Search

Your search keyword '"Morningstar, Jordan E."' showing total 26 results
Start Over Author "Morningstar, Jordan E."
26 results on '"Morningstar, Jordan E."'

1. Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients

Author

Spampinato, Ricardo A., Marin-Cuartas, Mateo, van Kampen, Antonia, Fahr, Florian, Sieg, Franz, Strotdrees, Elfriede, Jahnke, Cosima, Klaeske, Kristin, Wiesner, Karoline, Morningstar, Jordan E., Nagata, Yasufumi, Izquierdo-Garcia, David, Dieterlen, Maja-Theresa, Norris, Russell A., Levine, Robert A., Paetsch, Ingo, and Borger, Michael A.

Published
2024
Full Text
View/download PDF

2. Cellular and Molecular Mechanisms of MEK1 Inhibitor–Induced Cardiotoxicity

Author

Beck, Tyler C., Arhontoulis, Dimitrios C., Morningstar, Jordan E., Hyams, Nathaniel, Stoddard, Andrew, Springs, Kendra, Mukherjee, Rupak, Helke, Kris, Guo, Lilong, Moore, Kelsey, Gensemer, Cortney, Biggs, Rachel, Petrucci, Taylor, Kwon, Jennie, Stayer, Kristina, Koren, Natalie, Harvey, Andrew, Holman, Heather, Dunne, Jaclyn, Fulmer, Diana, Vohra, Ayesha, Mai, Le, Dooley, Sarah, Weninger, Julianna, Vaena, Silvia, Romeo, Martin, Muise-Helmericks, Robin C., Mei, Ying, and Norris, Russell A.

Published
2022
Full Text
View/download PDF

3. Cisplatin Analogs Confer Protection against Cyanide Poisoning

Author

Nath, Anjali K, Shi, Xu, Harrison, Devin L, Morningstar, Jordan E, Mahon, Sari, Chan, Adriano, Sips, Patrick, Lee, Jangwoen, MacRae, Calum A, Boss, Gerry R, Brenner, Matthew, Gerszten, Robert E, and Peterson, Randall T

Subjects
Prevention, Biodefense, Vaccine Related, Cancer, Animals, Antidotes, Cell Line, Cisplatin, Cyanides, Drug Approval, Electron Transport Complex IV, Humans, Lethal Dose 50, Oxidation-Reduction, Rabbits, Solubility, Sulfur, Zebrafish, antidote, cisplatin, cyanide, phenotypic screening, platinum, zebrafish
Abstract

Cisplatin holds an illustrious position in the history of chemistry most notably for its role in the virtual cure of testicular cancer. Here we describe a role for this small molecule in cyanide detoxification in vivo. Cyanide kills organisms as diverse as insects, fish, and humans within seconds to hours. Current antidotes exhibit limited efficacy and are not amenable to mass distribution requiring the development of new classes of antidotes. The binding affinity of the cyanide anion for the positively charged metal platinum is known to create an extremely stable complex in vitro. We therefore screened a panel of diverse cisplatin analogs and identified compounds that conferred protection from cyanide poisoning in zebrafish, mice, and rabbits. Cumulatively, this discovery pipeline begins to establish the characteristics of platinum ligands that influence their solubility, toxicity, and efficacy, and provides proof of concept that platinum-based complexes are effective antidotes for cyanide poisoning.

Published
2017

6. Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis

Author

Siegel, Julie B., primary, Nasarre, Patrick, additional, Hsu, Lillian, additional, Mukherjee, Rupak, additional, Gormley, Meghan, additional, Richardson, Bailey, additional, Khan, Imran, additional, Morningstar, Jordan E., additional, Hilliard, Eleanor, additional, O’Bryan, John P., additional, Helke, Kristi L., additional, Spruill, Laura, additional, Dolloff, Nathan G., additional, and Klauber-DeMore, Nancy, additional

Published
2023
Full Text
View/download PDF

7. Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients

Author

Spampinato, Ricardo A., primary, Marin-Cuartas, Mateo, additional, van Kampen, Antonia, additional, Fahr, Florian, additional, Sieg, Franz, additional, Strotdrees, Elfriede, additional, Jahnke, Cosima, additional, Klaeske, Kristin, additional, Wiesner, Karoline, additional, Morningstar, Jordan E., additional, Nagata, Yasufumi, additional, Izquierdo-Garcia, David, additional, Dieterlen, Maja-Theresa, additional, Norris, Russell A., additional, Levine, Robert A., additional, Paetsch, Ingo, additional, and Borger, Michael A., additional

