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Your search keyword '"Morneau-Vaillancourt, Genevieve"' showing total 24 results
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3. Factors associated with anxiety disorder comorbidity

Author

Davies, Molly R., Glen, Kiran, Mundy, Jessica, ter Kuile, Abigail R., Adey, Brett N., Armour, Chérie, Assary, Elham, Coleman, Jonathan R.I., Goldsmith, Kimberley A., Hirsch, Colette R., Hotopf, Matthew, Hübel, Christopher, Jones, Ian R., Kalsi, Gursharan, Krebs, Georgina, McIntosh, Andrew M., Morneau-Vaillancourt, Geneviève, Peel, Alicia J., Purves, Kirstin L., Lee, Sang Hyuck, Skelton, Megan, Smith, Daniel J., Veale, David, Walters, James T.R., Young, Katherine S., Zvrskovec, Johan, Breen, Gerome, and Eley, Thalia C.

Published
2023
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8. The intensity of formal child‐care attendance decreases the shared environment contribution to school readiness: A twin study

Author

Gagnon, Eloi, Boivin, Michel, Mimeau, Catherine, Feng, Bei, Morneau‐Vaillancourt, Genevieve, Aubé, Sophie, Brendgen, Mara, Vitaro, Frank, Dionne, Ginette, Gagnon, Eloi, Boivin, Michel, Mimeau, Catherine, Feng, Bei, Morneau‐Vaillancourt, Genevieve, Aubé, Sophie, Brendgen, Mara, Vitaro, Frank, and Dionne, Ginette

Abstract

The purpose of this study was to explore if child-care intensity (hours/weeks) and age of onset could moderate genetic and environmental contributions to school readiness. A sample of 648 (85% Whites; 50% Females) pairs of twins was used to compute a GxE, CxE and ExE interaction analyses. The moderation model showed that shared environment explains 48% of individual differences in school readiness for children not attending formal child-care, and decreased gradually to a mere 3% for children attending formal child-care full time, e.g., 40 h per week. Age of onset exerted no moderation effect. The results support the hypothesis that child-care acts as a normalizing environment, possibly buffering negative effects from low-quality home environments on school readiness.

Published
2022

9. TU10. CLINICAL CHARACTERISTICS AND ENVIRONMENTAL AND GENETIC INFLUENCES OF ANXIETY DISORDER COMORBIDITY IN THE GLAD AND COPING COHORTS

Author

Davies, Molly, primary, ter Kuile, Abigail, additional, Young, Katherine, additional, Purves, Kirstin, additional, Glen, Kiran, additional, Mundy, Jessica, additional, Goldsmith, Kimberley A, additional, Adey, Brett N, additional, Thompson, Katherine N, additional, Monssen, Dina, additional, Rogers, Henry C, additional, Källberg-Zvrskovec, Johan, additional, Hübel, Christopher, additional, Peel, Alicia J, additional, Skelton, Megan, additional, Krebs, Georgina, additional, Hirsch, Colette R, additional, Hotopf, Matthew, additional, Morneau-Vaillancourt, Genevieve, additional, Armour, Chérie, additional, Jones, Ian, additional, Kalsi, Gursharan, additional, McIntosh, Andrew, additional, Smith, Daniel, additional, Walters, James, additional, Veale, David, additional, Breen, Gerome, additional, and Eley, Thalia, additional

Published
2021
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10. W11. GENOME-WIDE ANALYSIS OF THE ANXIETY DISORDER SPECTRUM

Author

Kuile, Abigail ter, primary, Davies, Molly, additional, Purves, Kirstin, additional, Coleman, Jonathan, additional, Hübel, Christopher, additional, Kalsi, Gursharan, additional, Mundy, Jessica, additional, Skelton, Megan, additional, Morneau-Vaillancourt, Genevieve, additional, Zvrskovec, Johan, additional, Breen, Gerome, additional, and Eley, Thalia, additional

Published
2021
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17. The genetic and environmental hierarchical structure of anxiety and depression in the UK Biobank

