., Padovano, B., Migliorisi, M., De Nile, M. C., Seregni, E., Marchianò, A., Crippa, F., and Mazzaferro, V.

Published
2015
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31. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., primary, Blay, J.Y., additional, Abecassis, N., additional, Bajpai, J., additional, Bauer, S., additional, Biagini, R., additional, Bielack, S., additional, Bonvalot, S., additional, Boukovinas, I., additional, Bovee, J.V.M.G., additional, Boye, K., additional, Brodowicz, T., additional, Buonadonna, A., additional, De Álava, E., additional, Dei Tos, A.P., additional, Del Muro, X.G., additional, Dufresne, A., additional, Eriksson, M., additional, Fedenko, A., additional, Ferraresi, V., additional, Ferrari, A., additional, Frezza, A.M., additional, Gasperoni, S., additional, Gelderblom, H., additional, Gouin, F., additional, Grignani, G., additional, Haas, R., additional, Hassan, A.B., additional, Hindi, N., additional, Hohenberger, P., additional, Joensuu, H., additional, Jones, R.L., additional, Jungels, C., additional, Jutte, P., additional, Kasper, B., additional, Kawai, A., additional, Kopeckova, K., additional, Krákorová, D.A., additional, Le Cesne, A., additional, Le Grange, F., additional, Legius, E., additional, Leithner, A., additional, Lopez-Pousa, A., additional, Martin-Broto, J., additional, Merimsky, O., additional, Messiou, C., additional, Miah, A.B., additional, Mir, O., additional, Montemurro, M., additional, Morosi, C., additional, Palmerini, E., additional, Pantaleo, M.A., additional, Piana, R., additional, Piperno-Neumann, S., additional, Reichardt, P., additional, Rutkowski, P., additional, Safwat, A.A., additional, Sangalli, C., additional, Sbaraglia, M., additional, Scheipl, S., additional, Schöffski, P., additional, Sleijfer, S., additional, Strauss, D., additional, Strauss, S.J., additional, Hall, K Sundby, additional, Trama, A., additional, Unk, M., additional, van de Sande, M.A.J., additional, van der Graaf, W.T.A., additional, van Houdt, W.J., additional, Frebourg, T., additional, Gronchi, A., additional, and Stacchiotti, S., additional

Published
2022
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34. Renal tumor biopsy (RTB) in patients with cT1b-t4-m0 disease susceptible to radical nephrectomy: analysis of safety, accuracy and clinical impact on definitive management.

Author

Nazzani, S., primary, Catanzaro, M., additional, Macchi, A., additional, Zaborra, C., additional, Biasoni, D., additional, Torelli, T., additional, Stagni, S., additional, Tesone, A., additional, Lanocita, R., additional, Cascella, T., additional, Morosi, C., additional, Spreafico, C., additional, Marchianò, A., additional, Salvioni, R., additional, and Nicolai, N., additional

Published
2021
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37. European guideline for imaging in paediatric and adolescent rhabdomyosarcoma - joint statement by the European Paediatric Soft Tissue Sarcoma Study Group, the Cooperative Weichteilsarkom Studiengruppe and the Oncology Task Force of the European Society of Paediatric Radiology

Author

van Ewijk, R., Schoot, R. A., Sparber-Sauer, M., ter Horst, S. A. J., Jehanno, N., Borgwardt, L., de Keizer, B., Merks, J. H. M., de Luca, A., Mchugh, K., von Kalle, T., Schafer, J. F., van Rijn, R. R., Bouhamama, A., Coma, A., Di Paolo, P. L., Fajardo, R. D., Franzius, C., Giraudo, C., de Jonge, G. M., Levine, D., Macvicar, D., Mandeville, H., Moholkar, S., Morosi, C., Muller, L. -S. O., Pace, E., Rogers, T. N., van Scheltinga, S. T., and Tolboom, N.