Published
2023
Full Text
View/download PDF

8. Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

Author

van Kampen, Antonia, primary, Morningstar, Jordan E., additional, Goudot, Guillaume, additional, Ingels, Neil, additional, Wenk, Jonathan F., additional, Nagata, Yasufumi, additional, Yaghoubian, Koushiar M., additional, Norris, Russell A., additional, Borger, Michael A., additional, Melnitchouk, Serguei, additional, Levine, Robert A., additional, and Jensen, Morten O., additional

Published
2023
Full Text
View/download PDF

9. Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse

Author

Nagata, Yasufumi, primary, Bertrand, Philippe B., additional, Baliyan, Vinit, additional, Kochav, Jonathan, additional, Kagan, Ruth D., additional, Ujka, Kristian, additional, Alfraidi, Hassan, additional, van Kampen, Antonia, additional, Morningstar, Jordan E., additional, Dal-Bianco, Jacob P., additional, Melnitchouk, Serguei, additional, Holmvang, Godtfred, additional, Borger, Michael A., additional, Moore, Reece, additional, Hua, Lanqi, additional, Sultana, Razia, additional, Calle, Pablo Villar, additional, Yum, Brian, additional, Guerrero, J. Luis, additional, Neilan, Tomas G., additional, Picard, Michael H., additional, Kim, Jiwon, additional, Delling, Francesca N., additional, Hung, Judy, additional, Norris, Russell A., additional, Weinsaft, Jonathan W., additional, and Levine, Robert A., additional

Published
2023
Full Text
View/download PDF

10. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

Author

O'Sullivan, John F., Morningstar, Jordan E., Yang, Qiong, Zheng, Baohui, Gao, Yan, Jeanfavre, Sarah, Fernandez, Celine, Scott, Justin, Zheng, Hui, OConnor, Sean, Cohen, Paul, Vasan, Ramachandran S., Long, Michelle T., Wilson, James G., Melander, Olle, Wang, Thomas J., Fox, Caroline, Peterson, Randall T., Clish, Clary B., Corey, Kathleen E., and Gerszten, Robert E.

Subjects
Obesity -- Risk factors, Diabetes mellitus -- Risk factors, Liver diseases -- Risk factors, Dyslipidemias -- Risk factors, Health care industry
Abstract

Unbiased, 'nontargeted' metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CTdefined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases., Introduction Nonalcoholic fatty liver disease (NAFLD) is defined by the presence of hepatic steatosis (via histology or imaging) when there are no causes for secondary hepatic fat accumulation, and it [...]

Published
2017
Full Text
View/download PDF

11. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

Author

O’Sullivan, John F., Morningstar, Jordan E., Yang, Qiong, Zheng, Baohui, Gao, Yan, Jeanfavre, Sarah, Scott, Justin, Fernandez, Celine, Zheng, Hui, O’Connor, Sean, Cohen, Paul, Vasan, Ramachandran S., Long, Michelle T., Wilson, James G., Melander, Olle, Wang, Thomas J., Fox, Caroline, Peterson, Randall T., Clish, Clary B., Corey, Kathleen E., and Gerszten, Robert E.

Published
2017
Full Text
View/download PDF

14. Application of Pharmacokinetic Prediction Platforms in the Design of Optimized Anti-Cancer Drugs

Author

Beck, Tyler C., primary, Springs, Kendra, additional, Morningstar, Jordan E., additional, Mills, Catherine, additional, Stoddard, Andrew, additional, Guo, Lilong, additional, Moore, Kelsey, additional, Gensemer, Cortney, additional, Biggs, Rachel, additional, Petrucci, Taylor, additional, Kwon, Jennie, additional, Stayer, Kristina, additional, Koren, Natalie, additional, Dunne, Jaclyn, additional, Fulmer, Diana, additional, Vohra, Ayesha, additional, Mai, Le, additional, Dooley, Sarah, additional, Weninger, Julianna, additional, Peterson, Yuri, additional, Woster, Patrick, additional, Dix, Thomas A., additional, and Norris, Russell A., additional

Published
2022
Full Text
View/download PDF

15. DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse

Author

Moore, Kelsey S., primary, Moore, Reece, additional, Fulmer, Diana B., additional, Guo, Lilong, additional, Gensemer, Cortney, additional, Stairley, Rebecca, additional, Glover, Janiece, additional, Beck, Tyler C., additional, Morningstar, Jordan E., additional, Biggs, Rachel, additional, Muhkerjee, Rupak, additional, Awgulewitsch, Alexander, additional, and Norris, Russell A., additional

