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24 results on '"Morohara, Koji"'

8. Adult intussusceptions induced by a terminal ileum diverticulum: a case report

Author

Nakazawa, Nobuhiro, primary, Suzuki, Hideki, additional, Ebara, Gen, additional, Watanabe, Yu, additional, Tsukagoshi, Ritsuko, additional, Ieta, Keisuke, additional, Morohara, Koji, additional, Osawa, Hidenobu, additional, Katayama, Kazuhisa, additional, Yasuda, Yasukuni, additional, Tanaka, Shigehumi, additional, and Kuwano, Hiroyuki, additional

Published
2018
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9. Single-Incision Laparoscopic Surgery for a Small-Intestinal Gastrointestinal Stromal Tumor: Report of a Case

Author

Sakai, Makoto, primary, Wada, Wataru, additional, Kimura, Shintaro, additional, Okada, Akiko, additional, Hirakata, Tomoko, additional, Onozato, Ryoichi, additional, Saito, Kana, additional, Morohara, Koji, additional, Osawa, Hidenobu, additional, Katayama, Kazuhisa, additional, Yasuda, Naokuni, additional, Tanaka, Shigebumi, additional, and Kuwano, Hiroyuki, additional

Published
2014
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11. A Case of Curative Resected Triple Cancers: Intraductal Papillary-Mucinous Carcinoma in the Pancreatic Head; Cancer in the Lower Part of the Bile Duct; and Gall Bladder Cancer after Repeated Episodes of Pancreatitis and Cholangitis

Author

Takanashi, Shuichiro, primary, Suzuki, Kazuya, additional, Morohara, Koji, additional, Yasuda, Naokuni, additional, Kamisaka, Koji, additional, Suzuki, Yutaka, additional, Shimizu, Yoshinori, additional, and Murakami, Masahiko, additional

Published
2012
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24. Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations.

Author

Yamazaki K, Tajima Y, Makino R, Nishino N, Aoki S, Kato M, Sakamoto M, Morohara K, Kaetsu T, and Kusano M

Subjects
Adenocarcinoma chemistry, Adenoma chemistry, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic pathology, DNA, Neoplasm analysis, DNA, Neoplasm genetics, Gastric Mucins analysis, Gastric Mucins genetics, Gastric Mucins physiology, Gene Expression Regulation, Neoplastic physiology, Genes, APC physiology, Genes, Neoplasm physiology, Genes, p53 physiology, Genomic Instability genetics, Genomic Instability physiology, Humans, Microsatellite Repeats genetics, Mucin-2, Mucin-6, Mucins analysis, Mucins genetics, Mucins physiology, Mutation genetics, Mutation physiology, Neprilysin analysis, Neprilysin genetics, Neprilysin physiology, Phenotype, Stomach Neoplasms chemistry, Adenocarcinoma genetics, Adenocarcinoma pathology, Adenoma genetics, Adenoma pathology, Genes, Neoplasm genetics, Neoplasm Invasiveness genetics, Stomach Neoplasms genetics, Stomach Neoplasms pathology
Abstract

Aim: To clarify the relations between tumor differentiation phenotype and tumor invasion or genetic alterations in gastric differentiated-type tumors., Methods: We examined the tumor differentiation phenotype, the presence of mutations in APC and p53, and the microsatellite instability (MSI) status in 48 gastric adenomas and 171 differentiated-type carcinomas. The tumor differentiation phenotype was determined by examining the expression of human gastric mucin (HGM), MUC6, MUC2 and CD10. The tumors were then classified into gastric- (G-), gastric and intestinal mixed- (GI-), or intestinal- (I-) phenotypes, according to the immunopositivity of the above markers. The presence of mutations in APC and p53 and the MSI status were also investigated in all the tumors., Results: Gastric adenomas were significantly associated with CD10 expression, I-phenotype tumors and the presence of APC mutations, compared with carcinomas (66.7% vs 25.1%, P < 0.0001; 56.3% vs 14.6%, P < 0.0001; 39.6% vs 14.0%, P < 0.0001, respectively) and inversely associated with expressions of HGM and MUC6 and the presence of p53 mutations (10.4% vs 62.6%, P < 0.0001; 39.6% vs 64.3%, P = 0.003; 2.0% vs 26.3%, P = 0.001, respectively). The frequency of APC mutations was significantly higher in HGM-negative tumors, MUC6-negative tumors, CD10-positive tumors and I-phenotype tumors than in HGM-positive tumors, MUC6-positive tumors, CD10-negative tumors and G-phenotype tumors (32.7% vs 7.1%, P < 0.0001; 27.8% vs 14.0%, P = 0.0182; 37.3% vs 10.4%, P < 0.0001; and 38.5% vs 9.5%, P = 0.0017, respectively). The frequency of MSI was significantly higher in MUC6-positive tumors, CD10-negative tumors and G-phenotype tumors than in MUC6-negative tumors, CD10-positive tumors and I-phenotype tumors (24.8% vs 6.7%, P = 0.0009; 22.2% vs 8.0%, P = 0.0143; and 28.6% vs 9.6%, P = 0.0353, respectively)., Conclusion: The tumor differentiation phenotype is closely related to tumor invasion and genetic alterations in gastric differentiated-type tumors.

Published
2006
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