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136 results on '"Morley-Fletcher S"'

4. Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats

Author

Verhaeghe, R. (Remy), Gao, V. (Vance), MORLEY-FLETCHER, S. (Sara), Bouwalerh, H. (Hammou), Van Camp, G. (Gilles), Cisani, F. (Francesca), Nicoletti, F. (Ferdinando), Maccari, S. (Stefania), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], and Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Subjects
Early life stress, Sex differences, Brain aging, Behaviors, Hormones
Abstract

Brain aging may be programmed by early-life stress. Aging affects males and females differently, but how perinatal stress (PRS) affects brain aging between sexes is unknown. We showed behavioral and neurobiological sex differences in non-stressed control rats that were strongly reduced or inverted in PRS rats. In particular, PRS decreased risk-taking behavior, spatial memory, exploratory behavior, and fine motor behavior in male aged rats. In contrast, female aged PRS rats displayed only increased risk-taking behavior and reduced exploratory behavior. PRS induced large reductions in the expression of glutamate receptors in the ventral and dorsal hippocampus and prefrontal cortex only in male rats. PRS also reduced the expression of synaptic vesicle-associated proteins, glucocorticoid receptors (GR), and mineralocorticoid receptors (MR) in the ventral hippocampus of aged male rats. In contrast, in female aged rats, PRS enhanced the expression of MRs and brain-derived neurotrophic factor (BDNF) in the ventral hippocampus and the expression of glial fibrillary acidic protein (GFAP) and BDNF in the prefrontal cortex. A common PRS effect in both sexes was a reduction in exploratory behavior and metabotropic glutamate (mGlu2/3) receptors in the ventral hippocampus and prefrontal cortex. A multidimensional analysis revealed that PRS induced a demasculinization profile in glutamate-related proteins in the ventral and dorsal hippocampus and prefrontal cortex, as well as a demasculinization profile of stress markers only in the dorsal hippocampus. In contrast, defeminization was observed only in the ventral hippocampus. Measurements of testosterone and 17-β-estradiol in the plasma and aromatase in the dorsal hippocampus were consistent with a demasculinizing action of PRS. These findings confirm that the brains of males and females differentially respond to PRS and aging suggesting that females might be more protected against early stress and age-related inflammation and neurodegeneration. Taken together, these results may contribute to understanding how early environmental factors shape vulnerability to brain aging in both sexes and may lay the groundwork for future studies aimed at identifying new treatment strategies to improve the quality of life of older individuals, which is of particular interest given that there is a high growth of aging in populations around the world.

Published
2021

6. Maternal stress programs accelerated aging of the basal ganglia motor system in offspring

Author

Marrocco, J., Verhaeghe, R., Bucci, D., Di Menna, L., Traficante, A., Bouwalerh, H., Van Camp, G., Ghiglieri, V., Picconi, B., Calabresi, P., Ravasi, L., Cisani, F., Bagheri, F., Pittaluga, A., Bruno, V., Battaglia, G., Morley-Fletcher, S., Nicoletti, F., Maccari, S., Rockefeller University [New York], Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fondazione Santa Lucia [IRCCS], Clinical and Behavioral Neurology [IRCCS Santa Lucia], Pharmacologie de la mort neuronale et de la plasticité cérébrale, IFR114-Université de Lille, Droit et Santé, Université de Genève (UNIGE), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], and Université de Genève = University of Geneva [UNIGE]

Subjects
Aging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Nigrostriatal development, Motor behavior, Adenosine receptors, Synaptic proteins, Integrated study, lcsh:QP351-495, lcsh:RC346-429, lcsh:RC321-571, Settore MED/26 - NEUROLOGIA, lcsh:Neurophysiology and neuropsychology, Original Research Article, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system
Abstract

Early-life stress involved in the programming of stress-related illnesses can have a toxic influence on the functioning of the nigrostriatal motor system during aging. We examined the effects of perinatal stress (PRS) on the neurochemical, electrophysiological, histological, neuroimaging, and behavioral correlates of striatal motor function in adult (4 months of age) and old (21 months of age) male rats. Adult PRS offspring rats showed reduced dopamine (DA) release in the striatum associated with reductions in tyrosine hydroxylase-positive (TH+) cells and DA transporter (DAT) levels, with no loss of striatal dopaminergic terminals as assessed by positron emission tomography analysis with fluorine-18-l-dihydroxyphenylalanine. Striatal levels of DA and its metabolites were increased in PRS rats. In contrast, D2 DA receptor signaling was reduced and A2A adenosine receptor signaling was increased in the striatum of adult PRS rats. This indicated enhanced activity of the indirect pathway of the basal ganglia motor circuit. Adult PRS rats also showed poorer performance in the grip strength test and motor learning tasks. The aged PRS rats also showed a persistent reduction in striatal DA release and defective motor skills in the pasta matrix and ladder rung walking tests. In addition, the old rats showed large increases in the levels of SNAP-25 and synaptophysin, which are synaptic vesicle-related proteins in the striatum, and in the PRS group only, reductions in Syntaxin-1 and Rab3a protein levels were observed. Our findings indicated that the age-dependent threshold for motor dysfunction was lowered in PRS rats. This area of research is underdeveloped, and our study suggests that early-life stress can contribute to an increased understanding of how aging diseases are programmed in early-life.