Published
2022
Full Text
View/download PDF

16. Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

Author

Morningstar, Jordan E., primary, Gensemer, Cortney, additional, Moore, Reece, additional, Fulmer, Diana, additional, Beck, Tyler C., additional, Wang, Christina, additional, Moore, Kelsey, additional, Guo, Lilong, additional, Sieg, Franz, additional, Nagata, Yasufumi, additional, Bertrand, Philippe, additional, Spampinato, Ricardo A., additional, Glover, Janiece, additional, Poelzing, Stephen, additional, Gourdie, Robert G., additional, Watts, Kelsey, additional, Richardson, William J., additional, Levine, Robert A., additional, Borger, Michael A., additional, and Norris, Russell A., additional

Published
2021
Full Text
View/download PDF

17. Abstract 9400: Mitral Valve Prolapse Induces Regionalized Left Ventricular Fibrosis

Author

Morningstar, Jordan E, primary, Gensemer, Cortney, additional, Moore, Reece, additional, Fulmer, Diana B, additional, Beck, Tyler, additional, Wang, Christina, additional, Moore, Kelsey, additional, Guo, Lilong, additional, Vohra, Ayesha, additional, Sieg, Franz, additional, Nagata, Yasufumi, additional, Bertrand, Philippe, additional, Spampinato, Ricardo, additional, Glover, Janiece, additional, Poelzing, Stephen, additional, Gourdie, Robert G, additional, Richardson, William, additional, Levine, Robert A, additional, Borger, Michael, additional, and Norris, Russell A, additional

Published
2021
Full Text
View/download PDF

19. Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

Author

Morningstar, Jordan E., Gensemer, Cortney, Moore, Reece, Fulmer, Diana, Beck, Tyler C., Wang, Christina, Moore, Kelsey, Guo, Lilong, Sieg, Franz, Nagata, Yasufumi, Bertrand, Philippe, Spampinato, Ricardo A., Glover, Janiece, Poelzing, Steven, Gourdie, Robert G., Watts, Kelsey, Richardson, William J., Levine, Robert A., Borger, Michael A., Norris, Russell A., Morningstar, Jordan E., Gensemer, Cortney, Moore, Reece, Fulmer, Diana, Beck, Tyler C., Wang, Christina, Moore, Kelsey, Guo, Lilong, Sieg, Franz, Nagata, Yasufumi, Bertrand, Philippe, Spampinato, Ricardo A., Glover, Janiece, Poelzing, Steven, Gourdie, Robert G., Watts, Kelsey, Richardson, William J., Levine, Robert A., Borger, Michael A., and Norris, Russell A.

Abstract

Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular (LV) biopsies from peripapillary regions, inferobasal LV wall and apex on surgical patients with MVP, as well as in a mouse model of human MVP (Dzip1(S14R)(/+)). Tension-dependent molecular pathways were subsequently assessed using both computational modeling and cyclical stretch of primary human cardiac fibroblasts in vitro. Histopathology of LV biopsies revealed regionalized fibrosis in the peripapillary myocardium that correlated with increased macrophages and myofibroblasts. The MVP mouse model exhibited similar regional increases in collagen deposition that progress over time. As observed in the patient biopsies, increased macrophages and myofibroblasts were observed in fibrotic areas within the murine heart. Computational modeling revealed tension-dependent profibrotic cellular and molecular responses consistent with fibrosis locations related to valve-induced stress. These simulations also identified mechanosensing primary cilia as involved in profibrotic pathways, which was validated in vitro and in human biopsies. Finally, in vitro stretching of primary human cardiac fibroblasts showed that stretch directly activates profibrotic pathways and increases extracellular matrix protein production. Conclusions The presence of prominent regional LV fibrosis in patients and mice with MVP supports a relationship between MVP and progressive damaging effects on LV structure before overt alterations in cardiac function. The regionalized molecular and cellular changes suggest a react

Published
2021

20. Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk

Author

Ngo, Debby, primary, Benson, Mark D., additional, Long, Jonathan Z., additional, Chen, Zsu-Zsu, additional, Wang, Ruiqi, additional, Nath, Anjali K., additional, Keyes, Michelle J., additional, Shen, Dongxiao, additional, Sinha, Sumita, additional, Kuhn, Eric, additional, Morningstar, Jordan E., additional, Shi, Xu, additional, Peterson, Bennet D., additional, Chan, Christopher, additional, Katz, Daniel H., additional, Tahir, Usman A., additional, Farrell, Laurie A., additional, Melander, Olle, additional, Mosley, Jonathan D., additional, Carr, Steven A., additional, Vasan, Ramachandran S., additional, Larson, Martin G., additional, Smith, J. Gustav, additional, Wang, Thomas J., additional, Yang, Qiong, additional, and Gerszten, Robert E., additional