Author

Morneau-Vaillancourt, Genevieve, Coleman, Jonathan Richard Iain, Purves, Kirstin, Cheesman, Rosa, Rayner, Christopher David, Breen, Gerome Daniel, and Eley, Thalia Catherine

Abstract

Background. Anxiety and depressive disorders can be classified under a bi-dimensional model, where depression and generalized anxiety disorder are represented by distress and the other anxiety disorders, by fear. The phenotypic structure of this model has been validated, but twin studies only show partial evidence for genetic and environmental distinctions between distress and fear. Moreover, the effects of genetic variants are mostly shared between anxiety and depression, but the genome-wide genetic distinction between distress and fear remain unexplored. This study aimed to examine the degree of common genetic variation overlap between distress and fear, and their associations with the psychosocial risk factors of loneliness and social isolation. Methods. We used genome-wide data from 157,366 individuals in the UK Biobank who answered a mental health questionnaire. Results. Genetic correlations indicated that depression and generalized anxiety had a substantial genetic overlap, and that they were genetically partially distinct from fear disorders. Associations with loneliness, but not social isolation, showed that loneliness was more strongly associated with both distress disorders than with fear. Conclusions. Our findings shed light on genetic and environmental mechanisms that are common and unique to distress and fear and contribute to current knowledge on individuals’ susceptibility to anxiety and depression.

Published
2019

18. Genetic influences on treatment-seeking for common mental health problems in the UK Biobank

Author

Rayner, Christopher David, Coleman, Jonathan Richard Iain, Purves, Kirstin, Cheesman, Rosa, Huebel, Christopher, Gaspar, Héléna Alexandra, Glanville, Kylie Patricia, Krebs, Georgina, Morneau-Vaillancourt, Genevieve, Breen, Gerome Daniel, and Eley, Thalia Catherine

Abstract

The majority of those who experience clinical anxiety and/or depressive symptoms in the population do not receive treatment. Studies investigating inequalities in treatment outcomes rarely consider that individuals respond differently to their experience of the environment. Much of our environment is under genetic influence, via our behaviour, whereby individuals actively select their experiences. If genes influence who seeks and receives treatment, selection bias will confound genomic studies of treatment response. Furthermore, if some individuals are at high genetic risk of needing but not commencing treatment, then greater efforts could be made to engage them. The role of common genetic variation on four lifetime treatment-seeking behaviours (treatment-seeking, treatment-receipt, self-help, self-medication with alcohol/drugs) was examined in participants of the UK Biobank (sample size range: 48,106 - 75,322). Treatment-related behaviours were only modestly heritable in these data. Nonetheless, genetic correlations reveal substantial genetic overlap between lifetime treatment-related behaviours and psychiatric disorders, symptoms and behavioural traits. To our knowledge, this is the first study to examine genetic influences on treatment-related behaviours. Further work is required to determine whether genetic factors could be used alongside clinical, social and demographic factors to identify at risk groups and inform strategies which target early intervention.

Published
2019

20. EXPLORING THE GENOME-WIDE GENETIC OVERLAP BETWEEN ANXIETY AND FEAR DISORDERS

Author

ter Kuile, Abigail, Mitchell, Brittany, Peel, Alicia, Mundy, Jessica, Hübel, Christopher, Zvrskovec, Johan, Palmos, Alish, Coleman, Jonathan, Davies, Molly, Martin, Nick, Byrne, Enda M., Medland, Sarah E., Wray, Naomi R., Adey, Brett N., Lee, Sang Hyuck, Fürtjes, Anna E., Morneau-Vaillancourt, Geneviève, Purves, Kirstin, Skelton, Megan, Hotopf, Matthew, Smith, Daniel J., Veale, David, Armour, Chérie, McIntosh, Andrew, Walters, James T.R., Jones, Ian R., Hirsch, Colette R., Kalsi, Gursharan, Breen, Gerome, and Eley, Thalia

Published
2022
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