Published
2020
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8. Selective effect of agomelatine treatment on ventral hippocampal neurogenesis in the rat model of prenatal restraint stress: Implications for anxiety behavior

Author

Morley-Fletcher, S, Mairesse, Jacques, Soumier, A., Banasr, M., Zuena, A R, Van Reeth, Olivier, Mocaer, Elisabeth, Dassuta, A., Maccari, Stefania, Morley-Fletcher, S, Mairesse, Jacques, Soumier, A., Banasr, M., Zuena, A R, Van Reeth, Olivier, Mocaer, Elisabeth, Dassuta, A., and Maccari, Stefania

Abstract

DecretOANoAutActif, info:eu-repo/semantics/inPress

Published
2019

11. Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner

Author

Reynaert, M-L. (Marie-Line), Marrocco, J. (Jordan), Mairesse, J. (Jérôme), Lionetto, L. (Luana), Simmaco, M. (Maurizio), Deruyter, L. (Lucie), Allorge, D. (Delphine), Moles, A. (Anna), Pittaluga, A. (Anna), Maccari, S. (Stefania), MORLEY-FLETCHER, S. (Sara), Van Camp, G. (Gilles), Nicoletti, F. (Ferdinando), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Centro Neurolesi Bonino Pulejo Messina (IRCCS Messina), Azienda Ospedaliera Sant'Andrea [Roma], Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Università degli studi di Genova = University of Genoa (UniGe), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), CHU Lille, CNRS, Université de Lille, Institut Pasteur de Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.], Centro Neurolesi Bonino Pulejo Messina [IRCCS Messina], 171461|||Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, and IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483

Subjects
Male, Restraint, Physical, Serotonin, Dopamine, Hypothalamus, Prefrontal Cortex, Medicine (miscellaneous), Palatable food, Animal model, conditioned place preference, early life stress, palatable food, sex hormones, Rats, Sprague-Dawley, Food Preferences, Sex Factors, Reward, Pregnancy, Animals, Biogenic Monoamines, Sex hormones, RNA, Messenger, Pharmacology, Analysis of Variance, Finasteride, Brain, Dihydrotestosterone, Early life stress, Conditioned place preference, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Psychiatry and Mental Health, Prenatal Exposure Delayed Effects, Female, Stress, Psychological
Abstract

International audience; Palatable food is a strong activator of the reward circuitry and may cause addictive behavior leading to eating disorders. How early life events and sex interact in shaping hedonic sensitivity to palatable food is largely unknown. We used prenatally restraint stressed (PRS) rats, which show abnormalities in the reward system and anxious/depressive-like behavior. Some of the hallmarks of PRS rats are known to be sex-dependent. We report that PRS enhanced and reduced milk chocolate-induced conditioned place preference in males and females, respectively. Male PRS rats also show increases in plasma dihydrotestosterone (DHT) levels and dopamine (DA) levels in the nucleus accumbens (NAc), and reductions in 5-hydroxytryptamine (5-HT) levels in the NAc and prefrontal cortex (PFC). In male rats, systemic treatment with the DHT-lowering drug finasteride reduced both milk chocolate preference and NAc DA levels. Female PRS rats showed lower plasma estradiol (E2) levels and lower DA levels in the NAc, and 5-HT levels in the NAc and PFC. E2 supplementation reversed the reduction in milk chocolate preference and PFC 5-HT levels. In the hypothalamus, PRS increased ERα and ERβ estrogen receptor and CARTP (cocaine-and-amphetamine receptor transcript peptide) mRNA levels in males, and 5-HT2C receptor mRNA levels in females. Changes were corrected by treatments with finasteride and E2, respectively. These new findings show that early life stress has a profound impact on hedonic sensitivity to high-palatable food via long-lasting changes in gonadal hormones. This paves the way to the development of hormonal strategies aimed at correcting abnormalities in the response to natural rewards.

Published
2016
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37. The Effects of Antidepressant Treatment in Prenatally Stressed Rats Support the Glutamatergic Hypothesis of Stress-Related Disorders

Author

Marrocco, J., primary, Reynaert, M.-L., additional, Gatta, E., additional, Gabriel, C., additional, Mocaer, E., additional, Di Prisco, S., additional, Merega, E., additional, Pittaluga, A., additional, Nicoletti, F., additional, Maccari, S., additional, Morley-Fletcher, S., additional, and Mairesse, J., additional

Published
2014
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38. [Impact of socio-environmental factors on physiological processes of brain damage recovery: contribution of animal models]

Author

Morley-Fletcher S, Rea M, Adriani W, and Giovanni Laviola

Subjects
Male, Disease Models, Animal, Sociology, Animals, Humans, Brain Damage, Chronic, Female, Recovery of Function, Environment, Forecasting
Abstract

This review presents the experimental approaches more widely used in animal models to investigate possible strategies aimed to stimulate plasticity in the nervous system and possibly to increase spontaneous recovery from functional/neurological diseases such as neonatal anoxia. Methods used in laboratory rodents are briefly described. Attention is focused on possible enrichments of the social and physical environment during the development.