Subjects
Oncology, medicine.medical_specialty, Consensus, Staging, Adolescent, medicine.medical_treatment, Positron emission tomography/computed tomography, 030218 nuclear medicine & medical imaging, Child, Diagnosis, Magnetic resonance imaging, Rhabdomyosarcoma, Sarcoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Neuroradiology, Neoplasm Staging, medicine.diagnostic_test, business.industry, Soft tissue sarcoma, Guideline, Espr, medicine.disease, Radiation therapy, Positron emission tomography, 030220 oncology & carcinogenesis, Positron-Emission Tomography, Pediatrics, Perinatology and Child Health, Paediatric radiology, business, Radiology
Abstract

Appropriate imaging is essential in the treatment of children and adolescents with rhabdomyosarcoma. For adequate stratification and optimal individualised local treatment utilising surgery and radiotherapy, high-quality imaging is crucial. The paediatric radiologist, therefore, is an essential member of the multi-disciplinary team providing clinical care and research. This manuscript presents the European rhabdomyosarcoma imaging guideline, based on the recently developed guideline of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) Imaging Committee. This guideline was developed in collaboration between the EpSSG Imaging Committee, the Cooperative Weichteilsarkom Studiengruppe (CWS) Imaging Group, and the Oncology Task Force of the European Society of Paediatric Radiology (ESPR). MRI is recommended, at diagnosis and follow-up, for the evaluation of the primary tumour and its relationship to surrounding tissues, including assessment of neurovascular structures and loco-regional lymphadenopathy. Chest CT along with [F-18]2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT or PET/MRI are recommended for the detection and evaluation of loco-regional and distant metastatic disease. Guidance on the estimation of treatment response, optimal long-term follow-up, technical imaging settings and standardised reporting are described. This European imaging guideline outlines the recommendations for imaging in children and adolescents with rhabdomyosarcoma, with the aim to harmonise imaging and to advance patient care. Supplementary Information The online version contains supplementary material available at 10.1007/s00247-021-05081-0.

Published
2021

38. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Author

Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Stacchiotti, S., Miah, A. B., Frezza, A. M., Messiou, C., Morosi, C., Caraceni, A., Álava Casado, Enrique de, Gronchi, A., Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica, Stacchiotti, S., Miah, A. B., Frezza, A. M., Messiou, C., Morosi, C., Caraceni, A., Álava Casado, Enrique de, and Gronchi, A.

Abstract

Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarcomas. The degree of uncertainty in selecting the most appropriate therapy for EHE patients and the lack of guidelines on the clinical management of the disease make the adoption of new treatments inconsistent across the world, resulting in suboptimal outcomes for many EHE patients. To address the shortcoming, a global consensus meeting was organized in December 2020 under the umbrella of the European Society for Medical Oncology (ESMO) involving >80 experts from several disciplines from Europe, North America and Asia, together with a patient representative from the EHE Group, a global, disease-specific patient advocacy group, and Sarcoma Patient EuroNet (SPAEN). The meeting was aimed at defining, by consensus, evidence-based best practices for the optimal approach to primary and metastatic EHE. The consensus achieved during that meeting is the subject of the present publication.

Published
2021

44. Evaluation of response after pre-operative radiotherapy in soft tissue sarcomas; the European Organisation for Research and Treatment of Cancer – Soft Tissue and Bone Sarcoma Group (EORTC – STBSG) and Imaging Group recommendations for radiological examination and reporting with an emphasis on magnetic resonance imaging

Author

Messiou, C., Bonvalot, S., Gronchi, A., Vanel, D., Meyer, M., Robinson, P., Morosi, C., Bloem, J.L., Terrier, P.H., Lazar, A., Le Péchoux, C., Wardelman, E., Winfield, J.M., Boulet, B., Bovée, J., and Haas, R.L.

Subjects
Cancer Research, Radiotherapy, Oncology, Sarcoma, MRI
Abstract

At present, there is no standardised approach for the radiological evaluation of soft tissue sarcomas following radiotherapy (RT). This manuscript, produced by a European Organisation for Research and Treatment of Cancer – Soft Tissue and Bone Sarcoma Group (EORTC – STBSG) and Imaging Group endorsed task force, aims to propose standardisation of magnetic resonance imaging techniques and interpretation after neoadjuvant RT for routine use and within clinical trials.