Published
2021
Full Text
View/download PDF

23. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Author

Warren, Curtis R., primary, O’Sullivan, John F., additional, Friesen, Max, additional, Becker, Caroline E., additional, Zhang, Xiaoling, additional, Liu, Poching, additional, Wakabayashi, Yoshiyuki, additional, Morningstar, Jordan E., additional, Shi, Xu, additional, Choi, Jihoon, additional, Xia, Fang, additional, Peters, Derek T., additional, Florido, Mary H.C., additional, Tsankov, Alexander M., additional, Duberow, Eilene, additional, Comisar, Lauren, additional, Shay, Jennifer, additional, Jiang, Xin, additional, Meissner, Alexander, additional, Musunuru, Kiran, additional, Kathiresan, Sekar, additional, Daheron, Laurence, additional, Zhu, Jun, additional, Gerszten, Robert E., additional, Deo, Rahul C., additional, Vasan, Ramachandran S., additional, O’Donnell, Christopher J., additional, and Cowan, Chad A., additional

Published
2017
Full Text
View/download PDF

25. Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.

Author

Baohui Zheng, Peterson, Randall T., O'Sullivan, John F., O'Connor, Sean, Cohen, Paul, Long, Michelle T., Wang, Thomas J., Corey, Kathleen E., Morningstar, Jordan E., Gerszten, Robert E., Fox, Caroline, Vasan, Ramachandran S., Qiong Yang, Yan Gao, Wilson, James G., Jeanfavre, Sarah, Scott, Justin, Clish, Clary B., Fernandez, Celine, and Melander, Olle

Subjects
*VALERIC acid, *BIOMARKERS, *FATTY liver, *DIAGNOSIS of diabetes, *GUANIDINES, *PHENOTYPES, *GENETICS
Abstract

Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

26. Left Ventricular Fibrosis and CMR Tissue Characterization of Papillary Muscles in Mitral Valve Prolapse Patients.

Author

Spampinato RA, Marin-Cuartas M, Kampen A, Fahr F, Sieg F, Strotdrees E, Jahnke C, Klaeske K, Wiesner K, Morningstar JE, Nagata Y, Izquierdo-Garcia D, Dieterlen MT, Norris RA, Levine RA, Paetsch I, and Borger MA

Abstract

Purpose: Mitral valve prolapse (MVP) is associated with left ventricle (LV) fibrosis, including the papillary muscles (PM), which is in turn linked to malignant arrhythmias. This study aims to evaluate comprehensive tissue characterization of the PM by cardiovascular magnetic resonance (CMR) imaging and its association with LV fibrosis observed by intraoperative biopsies., Methods: MVP patients with indication for surgery due to severe mitral regurgitation (n=19) underwent a preoperative CMR with characterization of the PM: dark-appearance on cine, T1 mapping, conventional bright blood (BB) and dark blood (DB) late gadolinium enhancement (LGE). CMR T1 mapping was performed on 21 healthy volunteers as controls. LV inferobasal myocardial biopsies were obtained in MVP patients and compared to CMR findings., Results: MVP patients (54±10 years old, 14 male) had a dark-appearance of the PM with higher native T1 and extracellular volume (ECV) values compared with healthy volunteers (1096±78ms vs 994±54ms and 33.9±5.6% vs 25.9±3.1%, respectively, p<0.001). Seventeen MVP patients (89.5%) had fibrosis by biopsy. BB-LGE+ in LV and PM was identified in 5 (26.3%) patients, while DB-LGE+ was observed in LV in 9 (47.4%) and in PM in 15 (78.9%) patients. DB-LGE+ in PM was the only technique that showed no difference with detection of LV fibrosis by biopsy. Posteromedial PM was more frequently affected than the anterolateral (73.7% vs 36.8%, p=0.039) and correlated with biopsy-proven LV fibrosis (Rho 0.529, p=0.029)., Conclusions: CMR imaging in MVP patients referred for surgery shows a dark-appearance of the PM with higher T1 and ECV values compared with healthy volunteers. The presence of a positive DB-LGE at the posteromedial PM by CMR may serve as a better predictor of biopsy-proven LV inferobasal fibrosis than conventional CMR techniques.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results