Published
2002

42. Prenatal stress in rats predicts immobility behavior in the forced swim test. Effects of a chronic treatment with tianeptine.

Author

Morley-Fletcher, S, Darnaudery, M, Koehl, M, Casolini, P, Van Reeth, Olivier, Maccari, Stefania, Morley-Fletcher, S, Darnaudery, M, Koehl, M, Casolini, P, Van Reeth, Olivier, and Maccari, Stefania

Abstract

Prenatally-stressed (PS) rats are characterized by a general impairment of the hypothalamo-pituitary-adrenal (HPA) axis and sleep disturbances indicating that this model has face validity with some clinical features observed in a subpopulation of depressed patients. The prolonged corticosterone secretion shown by PS rats in response to stress was positively correlated with an increased immobility behavior in the forced swim test. To investigate the predictive validity of this model, a separate group of animals was chronically treated with the antidepressant tianeptine (10 mg/kg i.p. for 21 days). Such chronic treatment reduced in PS rats immobility time in the forced swim test. These findings suggest that the PS rat is an interesting animal model for the evaluation of antidepressant treatment., Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2003

43. Prenatal stress and long-term consequences: implications of glucocorticoid hormones.

Author

Maccari, Stefania, Darnaudery, M, Morley-Fletcher, S, Zuena, A R, Cinque, C, Van Reeth, Olivier, Maccari, Stefania, Darnaudery, M, Morley-Fletcher, S, Zuena, A R, Cinque, C, and Van Reeth, Olivier

Abstract

We have shown that prenatal restraint stress (PNRS) induces higher levels of anxiety, greater vulnerability to drugs, a phase advance in the circadian rhythm of locomotor activity and an increase in the paradoxical sleep in adult rats. These behavioral effects result from permanent modifications to the functioning of the brain, particularly in the feedback mechanisms of the hypothalamic-pituitary-adrenal (HPA) axis: the secretion of corticosterone is prolonged after stress and the number of the central glucocorticoid receptors is reduced. These abnormalities are associated with modifications in the synthesis and/or release of certain neurotransmitters. Dysfunction of the HPA axis is due, in part, to stress-induced maternal increase of glucocorticoids, which influences fetal brain development. Some biological abnormalities in depression can be related to those found in PNRS rats reinforcing the idea of the usefulness of PNRS rats as an appropriate animal model to study new pharmacological approaches., Journal Article, Research Support, Non-U.S. Gov't, Review, SCOPUS: cp.j, info:eu-repo/semantics/published

Published
2003

44. PW01-22 - Agomelatine Treatment Reverses Changes in Neuroplasticity Induced by Prenatal Stress in Rats

Author

Mairesse, J., primary, Morley-Fletcher, S., additional, Zuena, A., additional, Soumier, A., additional, Banasr, M., additional, Casolini, P., additional, Catalani, A., additional, Fagioli, F., additional, Van Reeth, O., additional, Gabriel-Gracia, C., additional, Mocaer, E., additional, Daszuta, A., additional, Nicoletti, F., additional, and Maccari, S., additional

Published
2010
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49. Chronic treatment with imipramine reverses immobility behaviour, hippocampal corticosteroid receptors and cortical 5-HT1A receptor mRNA in prenatally stressed rats

Author

Morley-Fletcher, S., Darnaudéry, M., Mocaer, E., Froger, N., Lanfumey, L., Laviola, G., Casolini, P., Zuena, A.R., Marzano, Lorenzo, Hamon, M., and Maccari, S.

Subjects
*CORTICOSTEROIDS, *RATS, *HIPPOCAMPUS (Brain), *MESSENGER RNA
Abstract

Prenatal stress in the rat induces enhanced reactivity of the hypothalamus–pituitary–adrenal (HPA) axis, disturbances in a variety of circadian rhythms and increased anxiety-like behaviour. Such abnormalities parallel those found in human depressed patients. Prenatally stressed (PS) rats could represent, therefore, an interesting animal model for the evaluation of the efficacy of pharmacotherapeutic intervention in psychiatric disorders that has often been addressed using control animals. In the present study, PS and non-stressed rats were chronically treated with the tricyclic antidepressant imipramine (10 mg/kg i.p. for 21 days) and assessed in the forced swim test. Glucocorticoid receptor binding sites in the hippocampus were measured and 5-HT1A receptor mRNA levels in the frontal cortex were also assessed. PS rats were characterised by increased immobility in the forced swim test, reduced hippocampal corticosteroid receptor binding and increased levels of cortical 5-HT1A mRNA. All these parameters were significantly reversed by chronic imipramine treatment. Conversely, no significant effects were observed for non-stressed rats. All these effects are consistent with the expected pharmacotherapy of depression-like abnormalities in PS rats. These results further indicate that PS rats are a relevant animal model of depression. [Copyright &y& Elsevier]

Published
2004
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