Published
2016
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46. Trabectedin with concurrent low-dose of radiation therapy for metastatic soft tissue sarcomas: A phase II trial of Spanish, French and Italian sarcoma groups

Author

Broto, J Martin, primary, Italiano, A., additional, Alvarez, R M Alvarez, additional, Rincon, I., additional, Peinado, J., additional, Sargos, P., additional, Alvarez, A., additional, Luna, P., additional, Pousa, A Lopez, additional, Redondo, A., additional, Alastuey, I., additional, Isern, J., additional, Belinchon, B., additional, Gutierrez, A., additional, Romagosa, C., additional, Marie, K., additional, Morosi, C., additional, Blay, J.-Y., additional, Gronchi, A., additional, and Hindi, N., additional

Published
2019
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48. Diagnostic accuracy of percutaneous biopsy in retroperitoneal sarcoma

Author

Almond, L M, primary, Tirotta, F, additional, Tattersall, H, additional, Hodson, J, additional, Cascella, T, additional, Barisella, M, additional, Marchianò, A, additional, Greco, G, additional, Desai, A, additional, Ford, S J, additional, Gronchi, A, additional, Fiore, M, additional, and Morosi, C, additional

Published
2019
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49. Activity of axitinib in progressive advanced solitary fibrous tumour: Results from an exploratory, investigator-driven phase 2 clinical study

Author

Stacchiotti, S., primary, Simeone, N., additional, Lo Vullo, S., additional, Morosi, C., additional, Greco, F.G., additional, Gronchi, A., additional, Barisella, M., additional, Collini, P., additional, Zaffaroni, N., additional, Dagrada, G.P., additional, Frezza, A.M., additional, Mariani, L., additional, and Casali, P.G., additional

Published
2019
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50. Loss of Heterozygosity Analysis at Different Chromosome Regions in Wilms Tumor Confirms 1p Allelic Loss as a Marker of Worse Prognosis: A Study from the Italian Association of Pediatric Hematology and Oncology

Author

Spreafico F, Gamba B, Mariani L, Collini P, D'Angelo P, Di Cataldo A, Indolfi P, Nantron M, Terenziani M, Morosi C, Radice P, Perotti D, AIEOP Wilms Tumor Working Group, PESSION, ANDREA, Spreafico F, Gamba B, Mariani L, Collini P, D'Angelo P, Pession A, Di Cataldo A, Indolfi P, Nantron M, Terenziani M, Morosi C, Radice P, Perotti D, and AIEOP Wilms Tumor Working Group

Subjects
Genetic Markers, Male, Oncology, medicine.medical_specialty, Vincristine, Multivariate analysis, Adolescent, pediatrics, kidney neoplasms, loss of heterozygosity, pediatrics, Wilms tumor, Urology, STAGE-I, CHILDRENS-CANCER, RENAL TUMORS, SHORT ARM, 16Q, ANAPLASIA, RELAPSE, GENE, 11Q, AGE, Loss of heterozygosity, Chromosome regions, Internal medicine, medicine, Overall survival, Humans, kidney neoplasms, Prospective Studies, Child, loss of heterozygosity, Wilms tumor, business.industry, Infant, Wilms' tumor, Prognosis, medicine.disease, Child, Preschool, Microsatellite, Female, business, Allelic loss, medicine.drug
Abstract

PURPOSE: The specific aims of the AIEOP-TW-2003 protocol included prospectively investigating a possible association of tumor loss of heterozygosity with outcomes in children treated for Wilms tumor. MATERIALS AND METHODS: We analyzed 125 unilateral favorable histology Wilms tumors registered between 2003 and 2008 in the Italian cooperative protocol for microsatellite markers mapped to chromosomes 1p, 7p, 11q, 16q and 22q. RESULTS: The 3-year disease-free survival and overall survival probabilities were 0.87 (95% CI 0.81-0.93) and 0.98 (95% CI 0.96-1.0), respectively. Loss of heterozygosity at 1p was significantly associated with a worse disease-free survival (probability 0.67 for patients with and 0.92 for those without 1p loss of heterozygosity, p = 0.0009), as confirmed also by multivariate analysis adjusting for tumor stage and patient age at diagnosis. There was no difference in disease-free survival probability among children with loss of heterozygosity in the other chromosomal regions tested. The worse outlook for children older than 2 years at diagnosis did not seem to be influenced by the loss of heterozygosity patterns considered. CONCLUSIONS: Chromosome 1p loss of heterozygosity seems to be a risk factor for nonanaplastic Wilms tumor, possibly regardless of other clinical factors. Our findings were uninformative regarding loss of heterozygosity in the other chromosomal regions tested.

Published
2013

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